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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-(6-acetamidohexyl)acetamide
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Accession:CHEBI:125472 term browser browse the term
Definition:An acetamide that has formula C10H20N2O2.
Synonyms:exact_synonym: hexamethylene bisacetamide
 related_synonym: Formula=C10H20N2O2;   InChI=1S/C10H20N2O2/c1-9(13)11-7-5-3-4-6-8-12-10(2)14/h3-8H2,1-2H3,(H,11,13)(H,12,14);   InChIKey=BNQSTAOJRULKNX-UHFFFAOYSA-N;   SMILES=CC(=O)NCCCCCCNC(=O)C
 alt_id: MESH:C014026
 xref: HMDB:HMDB0041901;   LINCS:LSM-36966
 xref_mesh: MESH:C014026


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N-(6-acetamidohexyl)acetamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator affects expression ISO hexamethylene bisacetamide affects the expression of BAX CTD PMID:15543656 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO hexamethylene bisacetamide affects the expression of BCL2 CTD PMID:15543656 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO [Tretinoin co-treated with arsenic trioxide co-treated with hexamethylene bisacetamide] results in increased expression of BCL2A1 mRNA; [Tretinoin co-treated with hexamethylene bisacetamide] results in increased expression of BCL2A1 mRNA CTD PMID:12130515 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bcl2l1 Bcl2-like 1 affects expression ISO hexamethylene bisacetamide affects the expression of BCL2L1 CTD PMID:15543656 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO hexamethylene bisacetamide results in decreased expression of CCNE1 mRNA CTD PMID:17349212 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cd2 Cd2 molecule decreases expression ISO hexamethylene bisacetamide results in decreased expression of CD2 mRNA CTD PMID:26941288 NCBI chr 2:203,666,706...203,680,073
Ensembl chr 2:203,666,637...203,680,083
JBrowse link
G Cd44 CD44 molecule (Indian blood group) decreases expression ISO hexamethylene bisacetamide results in decreased expression of CD44 mRNA CTD PMID:17349212 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cd52 CD52 molecule decreases expression ISO hexamethylene bisacetamide results in decreased expression of CD52 mRNA CTD PMID:26941288 NCBI chr 5:152,322,910...152,324,469
Ensembl chr 5:152,322,916...152,324,469
JBrowse link
G Cd69 Cd69 molecule decreases expression ISO hexamethylene bisacetamide results in decreased expression of CD69 mRNA CTD PMID:26941288 NCBI chr 4:163,041,147...163,049,065
Ensembl chr 4:163,041,141...163,049,084
JBrowse link
G Cd74 CD74 molecule decreases expression ISO hexamethylene bisacetamide results in decreased expression of CD74 mRNA CTD PMID:26941288 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Cdc6 cell division cycle 6 decreases expression ISO hexamethylene bisacetamide results in decreased expression of CDC6 mRNA CTD PMID:26941288 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
JBrowse link
G Cdc7 cell division cycle 7 decreases expression ISO hexamethylene bisacetamide results in decreased expression of CDC7 mRNA CTD PMID:26941288 NCBI chr14:3,826,658...3,846,891
Ensembl chr14:3,826,659...3,846,891
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO hexamethylene bisacetamide results in decreased expression of CDK2 mRNA CTD PMID:26941288 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO hexamethylene bisacetamide results in increased expression of CDKN1A mRNA; hexamethylene bisacetamide results in increased expression of CDKN1A protein
[Tretinoin co-treated with hexamethylene bisacetamide] results in increased expression of CDKN1A mRNA
CTD PMID:10597302 PMID:12130515 PMID:17349212 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO hexamethylene bisacetamide results in increased expression of CDKN1B mRNA CTD PMID:17349212 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdt1 chromatin licensing and DNA replication factor 1 decreases expression ISO hexamethylene bisacetamide results in decreased expression of CDT1 mRNA CTD PMID:26941288 NCBI chr19:55,381,565...55,386,511
Ensembl chr19:55,381,565...55,386,511
JBrowse link
G Cebpe CCAAT/enhancer binding protein epsilon multiple interactions ISO [Tretinoin co-treated with arsenic trioxide co-treated with hexamethylene bisacetamide] results in increased expression of CEBPE mRNA; [Tretinoin co-treated with hexamethylene bisacetamide] results in increased expression of CEBPE mRNA CTD PMID:12130515 NCBI chr15:33,356,119...33,357,517
