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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 1.14.99.66 (lysine-specific histone demethylase 1A) inhibitor
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Accession:CHEBI:131509 term browser browse the term
Definition:An EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of lysine-specific histone demethylase 1A (EC 1.14.99.66).
Synonyms:related_synonym: AOF2 inhibitor;   AOF2 inhibitors;   BHC110 inhibitor;   BHC110 inhibitors;   CPRF inhibitor;   CPRF inhibitors;   EC 1.14.99.66 (lysine-specific histone demethylase 1A) inhibitors;   EC 1.14.99.66 inhibitor;   EC 1.14.99.66 inhibitors;   KDM1A inhibitor;   KDM1A inhibitors;   KIAA0601 inhibitor;   KIAA0601 inhibitors;   LSD1 inhibitor;   LSD1 inhibitors;   [histone H3]-dimethyl-L-lysine(4)FAD-dependent demethylase 1A inhibitor;   [histone H3]-dimethyl-L-lysine(4)FAD-dependent demethylase 1A inhibitors;   amine oxidase (flavin containing) domain 2 inhibitor;   amine oxidase (flavin containing) domain 2 inhibitors;   lysine (K)-specific demethylase 1A inhibitor;   lysine (K)-specific demethylase 1A inhibitors;   lysine demethylase 1A inhibitor;   lysine demethylase 1A inhibitors;   lysine-specific demethylase 1A inhibitor;   lysine-specific demethylase 1A inhibitors;   lysine-specific histone demethylase 1A inhibitor;   lysine-specific histone demethylase 1A inhibitors
 xref: Wikipedia:KDM1A



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tranylcypromine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arc activity-regulated cytoskeleton-associated protein increases expression EXP Tranylcypromine results in increased expression of ARC mRNA CTD PMID:14580947 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Tranylcypromine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein] CTD PMID:19135049 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Tranylcypromine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein] CTD PMID:19135049 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Tranylcypromine results in increased expression of BDNF mRNA CTD PMID:8601816 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Tranylcypromine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] CTD PMID:19135049 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression EXP Tranylcypromine results in increased expression of CREB1 mRNA CTD PMID:8601816 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]
Tranylcypromine results in decreased activity of CYP1A2 protein
CTD PMID:15916432 PMID:24120545 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 multiple interactions ISO Tranylcypromine inhibits the reaction [CYP2A13 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] CTD PMID:18669584 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
decreases activity
ISO Tranylcypromine inhibits the reaction [[CYP2B6 protein results in increased metabolism of 7-ethoxy-4-trifluoromethylcoumarin] which results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]; Tranylcypromine inhibits the reaction [CYP2B6 protein results in increased metabolism of Bupropion]
Tranylcypromine results in decreased activity of CYP2B6 protein
CTD PMID:23850985 PMID:28119166 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
decreases activity
ISO Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Tranylcypromine inhibits the reaction [[CYP2C19 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein]; Tranylcypromine inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]
Tranylcypromine results in decreased activity of CYP2C19 protein
CTD PMID:12569440 PMID:15306208 PMID:23850985 PMID:24120545 PMID:28119166 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Tranylcypromine results in decreased activity of CYP2E1 protein CTD PMID:15155557 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO Tranylcypromine results in decreased activity of CYP2J2 protein CTD PMID:12851038 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Egr1 early growth response 1 decreases expression EXP Tranylcypromine results in decreased expression of EGR1 mRNA CTD PMID:7612155 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Tranylcypromine results in decreased expression of FOS mRNA CTD PMID:7612155 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Tranylcypromine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA] CTD PMID:12763371 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression EXP Tranylcypromine results in increased expression of NTRK2 mRNA CTD PMID:8601816 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions
ISO Tranylcypromine results in increased activity of TAAR1 protein
[Tranylcypromine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD PMID:19725810 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084
JBrowse link

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  CHEBI ontology 19812
    role 19763
      biological role 19763
        biochemical role 19380
          enzyme inhibitor 18391
            EC 1.* (oxidoreductase) inhibitor 16724
              EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 14307
                EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 12619
                  EC 1.14.99.66 (lysine-specific histone demethylase 1A) inhibitor 21
                    GSK2879552 0
                    tranylcypromine 21
                    tranylcypromine hydrochloride 0
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