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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:disodium cromoglycate
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Accession:CHEBI:128458 term browser browse the term
Definition:An organic sodium salt that is the disodium salt of cromoglycic acid.
Synonyms:exact_synonym: disodium 5,5'-[(2-hydroxypropane-1,3-diyl)bis(oxy)]bis(4-oxo-4H-chromene-2-carboxylate)
 related_synonym: DSCG;   Dinatrium salz von 1,3-bis-(2-carboxychromon-5-yloxy)-2-hydroxypropan;   Disodium 5,5'-((2-hydroxytrimethylene)bis(oxy))bis(4-oxo-4H-1-benzopyran-2-carboxylate);   FPL-670;   Formula=C23H14Na2O11;   InChI=1S/C23H16O11.2Na/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30;;/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30);;/q;2*+1/p-2;   InChIKey=VLARUOGDXDTHEH-UHFFFAOYSA-L;   Natrium cromoglicat;   SMILES=[Na+].[Na+].OC(COc1cccc2oc(cc(=O)c12)C([O-])=O)COc1cccc2oc(cc(=O)c12)C([O-])=O;   Sodium cromoglicate;   Sodium cromoglycate;   Sodium cromolyn;   Sodium salt of 5-[3-(2-carboxy-4-oxo-4H-5-chromenyloxy)-2-hydroxypropoxy]-4-oxo-4H-2-chromenecarboxylic acid;   disodium 5-[3-(2-carboxylato-4-oxo-4H-5-chromenyloxy)-2-hydroxypropoxy]-4-oxo-4H-2-chromenecarboxylate;   disodium 5-{3-[(2-carboxylato-4-oxo-4H-chromen-5-yl)oxy]-2-hydroxypropoxy}-4-oxo-4H-chromene-2-carboxylate
 alt_id: CHEBI:106480;   CHEBI:3922;   CHEBI:3923
 xref: Beilstein:3647577;   CAS:15826-37-6;   KEGG:D00526
 xref_mesh: MESH:D004205
 xref: PMID:12001789;   PMID:19107959;   PMID:26176755;   PMID:26656593;   PMID:26871132;   PMID:26964003;   PMID:3128591


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disodium cromoglycate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Cromolyn Sodium results in increased expression of ADIPOQ protein CTD PMID:23784744 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Adora3 adenosine A3 receptor decreases activity EXP Cromolyn Sodium results in decreased activity of ADORA3 protein CTD PMID:15641640 NCBI chr 2:208,336,909...208,379,217
Ensembl chr 2:208,373,154...208,376,803
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of AKT1 protein] CTD PMID:28732690 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of BCL2 protein] CTD PMID:28732690 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Cromolyn Sodium inhibits the reaction [Paclitaxel results in increased expression of CALCA protein] CTD PMID:15033348 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of CTNNB1 protein] CTD PMID:28732690 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctsd cathepsin D multiple interactions ISO [pristane co-treated with Cromolyn Sodium] results in increased expression of CTSD protein CTD PMID:8812242 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of GSK3B protein] CTD PMID:28732690 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of MAPK3 protein] CTD PMID:28732690 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases expression
EXP Cromolyn Sodium inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]
Cromolyn Sodium results in increased expression of MMP2 mRNA
CTD PMID:14577597 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP Cromolyn Sodium inhibits the reaction [POMC results in increased secretion of Corticosterone] CTD PMID:1659878 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of RELA protein] CTD PMID:28732690 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Retn resistin decreases expression ISO Cromolyn Sodium results in decreased expression of RETN protein CTD PMID:23784744 NCBI chr12:2,201,909...2,203,649
Ensembl chr12:2,201,891...2,204,249
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Cromolyn Sodium inhibits the reaction [Paclitaxel results in increased expression of TAC1 protein] CTD PMID:15033348 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Cromolyn Sodium inhibits the reaction [[hydroquinone results in increased expression of TNF protein] which results in increased susceptibility to Methacholine Chloride] CTD PMID:22414385 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

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  CHEBI ontology 19785
    role 19732
      application 19391
        anti-asthmatic agent 9173
          anti-asthmatic drug 8547
            disodium cromoglycate 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic ion 8320
                              organic anion 3011
                                carboxylic acid anion 2385
                                  dicarboxylic acid anion 213
                                    dicarboxylic acid dianion 213
                                      cromoglycate(2-) 15
                                        disodium cromoglycate 15
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