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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3,3',5,5'-tetraiodothyroacetic acid
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Accession:CHEBI:131194 term browser browse the term
Definition:A monocarboxylic acid that is thyroacetic acid carrying four iodo substituents at positions 3, 3', 5 and 5'.
Synonyms:related_synonym: 3,5-Diiodo-4-(4-hydroxy-3,5-diiodophenoxy)benzeneacetic acid;   Acide 3,5,3',5'-tetraiodothyroacetique;   Formula=C14H8I4O4;   InChI=1S/C14H8I4O4/c15-8-4-7(5-9(16)13(8)21)22-14-10(17)1-6(2-11(14)18)3-12(19)20/h1-2,4-5,21H,3H2,(H,19,20);   InChIKey=PPJYSSNKSXAVDB-UHFFFAOYSA-N;   SMILES=O(C1=CC(=C(C(=C1)I)O)I)C=2C(=CC(=CC2I)CC(O)=O)I;   Tetrac;   Tetraiodothyroacetic acid
 alt_id: CHEBI:45954
 xref: CAS:67-30-1;   DrugBank:DB01751;   LINCS:LSM-25628
 xref_mesh: MESH:C011126
 xref: MetaCyc:CPD-11403;   PDBeChem:T4A;   PMID:23103412;   PMID:24214887;   PMID:25258542;   PMID:25628605;   PMID:25866761;   PMID:26041883;   PMID:26307023;   PMID:26384643;   PMID:26756636;   Reaxys:2173215


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3,3',5,5'-tetraiodothyroacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp2 caspase 2 increases expression
multiple interactions
decreases expression		 ISO tetraiodothyroacetic acid results in increased expression of CASP2 mRNA
heteronemin inhibits the reaction [tetraiodothyroacetic acid results in increased expression of CASP2 mRNA]; heteronemin promotes the reaction [tetraiodothyroacetic acid results in decreased expression of CASP2 mRNA]; tetraiodothyroacetic acid inhibits the reaction [heteronemin results in decreased expression of CASP2 mRNA]		 CTD PMID:35151786 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions		 ISO tetraiodothyroacetic acid results in increased expression of CASP3 protein modified form
heteronemin promotes the reaction [tetraiodothyroacetic acid results in increased expression of CASP3 protein modified form]; tetraiodothyroacetic acid promotes the reaction [heteronemin results in increased expression of CASP3 protein modified form]		 CTD PMID:35151786 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression		 ISO [tetraiodothyroacetic acid affects the susceptibility to heteronemin] which results in increased expression of CASP8 protein modified form; heteronemin promotes the reaction [tetraiodothyroacetic acid results in increased expression of CASP8 protein modified form]
tetraiodothyroacetic acid results in increased expression of CASP8 protein; tetraiodothyroacetic acid results in increased expression of CASP8 protein modified form		 CTD PMID:35151786 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
decreases expression		 ISO tetraiodothyroacetic acid inhibits the reaction [heteronemin results in increased expression of CASP9 protein modified form]
tetraiodothyroacetic acid results in decreased expression of CASP9 protein		 CTD PMID:35151786 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions		 ISO tetraiodothyroacetic acid results in decreased expression of CCND1 mRNA
[heteronemin affects the susceptibility to tetraiodothyroacetic acid] which results in decreased expression of CCND1 protein; [tetraiodothyroacetic acid affects the susceptibility to heteronemin] which results in decreased expression of CCND1 mRNA; [tetraiodothyroacetic acid affects the susceptibility to heteronemin] which results in increased expression of CCND1 protein; heteronemin inhibits the reaction [tetraiodothyroacetic acid results in decreased expression of CCND1 mRNA]; tetraiodothyroacetic acid promotes the reaction [heteronemin results in decreased expression of CCND1 protein]		 CTD PMID:35151786 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
increases expression
multiple interactions		 ISO tetraiodothyroacetic acid results in decreased expression of CDKN1A mRNA
tetraiodothyroacetic acid results in increased expression of CDKN1A mRNA
heteronemin inhibits the reaction [tetraiodothyroacetic acid results in decreased expression of CDKN1A mRNA]; heteronemin inhibits the reaction [tetraiodothyroacetic acid results in increased expression of CDKN1A mRNA]; tetraiodothyroacetic acid inhibits the reaction [heteronemin affects the expression of CDKN1A mRNA]; tetraiodothyroacetic acid inhibits the reaction [heteronemin results in decreased expression of CDKN1A mRNA]		 CTD PMID:35151786 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cycs cytochrome c, somatic increases expression
multiple interactions		 ISO tetraiodothyroacetic acid results in increased expression of CYCS protein
tetraiodothyroacetic acid promotes the reaction [heteronemin results in increased expression of CYCS protein]		 CTD PMID:35151786 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Kdr kinase insert domain receptor decreases phosphorylation ISO tetraiodothyroacetic acid results in decreased phosphorylation of KDR protein CTD PMID:35151786 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases expression		 ISO
