Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:CGS 15943
go back to main search page
Accession:CHEBI:131351 term browser browse the term
Definition:A member of the class of triazoloquinazolines that is [1,2,4]triazolo[1,5-c]quinazoline substited at positions 2, 5 and 9 by furan-2-yl, amino and chloro groups respectively. A potent antagonist at adenosine A1 and adenosine A2A receptors.
Synonyms:exact_synonym: 9-chloro-2-(furan-2-yl)[1,2,4]triazolo[1,5-c]quinazolin-5-amine
 related_synonym: 9-Chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine;   CGS 15943A;   CGS15943;   Formula=C13H8ClN5O;   InChI=1S/C13H8ClN5O/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h1-6H,(H2,15,16);   InChIKey=MSJODEOZODDVGW-UHFFFAOYSA-N;   SMILES=N=1C2=C(C=3N(C1N)N=C(N3)C=4OC=CC4)C=C(C=C2)Cl
 xref: CAS:104615-18-1
 xref_mesh: MESH:C052410
 xref: PMID:10440083;   PMID:1888997;   PMID:1943461;   PMID:1953988;   PMID:1987452;   PMID:24521981;   PMID:2883298;   PMID:7689104;   PMID:7723470;   PMID:8007757;   PMID:8229772;   PMID:8627553;   PMID:8760180;   PMID:9933143;   Reaxys:4237267;   Wikipedia:CGS-15943


show annotations for term's descendants           Sort by:
 
CGS 15943 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 multiple interactions ISO 9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]; 9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form] CTD PMID:25633564 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Bmpr1b bone morphogenetic protein receptor type 1B increases expression ISO 9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine results in increased expression of BMPR1B mRNA CTD PMID:25633564 NCBI chr 2:247,392,195...247,662,026
Ensembl chr 2:247,403,920...247,446,882
JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 increases expression ISO 9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine results in increased expression of BMPR2 mRNA CTD PMID:25633564 NCBI chr 9:66,568,074...66,683,019
Ensembl chr 9:66,568,074...66,676,494
JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) decreases expression ISO 9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine results in decreased expression of FURIN mRNA CTD PMID:25633564 NCBI chr 1:142,185,092...142,198,167
Ensembl chr 1:142,185,094...142,197,182
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases secretion
multiple interactions
decreases expression
ISO 9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine results in decreased secretion of HAMP protein modified form
9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]; 9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]
9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine results in decreased expression of HAMP mRNA
CTD PMID:25633564 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Hjv hemojuvelin BMP co-receptor decreases expression ISO 9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine results in decreased expression of HJV mRNA CTD PMID:25633564 NCBI chr 2:198,655,437...198,659,318
Ensembl chr 2:198,655,437...198,659,317
JBrowse link
G Tfr2 transferrin receptor 2 decreases expression ISO 9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine results in decreased expression of TFR2 mRNA; 9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine results in decreased expression of TFR2 protein CTD PMID:25633564 NCBI chr12:22,177,382...22,194,330
Ensembl chr12:22,177,382...22,194,299
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            antineoplastic agent 16985
              CGS 15943 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        primary amino compound 7860
                                          CGS 15943 7
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.