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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
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Accession:CHEBI:125562 term browser browse the term
Definition:A benzamide resulting from the formal condensation of the carboxy group of 4-(dimethylamino)benzoic acid with the amino group of 7-amino-N-hydroxyheptanamide. It is a potent inhibitor of histone deacetylases and induces cell cycle arrest and apoptosis in several human cancer cell lines.
Synonyms:related_synonym: 4-dimethylamino-N-(6-hydroxycarbamoylhexyl)benzamide;   D237;   M-344;   M344;   N-hydroxy-7-(4-dimethylaminobenzoyl)aminoheptanamide;   histone deacetylase inhibitor III
 xref: DrugBank:DB02565;   Reaxys:8570090;   lincs.smallmolecule:LSM-37091;   pubmed:10579829;   pubmed:11831887;   pubmed:16263156;   pubmed:16724231;   pubmed:16773328;   pubmed:20526416;   pubmed:20828393;   pubmed:21854619;   pubmed:22436652;   pubmed:23638461;   pubmed:28380503;   pubmed:29073110
 chemrof_formula: C16H25N3O3
 chemrof_smiles: CN(C)c1ccc(C(=O)NCCCCCCC(=O)NO)cc1
 chemrof_inchi: InChI=1S/C16H25N3O3/c1-19(2)14-10-8-13(9-11-14)16(21)17-12-6-4-3-5-7-15(20)18-22/h8-11,22H,3-7,12H2,1-2H3,(H,17,21)(H,18,20)
 chemrof_inchikey: MXWDSZWTBOCWBK-UHFFFAOYSA-N


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Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        biochemical role 19888
          apoptosis inducer 13591
            4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  carboxamide 17697
                                    monocarboxylic acid amide 14860
                                      arenecarboxamide 8280
                                        benzamides 8283
                                          4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide 0
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