Ensembl chr15:33,355,947...33,358,138
JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 multiple interactions ISO [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [CHD4 protein binds to OGT protein]; [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [thiamet G results in increased O-linked glycosylation of CHD4 protein]; [Hemin co-treated with hexamethylene bisacetamide] results in decreased O-linked glycosylation of CHD4 protein CTD PMID:27231347 NCBI chr 4:157,612,531...157,645,660
Ensembl chr 4:157,612,536...157,645,659
JBrowse link
G Csf1r colony stimulating factor 1 receptor increases expression ISO hexamethylene bisacetamide results in increased expression of CSF1R mRNA CTD PMID:8445950 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
JBrowse link
G Dbf4 DBF4 zinc finger decreases expression ISO hexamethylene bisacetamide results in decreased expression of DBF4 mRNA CTD PMID:26941288 NCBI chr 4:22,898,527...22,914,091
Ensembl chr 4:22,898,527...22,914,177
JBrowse link
G Dusp6 dual specificity phosphatase 6 decreases expression ISO hexamethylene bisacetamide results in decreased expression of DUSP6 protein mutant form CTD PMID:17569113 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
JBrowse link
G Eif6 eukaryotic translation initiation factor 6 increases expression ISO hexamethylene bisacetamide results in increased expression of EIF6 protein CTD PMID:17569113 NCBI chr 3:151,356,867...151,363,201
Ensembl chr 3:151,356,868...151,363,115
JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 increases expression ISO hexamethylene bisacetamide results in increased expression of HBA-A1 mRNA CTD PMID:26941288 NCBI chr10:15,602,794...15,603,649
Ensembl chr10:15,602,794...15,603,649
JBrowse link
G Hexim1 HEXIM P-TEFb complex subunit 1 increases expression ISO hexamethylene bisacetamide results in increased expression of HEXIM1 mRNA; hexamethylene bisacetamide results in increased expression of HEXIM1 protein CTD PMID:16222702 NCBI chr10:91,200,874...91,202,986
Ensembl chr10:91,200,874...91,202,984
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO hexamethylene bisacetamide inhibits the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA] CTD PMID:12042074 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hoxa9 homeobox A9 increases expression ISO hexamethylene bisacetamide results in increased expression of HOXA9 protein CTD PMID:16973558
G Hpx hemopexin multiple interactions ISO hexamethylene bisacetamide inhibits the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA]; hexamethylene bisacetamide promotes the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased expression of MT1 mRNA]; hexamethylene bisacetamide promotes the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased expression of MT2 mRNA]; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT1 mRNA]; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT2 mRNA] CTD PMID:12042074 NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 multiple interactions ISO [Tretinoin co-treated with hexamethylene bisacetamide] results in increased expression of IFIT3 mRNA CTD PMID:12130515 NCBI chr 1:252,906,234...252,911,377
Ensembl chr 1:252,906,234...252,911,382
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 decreases expression ISO hexamethylene bisacetamide results in decreased expression of IGFBP2 mRNA CTD PMID:26941288 NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789
JBrowse link
G Itgam integrin subunit alpha M increases expression ISO hexamethylene bisacetamide results in increased expression of ITGAM protein CTD PMID:10597302 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation
increases expression
ISO hexamethylene bisacetamide results in increased phosphorylation of JUN protein
hexamethylene bisacetamide results in increased expression of JUN protein
CTD PMID:10597302 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G LOC100909544 bromodomain-containing protein 2-like multiple interactions ISO hexamethylene bisacetamide inhibits the reaction [BRD2 protein binds to SRM promoter] CTD PMID:26941288 NCBI chr20:3,910,555...3,918,348
