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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phosphonoformic acid
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Accession:CHEBI:127780 term browser browse the term
Definition:Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.
Synonyms:exact_synonym: dihydroxyphosphanecarboxylic acid oxide
 related_synonym: Formula=CH3O5P;   Foscarmet;   InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6);   InChIKey=ZJAOAACCNHFJAH-UHFFFAOYSA-N;   SMILES=OC(=O)P(O)(O)=O;   carboxyphosphonic acid;   foscarnet;   phosphonomethanoic acid
 alt_id: CHEBI:45085;   CHEBI:8158
 xref: CAS:4428-95-9;   DrugBank:DB00529;   Drug_Central:1241;   HMDB:HMDB0014670;   KEGG:C06456;   KNApSAcK:C00000800
 xref_mesh: MESH:D017245
 xref: PDBeChem:PPF;   PMID:11576919;   PMID:15182735;   PMID:16858125;   PMID:19213941;   PMID:19288498;   PMID:21056575;   PMID:21566148;   PMID:7518199;   Reaxys:1756501;   Wikipedia:Foscarnet
 cyclic_relationship: is_conjugate_acid_of CHEBI:60268;   is_conjugate_acid_of CHEBI:91254


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phosphonoformic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Foscarnet inhibits the reaction [Phosphates results in decreased expression of AKT1 mRNA] CTD PMID:23308213 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Dmp1 dentin matrix acidic phosphoprotein 1 multiple interactions ISO Foscarnet inhibits the reaction [Phosphates results in increased expression of DMP1 mRNA] CTD PMID:20185895 NCBI chr14:5,528,441...5,542,078
Ensembl chr14:5,528,431...5,539,323 		JBrowse link
G Phex phosphate regulating endopeptidase X-linked multiple interactions ISO Foscarnet inhibits the reaction [beta-glycerophosphoric acid results in increased expression of PHEX mRNA] CTD PMID:18500657 NCBI chr  X:37,607,553...37,856,183
Ensembl chr  X:37,610,760...37,854,469 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 increases import
multiple interactions		 EXP SLC16A1 protein results in increased import of Foscarnet
Foscarnet inhibits the reaction [SLC16A1 protein results in increased transport of Benzoic Acid]		 CTD PMID:10579682 PMID:10714609 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611 		JBrowse link
G Slc20a1 solute carrier family 20 member 1 decreases activity
increases expression
multiple interactions		 ISO
EXP		 Foscarnet results in decreased activity of SLC20A1 protein
Foscarnet results in increased expression of SLC20A1 mRNA
Foscarnet inhibits the reaction [Phosphates results in increased expression of SLC20A1 mRNA]		 CTD PMID:15641067 PMID:17438129 PMID:23308213 NCBI chr 3:116,427,095...116,441,049
Ensembl chr 3:116,427,098...116,441,051 		JBrowse link
G Slc20a2 solute carrier family 20 member 2 multiple interactions ISO Foscarnet inhibits the reaction [Phosphates results in increased expression of SLC20A2 mRNA] CTD PMID:23308213 NCBI chr16:69,460,850...69,551,418
Ensembl chr16:69,460,462...69,521,711 		JBrowse link
G Slc23a2 solute carrier family 23 member 2 multiple interactions ISO Foscarnet inhibits the reaction [Calcium results in increased expression of SLC23A2 mRNA]; Foscarnet inhibits the reaction [Phosphates results in increased expression of SLC23A2 mRNA] CTD PMID:12788230 NCBI chr 3:119,302,651...119,395,289
Ensembl chr 3:119,302,666...119,460,343 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO Foscarnet inhibits the reaction [Calcium results in increased expression of SPP1 mRNA]; Foscarnet inhibits the reaction [Phosphates results in increased expression of SPP1 mRNA]; Foscarnet inhibits the reaction [Phosphates results in increased expression of SPP1 protein] CTD PMID:12788230 PMID:17383965 PMID:18412142 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Stc1 stanniocalcin 1 increases expression EXP Foscarnet results in increased expression of STC1 mRNA CTD PMID:17438129 NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19751
    role 19724
      application 19557
        solvent 16713
          formic acid 8868
            phosphonoformic acid 9
              CMP-5'-phosphonoformic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19751
    subatomic particle 19749
      composite particle 19749
        hadron 19749
          baryon 19749
            nucleon 19749
              atomic nucleus 19749
                atom 19749
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19644
                        carbon atom 19640
                          organic molecular entity 19640
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18799
                                    carbonyl compound 18799
                                      carboxylic acid 18515
                                        monocarboxylic acid 17853
                                          formic acid 8868
                                            phosphonoformic acid 9
                                              CMP-5'-phosphonoformic acid 0
paths to the root