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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:atomoxetine
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Accession:CHEBI:127342 term browser browse the term
Definition:A secondary amino compound having methyl and 3-(2-methylphenoxy)-3-phenylpropan-1-yl substituents.
Synonyms:exact_synonym: (3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine
 related_synonym: Formula=C17H21NO;   InChI=1S/C17H21NO/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15/h3-11,17-18H,12-13H2,1-2H3/t17-/m1/s1;   InChIKey=VHGCDTVCOLNTBX-QGZVFWFLSA-N;   SMILES=CNCC[C@@H](Oc1ccccc1C)c1ccccc1;   Tomoxetina;   Tomoxetinum;   tomoxetine
 xref: Beilstein:4318684;   CAS:83015-26-3;   DrugBank:DB00289;   Drug_Central:256;   HMDB:HMDB0014434;   KEGG:D07473;   LINCS:LSM-2452
 xref_mesh: MESH:C041930
 xref: PMID:15338851;   PMID:23048018;   Reaxys:4318684;   Wikipedia:Atomoxetine



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atomoxetine hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases hydroxylation
increases metabolic processing
multiple interactions
ISO CYP2D6 protein results in increased hydroxylation of Atomoxetine Hydrochloride
CYP2D6 protein results in increased metabolism of Atomoxetine Hydrochloride
Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Atomoxetine Hydrochloride]
CTD PMID:17470523 PMID:34431675 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Term Annotations click to browse term
  CHEBI ontology 19659
    role 19634
      biological role 19633
        xenobiotic 18547
          atomoxetine 1
            atomoxetine hydrochloride 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    main group molecular entity 19649
                      s-block molecular entity 19457
                        hydrogen molecular entity 19450
                          hydrides 18928
                            inorganic hydride 17765
                              pnictogen hydride 17748
                                nitrogen hydride 17633
                                  azane 17403
                                    ammonia 17402
                                      organic amino compound 17402
                                        secondary amino compound 6679
                                          atomoxetine 1
                                            atomoxetine hydrochloride 1
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