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G |
Casp3 |
caspase 3 |
increases cleavage increases activity |
ISO |
bromopyruvate results in increased cleavage of CASP3 protein bromopyruvate results in increased activity of CASP3 protein |
CTD |
PMID:24307199 PMID:28433571 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
decreases expression |
ISO |
bromopyruvate results in decreased expression of GAPDH mRNA |
CTD |
PMID:28433571 |
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NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
decreases expression |
ISO |
bromopyruvate results in decreased expression of HIF1A |
CTD |
PMID:28433571 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hk1 |
hexokinase 1 |
decreases activity |
EXP |
bromopyruvate results in decreased activity of HK1 protein |
CTD |
PMID:22349057 |
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NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131
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G |
Hk2 |
hexokinase 2 |
decreases activity decreases expression decreases response to substance |
ISO |
bromopyruvate results in decreased activity of HK2 protein bromopyruvate results in decreased expression of HK2 mRNA; bromopyruvate results in decreased expression of HK2 protein HK2 protein results in decreased susceptibility to bromopyruvate |
CTD |
PMID:21548882 PMID:28433571 |
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NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
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G |
Ldha |
lactate dehydrogenase A |
decreases expression |
ISO |
bromopyruvate results in decreased expression of LDHA mRNA |
CTD |
PMID:28433571 |
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NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
ISO |
Curcumin inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK1 protein]; S-ethyl glutathione inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:24307199 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation |
ISO |
Curcumin inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK3 protein]; S-ethyl glutathione inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:24307199 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression |
ISO |
bromopyruvate results in decreased expression of MCL1 |
CTD |
PMID:28433571 |
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NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Mtor |
mechanistic target of rapamycin kinase |
increases expression |
ISO |
bromopyruvate results in increased expression of MTOR protein modified form |
CTD |
PMID:24307199 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
increases expression |
ISO |
bromopyruvate results in increased expression of RPS6KB1 protein modified form |
CTD |
PMID:24307199 |
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NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Sdha |
succinate dehydrogenase complex flavoprotein subunit A |
decreases expression |
ISO |
bromopyruvate results in decreased expression of SDHA mRNA |
CTD |
PMID:28433571 |
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NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535
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G |
Slc16a1 |
solute carrier family 16 member 1 |
multiple interactions |
ISO |
SLC16A1 protein results in increased uptake of and results in increased susceptibility to bromopyruvate |
CTD |
PMID:23202129 |
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NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
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G |
Slc2a1 |
solute carrier family 2 member 1 |
multiple interactions decreases expression |
ISO |
[bromopyruvate results in decreased expression of SLC2A1 protein] which results in decreased uptake of Glucose bromopyruvate results in decreased expression of SLC2A1 mRNA; bromopyruvate results in decreased expression of SLC2A1 protein |
CTD |
PMID:28433571 |
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NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
SOD1 protein inhibits the reaction [bromopyruvate promotes the reaction [bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II) results in increased expression of TP53 protein]]; SOD1 protein results in decreased susceptibility to [bromopyruvate co-treated with bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II)] |
CTD |
PMID:21548882 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Stk11 |
serine/threonine kinase 11 |
decreases expression |
ISO |
bromopyruvate results in decreased expression of STK11 protein modified form |
CTD |
PMID:24307199 |
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NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
bromopyruvate promotes the reaction [bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II) results in increased expression of TP53 protein]; SOD1 protein inhibits the reaction [bromopyruvate promotes the reaction [bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II) results in increased expression of TP53 protein]] |
CTD |
PMID:21548882 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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