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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cefalotin
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Accession:CHEBI:124991 term browser browse the term
Definition:A semisynthetic, first-generation cephalosporin antibiotic with acetoxymethyl and (2-thienylacetyl)nitrilo moieties at positions 3 and 7, respectively, of the core structure. Administered parenterally during surgery and to treat a wide spectrum of blood infections.
Synonyms:exact_synonym: (6R,7R)-3-(acetoxymethyl)-8-oxo-7-(thiophen-2-ylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   7beta-(thiophen-2-ylacetamido)-3-acetoxymethyl-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: 3-Acetoxymethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid;   7-(2-Thienylacetamido)cephalosporanic acid;   7-(Thiophene-2-acetamido)cephalosporin;   CET;   Cefalothin;   Cephalothin;   Cephalotin;   Formula=C16H16N2O6S2;   InChI=1S/C16H16N2O6S2/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23)/t12-,15-/m1/s1;   InChIKey=XIURVHNZVLADCM-IUODEOHRSA-N;   SMILES=[H][C@@]1(NC(=O)Cc2cccs2)C(=O)N2C(C(O)=O)=C(COC(C)=O)CS[C@]12[H];   cefalotina;   cefalotine;   cefalotinum
 alt_id: CHEBI:41547;   CHEBI:50895
 xref: Beilstein:945586;   CAS:153-61-7;   DrugBank:DB00456;   Drug_Central:574;   HMDB:HMDB0014599;   KEGG:C07761;   KEGG:D07635;   LINCS:LSM-15184
 xref_mesh: MESH:D002512
 xref: PDBeChem:CLS;   PMID:10930630;   PMID:12569987;   PMID:12833570;   PMID:1384868;   PMID:13963283;   PMID:1701026;   PMID:2083978;   PMID:23472927;   PMID:23680238;   PMID:29017833;   PMID:6176550;   Patent:FR1384197;   Patent:US3218318;   Reaxys:945586;   Wikipedia:Cephalothin
 cyclic_relationship: is_conjugate_acid_of CHEBI:50897



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cefalotin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of ABCB11 mRNA CTD PMID:24657338 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of ABCC2 mRNA CTD PMID:24657338 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of ABCC3 mRNA CTD PMID:24657338 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Cephalothin results in increased expression of BAX protein CTD PMID:15012731 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Cephalothin results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:15012731 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in decreased expression of CYP8B1 mRNA CTD PMID:24657338 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Fgf19 fibroblast growth factor 19 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of FGF15 mRNA CTD PMID:24657338 NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287
JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of NPC1L1 mRNA CTD PMID:24657338 NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of NR5A2 mRNA CTD PMID:24657338 NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326
JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of SLC10A1 mRNA CTD PMID:24657338 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc25a20 solute carrier family 25 member 20 multiple interactions EXP Cephalothin binds to and results in decreased activity of SLC25A20 protein; Cephalothin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine] CTD PMID:18452908 NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512
JBrowse link
G Slc51b SLC51 subunit beta multiple interactions ISO [Cephalothin co-treated with Neomycin] results in decreased expression of SLC51B mRNA CTD PMID:24657338 NCBI chr 8:65,931,891...65,939,953
Ensembl chr 8:65,931,890...65,940,145
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of SLCO1B2 mRNA CTD PMID:24657338 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Cephalothin results in increased expression of TP53 protein CTD PMID:15012731 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vdr vitamin D receptor multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of VDR mRNA CTD PMID:24657338 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19870
      biological role 19868
        antimicrobial agent 18273
          cefalotin 15
            cephalothin sodium 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19836
                    p-block element atom 19836
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            heteroorganic entity 19537
                              organochalcogen compound 19297
                                organooxygen compound 19215
                                  carbon oxoacid 18693
                                    carboxylic acid 18690
                                      carboacyl group 17730
                                        univalent carboacyl group 17730
                                          carbamoyl group 17575
                                            carboxamide 17575
                                              lactam 8399
                                                beta-lactam 834
                                                  beta-lactam antibiotic 819
                                                    cephem 551
                                                      cephalosporin 550
                                                        cefalotin 15
                                                          cephalothin sodium 0
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