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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:7-[3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid
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Accession:CHEBI:131502 term browser browse the term
Definition:A imidazolidine-2,4-dione that is 7-(2,5-dioxoimidazolidin-4-yl)heptanoic acid in which the imidazoline ring as substituted at position 3 by a 3-(3-cyclohexyl-3-hydroxypropyl) group.
Synonyms:related_synonym: 3-(3-Cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidine-4-heptanoic acid;   Formula=C19H32N2O5;   InChI=1S/C19H32N2O5/c22-16(14-8-4-3-5-9-14)12-13-21-15(18(25)20-19(21)26)10-6-1-2-7-11-17(23)24/h14-16,22H,1-13H2,(H,23,24)(H,20,25,26);   InChIKey=ZIDQIOZJEJFMOH-UHFFFAOYSA-N;   SMILES=C(CN1C(NC(C1CCCCCCC(O)=O)=O)=O)C(C2CCCCC2)O
 xref: CAS:75693-75-3
 xref_mesh: MESH:C030669
 xref: Reaxys:964618


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7-[3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgdr prostaglandin D2 receptor multiple interactions ISO
EXP
BW 245C binds to and results in increased activity of PTGDR protein; BW 245C inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] CTD PMID:9579725, PMID:15528449, PMID:20719937 NCBI chr15:19,195,606...19,196,508 JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases response to substance ISO BW 245C results in decreased susceptibility to TGFB1 protein CTD PMID:20719937 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      chemical role 19250
        donor 18378
          Bronsted acid 18241
            oxoacid 18193
              carbon oxoacid 18073
                carboxylic acid 18061
                  monocarboxylic acid 17407
                    7-[3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid 2
                      (3R,4S)-BW 245C + 0
                      (3S,4R)-BW 245C + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organic heteromonocyclic compound 16445
                                    diazolidine 583
                                      imidazolidines 573
                                        imidazolidinone 477
                                          imidazolidine-2,4-dione 456
                                            7-[3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid 2
                                              (3R,4S)-BW 245C + 0
                                              (3S,4R)-BW 245C + 0
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