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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:CGS 15943
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Accession:CHEBI:131351 term browser browse the term
Definition:A member of the class of triazoloquinazolines that is [1,2,4]triazolo[1,5-c]quinazoline substited at positions 2, 5 and 9 by furan-2-yl, amino and chloro groups respectively. A potent antagonist at adenosine A1 and adenosine A2A receptors.
Synonyms:exact_synonym: 9-chloro-2-(furan-2-yl)[1,2,4]triazolo[1,5-c]quinazolin-5-amine
 related_synonym: 9-Chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine;   CGS 15943A;   CGS15943;   Formula=C13H8ClN5O;   InChI=1S/C13H8ClN5O/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h1-6H,(H2,15,16);   InChIKey=MSJODEOZODDVGW-UHFFFAOYSA-N;   SMILES=N=1C2=C(C=3N(C1N)N=C(N3)C=4OC=CC4)C=C(C=C2)Cl
 xref: CAS:104615-18-1
 xref_mesh: MESH:C052410
 xref: PMID:10440083;   PMID:1888997;   PMID:1943461;   PMID:1953988;   PMID:1987452;   PMID:24521981;   PMID:2883298;   PMID:7689104;   PMID:7723470;   PMID:8007757;   PMID:8229772;   PMID:8627553;   PMID:8760180;   PMID:9933143;   Reaxys:4237267;   Wikipedia:CGS-15943



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CGS 15943 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 multiple interactions ISO 9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]; 9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form] CTD PMID:25633564 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Bmpr1b bone morphogenetic protein receptor type 1B increases expression ISO 9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine results in increased expression of BMPR1B mRNA CTD PMID:25633564 NCBI chr 2:230,538,252...230,871,077
Ensembl chr 2:230,541,558...230,871,368
JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 increases expression ISO 9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine results in increased expression of BMPR2 mRNA CTD PMID:25633564 NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809
JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) decreases expression ISO 9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine results in decreased expression of FURIN mRNA CTD PMID:25633564 NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases secretion
multiple interactions
decreases expression
ISO 9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine results in decreased secretion of HAMP protein modified form
9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]; 9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]
9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine results in decreased expression of HAMP mRNA
CTD PMID:25633564 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Hjv hemojuvelin BMP co-receptor decreases expression ISO 9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine results in decreased expression of HJV mRNA CTD PMID:25633564 NCBI chr 2:184,065,970...184,069,851
Ensembl chr 2:184,065,970...184,069,850
JBrowse link
G Tfr2 transferrin receptor 2 decreases expression ISO 9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine results in decreased expression of TFR2 mRNA; 9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine results in decreased expression of TFR2 protein CTD PMID:25633564 NCBI chr12:19,107,673...19,124,622
Ensembl chr12:19,107,673...19,124,591
JBrowse link

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  CHEBI ontology 20089
    role 20042
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          drug 19655
            antineoplastic agent 17669
              CGS 15943 7
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  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
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                  main group element atom 19960
                    main group molecular entity 19960
                      s-block molecular entity 19784
                        hydrogen molecular entity 19777
                          hydrides 19115
                            inorganic hydride 17901
                              pnictogen hydride 17884
                                nitrogen hydride 17773
                                  azane 17503
                                    ammonia 17521
                                      organic amino compound 17521
                                        primary amino compound 8282
                                          CGS 15943 7
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