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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fentanyl
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Accession:CHEBI:119915 term browser browse the term
Definition:A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Synonyms:exact_synonym: N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
 related_synonym: 1-phenethyl-4-(N-phenylpropionamido)piperidine;   1-phenethyl-4-N-propionylanilinopiperidine;   Duragesic;   Formula=C22H28N2O;   InChI=1S/C22H28N2O/c1-2-22(25)24(20-11-7-4-8-12-20)21-14-17-23(18-15-21)16-13-19-9-5-3-6-10-19/h3-12,21H,2,13-18H2,1H3;   InChIKey=PJMPHNIQZUBGLI-UHFFFAOYSA-N;   N-(1-Phenethyl-piperidin-4-yl)-N-phenyl-propionamide;   N-(1-phenethyl-4-piperidinyl)-N-phenylpropionamide;   N-(1-phenethyl-4-piperidyl)propionanilide;   N-(1-phenethylpiperidin-4-yl)-N-phenylpropionamide;   N-phenethyl-4-(N-propionylanilino)piperidine;   N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide;   SMILES=CCC(=O)N(C1CCN(CC1)CCc1ccccc1)c1ccccc1;   fentanilo;   fentanylum;   phentanyl
 alt_id: CHEBI:310077;   CHEBI:5012
 xref: CAS:437-38-7;   DrugBank:DB00813;   Drug_Central:1164;   KEGG:D00320
 xref_mesh: MESH:D005283
 xref: PMID:10669565;   PMID:10987438;   PMID:11585443;   PMID:14698188;   PMID:16621415;   PMID:18462178;   PMID:18728103;   PMID:30176422;   PMID:30305277;   Patent:FR1344366;   Patent:US3164600;   Reaxys:494484;   VSDB:1864;   Wikipedia:Fentanyl


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fentanyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
increases response to substance
multiple interactions 		ISO
EXP 		ABCB1 protein results in increased transport of Fentanyl
ABCB1 protein results in increased susceptibility to Fentanyl
tariquidar inhibits the reaction [ABCB1 protein results in increased transport of Fentanyl] 		CTD PMID:29669042 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Acan aggrecan decreases expression EXP Fentanyl results in decreased expression of ACAN mRNA CTD PMID:36032789 NCBI chr 1:142,390,951...142,453,779
Ensembl chr 1:142,390,951...142,453,779 		JBrowse link
G Adamts14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 decreases expression EXP Fentanyl results in decreased expression of ADAMTS14 mRNA CTD PMID:36032789 NCBI chr20:29,143,029...29,219,846
Ensembl chr20:29,685,876...29,762,682 		JBrowse link
G Adamtsl3 ADAMTS-like 3 affects expression EXP Fentanyl affects the expression of ADAMTSL3 mRNA CTD PMID:36032789 NCBI chr 1:145,698,004...146,006,195
Ensembl chr 1:145,698,004...146,006,195 		JBrowse link
G Akap5 A-kinase anchoring protein 5 increases expression EXP Fentanyl results in increased expression of AKAP5 mRNA CTD PMID:36032789 NCBI chr 6:100,787,169...100,796,712
Ensembl chr 6:100,790,148...100,796,620 		JBrowse link
G Apln apelin decreases expression EXP Fentanyl results in decreased expression of APLN mRNA CTD PMID:36032789 NCBI chr  X:127,180,801...127,213,567
Ensembl chr  X:132,081,759...132,091,246 		JBrowse link
G Arrb2 arrestin, beta 2 affects localization
multiple interactions 		ISO
EXP 		Fentanyl affects the localization of ARRB2 protein
[Fentanyl binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein 		CTD PMID:27030709 PMID:35477798 NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,645,357...55,653,487 		JBrowse link
G Bdnf brain-derived neurotrophic factor affects expression EXP Fentanyl affects the expression of BDNF mRNA CTD PMID:36032789 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Bgn biglycan affects expression EXP Fentanyl affects the expression of BGN mRNA CTD PMID:36032789 NCBI chr  X:156,348,633...156,360,797
Ensembl chr  X:156,348,615...156,360,799 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression EXP Fentanyl results in increased expression of BIRC3 mRNA CTD PMID:36032789 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590 		JBrowse link
G Bst2 bone marrow stromal cell antigen 2 increases expression EXP Fentanyl results in increased expression of BST2 mRNA CTD PMID:36032789 NCBI chr16:18,250,593...18,254,967
Ensembl chr16:18,251,847...18,254,967 		JBrowse link
