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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:plerixafor
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Accession:CHEBI:125354 term browser browse the term
Definition:An azamacrocycle consisting of two cyclam rings connected by a 1,4-phenylenebis(methylene) linker. It is a CXCR4 chemokine receptor antagonist and a hematopoietic stem cell mobilizer. It is used in combination with grulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells to the perpheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma.
Synonyms:exact_synonym: 1,1'-(benzene-1,4-diyldimethanediyl)bis(1,4,8,11-tetraazacyclotetradecane)
 related_synonym: 1,1'-[1,4-phenylenebis(methylene)]bis(1,4,8,11-tetraazacyclotetradecane);   1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane;   AMD-3100;   AMD3100;   Formula=C28H54N8;   InChI=1S/C28H54N8/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36/h5-8,29-34H,1-4,9-26H2;   InChIKey=YIQPUIGJQJDJOS-UHFFFAOYSA-N;   JKL 169;   JM3100;   SDZ SID 791;   SMILES=C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3;   mozobil;   plerixaforum
 xref: CAS:110078-46-1;   DrugBank:DB06809;   Drug_Central:4410;   HMDB:HMDB0015681;   KEGG:D08971;   LINCS:LSM-36826
 xref_mesh: MESH:C088327
 xref: PMID:17324009;   PMID:18847313;   PMID:24179472;   PMID:26106388;   PMID:26154069;   PMID:26600122;   PMID:27575003;   PMID:28411174;   PMID:29461034;   PMID:30037618;   PMID:30290049;   PMID:30422351;   PMID:30776910;   PMID:7913308;   Wikipedia:Plerixafor


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plerixafor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP
ISO
plerixafor inhibits the reaction [naringin results in increased phosphorylation of AKT1 protein]
plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]
CTD PMID:18660423 PMID:29510123 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO plerixafor inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]; plerixafor inhibits the reaction [Estradiol results in decreased expression of CDH1 protein]; plerixafor inhibits the reaction [Triclosan results in decreased expression of CDH1 protein] CTD PMID:28844962 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions
decreases expression
ISO plerixafor inhibits the reaction [CXCL12 protein affects the localization of CXCR4 protein]; plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein]
plerixafor results in decreased expression of CXCL12 mRNA
CTD PMID:12220670 PMID:18660423 PMID:24157575 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases activity
decreases expression
multiple interactions
ISO plerixafor results in decreased activity of CXCR4 protein
plerixafor results in decreased expression of CXCR4 protein
plerixafor binds to and results in decreased activity of CXCR4 protein; plerixafor inhibits the reaction [bisphenol A results in increased expression of CXCR4 protein]; plerixafor inhibits the reaction [CXCL12 protein affects the localization of CXCR4 protein]; plerixafor inhibits the reaction [Estradiol results in increased expression of CXCR4 protein]; plerixafor inhibits the reaction [Triclosan results in increased expression of CXCR4 protein]
CTD PMID:12220670 PMID:17121897 PMID:28844962 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein] CTD PMID:18660423 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions ISO plerixafor inhibits the reaction [bisphenol A results in increased expression of SNAI2 protein]; plerixafor inhibits the reaction [Estradiol results in increased expression of SNAI2 protein]; plerixafor inhibits the reaction [Triclosan results in increased expression of SNAI2 protein] CTD PMID:28844962 NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Particulate Matter results in decreased susceptibility to [VEGFA protein modified form co-treated with plerixafor]
plerixafor inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]
CTD PMID:22418586 PMID:25815440 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      biological role 19723
        immunomodulator 14886
          immunological adjuvant 599
            plerixafor 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    main group molecular entity 19665
                      s-block molecular entity 19430
                        hydrogen molecular entity 19424
                          hydrides 18758
                            organic hydride 18356
                              organic fundamental parent 18356
                                hydrocarbon 18076
                                  cyclic hydrocarbon 17091
                                    monocyclic hydrocarbon 5813
                                      cycloalkane 507
                                        cyclotetradecane 7
                                          1,4,8,11-tetraazacyclotetradecane 7
                                            plerixafor 7
paths to the root