|
G
|
Casp2
|
caspase 2
|
increases expression multiple interactions decreases expression
|
ISO
|
tetraiodothyroacetic acid results in increased expression of CASP2 mRNA heteronemin inhibits the reaction [tetraiodothyroacetic acid results in increased expression of CASP2 mRNA]; heteronemin promotes the reaction [tetraiodothyroacetic acid results in decreased expression of CASP2 mRNA]; tetraiodothyroacetic acid inhibits the reaction [heteronemin results in decreased expression of CASP2 mRNA]
|
CTD |
PMID:35151786 |
|
NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022
|
|
G
|
Casp3
|
caspase 3
|
increases expression multiple interactions
|
ISO
|
tetraiodothyroacetic acid results in increased expression of CASP3 protein modified form heteronemin promotes the reaction [tetraiodothyroacetic acid results in increased expression of CASP3 protein modified form]; tetraiodothyroacetic acid promotes the reaction [heteronemin results in increased expression of CASP3 protein modified form]
|
CTD |
PMID:35151786 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
G
|
Casp8
|
caspase 8
|
multiple interactions increases expression
|
ISO
|
[tetraiodothyroacetic acid affects the susceptibility to heteronemin] which results in increased expression of CASP8 protein modified form; heteronemin promotes the reaction [tetraiodothyroacetic acid results in increased expression of CASP8 protein modified form] tetraiodothyroacetic acid results in increased expression of CASP8 protein; tetraiodothyroacetic acid results in increased expression of CASP8 protein modified form
|
CTD |
PMID:35151786 |
|
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
|
|
G
|
Casp9
|
caspase 9
|
multiple interactions decreases expression
|
ISO
|
tetraiodothyroacetic acid inhibits the reaction [heteronemin results in increased expression of CASP9 protein modified form] tetraiodothyroacetic acid results in decreased expression of CASP9 protein
|
CTD |
PMID:35151786 |
|
Ensembl chr 5:159,391,188...159,409,648
|
|
G
|
Ccnd1
|
cyclin D1
|
decreases expression multiple interactions
|
ISO
|
tetraiodothyroacetic acid results in decreased expression of CCND1 mRNA [heteronemin affects the susceptibility to tetraiodothyroacetic acid] which results in decreased expression of CCND1 protein; [tetraiodothyroacetic acid affects the susceptibility to heteronemin] which results in decreased expression of CCND1 mRNA; [tetraiodothyroacetic acid affects the susceptibility to heteronemin] which results in increased expression of CCND1 protein; heteronemin inhibits the reaction [tetraiodothyroacetic acid results in decreased expression of CCND1 mRNA]; tetraiodothyroacetic acid promotes the reaction [heteronemin results in decreased expression of CCND1 protein]
|
CTD |
PMID:35151786 |
|
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
|
|
G
|
Cdkn1a
|
cyclin-dependent kinase inhibitor 1A
|
decreases expression increases expression multiple interactions
|
ISO
|
tetraiodothyroacetic acid results in decreased expression of CDKN1A mRNA tetraiodothyroacetic acid results in increased expression of CDKN1A mRNA heteronemin inhibits the reaction [tetraiodothyroacetic acid results in decreased expression of CDKN1A mRNA]; heteronemin inhibits the reaction [tetraiodothyroacetic acid results in increased expression of CDKN1A mRNA]; tetraiodothyroacetic acid inhibits the reaction [heteronemin affects the expression of CDKN1A mRNA]; tetraiodothyroacetic acid inhibits the reaction [heteronemin results in decreased expression of CDKN1A mRNA]
|
CTD |
PMID:35151786 |
|
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
|
|
G
|
Cycs
|
cytochrome c, somatic
|
increases expression multiple interactions
|
ISO
|
tetraiodothyroacetic acid results in increased expression of CYCS protein tetraiodothyroacetic acid promotes the reaction [heteronemin results in increased expression of CYCS protein]
|
CTD |
PMID:35151786 |
|
NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816 Ensembl chr18:80,982,668...80,984,816
|
|
G
|
Kdr
|
kinase insert domain receptor
|
decreases phosphorylation
|
ISO
|
tetraiodothyroacetic acid results in decreased phosphorylation of KDR protein
|
CTD |
PMID:35151786 |
|
NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192
|
|
G
|
Mapk1
|
mitogen activated protein kinase 1
|
multiple interactions decreases expression
|
ISO EXP
|
[heteronemin affects the susceptibility to tetraiodothyroacetic acid] which results in decreased expression of MAPK1 protein modified form; heteronemin promotes the reaction [tetraiodothyroacetic acid results in decreased expression of MAPK1 protein modified form]; tetraiodothyroacetic acid promotes the reaction [heteronemin results in decreased expression of MAPK1 protein modified form] tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of MAPK1 protein]
|
CTD |
PMID:17984113 PMID:35151786 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
|
|
G
|
Mapk3
|
mitogen activated protein kinase 3
|
multiple interactions decreases expression
|
ISO EXP
|