Ensembl chr20:3,910,555...3,917,426
JBrowse link
G Mcm10 minichromosome maintenance 10 replication initiation factor decreases expression ISO hexamethylene bisacetamide results in decreased expression of MCM10 mRNA CTD PMID:26941288 NCBI chr17:77,224,218...77,245,486
Ensembl chr17:77,224,112...77,246,478
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression ISO hexamethylene bisacetamide results in decreased expression of MCM2 mRNA CTD PMID:26941288 NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 decreases expression ISO hexamethylene bisacetamide results in decreased expression of MCM3 mRNA CTD PMID:26941288 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 decreases expression ISO hexamethylene bisacetamide results in decreased expression of MCM4 mRNA CTD PMID:26941288 NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892
JBrowse link
G Mcm5 minichromosome maintenance complex component 5 decreases expression ISO hexamethylene bisacetamide results in decreased expression of MCM5 mRNA CTD PMID:26941288 NCBI chr19:14,523,482...14,561,281
Ensembl chr19:14,523,554...14,561,278
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 decreases expression ISO hexamethylene bisacetamide results in decreased expression of MCM6 mRNA CTD PMID:26941288 NCBI chr13:45,042,882...45,068,073
Ensembl chr13:45,042,882...45,068,077
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 decreases expression ISO hexamethylene bisacetamide results in decreased expression of MCM7 mRNA CTD PMID:26941288 NCBI chr12:19,306,615...19,313,877
Ensembl chr12:19,306,607...19,314,016
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [Tretinoin co-treated with arsenic trioxide co-treated with hexamethylene bisacetamide] results in decreased expression of MPO mRNA CTD PMID:12130515 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO hexamethylene bisacetamide promotes the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased expression of MT1 mRNA]; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT1 mRNA] CTD PMID:12042074 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO hexamethylene bisacetamide promotes the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased expression of MT2 mRNA]; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT2 mRNA] CTD PMID:12042074 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Myb MYB proto-oncogene, transcription factor decreases expression ISO hexamethylene bisacetamide results in decreased expression of MYB protein CTD PMID:10597302 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO hexamethylene bisacetamide results in decreased expression of MYC protein CTD PMID:10597302 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Npm1 nucleophosmin 1 decreases expression ISO hexamethylene bisacetamide results in decreased expression of NPM1 protein CTD PMID:17569113 NCBI chr10:18,080,949...18,091,062
Ensembl chr10:18,080,950...18,090,950
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase multiple interactions ISO [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [CHD4 protein binds to OGT protein] CTD PMID:27231347 NCBI chr  X:71,540,870...71,585,906
Ensembl chr  X:71,528,988...71,585,908
JBrowse link
G Pml PML nuclear body scaffold multiple interactions ISO [Tretinoin co-treated with hexamethylene bisacetamide] results in increased cleavage of PML protein mutant form CTD PMID:12130515 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Pola2 DNA polymerase alpha 2, accessory subunit decreases expression ISO hexamethylene bisacetamide results in decreased expression of POLA2 mRNA CTD PMID:26941288 NCBI chr 1:221,297,417...221,321,601
Ensembl chr 1:221,273,538...221,321,570
JBrowse link
G Pole DNA polymerase epsilon, catalytic subunit decreases expression ISO hexamethylene bisacetamide results in decreased expression of POLE mRNA CTD PMID:26941288 NCBI chr12:52,403,533...52,452,075
Ensembl chr12:52,403,529...52,452,040
JBrowse link
G Prim1 DNA primase subunit 1 decreases expression ISO hexamethylene bisacetamide results in decreased expression of PRIM1 mRNA CTD PMID:26941288 NCBI chr 7:2,435,524...2,451,169
Ensembl chr 7:2,435,553...2,451,165
JBrowse link
G Prim2 DNA primase subunit 2 decreases expression ISO hexamethylene bisacetamide results in decreased expression of PRIM2 mRNA CTD PMID:26941288 NCBI chr 9:38,535,435...38,745,058
