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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:BAY 60-6583
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Accession:CHEBI:131358 term browser browse the term
Definition:A member of the class of cyanopyridines that is 6-amino-3,5-dicyano-4-(4-hydroxyphenyl)-2-sulfanylpyridine in which the hydroxy and sulfanyl hydrogens are replaced by cyclopropylmethyl and carboxamidomethyl groups respectively.
Synonyms:exact_synonym: 2-({6-amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl}sulfanyl)acetamide
 related_synonym: Formula=C19H17N5O2S;   InChI=1S/C19H17N5O2S/c20-7-14-17(12-3-5-13(6-4-12)26-9-11-1-2-11)15(8-21)19(24-18(14)23)27-10-16(22)25/h3-6,11H,1-2,9-10H2,(H2,22,25)(H2,23,24);   InChIKey=ZTYHZMAZUWOXNC-UHFFFAOYSA-N;   SMILES=C=1(C(=C(N=C(C1C#N)N)SCC(=O)N)C#N)C2=CC=C(C=C2)OCC3CC3
 xref: CAS:910487-58-0
 xref_mesh: MESH:C518875
 xref: PMID:24633424;   PMID:25704806;   PMID:25728851;   PMID:26161239;   PMID:26447087;   Reaxys:15017054;   Wikipedia:BAY_60-6583



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BAY 60-6583 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2B receptor multiple interactions
increases expression
EXP
ISO
BAY 60-6583 binds to and results in increased activity of ADORA2B protein
BAY 60-6583 results in increased expression of ADORA2B mRNA; BAY 60-6583 results in increased expression of ADORA2B protein
BAY 60-6583 promotes the reaction [Ethanol results in increased expression of ADORA2B mRNA]; BAY 60-6583 promotes the reaction [Ethanol results in increased expression of ADORA2B protein]
CTD PMID:19749167 PMID:35143882 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions
increases expression
ISO 1-propyl-8-(4-sulfophenyl)xanthine inhibits the reaction [[BAY 60-6583 co-treated with cobaltous chloride] results in increased expression of CXCL12 protein]; 1-propyl-8-(4-sulfophenyl)xanthine inhibits the reaction [BAY 60-6583 results in increased expression of CXCL12 protein]; [BAY 60-6583 co-treated with cobaltous chloride] results in increased expression of CXCL12 protein CTD PMID:27590504 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases expression
ISO 1-propyl-8-(4-sulfophenyl)xanthine inhibits the reaction [BAY 60-6583 results in increased expression of FGF2 protein]; [BAY 60-6583 co-treated with cobaltous chloride] results in increased expression of FGF2 protein CTD PMID:27590504 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO BAY 60-6583 inhibits the reaction [Ethanol results in increased activity of GPT protein] CTD PMID:35143882 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions
ISO BAY 60-6583 results in decreased expression of IL1B mRNA
BAY 60-6583 inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]; BAY 60-6583 inhibits the reaction [Ethanol results in increased expression of IL1B protein]
CTD PMID:35143882 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO BAY 60-6583 inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; BAY 60-6583 inhibits the reaction [Ethanol results in increased expression of IL6 protein]
BAY 60-6583 results in decreased expression of IL6 protein
CTD PMID:35143882 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO BAY 60-6583 results in increased phosphorylation of MAPK1 protein CTD PMID:27590504 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO BAY 60-6583 results in increased phosphorylation of MAPK3 protein CTD PMID:27590504 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO BAY 60-6583 inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; BAY 60-6583 inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:35143882 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

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  CHEBI ontology 19757
    role 19730
      application 19563
        anti-inflammatory agent 16462
          BAY 60-6583 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19757
    subatomic particle 19755
      composite particle 19755
        hadron 19755
          baryon 19755
            nucleon 19755
              atomic nucleus 19755
                atom 19755
                  main group element atom 19703
                    p-block element atom 19703
                      carbon group element atom 19649
                        carbon atom 19645
                          organic molecular entity 19645
                            organic group 18859
                              organic divalent group 18845
                                organodiyl group 18845
                                  carbonyl group 18809
                                    carbonyl compound 18809
                                      carboxylic acid 18530
                                        carboacyl group 17659
                                          univalent carboacyl group 17659
                                            carbamoyl group 17499
                                              carboxamide 17499
                                                monocarboxylic acid amide 15559
                                                  BAY 60-6583 9
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