Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cefalotin
go back to main search page
Accession:CHEBI:124991 term browser browse the term
Definition:A semisynthetic, first-generation cephalosporin antibiotic with acetoxymethyl and (2-thienylacetyl)nitrilo moieties at positions 3 and 7, respectively, of the core structure. Administered parenterally during surgery and to treat a wide spectrum of blood infections.
Synonyms:exact_synonym: (6R,7R)-3-(acetoxymethyl)-8-oxo-7-(thiophen-2-ylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   7beta-(thiophen-2-ylacetamido)-3-acetoxymethyl-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: 3-Acetoxymethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid;   7-(2-Thienylacetamido)cephalosporanic acid;   7-(Thiophene-2-acetamido)cephalosporin;   CET;   Cefalothin;   Cephalothin;   Cephalotin;   Formula=C16H16N2O6S2;   InChI=1S/C16H16N2O6S2/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23)/t12-,15-/m1/s1;   InChIKey=XIURVHNZVLADCM-IUODEOHRSA-N;   SMILES=[H][C@@]1(NC(=O)Cc2cccs2)C(=O)N2C(C(O)=O)=C(COC(C)=O)CS[C@]12[H];   cefalotina;   cefalotine;   cefalotinum
 alt_id: CHEBI:41547;   CHEBI:50895
 xref: Beilstein:945586;   CAS:153-61-7;   DrugBank:DB00456;   Drug_Central:574;   HMDB:HMDB0014599;   KEGG:C07761;   KEGG:D07635;   LINCS:LSM-15184
 xref_mesh: MESH:D002512
 xref: PDBeChem:CLS;   PMID:10930630;   PMID:12569987;   PMID:12833570;   PMID:1384868;   PMID:13963283;   PMID:1701026;   PMID:2083978;   PMID:23472927;   PMID:23680238;   PMID:29017833;   PMID:6176550;   Patent:FR1384197;   Patent:US3218318;   Reaxys:945586;   Wikipedia:Cephalothin
 cyclic_relationship: is_conjugate_acid_of CHEBI:50897


show annotations for term's descendants           Sort by:
 
cefalotin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of ABCB11 mRNA CTD PMID:24657338 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of ABCC2 mRNA CTD PMID:24657338 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of ABCC3 mRNA CTD PMID:24657338 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Cephalothin results in increased expression of BAX protein CTD PMID:15012731 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Cephalothin results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:15012731 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in decreased expression of CYP8B1 mRNA CTD PMID:24657338 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Fgf19 fibroblast growth factor 19 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of FGF15 mRNA CTD PMID:24657338 NCBI chr 1:218,058,405...218,061,693
Ensembl chr 1:218,058,405...218,061,693
JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of NPC1L1 mRNA CTD PMID:24657338 NCBI chr14:86,345,946...86,560,694
Ensembl chr14:86,345,953...86,560,694
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of NR5A2 mRNA CTD PMID:24657338 NCBI chr13:53,750,470...53,870,288
Ensembl chr13:53,750,473...53,870,428
JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of SLC10A1 mRNA CTD PMID:24657338 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc25a20 solute carrier family 25 member 20 multiple interactions EXP Cephalothin binds to and results in decreased activity of SLC25A20 protein; Cephalothin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine] CTD PMID:18452908 NCBI chr 8:117,455,308...117,476,762
Ensembl chr 8:117,455,262...117,476,734
JBrowse link
G Slc51b solute carrier family 51 subunit beta multiple interactions ISO [Cephalothin co-treated with Neomycin] results in decreased expression of SLC51B mRNA CTD PMID:24657338 NCBI chr 8:70,930,196...70,938,559
Ensembl chr 8:70,930,347...70,932,986
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of SLCO1B2 mRNA CTD PMID:24657338 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Cephalothin results in increased expression of TP53 protein CTD PMID:15012731 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vdr vitamin D receptor multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of VDR mRNA CTD PMID:24657338 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          cefalotin 15
            cephalothin sodium 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                lactam 8027
                                                  beta-lactam 789
                                                    beta-lactam antibiotic 777
                                                      cephem 544
                                                        cephalosporin 543
                                                          cefalotin 15
                                                            cephalothin sodium 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.