G C3 complement C3 increases expression EXP Fentanyl results in increased expression of C3 mRNA CTD PMID:36032789 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339 		JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E affects expression EXP Fentanyl affects the expression of CACNA1E mRNA CTD PMID:36032789 NCBI chr13:69,125,048...69,613,795
Ensembl chr13:69,132,305...69,612,983 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Fentanyl inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]; Naloxone inhibits the reaction [Fentanyl inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]] CTD PMID:27030709 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529 		JBrowse link
G Cckbr cholecystokinin B receptor decreases expression EXP Fentanyl results in decreased expression of CCKBR mRNA CTD PMID:36032789 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:169,183,194...169,193,745 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP Fentanyl results in increased expression of CCL2 mRNA CTD PMID:36032789 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression EXP Fentanyl results in increased expression of CCL20 mRNA CTD PMID:36032789 NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression EXP Fentanyl results in increased expression of CCL7 mRNA CTD PMID:36032789 NCBI chr10:67,514,095...67,515,945
Ensembl chr10:67,514,091...67,515,947 		JBrowse link
G Cfb complement factor B increases expression EXP Fentanyl results in increased expression of CFB mRNA CTD PMID:36032789 NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,955,776...3,981,740 		JBrowse link
G Chi3l1 chitinase 3 like 1 increases expression EXP Fentanyl results in increased expression of CHI3L1 mRNA CTD PMID:36032789 NCBI chr13:48,193,839...48,201,822
Ensembl chr13:48,193,800...48,201,825 		JBrowse link
G Clstn2 calsyntenin 2 affects expression EXP Fentanyl affects the expression of CLSTN2 mRNA CTD PMID:36032789 NCBI chr 8:98,020,406...98,637,232
Ensembl chr 8:106,899,894...107,040,053 		JBrowse link
G Cntf ciliary neurotrophic factor increases expression EXP Fentanyl results in increased expression of CNTF mRNA CTD PMID:36032789 NCBI chr 1:219,312,512...219,314,535
Ensembl chr 1:219,312,512...219,314,488 		JBrowse link
G Col15a1 collagen type XV alpha 1 chain increases expression EXP Fentanyl results in increased expression of COL15A1 mRNA CTD PMID:36032789 NCBI chr 5:66,297,546...66,403,172
Ensembl chr 5:66,297,461...66,403,170 		JBrowse link
G Col26a1 collagen type XXVI alpha 1 chain increases expression EXP Fentanyl results in increased expression of COL26A1 mRNA CTD PMID:36032789 NCBI chr12:19,792,693...19,938,556
Ensembl chr12:25,429,387...25,575,206 		JBrowse link
G Col3a1 collagen type III alpha 1 chain affects expression EXP Fentanyl affects the expression of COL3A1 mRNA CTD PMID:36032789 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232 		JBrowse link
G Crh corticotropin releasing hormone affects expression
increases expression 		EXP Fentanyl affects the expression of CRH mRNA
Fentanyl results in increased expression of CRH mRNA 		CTD PMID:18819432 PMID:36032789 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386 		JBrowse link
G Crlf1 cytokine receptor-like factor 1 affects expression EXP Fentanyl affects the expression of CRLF1 mRNA CTD PMID:36032789 NCBI chr16:18,924,722...18,936,049
Ensembl chr16:18,957,956...18,969,970 		JBrowse link
G Csf1 colony stimulating factor 1 increases expression EXP Fentanyl results in increased expression of CSF1 mRNA CTD PMID:36032789 NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:198,065,405...198,084,468 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP Fentanyl results in increased expression of CXCL1 mRNA CTD PMID:36032789 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression EXP Fentanyl results in increased expression of CXCL10 mRNA CTD PMID:36032789 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression EXP Fentanyl results in increased expression of CXCL11 mRNA CTD PMID:36032789 NCBI chr14:15,973,728...15,976,503
Ensembl chr14:15,973,720...15,976,567 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression EXP Fentanyl results in increased expression of CXCL12 mRNA CTD PMID:36032789 NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627 		JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 increases expression EXP Fentanyl results in increased expression of CXCL13 mRNA CTD PMID:36032789 NCBI chr14:13,912,858...13,917,920