EXP		 [heteronemin affects the susceptibility to tetraiodothyroacetic acid] which results in decreased expression of MAPK1 protein modified form; heteronemin promotes the reaction [tetraiodothyroacetic acid results in decreased expression of MAPK1 protein modified form]; tetraiodothyroacetic acid promotes the reaction [heteronemin results in decreased expression of MAPK1 protein modified form]
tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of MAPK1 protein]		 CTD PMID:17984113 PMID:35151786 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases expression		 ISO
EXP		 [heteronemin affects the susceptibility to tetraiodothyroacetic acid] which results in decreased expression of MAPK3 protein modified form; heteronemin promotes the reaction [tetraiodothyroacetic acid results in decreased expression of MAPK3 protein modified form]; tetraiodothyroacetic acid promotes the reaction [heteronemin results in decreased expression of MAPK3 protein modified form]
tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of MAPK3 protein]		 CTD PMID:17984113 PMID:35151786 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions		 ISO tetraiodothyroacetic acid results in decreased expression of MMP9 mRNA
heteronemin inhibits the reaction [tetraiodothyroacetic acid results in decreased expression of MMP9 mRNA]; tetraiodothyroacetic acid inhibits the reaction [heteronemin results in increased expression of MMP9 mRNA]		 CTD PMID:35151786 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO tetraiodothyroacetic acid promotes the reaction [THRA protein binds to NCOA2 protein]; tetraiodothyroacetic acid promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]] CTD PMID:22227104 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]] CTD PMID:22227104 NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO tetraiodothyroacetic acid binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
decreases expression
increases expression		 ISO [tetraiodothyroacetic acid affects the susceptibility to heteronemin] which results in increased expression of PCNA protein; heteronemin inhibits the reaction [tetraiodothyroacetic acid results in increased expression of PCNA protein]; heteronemin promotes the reaction [tetraiodothyroacetic acid results in decreased expression of PCNA mRNA]; tetraiodothyroacetic acid promotes the reaction [heteronemin results in decreased expression of PCNA mRNA] CTD PMID:35151786 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO tetraiodothyroacetic acid binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Rxra retinoid X receptor alpha affects binding ISO tetraiodothyroacetic acid binds to RXRA protein CTD PMID:31566444 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases expression		 ISO [heteronemin co-treated with tetraiodothyroacetic acid] results in decreased expression of STAT3 protein
tetraiodothyroacetic acid results in decreased expression of STAT3 protein modified form		 CTD PMID:35151786 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO tetraiodothyroacetic acid binds to and results in increased activity of THRA protein; tetraiodothyroacetic acid promotes the reaction [THRA protein binds to NCOA2 protein] CTD PMID:31566444 PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions
increases activity
affects binding		 ISO tetraiodothyroacetic acid binds to and results in increased activity of THRB protein; tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; tetraiodothyroacetic acid promotes the reaction [THRB protein binds to NCOA2 protein]
tetraiodothyroacetic acid results in increased activity of THRB protein
tetraiodothyroacetic acid binds to THRB protein		 CTD PMID:22227104 PMID:31077750 PMID:31566444 PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
decreases expression		 EXP
ISO		 tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of TP53 protein modified form]
tetraiodothyroacetic acid results in decreased expression of TP53 mRNA
[heteronemin affects the susceptibility to tetraiodothyroacetic acid] which results in decreased expression of TP53 mRNA; heteronemin promotes the reaction [tetraiodothyroacetic acid results in decreased expression of TP53 mRNA]; tetraiodothyroacetic acid promotes the reaction [heteronemin results in decreased expression of TP53 mRNA]		 CTD PMID:17984113 PMID:35151786 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        biochemical role 19582
          apoptosis inducer 13663
            3,3',5,5'-tetraiodothyroacetic acid 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            organic molecule 19737
                              organic cyclic compound 19526
                                organic aromatic compound 19390
                                  phenols 18674
                                    halophenol 2540
                                      iodophenol 458
                                        3,3',5,5'-tetraiodothyroacetic acid 22
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