Ensembl chr 9:38,536,920...38,745,099
JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions ISO [Tretinoin co-treated with hexamethylene bisacetamide] results in increased cleavage of RARA protein mutant form CTD PMID:12130515 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO hexamethylene bisacetamide results in decreased phosphorylation of RB1 protein CTD PMID:10597302 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rpa1 replication protein A1 decreases expression ISO hexamethylene bisacetamide results in decreased expression of RPA1 mRNA CTD PMID:26941288 NCBI chr10:62,140,419...62,191,518
Ensembl chr10:62,140,419...62,191,512
JBrowse link
G Rpa2 replication protein A2 decreases expression ISO hexamethylene bisacetamide results in decreased expression of RPA2 mRNA CTD PMID:26941288 NCBI chr 5:150,957,041...150,967,597
Ensembl chr 5:150,957,001...150,968,269
JBrowse link
G Rpa3 replication protein A3 decreases expression ISO hexamethylene bisacetamide results in decreased expression of RPA3 mRNA CTD PMID:26941288 NCBI chr 4:34,279,320...34,282,351
Ensembl chr 4:34,279,320...34,282,351
JBrowse link
G RT1-Ba RT1 class II, locus Ba decreases expression ISO hexamethylene bisacetamide results in decreased expression of H2-AA mRNA CTD PMID:26941288 NCBI chr20:4,066,133...4,070,726
Ensembl chr20:4,066,132...4,070,721
JBrowse link
G RT1-Bb RT1 class II, locus Bb decreases expression ISO hexamethylene bisacetamide results in decreased expression of H2-AB1 mRNA CTD PMID:26941288 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 decreases expression ISO hexamethylene bisacetamide results in decreased expression of H2-EB1 mRNA CTD PMID:26941288 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
JBrowse link
G Sin3b SIN3 transcription regulator family member B increases expression ISO hexamethylene bisacetamide results in increased expression of SIN3B protein CTD PMID:17569113 NCBI chr16:18,842,456...18,860,086
Ensembl chr16:18,842,456...18,860,086
JBrowse link
G Sla src-like adaptor decreases expression ISO hexamethylene bisacetamide results in decreased expression of SLA mRNA CTD PMID:26941288 NCBI chr 7:107,585,055...107,604,950
Ensembl chr 7:107,584,118...107,634,335
JBrowse link
G Slamf9 SLAM family member 9 decreases expression ISO hexamethylene bisacetamide results in decreased expression of SLAMF9 mRNA CTD PMID:26941288 NCBI chr13:90,836,419...90,856,913
Ensembl chr13:90,836,361...90,839,411
JBrowse link
G Srm spermidine synthase multiple interactions
decreases expression
ISO hexamethylene bisacetamide inhibits the reaction [BRD2 protein binds to SRM promoter]
hexamethylene bisacetamide results in decreased expression of SRM mRNA
CTD PMID:26941288 NCBI chr 5:165,405,168...165,408,325
Ensembl chr 5:165,405,168...165,408,320
JBrowse link
G Srsf1 serine and arginine rich splicing factor 1 increases expression ISO hexamethylene bisacetamide results in increased expression of SRSF1 protein CTD PMID:17569113 NCBI chr10:75,334,200...75,341,197
Ensembl chr10:75,335,146...75,341,197
JBrowse link
G Tubb4b tubulin, beta 4B class IVb increases expression ISO hexamethylene bisacetamide results in increased expression of TUBB4B protein CTD PMID:17569113 NCBI chr 3:2,441,585...2,444,369
Ensembl chr 3:2,441,733...2,444,281
JBrowse link

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  CHEBI ontology 19841
    chemical entity 19841
      atom 19839
        nonmetal atom 19720
          nitrogen atom 18613
            nitrogen molecular entity 18613
              organonitrogen compound 18386
                carboxamide 17164
                  acetamides 12401
                    N-(6-acetamidohexyl)acetamide 65
Path 2
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  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18113
                                        carboacyl group 17377
                                          univalent carboacyl group 17377
                                            carbamoyl group 17164
                                              carboxamide 17164
                                                acetamides 12401
                                                  N-(6-acetamidohexyl)acetamide 65
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