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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Wnt signalling activator
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Accession:CHEBI:131492 term browser browse the term
Definition:A substance that activates any of the Wnt signalling pathway, a group of signal transduction pathways made of proteins that pass signals from outside of a cell through cell surface receptors to the inside of the cell.
Synonyms:related_synonym: Wnt signaling activator;   Wnt signaling activators;   Wnt signalling activators


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CHIR-98014 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nanog Nanog homeobox decreases expression ISO Chir 98014 results in decreased expression of NANOG mRNA CTD PMID:22723015 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Otx2 orthodenticle homeobox 2 decreases expression ISO Chir 98014 results in decreased expression of OTX2 mRNA CTD PMID:22723015 NCBI chr15:21,942,233...21,953,034
Ensembl chr15:21,943,191...21,953,416 		JBrowse link
G Pax6 paired box 6 decreases expression ISO Chir 98014 results in decreased expression of PAX6 mRNA CTD PMID:22723015 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014 		JBrowse link
sporidesmin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 affects localization ISO sporidesmin affects the localization of CTNNB1 protein CTD PMID:28193462 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects expression ISO sporidesmin affects the expression of CYP1A2 mRNA CTD PMID:28193462 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 multiple interactions
increases expression		 ISO MIR21 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]; MIR31 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]
sporidesmin results in increased expression of CYP2C18 mRNA; sporidesmin results in increased expression of CYP2C18 protein		 CTD PMID:28193462 NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects expression
multiple interactions		 ISO sporidesmin affects the expression of CYP2C8 mRNA
MIR21 mRNA affects the reaction [sporidesmin affects the expression of CYP2C8 mRNA]		 CTD PMID:28193462
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 decreases expression ISO sporidesmin results in decreased expression of DKK3 mRNA CTD PMID:28193462 NCBI chr 1:166,237,969...166,281,271
Ensembl chr 1:166,238,238...166,280,590 		JBrowse link
G Mir132 microRNA 132 increases expression ISO sporidesmin results in increased expression of MIR132 mRNA CTD PMID:28193462 NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796 		JBrowse link
G Mir138-2 microRNA 138-2 increases expression ISO sporidesmin results in increased expression of MIR138-2 mRNA alternative form CTD PMID:28193462 NCBI chr19:10,674,193...10,674,274
Ensembl chr19:10,674,193...10,674,274 		JBrowse link
G Mir139 microRNA 139 increases expression ISO sporidesmin results in increased expression of MIR139 mRNA CTD PMID:28193462 NCBI chr 1:155,878,828...155,878,895
Ensembl chr 1:155,878,825...155,878,902 		JBrowse link
G Mir150 microRNA 150 increases expression ISO sporidesmin results in increased expression of MIR150 mRNA CTD PMID:28193462 NCBI chr 1:95,605,024...95,605,108
Ensembl chr 1:95,605,024...95,605,108 		JBrowse link
G Mir184 microRNA 184 increases expression ISO sporidesmin results in increased expression of MIR184 mRNA CTD PMID:28193462 NCBI chr 8:90,343,134...90,343,210
Ensembl chr 8:90,343,134...90,343,210 		JBrowse link
G Mir21 microRNA 21 multiple interactions
increases expression		 ISO MIR21 mRNA affects the reaction [sporidesmin affects the expression of CYP2C8 mRNA]; MIR21 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]
sporidesmin results in increased expression of MIR21 mRNA		 CTD PMID:28193462 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir293 microRNA 293 increases expression ISO sporidesmin results in increased expression of MIR371A mRNA CTD PMID:28193462 NCBI chr 1:65,963,050...65,963,121
Ensembl chr 1:65,963,050...65,963,121 		JBrowse link
G Mir295-1 microRNA 295-1 increases expression ISO sporidesmin results in increased expression of MIR372 mRNA CTD PMID:28193462 NCBI chr 1:65,962,566...65,962,646
Ensembl chr 1:65,962,566...65,962,646 		JBrowse link
G Mir31 microRNA 31 multiple interactions
increases expression		 ISO MIR31 mRNA affects the reaction [sporidesmin affects the expression of WIF1 mRNA]; MIR31 mRNA affects the reaction [sporidesmin results in decreased expression of SFRP1 mRNA]; MIR31 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]
sporidesmin results in increased expression of MIR31 mRNA		 CTD PMID:28193462 NCBI chr 5:103,599,038...103,599,143 JBrowse link
G Mir375 microRNA 375 increases expression ISO sporidesmin results in increased expression of MIR375 mRNA CTD PMID:28193462 NCBI chr 9:76,457,911...76,457,985
Ensembl chr 9:76,457,911...76,457,985 		JBrowse link
G Mir409 microRNA 409 increases expression ISO sporidesmin results in increased expression of MIR409 mRNA CTD PMID:28193462 NCBI chr 6:128,757,780...128,757,856
Ensembl chr 6:128,757,779...128,757,858 		JBrowse link
G Mir487b microRNA 487b increases expression ISO sporidesmin results in increased expression of MIR487B mRNA CTD PMID:28193462 NCBI chr 6:128,741,485...128,741,566
Ensembl chr 6:128,741,485...128,741,566 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 multiple interactions
decreases expression		 ISO MIR31 mRNA affects the reaction [sporidesmin results in decreased expression of SFRP1 mRNA] CTD PMID:28193462 NCBI chr16:68,575,763...68,613,905
Ensembl chr16:68,575,763...68,614,286 		JBrowse link
G Wif1 Wnt inhibitory factor 1 multiple interactions
affects expression		 ISO MIR31 mRNA affects the reaction [sporidesmin affects the expression of WIF1 mRNA] CTD PMID:28193462 NCBI chr 7:56,548,058...56,618,364
Ensembl chr 7:56,548,053...56,618,360 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19751
    role 19724
      biological role 19722
        biochemical role 19443
          Wnt signalling activator 22
            1-azakenpaullone 0
            AZD2858 0
            CHIR-98014 3
            LY-2090314 0
            sporidesmin A 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19751
    role 19724
      biological role 19722
        biochemical role 19443
          effector 124
            Wnt signalling activator 22
              1-azakenpaullone 0
              AZD2858 0
              CHIR-98014 3
              LY-2090314 0
              sporidesmin A 19
paths to the root