CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: N-(6-acetamidohexyl)acetamide
Accession: CHEBI:125472
browse the term
Definition: An acetamide that has formula C10H20N2O2.
Synonyms: exact_synonym: hexamethylene bisacetamide
related_synonym: Formula=C10H20N2O2; InChI=1S/C10H20N2O2/c1-9(13)11-7-5-3-4-6-8-12-10(2)14/h3-8H2,1-2H3,(H,11,13)(H,12,14); InChIKey=BNQSTAOJRULKNX-UHFFFAOYSA-N; SMILES=CC(=O)NCCCCCCNC(=O)C
alt_id: MESH:C014026
xref: HMDB:HMDB0041901; LINCS:LSM-36966
xref_mesh: MESH:C014026
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Bax
BCL2 associated X, apoptosis regulator
affects expression
ISO
hexamethylene bisacetamide affects the expression of BAX
CTD
PMID:15543656
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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Bcl2
BCL2, apoptosis regulator
affects expression
ISO
hexamethylene bisacetamide affects the expression of BCL2
CTD
PMID:15543656
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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Bcl2a1
BCL2-related protein A1
multiple interactions
ISO
[Tretinoin co-treated with arsenic trioxide co-treated with hexamethylene bisacetamide] results in increased expression of BCL2A1 mRNA; [Tretinoin co-treated with hexamethylene bisacetamide] results in increased expression of BCL2A1 mRNA
CTD
PMID:12130515
NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
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Bcl2l1
Bcl2-like 1
affects expression
ISO
hexamethylene bisacetamide affects the expression of BCL2L1
CTD
PMID:15543656
NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
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Ccne1
cyclin E1
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of CCNE1 mRNA
CTD
PMID:17349212
NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
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Cd2
Cd2 molecule
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of CD2 mRNA
CTD
PMID:26941288
NCBI chr 2:203,666,706...203,680,073
Ensembl chr 2:203,666,637...203,680,083
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Cd44
CD44 molecule (Indian blood group)
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of CD44 mRNA
CTD
PMID:17349212
NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
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Cd52
CD52 molecule
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of CD52 mRNA
CTD
PMID:26941288
NCBI chr 5:152,322,910...152,324,469
Ensembl chr 5:152,322,916...152,324,469
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Cd69
Cd69 molecule
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of CD69 mRNA
CTD
PMID:26941288
NCBI chr 4:163,041,147...163,049,065
Ensembl chr 4:163,041,141...163,049,084
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Cd74
CD74 molecule
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of CD74 mRNA
CTD
PMID:26941288
NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
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Cdc6
cell division cycle 6
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of CDC6 mRNA
CTD
PMID:26941288
NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
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Cdc7
cell division cycle 7
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of CDC7 mRNA
CTD
PMID:26941288
NCBI chr14:3,826,658...3,846,891
Ensembl chr14:3,826,659...3,846,891
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Cdk2
cyclin dependent kinase 2
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of CDK2 mRNA
CTD
PMID:26941288
NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression multiple interactions
ISO
hexamethylene bisacetamide results in increased expression of CDKN1A mRNA; hexamethylene bisacetamide results in increased expression of CDKN1A protein [Tretinoin co-treated with hexamethylene bisacetamide] results in increased expression of CDKN1A mRNA
CTD
PMID:10597302 PMID:12130515 PMID:17349212
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression
ISO
hexamethylene bisacetamide results in increased expression of CDKN1B mRNA
CTD
PMID:17349212
NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
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Cdt1
chromatin licensing and DNA replication factor 1
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of CDT1 mRNA
CTD
PMID:26941288
NCBI chr19:55,381,565...55,386,511
Ensembl chr19:55,381,565...55,386,511
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Cebpe
CCAAT/enhancer binding protein epsilon
multiple interactions
ISO
[Tretinoin co-treated with arsenic trioxide co-treated with hexamethylene bisacetamide] results in increased expression of CEBPE mRNA; [Tretinoin co-treated with hexamethylene bisacetamide] results in increased expression of CEBPE mRNA
CTD
PMID:12130515
NCBI chr15:33,356,119...33,357,517
Ensembl chr15:33,355,947...33,358,138
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Chd4
chromodomain helicase DNA binding protein 4
multiple interactions
ISO
[Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [CHD4 protein binds to OGT protein]; [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [thiamet G results in increased O-linked glycosylation of CHD4 protein]; [Hemin co-treated with hexamethylene bisacetamide] results in decreased O-linked glycosylation of CHD4 protein
CTD
PMID:27231347
NCBI chr 4:157,612,531...157,645,660
Ensembl chr 4:157,612,536...157,645,659
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Csf1r
colony stimulating factor 1 receptor
increases expression
ISO
hexamethylene bisacetamide results in increased expression of CSF1R mRNA
CTD
PMID:8445950
NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
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Dbf4
DBF4 zinc finger
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of DBF4 mRNA
CTD
PMID:26941288
NCBI chr 4:22,898,527...22,914,091
Ensembl chr 4:22,898,527...22,914,177
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Dusp6
dual specificity phosphatase 6
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of DUSP6 protein mutant form
CTD
PMID:17569113
NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
