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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1,2,3,4-tetrahydroisoquinoline
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Accession:CHEBI:125498 term browser browse the term
Definition:An isoquinoline that has formula C9H11N.
Synonyms:related_synonym: Formula=C9H11N;   InChI=1S/C9H11N/c1-2-4-9-7-10-6-5-8(9)3-1/h1-4,10H,5-7H2;   InChIKey=UWYZHKAOTLEWKK-UHFFFAOYSA-N;   SMILES=C1CNCC2=CC=CC=C21
 xref: HMDB:HMDB0012489;   LINCS:LSM-37002
 xref_mesh: MESH:C014843


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1,2,3,4-tetrahydroisoquinoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO 1,2,3,4-tetrahydroisoquinoline binds to and results in increased activity of AHR protein CTD PMID:11790108 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Drd3 dopamine receptor D3 affects binding ISO 1,2,3,4-tetrahydroisoquinoline analog binds to DRD3 protein CTD PMID:15185375 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Il6 interleukin 6 decreases expression
decreases response to substance
EXP
ISO
1,2,3,4-tetrahydroisoquinoline results in decreased expression of IL6 mRNA
IL6 protein results in decreased susceptibility to 1,2,3,4-tetrahydroisoquinoline
CTD PMID:14737019 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Pla2g4a phospholipase A2 group IVA decreases expression EXP 1,2,3,4-tetrahydroisoquinoline results in decreased expression of PLA2G4A mRNA CTD PMID:15683734 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    chemical entity 19853
      atom 19851
        nonmetal atom 19733
          nitrogen atom 18620
            nitrogen molecular entity 18620
              organonitrogen compound 18395
                organonitrogen heterocyclic compound 17564
                  isoquinolines 434
                    1,2,3,4-tetrahydroisoquinoline 4
                      perquinoline 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      carbon group element atom 19650
                        carbon atom 19639
                          organic molecular entity 19639
                            organic molecule 19568
                              organic cyclic compound 19378
                                organic heterocyclic compound 18495
                                  organonitrogen heterocyclic compound 17564
                                    isoquinolines 434
                                      1,2,3,4-tetrahydroisoquinoline 4
                                        perquinoline 0
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