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ONTOLOGY REPORT - ANNOTATIONS


Term:cefalotin
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Accession:CHEBI:124991 term browser browse the term
Definition:A semisynthetic, first-generation cephalosporin antibiotic with acetoxymethyl and (2-thienylacetyl)nitrilo moieties at positions 3 and 7, respectively, of the core structure. Administered parenterally during surgery and to treat a wide spectrum of blood infections.
Synonyms:exact_synonym: (6R,7R)-3-(acetoxymethyl)-8-oxo-7-(thiophen-2-ylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   7beta-(thiophen-2-ylacetamido)-3-acetoxymethyl-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: 3-Acetoxymethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid;   7-(2-Thienylacetamido)cephalosporanic acid;   7-(Thiophene-2-acetamido)cephalosporin;   CET;   Cefalothin;   Cephalothin;   Cephalotin;   Formula=C16H16N2O6S2;   InChI=1S/C16H16N2O6S2/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23)/t12-,15-/m1/s1;   InChIKey=XIURVHNZVLADCM-IUODEOHRSA-N;   SMILES=[H][C@@]1(NC(=O)Cc2cccs2)C(=O)N2C(C(O)=O)=C(COC(C)=O)CS[C@]12[H];   cefalotina;   cefalotine;   cefalotinum
 alt_id: CHEBI:41547;   CHEBI:50895
 xref: Beilstein:945586 "Beilstein";   CAS:153-61-7 "ChemIDplus";   DrugBank:DB00456;   Drug_Central:574 "DrugCentral";   HMDB:HMDB0014599;   KEGG:C07761;   KEGG:D07635;   LINCS:LSM-15184
 xref_mesh: MESH:D002512
 xref: PDBeChem:CLS;   PMID:10930630 "Europe PMC";   PMID:12569987 "Europe PMC";   PMID:12833570 "Europe PMC";   PMID:1384868 "Europe PMC";   PMID:13963283 "Europe PMC";   PMID:1701026 "Europe PMC";   PMID:2083978 "Europe PMC";   PMID:23472927 "Europe PMC";   PMID:23680238 "Europe PMC";   PMID:29017833 "Europe PMC";   PMID:6176550 "Europe PMC";   Patent:FR1384197;   Patent:US3218318;   Reaxys:945586 "Reaxys";   Wikipedia:Cephalothin
 cyclic_relationship: is_conjugate_acid_of CHEBI:50897


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cefalotin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb11 ATP binding cassette subfamily B member 11 JBrowse link 3 55,480,024 55,587,946 RGD:6480464
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 JBrowse link 8 130,548,418 130,550,388 RGD:6480464
G Fgf19 fibroblast growth factor 19 JBrowse link 1 218,058,405 218,061,693 RGD:6480464
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 JBrowse link 14 86,345,946 86,560,694 RGD:6480464
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 JBrowse link 13 53,750,470 53,870,288 RGD:6480464
G Slc10a1 solute carrier family 10 member 1 JBrowse link 6 104,617,730 104,631,355 RGD:6480464
G Slc25a20 solute carrier family 25 member 20 JBrowse link 8 117,455,308 117,476,762 RGD:6480464
G Slc51b solute carrier family 51, beta subunit JBrowse link 8 70,930,196 70,938,559 RGD:6480464
G Slco1b2 solute carrier organic anion transporter family, member 1B2 JBrowse link 4 175,814,118 175,881,775 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Vdr vitamin D receptor JBrowse link 7 139,344,452 139,394,138 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        antimicrobial agent 17154
          cefalotin 15
            cephalothin sodium 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic group 18340
                              organic divalent group 18330
                                organodiyl group 18330
                                  carbonyl group 18217
                                    carbonyl compound 18217
                                      carboxylic acid 17921
                                        carboacyl group 16944
                                          univalent carboacyl group 16944
                                            carbamoyl group 16623
                                              carboxamide 16623
                                                lactam 2855
                                                  beta-lactam 708
                                                    beta-lactam antibiotic 696
                                                      cephem 536
                                                        cephalosporin 535
                                                          cefalotin 15
                                                            cephalothin sodium 0
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