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Eif6
eukaryotic translation initiation factor 6
increases expression
ISO
hexamethylene bisacetamide results in increased expression of EIF6 protein
CTD
PMID:17569113
NCBI chr 3:151,356,867...151,363,201
Ensembl chr 3:151,356,868...151,363,115
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Hba-a1
hemoglobin alpha, adult chain 1
increases expression
ISO
hexamethylene bisacetamide results in increased expression of HBA-A1 mRNA
CTD
PMID:26941288
NCBI chr10:15,602,794...15,603,649
Ensembl chr10:15,602,794...15,603,649
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Hexim1
HEXIM P-TEFb complex subunit 1
increases expression
ISO
hexamethylene bisacetamide results in increased expression of HEXIM1 mRNA; hexamethylene bisacetamide results in increased expression of HEXIM1 protein
CTD
PMID:16222702
NCBI chr10:91,200,874...91,202,986
Ensembl chr10:91,200,874...91,202,984
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Hmox1
heme oxygenase 1
multiple interactions
ISO
hexamethylene bisacetamide inhibits the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA]
CTD
PMID:12042074
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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Hoxa9
homeobox A9
increases expression
ISO
hexamethylene bisacetamide results in increased expression of HOXA9 protein
CTD
PMID:16973558
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Hpx
hemopexin
multiple interactions
ISO
hexamethylene bisacetamide inhibits the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA]; hexamethylene bisacetamide promotes the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased expression of MT1 mRNA]; hexamethylene bisacetamide promotes the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased expression of MT2 mRNA]; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT1 mRNA]; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT2 mRNA]
CTD
PMID:12042074
NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073
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Ifit3
interferon-induced protein with tetratricopeptide repeats 3
multiple interactions
ISO
[Tretinoin co-treated with hexamethylene bisacetamide] results in increased expression of IFIT3 mRNA
CTD
PMID:12130515
NCBI chr 1:252,906,234...252,911,377
Ensembl chr 1:252,906,234...252,911,382
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Igfbp2
insulin-like growth factor binding protein 2
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of IGFBP2 mRNA
CTD
PMID:26941288
NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789
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Itgam
integrin subunit alpha M
increases expression
ISO
hexamethylene bisacetamide results in increased expression of ITGAM protein
CTD
PMID:10597302
NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases phosphorylation increases expression
ISO
hexamethylene bisacetamide results in increased phosphorylation of JUN protein hexamethylene bisacetamide results in increased expression of JUN protein
CTD
PMID:10597302
NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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LOC100909544
bromodomain-containing protein 2-like
multiple interactions
ISO
hexamethylene bisacetamide inhibits the reaction [BRD2 protein binds to SRM promoter]
CTD
PMID:26941288
NCBI chr20:3,910,555...3,918,348
Ensembl chr20:3,910,555...3,917,426
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Mcm10
minichromosome maintenance 10 replication initiation factor
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of MCM10 mRNA
CTD
PMID:26941288
NCBI chr17:77,224,218...77,245,486
Ensembl chr17:77,224,112...77,246,478
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Mcm2
minichromosome maintenance complex component 2
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of MCM2 mRNA
CTD
PMID:26941288
NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111
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Mcm3
minichromosome maintenance complex component 3
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of MCM3 mRNA
CTD
PMID:26941288
NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
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Mcm4
minichromosome maintenance complex component 4
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of MCM4 mRNA
CTD
PMID:26941288
NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892
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Mcm5
minichromosome maintenance complex component 5
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of MCM5 mRNA
CTD
PMID:26941288
NCBI chr19:14,523,482...14,561,281
Ensembl chr19:14,523,554...14,561,278
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Mcm6
minichromosome maintenance complex component 6
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of MCM6 mRNA
CTD
PMID:26941288
NCBI chr13:45,042,882...45,068,073
Ensembl chr13:45,042,882...45,068,077
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Mcm7
minichromosome maintenance complex component 7
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of MCM7 mRNA
CTD
PMID:26941288
NCBI chr12:19,306,615...19,313,877
Ensembl chr12:19,306,607...19,314,016
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Mpo
myeloperoxidase
multiple interactions
ISO
[Tretinoin co-treated with arsenic trioxide co-treated with hexamethylene bisacetamide] results in decreased expression of MPO mRNA
CTD
PMID:12130515
NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
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Mt1
metallothionein 1
multiple interactions
ISO
hexamethylene bisacetamide promotes the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased expression of MT1 mRNA]; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT1 mRNA]
CTD
PMID:12042074
NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
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Mt2A
metallothionein 2A
multiple interactions
ISO
hexamethylene bisacetamide promotes the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased expression of MT2 mRNA]; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT2 mRNA]
