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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3,3',5,5'-tetraiodothyroacetic acid
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Accession:CHEBI:131194 term browser browse the term
Definition:A monocarboxylic acid that is thyroacetic acid carrying four iodo substituents at positions 3, 3', 5 and 5'.
Synonyms:related_synonym: 3,5-Diiodo-4-(4-hydroxy-3,5-diiodophenoxy)benzeneacetic acid;   Acide 3,5,3',5'-tetraiodothyroacetique;   Formula=C14H8I4O4;   InChI=1S/C14H8I4O4/c15-8-4-7(5-9(16)13(8)21)22-14-10(17)1-6(2-11(14)18)3-12(19)20/h1-2,4-5,21H,3H2,(H,19,20);   InChIKey=PPJYSSNKSXAVDB-UHFFFAOYSA-N;   SMILES=O(C1=CC(=C(C(=C1)I)O)I)C=2C(=CC(=CC2I)CC(O)=O)I;   Tetrac;   Tetraiodothyroacetic acid
 alt_id: CHEBI:45954
 xref: CAS:67-30-1;   DrugBank:DB01751;   LINCS:LSM-25628
 xref_mesh: MESH:C011126
 xref: MetaCyc:CPD-11403;   PDBeChem:T4A;   PMID:23103412;   PMID:24214887;   PMID:25258542;   PMID:25628605;   PMID:25866761;   PMID:26041883;   PMID:26307023;   PMID:26384643;   PMID:26756636;   Reaxys:2173215


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3,3',5,5'-tetraiodothyroacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp2 caspase 2 increases expression
multiple interactions
decreases expression 		ISO tetraiodothyroacetic acid results in increased expression of CASP2 mRNA
heteronemin inhibits the reaction [tetraiodothyroacetic acid results in increased expression of CASP2 mRNA]; heteronemin promotes the reaction [tetraiodothyroacetic acid results in decreased expression of CASP2 mRNA]; tetraiodothyroacetic acid inhibits the reaction [heteronemin results in decreased expression of CASP2 mRNA] 		CTD PMID:35151786 NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions 		ISO tetraiodothyroacetic acid results in increased expression of CASP3 protein modified form
heteronemin promotes the reaction [tetraiodothyroacetic acid results in increased expression of CASP3 protein modified form]; tetraiodothyroacetic acid promotes the reaction [heteronemin results in increased expression of CASP3 protein modified form] 		CTD PMID:35151786 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression 		ISO [tetraiodothyroacetic acid affects the susceptibility to heteronemin] which results in increased expression of CASP8 protein modified form; heteronemin promotes the reaction [tetraiodothyroacetic acid results in increased expression of CASP8 protein modified form]
tetraiodothyroacetic acid results in increased expression of CASP8 protein; tetraiodothyroacetic acid results in increased expression of CASP8 protein modified form 		CTD PMID:35151786 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 multiple interactions
decreases expression 		ISO tetraiodothyroacetic acid inhibits the reaction [heteronemin results in increased expression of CASP9 protein modified form]
tetraiodothyroacetic acid results in decreased expression of CASP9 protein 		CTD PMID:35151786 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions 		ISO tetraiodothyroacetic acid results in decreased expression of CCND1 mRNA
[heteronemin affects the susceptibility to tetraiodothyroacetic acid] which results in decreased expression of CCND1 protein; [tetraiodothyroacetic acid affects the susceptibility to heteronemin] which results in decreased expression of CCND1 mRNA; [tetraiodothyroacetic acid affects the susceptibility to heteronemin] which results in increased expression of CCND1 protein; heteronemin inhibits the reaction [tetraiodothyroacetic acid results in decreased expression of CCND1 mRNA]; tetraiodothyroacetic acid promotes the reaction [heteronemin results in decreased expression of CCND1 protein] 		CTD PMID:35151786 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
increases expression
multiple interactions 		ISO tetraiodothyroacetic acid results in decreased expression of CDKN1A mRNA
tetraiodothyroacetic acid results in increased expression of CDKN1A mRNA
heteronemin inhibits the reaction [tetraiodothyroacetic acid results in decreased expression of CDKN1A mRNA]; heteronemin inhibits the reaction [tetraiodothyroacetic acid results in increased expression of CDKN1A mRNA]; tetraiodothyroacetic acid inhibits the reaction [heteronemin affects the expression of CDKN1A mRNA]; tetraiodothyroacetic acid inhibits the reaction [heteronemin results in decreased expression of CDKN1A mRNA] 		CTD PMID:35151786 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cycs cytochrome c, somatic increases expression
multiple interactions 		ISO tetraiodothyroacetic acid results in increased expression of CYCS protein
tetraiodothyroacetic acid promotes the reaction [heteronemin results in increased expression of CYCS protein] 		CTD PMID:35151786 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Kdr kinase insert domain receptor decreases phosphorylation ISO tetraiodothyroacetic acid results in decreased phosphorylation of KDR protein CTD PMID:35151786 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases expression 		ISO
