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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:131196 term browser browse the term
Definition:A member of the class of pyrazoles that is N-[4-(pyrazol-1-yl)phenyl]glycinamide in which the pyrazole ring is substituted at positions 3 and 5 by trifluoromethyl and phenanthrene-2-yl groups respectively.
Synonyms:exact_synonym: N-{4-[5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}glycinamide
 related_synonym: AR-12;   Formula=C26H19F3N4O;   InChI=1S/C26H19F3N4O/c27-26(28,29)24-14-23(33(32-24)20-10-8-19(9-11-20)31-25(34)15-30)18-7-12-22-17(13-18)6-5-16-3-1-2-4-21(16)22/h1-14H,15,30H2,(H,31,34);   InChIKey=YULUCECVQOCQFQ-UHFFFAOYSA-N;   PDK1 inhibitor AR-12;   SMILES=C(=O)(NC1=CC=C(C=C1)N2N=C(C=C2C3=CC=4C(=C5C(=CC4)C=CC=C5)C=C3)C(F)(F)F)CN
 xref: CAS:742112-33-0
 xref_mesh: MESH:C500894
 xref: PMID:22354011;   PMID:23652278;   PMID:23706161;   PMID:25103559;   PMID:25267669;   PMID:25447826;   PMID:25482718;   PMID:25546329;   PMID:25689303;   PMID:25736380;   PMID:26419972;   PMID:26768723;   PMID:26787696;   PMID:26887051;   Reaxys:11001693;   Wikipedia:OSU-03012

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OSU-03012 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
decreases response to substance
ISO OSU 03012 results in decreased phosphorylation of AKT1 protein
AKT1 protein modified form results in decreased susceptibility to OSU 03012
CTD PMID:15205346 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 multiple interactions
decreases response to substance
ISO OSU 03012 binds to and results in decreased activity of PDPK1 protein
PDPK1 protein modified form results in decreased susceptibility to OSU 03012
CTD PMID:15205346 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        xenobiotic 18664
          phenanthrenes 251
            OSU-03012 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      carboxylic acid 18594
                                        amino acid 14919
                                          alpha-amino acid 12937
                                            L-alpha-amino acid 11598
                                              serine family amino acid 2575
                                                glycine 1617
                                                  glycine derivative 1604
                                                    OSU-03012 2
paths to the root