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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 1.14.99.66 (lysine-specific histone demethylase 1A) inhibitor
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Accession:CHEBI:131509 term browser browse the term
Definition:An EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of lysine-specific histone demethylase 1A (EC 1.14.99.66).
Synonyms:related_synonym: AOF2 inhibitor;   AOF2 inhibitors;   BHC110 inhibitor;   BHC110 inhibitors;   CPRF inhibitor;   CPRF inhibitors;   EC 1.14.99.66 (lysine-specific histone demethylase 1A) inhibitors;   EC 1.14.99.66 inhibitor;   EC 1.14.99.66 inhibitors;   KDM1A inhibitor;   KDM1A inhibitors;   KIAA0601 inhibitor;   KIAA0601 inhibitors;   LSD1 inhibitor;   LSD1 inhibitors;   [histone H3]-dimethyl-L-lysine(4)FAD-dependent demethylase 1A inhibitor;   [histone H3]-dimethyl-L-lysine(4)FAD-dependent demethylase 1A inhibitors;   amine oxidase (flavin containing) domain 2 inhibitor;   amine oxidase (flavin containing) domain 2 inhibitors;   lysine (K)-specific demethylase 1A inhibitor;   lysine (K)-specific demethylase 1A inhibitors;   lysine demethylase 1A inhibitor;   lysine demethylase 1A inhibitors;   lysine-specific demethylase 1A inhibitor;   lysine-specific demethylase 1A inhibitors;   lysine-specific histone demethylase 1A inhibitor;   lysine-specific histone demethylase 1A inhibitors
 xref: Wikipedia:KDM1A



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tranylcypromine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arc activity regulated cytoskeletal-associated protein increases expression ISO Tranylcypromine results in increased expression of ARC mRNA CTD PMID:14580947 NCBI chr15:74,669,081...74,672,570
Ensembl chr15:74,669,083...74,672,570
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO Tranylcypromine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein] CTD PMID:19135049 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO Tranylcypromine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein] CTD PMID:19135049 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bdnf brain derived neurotrophic factor increases expression ISO Tranylcypromine results in increased expression of BDNF mRNA CTD PMID:8601816 NCBI chr 2:109,674,700...109,727,043
Ensembl chr 2:109,674,700...109,727,007
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Tranylcypromine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] CTD PMID:19135049 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression ISO Tranylcypromine results in increased expression of CREB1 mRNA CTD PMID:8601816 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]
Tranylcypromine results in decreased activity of CYP1A2 protein
CTD PMID:15916432 PMID:24120545 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 multiple interactions
decreases activity
ISO [[Tranylcypromine results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin] which results in decreased chemical synthesis of 3-cyano-7-hydroxycoumarin; [Tranylcypromine results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin; [Tranylcypromine results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; Tranylcypromine inhibits the reaction [CYP2A6 protein results in increased chemical synthesis of 7-hydroxycoumarin]; Tranylcypromine inhibits the reaction [CYP2A6 protein results in increased glutathionylation of Lamotrigine]; Tranylcypromine inhibits the reaction [CYP2A6 protein results in increased metabolism of coumarin]; Tranylcypromine inhibits the reaction [CYP2A6 protein results in increased metabolism of Nicotine] CTD PMID:10911933 PMID:11353760 PMID:15155557 PMID:15980104 PMID:19328226 More... NCBI chr 7:26,835,339...26,843,264
Ensembl chr 7:26,835,305...26,843,548
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions
decreases activity
ISO Tranylcypromine inhibits the reaction [[CYP2B6 protein results in increased metabolism of 7-ethoxy-4-trifluoromethylcoumarin] which results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]; Tranylcypromine inhibits the reaction [CYP2B6 protein results in increased metabolism of Bupropion]
Tranylcypromine results in decreased activity of CYP2B6 protein
CTD PMID:23850985 PMID:28119166 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 multiple interactions ISO Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr19:39,287,044...39,330,713
Ensembl chr19:39,269,405...39,330,713
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 multiple interactions
decreases activity
ISO Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Tranylcypromine inhibits the reaction [[CYP2C19 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein]; Tranylcypromine inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]
Tranylcypromine results in decreased activity of CYP2C19 protein
CTD PMID:12569440 PMID:15306208 PMID:23850985 PMID:24120545 PMID:28119166 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions ISO Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 multiple interactions ISO Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 multiple interactions ISO Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Tranylcypromine results in decreased activity of CYP2E1 protein CTD PMID:15155557 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 decreases activity ISO Tranylcypromine results in decreased activity of CYP2J2 protein CTD PMID:12851038 NCBI chr 4:96,568,424...96,592,523
Ensembl chr 4:96,568,429...96,591,578
JBrowse link
G Egr1 early growth response 1 decreases expression ISO Tranylcypromine results in decreased expression of EGR1 mRNA CTD PMID:7612155 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Fos FBJ osteosarcoma oncogene decreases expression ISO Tranylcypromine results in decreased expression of FOS mRNA CTD PMID:7612155 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Tranylcypromine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA] CTD PMID:12763371 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 increases expression ISO Tranylcypromine results in increased expression of NTRK2 mRNA CTD PMID:8601816 NCBI chr13:58,806,472...59,133,970
Ensembl chr13:58,806,569...59,133,970
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr 5:135,670,040...135,735,326
Ensembl chr 5:135,670,033...135,735,326
JBrowse link
G Taar1 trace amine-associated receptor 1 increases activity
multiple interactions
EXP Tranylcypromine results in increased activity of TAAR1 protein
[Tranylcypromine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD PMID:19725810 NCBI chr10:23,920,406...23,921,404
Ensembl chr10:23,920,356...23,921,469
JBrowse link

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  CHEBI ontology 21791
    role 21770
      biological role 21768
        biochemical role 21001
          enzyme inhibitor 19342
            EC 1.* (oxidoreductase) inhibitor 16967
              EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 14513
                EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 12913
                  EC 1.14.99.66 (lysine-specific histone demethylase 1A) inhibitor 22
                    GSK2879552 0
                    tranylcypromine 22
                    tranylcypromine hydrochloride 0
paths to the root