Ensembl chr14:13,912,858...13,917,920 		JBrowse link
G Cxcl16 C-X-C motif chemokine ligand 16 increases expression EXP Fentanyl results in increased expression of CXCL16 mRNA CTD PMID:36032789 NCBI chr10:55,665,355...55,669,950
Ensembl chr10:55,664,742...55,670,226 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity ISO Fentanyl results in increased activity of CYP2B6 protein CTD PMID:35914676 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of Fentanyl CTD PMID:11811955 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Dcn decorin increases expression EXP Fentanyl results in increased expression of DCN mRNA CTD PMID:36032789 NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:34,163,011...34,218,926 		JBrowse link
G Ednrb endothelin receptor type B decreases expression EXP Fentanyl results in decreased expression of EDNRB mRNA CTD PMID:36032789 NCBI chr15:87,055,490...87,086,765
Ensembl chr15:87,057,691...87,086,765 		JBrowse link
G Fbln5 fibulin 5 decreases expression EXP Fentanyl results in decreased expression of FBLN5 mRNA CTD PMID:36032789 NCBI chr 6:120,899,219...120,977,829
Ensembl chr 6:126,664,100...126,746,296 		JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase increases expression EXP Fentanyl results in increased expression of FGR mRNA CTD PMID:36032789 NCBI chr 5:150,473,767...150,503,524
Ensembl chr 5:150,473,792...150,503,169 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Fentanyl results in increased expression of FOS protein CTD PMID:7970238 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Gast gastrin multiple interactions EXP [fluanisone co-treated with Fentanyl co-treated with Midazolam] inhibits the reaction [GAST protein results in increased secretion of Histamine] CTD PMID:10864877 NCBI chr10:85,765,216...85,767,881
Ensembl chr10:85,765,216...85,767,880 		JBrowse link
G Gbp2 guanylate binding protein 2 increases expression EXP Fentanyl results in increased expression of GBP2 mRNA CTD PMID:36032789 NCBI chr 2:234,005,727...234,021,812
Ensembl chr 2:234,008,590...234,021,810 		JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist decreases expression EXP Fentanyl results in decreased expression of GREM1 mRNA CTD PMID:36032789 NCBI chr 3:120,966,639...120,978,319
Ensembl chr 3:120,966,623...120,979,089 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A affects expression EXP Fentanyl affects the expression of GRIN2A mRNA CTD PMID:36032789 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B affects expression EXP Fentanyl affects the expression of GRIN2B mRNA CTD PMID:36032789 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570 		JBrowse link
G Grm1 glutamate metabotropic receptor 1 affects expression EXP Fentanyl affects the expression of GRM1 mRNA CTD PMID:36032789 NCBI chr 1:6,878,542...7,273,447
Ensembl chr 1:6,878,545...7,273,443 		JBrowse link
G Grm3 glutamate metabotropic receptor 3 affects expression EXP Fentanyl affects the expression of GRM3 mRNA CTD PMID:36032789 NCBI chr 4:25,319,218...25,600,721
Ensembl chr 4:25,319,942...25,564,764 		JBrowse link
G Has1 hyaluronan synthase 1 decreases expression EXP Fentanyl results in decreased expression of HAS1 mRNA CTD PMID:36032789 NCBI chr 1:67,366,460...67,378,686
Ensembl chr 1:67,366,460...67,378,444 		JBrowse link
G Hcrtr1 hypocretin receptor 1 decreases expression EXP Fentanyl results in decreased expression of HCRTR1 mRNA CTD PMID:36032789 NCBI chr 5:142,477,214...142,486,674
Ensembl chr 5:147,760,145...147,770,850 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A affects expression EXP Fentanyl affects the expression of HTR2A mRNA CTD PMID:36032789 NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619 		JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 increases expression EXP Fentanyl results in increased expression of IFIT3 mRNA CTD PMID:36032789 NCBI chr 1:241,527,326...241,532,469
Ensembl chr 1:241,526,880...241,532,521 		JBrowse link
