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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alpha-cyclopiazonic acids
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Accession:CHEBI:12336 term browser browse the term
Synonyms:related_synonym: alpha-Cyclopiazonsaeure;   alpha-Zyklopiazonsaeure
 chemrof_formula: C20H20N2O3


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(6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO cyclopiazonic acid results in decreased expression of BCL2 mRNA CTD PMID:33400354 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression 		ISO cyclopiazonic acid inhibits the reaction [Demecolcine results in increased activity of CASP3 protein]
cyclopiazonic acid results in increased expression of CASP3 mRNA 		CTD PMID:12530016 PMID:33400354 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 multiple interactions ISO cyclopiazonic acid inhibits the reaction [F2RL1 protein results in increased transport of Chlorides] CTD PMID:11804840 NCBI chr 2:28,507,003...28,519,954
Ensembl chr 2:28,507,003...28,519,954 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit affects response to substance EXP JUNB mRNA affects the susceptibility to cyclopiazonic acid CTD PMID:18716665 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218 		JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases cleavage ISO cyclopiazonic acid results in increased cleavage of SPTAN1 protein CTD PMID:21516125 NCBI chr 3:33,639,020...33,703,890
Ensembl chr 3:33,607,210...33,703,889 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression EXP cyclopiazonic acid results in increased expression of STAR protein CTD PMID:22001352 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO cyclopiazonic acid results in increased expression of TRP53 mRNA CTD PMID:33400354 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tp73 tumor protein p73 increases degradation ISO cyclopiazonic acid results in increased degradation of TP73 protein modified form CTD PMID:21516125 NCBI chr 5:169,903,801...169,988,075
Ensembl chr 5:169,903,801...169,963,552 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        poison 17837
          toxin 16034
            mycotoxin 12275
              cyclopiazonic acid 8
                alpha-cyclopiazonic acids 8
                  (6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one 8
                  alpha-cyclopiazonic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  organic heteropolycyclic compound 18616
                                    organic heterobicyclic compound 17442
                                      benzopyrrole 6369
                                        indoles 5968
                                          cyclopiazonic acid 8
                                            alpha-cyclopiazonic acids 8
                                              (6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one 8
                                              alpha-cyclopiazonic acid 0
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