EXP 		[heteronemin affects the susceptibility to tetraiodothyroacetic acid] which results in decreased expression of MAPK1 protein modified form; heteronemin promotes the reaction [tetraiodothyroacetic acid results in decreased expression of MAPK1 protein modified form]; tetraiodothyroacetic acid promotes the reaction [heteronemin results in decreased expression of MAPK1 protein modified form]
tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of MAPK1 protein] 		CTD PMID:17984113 PMID:35151786 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases expression 		ISO
EXP 		[heteronemin affects the susceptibility to tetraiodothyroacetic acid] which results in decreased expression of MAPK3 protein modified form; heteronemin promotes the reaction [tetraiodothyroacetic acid results in decreased expression of MAPK3 protein modified form]; tetraiodothyroacetic acid promotes the reaction [heteronemin results in decreased expression of MAPK3 protein modified form]
tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of MAPK3 protein] 		CTD PMID:17984113 PMID:35151786 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions 		ISO tetraiodothyroacetic acid results in decreased expression of MMP9 mRNA
heteronemin inhibits the reaction [tetraiodothyroacetic acid results in decreased expression of MMP9 mRNA]; tetraiodothyroacetic acid inhibits the reaction [heteronemin results in increased expression of MMP9 mRNA] 		CTD PMID:35151786 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO tetraiodothyroacetic acid promotes the reaction [THRA protein binds to NCOA2 protein]; tetraiodothyroacetic acid promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:10,618,722...10,852,776 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]] CTD PMID:22227104 NCBI chr10:47,498,852...47,641,612
Ensembl chr10:47,498,852...47,640,350 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]] CTD PMID:22227104 NCBI chr12:37,127,736...37,289,612
Ensembl chr12:37,127,686...37,289,612 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO tetraiodothyroacetic acid binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
decreases expression
increases expression 		ISO [tetraiodothyroacetic acid affects the susceptibility to heteronemin] which results in increased expression of PCNA protein; heteronemin inhibits the reaction [tetraiodothyroacetic acid results in increased expression of PCNA protein]; heteronemin promotes the reaction [tetraiodothyroacetic acid results in decreased expression of PCNA mRNA]; tetraiodothyroacetic acid promotes the reaction [heteronemin results in decreased expression of PCNA mRNA] CTD PMID:35151786 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO tetraiodothyroacetic acid binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Rxra retinoid X receptor alpha affects binding ISO tetraiodothyroacetic acid binds to RXRA protein CTD PMID:31566444 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases expression 		ISO [heteronemin co-treated with tetraiodothyroacetic acid] results in decreased expression of STAT3 protein
tetraiodothyroacetic acid results in decreased expression of STAT3 protein modified form 		CTD PMID:35151786 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO tetraiodothyroacetic acid binds to and results in increased activity of THRA protein; tetraiodothyroacetic acid promotes the reaction [THRA protein binds to NCOA2 protein] CTD PMID:31566444 PMID:33049310 NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions
increases activity
affects binding 		ISO tetraiodothyroacetic acid binds to and results in increased activity of THRB protein; tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; tetraiodothyroacetic acid promotes the reaction [THRB protein binds to NCOA2 protein]
tetraiodothyroacetic acid results in increased activity of THRB protein
tetraiodothyroacetic acid binds to THRB protein 		CTD PMID:22227104 PMID:31077750 PMID:31566444 PMID:33049310 NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
decreases expression 		EXP
ISO 		tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of TP53 protein modified form]
tetraiodothyroacetic acid results in decreased expression of TP53 mRNA
[heteronemin affects the susceptibility to tetraiodothyroacetic acid] which results in decreased expression of TP53 mRNA; heteronemin promotes the reaction [tetraiodothyroacetic acid results in decreased expression of TP53 mRNA]; tetraiodothyroacetic acid promotes the reaction [heteronemin results in decreased expression of TP53 mRNA] 		CTD PMID:17984113 PMID:35151786 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        biochemical role 20264
          apoptosis inducer 13731
            3,3',5,5'-tetraiodothyroacetic acid 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic aromatic compound 20237
                                  phenols 19435
                                    halophenol 2552
                                      iodophenol 464
                                        3,3',5,5'-tetraiodothyroacetic acid 22
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