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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:atomoxetine
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Accession:CHEBI:127342 term browser browse the term
Definition:A secondary amino compound having methyl and 3-(2-methylphenoxy)-3-phenylpropan-1-yl substituents.
Synonyms:exact_synonym: (3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine
 related_synonym: Formula=C17H21NO;   InChI=1S/C17H21NO/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15/h3-11,17-18H,12-13H2,1-2H3/t17-/m1/s1;   InChIKey=VHGCDTVCOLNTBX-QGZVFWFLSA-N;   SMILES=CNCC[C@@H](Oc1ccccc1C)c1ccccc1;   Tomoxetina;   Tomoxetinum;   tomoxetine
 xref: CAS:83015-26-3;   DrugBank:DB00289;   Drug_Central:256;   HMDB:HMDB0014434;   KEGG:D07473;   LINCS:LSM-2452
 xref_mesh: MESH:C041930
 xref: PMID:15338851;   PMID:23048018;   Reaxys:4318684;   Wikipedia:Atomoxetine


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atomoxetine hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases hydroxylation
increases metabolic processing
multiple interactions		 ISO CYP2D6 protein results in increased hydroxylation of Atomoxetine Hydrochloride
CYP2D6 protein results in increased metabolism of Atomoxetine Hydrochloride
Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Atomoxetine Hydrochloride]		 CTD PMID:17470523 PMID:34431675 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        xenobiotic 18728
          atomoxetine 1
            atomoxetine hydrochloride 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      s-block molecular entity 19653
                        hydrogen molecular entity 19634
                          hydrides 19144
                            inorganic hydride 18161
                              pnictogen hydride 18151
                                nitrogen hydride 18064
                                  azane 17872
                                    ammonia 17871
                                      organic amino compound 17871
                                        secondary amino compound 6954
                                          atomoxetine 1
                                            atomoxetine hydrochloride 1
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