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Term:phosphonoformic acid
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Accession:CHEBI:127780 term browser browse the term
Definition:Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.
Synonyms:exact_synonym: dihydroxyphosphanecarboxylic acid oxide
 related_synonym: Formula=CH3O5P;   Foscarmet;   InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6);   InChIKey=ZJAOAACCNHFJAH-UHFFFAOYSA-N;   SMILES=OC(=O)P(O)(O)=O;   carboxyphosphonic acid;   foscarnet;   phosphonomethanoic acid
 alt_id: CHEBI:45085;   CHEBI:8158
 xref: CAS:4428-95-9;   DrugBank:DB00529;   Drug_Central:1241;   KEGG:C06456;   KNApSAcK:C00000800
 xref_mesh: MESH:D017245
 xref: PDBeChem:PPF;   PMID:11576919;   PMID:15182735;   PMID:16858125;   PMID:19213941;   PMID:19288498;   PMID:21056575;   PMID:21566148;   Reaxys:1756501;   Wikipedia:Foscarnet
 cyclic_relationship: is_conjugate_acid_of CHEBI:60268;   is_conjugate_acid_of CHEBI:91254

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phosphonoformic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Dmp1 dentin matrix acidic phosphoprotein 1 JBrowse link 14 6,889,851 6,923,961 RGD:6480464
G Phex phosphate regulating endopeptidase homolog, X-linked JBrowse link X 40,460,047 40,717,982 RGD:6480464
G Slc16a1 solute carrier family 16 member 1 JBrowse link 2 207,108,552 207,129,352 RGD:6480464
G Slc20a1 solute carrier family 20 member 1 JBrowse link 3 121,725,204 121,739,160 RGD:6480464
G Slc20a2 solute carrier family 20 member 2 JBrowse link 16 74,318,287 74,408,030 RGD:6480464
G Slc23a2 solute carrier family 23 member 2 JBrowse link 3 124,632,491 124,842,225 RGD:6480464
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:6480464
G Stc1 stanniocalcin 1 JBrowse link 15 50,891,137 50,901,791 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19790
    role 19738
      application 19385
        solvent 16446
          formic acid 7883
            phosphonoformic acid 9
              CMP-5'-phosphonoformic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19790
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19674
                    p-block element atom 19674
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18475
                              organic divalent group 18468
                                organodiyl group 18468
                                  carbonyl group 18366
                                    carbonyl compound 18366
                                      carboxylic acid 18034
                                        monocarboxylic acid 17285
                                          formic acid 7883
                                            phosphonoformic acid 9
                                              CMP-5'-phosphonoformic acid 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.