CTD
PMID:12042074
NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
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Myb
MYB proto-oncogene, transcription factor
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of MYB protein
CTD
PMID:10597302
NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
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Myc
MYC proto-oncogene, bHLH transcription factor
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of MYC protein
CTD
PMID:10597302
NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
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Npm1
nucleophosmin 1
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of NPM1 protein
CTD
PMID:17569113
NCBI chr10:18,080,949...18,091,062
Ensembl chr10:18,080,950...18,090,950
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Ogt
O-linked N-acetylglucosamine (GlcNAc) transferase
multiple interactions
ISO
[Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [CHD4 protein binds to OGT protein]
CTD
PMID:27231347
NCBI chr X:71,540,870...71,585,906
Ensembl chr X:71,528,988...71,585,908
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Pml
PML nuclear body scaffold
multiple interactions
ISO
[Tretinoin co-treated with hexamethylene bisacetamide] results in increased cleavage of PML protein mutant form
CTD
PMID:12130515
NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
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Pola2
DNA polymerase alpha 2, accessory subunit
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of POLA2 mRNA
CTD
PMID:26941288
NCBI chr 1:221,297,417...221,321,601
Ensembl chr 1:221,273,538...221,321,570
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Pole
DNA polymerase epsilon, catalytic subunit
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of POLE mRNA
CTD
PMID:26941288
NCBI chr12:52,403,533...52,452,075
Ensembl chr12:52,403,529...52,452,040
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Prim1
DNA primase subunit 1
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of PRIM1 mRNA
CTD
PMID:26941288
NCBI chr 7:2,435,524...2,451,169
Ensembl chr 7:2,435,553...2,451,165
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Prim2
DNA primase subunit 2
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of PRIM2 mRNA
CTD
PMID:26941288
NCBI chr 9:38,535,435...38,745,058
Ensembl chr 9:38,536,920...38,745,099
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Rara
retinoic acid receptor, alpha
multiple interactions
ISO
[Tretinoin co-treated with hexamethylene bisacetamide] results in increased cleavage of RARA protein mutant form
CTD
PMID:12130515
NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
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Rb1
RB transcriptional corepressor 1
decreases phosphorylation
ISO
hexamethylene bisacetamide results in decreased phosphorylation of RB1 protein
CTD
PMID:10597302
NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
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Rpa1
replication protein A1
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of RPA1 mRNA
CTD
PMID:26941288
NCBI chr10:62,140,419...62,191,518
Ensembl chr10:62,140,419...62,191,512
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Rpa2
replication protein A2
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of RPA2 mRNA
CTD
PMID:26941288
NCBI chr 5:150,957,041...150,967,597
Ensembl chr 5:150,957,001...150,968,269
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Rpa3
replication protein A3
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of RPA3 mRNA
CTD
PMID:26941288
NCBI chr 4:34,279,320...34,282,351
Ensembl chr 4:34,279,320...34,282,351
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RT1-Ba
RT1 class II, locus Ba
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of H2-AA mRNA
CTD
PMID:26941288
NCBI chr20:4,066,133...4,070,726
Ensembl chr20:4,066,132...4,070,721
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RT1-Bb
RT1 class II, locus Bb
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of H2-AB1 mRNA
CTD
PMID:26941288
NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
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RT1-Db1
RT1 class II, locus Db1
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of H2-EB1 mRNA
CTD
PMID:26941288
NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
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Sin3b
SIN3 transcription regulator family member B
increases expression
ISO
hexamethylene bisacetamide results in increased expression of SIN3B protein
CTD
PMID:17569113
NCBI chr16:18,842,456...18,860,086
Ensembl chr16:18,842,456...18,860,086
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Sla
src-like adaptor
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of SLA mRNA
CTD
PMID:26941288
NCBI chr 7:107,585,055...107,604,950
Ensembl chr 7:107,584,118...107,634,335
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Slamf9
SLAM family member 9
decreases expression
ISO
hexamethylene bisacetamide results in decreased expression of SLAMF9 mRNA
CTD
PMID:26941288
NCBI chr13:90,836,419...90,856,913
Ensembl chr13:90,836,361...90,839,411
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Srm
spermidine synthase
multiple interactions decreases expression
ISO
hexamethylene bisacetamide inhibits the reaction [BRD2 protein binds to SRM promoter] hexamethylene bisacetamide results in decreased expression of SRM mRNA
CTD
PMID:26941288
NCBI chr 5:165,405,168...165,408,325
Ensembl chr 5:165,405,168...165,408,320
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Srsf1
serine and arginine rich splicing factor 1
increases expression
ISO
hexamethylene bisacetamide results in increased expression of SRSF1 protein
CTD
PMID:17569113
NCBI chr10:75,334,200...75,341,197
Ensembl chr10:75,335,146...75,341,197
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Tubb4b
tubulin, beta 4B class IVb
increases expression
ISO
hexamethylene bisacetamide results in increased expression of TUBB4B protein
CTD
PMID:17569113
NCBI chr 3:2,441,585...2,444,369
Ensembl chr 3:2,441,733...2,444,281
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