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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3-bromopyruvic acid
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Accession:CHEBI:131461 term browser browse the term
Definition:A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is replaced by bromine. Synthetic brominated derivative and structural analog of pyruvic acid. Highly reactive alkylating agent. Anti-cancer drug
Synonyms:exact_synonym: 3-bromo-2-oxopropanoic acid
 related_synonym: 3-BP;   3-Bromopyruvate;   Formula=C3H3BrO3;   InChI=1S/C3H3BrO3/c4-1-2(5)3(6)7/h1H2,(H,6,7);   InChIKey=PRRZDZJYSJLDBS-UHFFFAOYSA-N;   SMILES=C(O)(C(=O)CBr)=O;   bromopyruvate;   bromopyruvic acid
 xref: CAS:1113-59-3
 xref_mesh: MESH:C017092
 xref: MetaCyc:3-BROMOPYRUVATE;   PMID:26053972;   PMID:26530887;   PMID:26708213;   PMID:26715289;   PMID:26740252;   PMID:26815411;   PMID:26825851;   PMID:26862728;   PMID:26922560;   Reaxys:1746786;   Wikipedia:Bromopyruvic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:131592


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3-bromopyruvic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases cleavage
increases activity
ISO bromopyruvate results in increased cleavage of CASP3 protein
bromopyruvate results in increased activity of CASP3 protein
CTD PMID:24307199, PMID:28433571 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases expression ISO bromopyruvate results in decreased expression of GAPDH mRNA CTD PMID:28433571 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO bromopyruvate results in decreased expression of HIF1A CTD PMID:28433571 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hk1 hexokinase 1 decreases activity EXP bromopyruvate results in decreased activity of HK1 protein CTD PMID:22349057 NCBI chr20:31,911,460...31,979,780
Ensembl chr20:31,912,262...31,956,649
JBrowse link
G Hk2 hexokinase 2 decreases activity
decreases response to substance
decreases expression
ISO bromopyruvate results in decreased activity of HK2 protein
HK2 protein results in decreased susceptibility to bromopyruvate
bromopyruvate results in decreased expression of HK2 mRNA; bromopyruvate results in decreased expression of HK2 protein
CTD PMID:21548882, PMID:28433571 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO bromopyruvate results in decreased expression of LDHA mRNA CTD PMID:28433571 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO Curcumin inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK1 protein]; S-ethyl glutathione inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK1 protein] CTD PMID:24307199 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO Curcumin inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK3 protein]; S-ethyl glutathione inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK3 protein] CTD PMID:24307199 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO bromopyruvate results in decreased expression of MCL1 CTD PMID:28433571 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mtor mechanistic target of rapamycin kinase increases expression ISO bromopyruvate results in increased expression of MTOR protein modified form CTD PMID:24307199 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases expression ISO bromopyruvate results in increased expression of RPS6KB1 protein modified form CTD PMID:24307199 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A decreases expression ISO bromopyruvate results in decreased expression of SDHA mRNA CTD PMID:28433571 NCBI chr 1:31,545,631...31,570,601
Ensembl chr 1:31,545,631...31,570,601
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions ISO SLC16A1 protein results in increased uptake of and results in increased susceptibility to bromopyruvate CTD PMID:23202129 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
decreases expression
ISO [bromopyruvate results in decreased expression of SLC2A1 protein] which results in decreased uptake of Glucose
bromopyruvate results in decreased expression of SLC2A1 mRNA; bromopyruvate results in decreased expression of SLC2A1 protein
CTD PMID:28433571 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO SOD1 protein inhibits the reaction [bromopyruvate promotes the reaction [bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II) results in increased expression of TP53 protein]]; SOD1 protein results in decreased susceptibility to [bromopyruvate co-treated with bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II)] CTD PMID:21548882 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Stk11 serine/threonine kinase 11 decreases expression ISO bromopyruvate results in decreased expression of STK11 protein modified form CTD PMID:24307199 NCBI chr 7:12,440,751...12,457,513
Ensembl chr 7:12,440,751...12,457,513
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO bromopyruvate promotes the reaction [bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II) results in increased expression of TP53 protein]; SOD1 protein inhibits the reaction [bromopyruvate promotes the reaction [bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II) results in increased expression of TP53 protein]] CTD PMID:21548882 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          cofactor 15531
            pyruvic acid 48
              3-bromopyruvic acid 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          fatty acid 15845
                                            saturated fatty acid 15812
                                              propionic acid 3666
                                                pyruvic acid 48
                                                  3-bromopyruvic acid 17
paths to the root

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