[heteronemin affects the susceptibility to tetraiodothyroacetic acid] which results in decreased expression of MAPK3 protein modified form; heteronemin promotes the reaction [tetraiodothyroacetic acid results in decreased expression of MAPK3 protein modified form]; tetraiodothyroacetic acid promotes the reaction [heteronemin results in decreased expression of MAPK3 protein modified form] tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of MAPK3 protein]
|
CTD |
PMID:17984113 PMID:35151786 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
|
|
G
|
Mmp9
|
matrix metallopeptidase 9
|
decreases expression multiple interactions
|
ISO
|
tetraiodothyroacetic acid results in decreased expression of MMP9 mRNA heteronemin inhibits the reaction [tetraiodothyroacetic acid results in decreased expression of MMP9 mRNA]; tetraiodothyroacetic acid inhibits the reaction [heteronemin results in increased expression of MMP9 mRNA]
|
CTD |
PMID:35151786 |
|
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
|
|
G
|
Ncoa2
|
nuclear receptor coactivator 2
|
multiple interactions
|
ISO
|
tetraiodothyroacetic acid promotes the reaction [THRA protein binds to NCOA2 protein]; tetraiodothyroacetic acid promotes the reaction [THRB protein binds to NCOA2 protein]
|
CTD |
PMID:31566444 |
|
NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:10,618,722...10,852,776
|
|
G
|
Ncor1
|
nuclear receptor co-repressor 1
|
multiple interactions
|
ISO
|
tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]
|
CTD |
PMID:22227104 |
|
NCBI chr10:47,498,852...47,641,612
Ensembl chr10:47,498,852...47,640,350
|
|
G
|
Ncor2
|
nuclear receptor co-repressor 2
|
multiple interactions
|
ISO
|
tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]
|
CTD |
PMID:22227104 |
|
NCBI chr12:37,127,736...37,289,612
Ensembl chr12:37,127,686...37,289,612
|
|
G
|
Nr1i2
|
nuclear receptor subfamily 1, group I, member 2
|
multiple interactions
|
ISO
|
tetraiodothyroacetic acid binds to and results in increased activity of NR1I2 protein
|
CTD |
PMID:33049310 |
|
NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380
|
|
G
|
Pcna
|
proliferating cell nuclear antigen
|
multiple interactions decreases expression increases expression
|
ISO
|
[tetraiodothyroacetic acid affects the susceptibility to heteronemin] which results in increased expression of PCNA protein; heteronemin inhibits the reaction [tetraiodothyroacetic acid results in increased expression of PCNA protein]; heteronemin promotes the reaction [tetraiodothyroacetic acid results in decreased expression of PCNA mRNA]; tetraiodothyroacetic acid promotes the reaction [heteronemin results in decreased expression of PCNA mRNA]
|
CTD |
PMID:35151786 |
|
NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901
|
|
G
|
Pparg
|
peroxisome proliferator-activated receptor gamma
|
multiple interactions
|
ISO
|
tetraiodothyroacetic acid binds to and results in increased activity of PPARG protein
|
CTD |
PMID:33049310 |
|
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
|
|
G
|
Rxra
|
retinoid X receptor alpha
|
affects binding
|
ISO
|
tetraiodothyroacetic acid binds to RXRA protein
|
CTD |
PMID:31566444 |
|
NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417
|
|
G
|
Stat3
|
signal transducer and activator of transcription 3
|
multiple interactions decreases expression
|
ISO
|
[heteronemin co-treated with tetraiodothyroacetic acid] results in decreased expression of STAT3 protein tetraiodothyroacetic acid results in decreased expression of STAT3 protein modified form
|
CTD |
PMID:35151786 |
|
NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359
|
|
G
|
Thra
|
thyroid hormone receptor alpha
|
multiple interactions
|
ISO
|
tetraiodothyroacetic acid binds to and results in increased activity of THRA protein; tetraiodothyroacetic acid promotes the reaction [THRA protein binds to NCOA2 protein]
|
CTD |
PMID:31566444 PMID:33049310 |
|
NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657
|
|
G
|
Thrb
|
thyroid hormone receptor beta
|
multiple interactions increases activity affects binding
|
ISO
|
tetraiodothyroacetic acid binds to and results in increased activity of THRB protein; tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; tetraiodothyroacetic acid promotes the reaction [THRB protein binds to NCOA2 protein] tetraiodothyroacetic acid results in increased activity of THRB protein tetraiodothyroacetic acid binds to THRB protein
|
CTD |
PMID:22227104 PMID:31077750 PMID:31566444 PMID:33049310 |
|
NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680
|
|
G
|
Tp53
|
tumor protein p53
|
multiple interactions decreases expression
|
EXP ISO
|
tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of TP53 protein modified form] tetraiodothyroacetic acid results in decreased expression of TP53 mRNA [heteronemin affects the susceptibility to tetraiodothyroacetic acid] which results in decreased expression of TP53 mRNA; heteronemin promotes the reaction [tetraiodothyroacetic acid results in decreased expression of TP53 mRNA]; tetraiodothyroacetic acid promotes the reaction [heteronemin results in decreased expression of TP53 mRNA]
|
CTD |
PMID:17984113 PMID:35151786 |
|
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
|
|