G Il1a interleukin 1 alpha increases expression EXP Fentanyl results in increased expression of IL1A mRNA CTD PMID:36032789 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il2 interleukin 2 decreases expression ISO Fentanyl results in decreased expression of IL2 mRNA CTD PMID:23965172 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Il4 interleukin 4 increases expression ISO Fentanyl results in increased expression of IL4 mRNA CTD PMID:23965172 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il7 interleukin 7 increases expression EXP Fentanyl results in increased expression of IL7 mRNA CTD PMID:36032789 NCBI chr 2:96,142,523...96,186,282
Ensembl chr 2:96,142,092...96,187,389 		JBrowse link
G Irf7 interferon regulatory factor 7 increases expression EXP Fentanyl results in increased expression of IRF7 mRNA CTD PMID:36032789 NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:205,796,959...205,800,023 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier increases expression EXP Fentanyl results in increased expression of ISG15 mRNA CTD PMID:36032789 NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:172,066,369...172,067,656 		JBrowse link
G Itga11 integrin subunit alpha 11 increases expression EXP Fentanyl results in increased expression of ITGA11 mRNA CTD PMID:36032789 NCBI chr 8:72,041,432...72,150,137
Ensembl chr 8:72,016,652...72,150,137 		JBrowse link
G Itgal integrin subunit alpha L increases expression EXP Fentanyl results in increased expression of ITGAL mRNA CTD PMID:36032789 NCBI chr 1:191,348,424...191,386,228
Ensembl chr 1:191,348,542...191,386,225 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Fentanyl results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
G Lamb3 laminin subunit beta 3 decreases expression EXP Fentanyl results in decreased expression of LAMB3 mRNA CTD PMID:36032789 NCBI chr13:107,362,514...107,404,081
Ensembl chr13:107,322,526...107,404,081 		JBrowse link
G Lamc2 laminin subunit gamma 2 affects expression EXP Fentanyl affects the expression of LAMC2 mRNA CTD PMID:36032789 NCBI chr13:67,835,199...67,894,694
Ensembl chr13:67,835,199...67,895,102 		JBrowse link
G Lcn2 lipocalin 2 increases expression EXP Fentanyl results in increased expression of LCN2 mRNA CTD PMID:36032789 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842 		JBrowse link
G Lox lysyl oxidase decreases expression EXP Fentanyl results in decreased expression of LOX mRNA CTD PMID:36032789 NCBI chr18:48,162,889...48,175,640
Ensembl chr18:48,165,688...48,239,810 		JBrowse link
G Loxl1 lysyl oxidase-like 1 increases expression EXP Fentanyl results in increased expression of LOXL1 mRNA CTD PMID:36032789 NCBI chr 8:67,587,636...67,612,224
Ensembl chr 8:67,587,636...67,612,224 		JBrowse link
G Loxl2 lysyl oxidase-like 2 decreases expression EXP Fentanyl results in decreased expression of LOXL2 mRNA CTD PMID:36032789 NCBI chr15:44,683,449...44,773,067
Ensembl chr15:51,069,997...51,182,842 		JBrowse link
G Ltb lymphotoxin beta increases expression EXP Fentanyl results in increased expression of LTB mRNA CTD PMID:36032789 NCBI chr20:3,632,209...3,634,054
Ensembl chr20:3,632,210...3,634,054 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Fentanyl results in increased phosphorylation of MAPK1 protein CTD PMID:23965172 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Fentanyl results in increased phosphorylation of MAPK3 protein CTD PMID:23965172 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor decreases expression EXP Fentanyl results in decreased expression of MAS1 mRNA CTD PMID:36032789 NCBI chr 1:50,428,064...50,459,537
Ensembl chr 1:50,425,257...50,500,561 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression EXP Fentanyl results in increased expression of MMP2 mRNA CTD PMID:36032789 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression EXP Fentanyl results in decreased expression of MMP9 mRNA CTD PMID:36032789 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mx1 MX dynamin like GTPase 1 increases expression EXP Fentanyl results in increased expression of MX1 mRNA CTD PMID:36032789 NCBI chr11:50,269,056...50,294,699
Ensembl chr11:50,269,057...50,292,904 		JBrowse link
G Mx2 MX dynamin like GTPase 2 increases expression EXP Fentanyl results in increased expression of MX2 mRNA CTD PMID:36032789 NCBI chr11:50,375,101...50,399,373
Ensembl chr11:50,375,191...50,402,478 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO
EXP 		Fentanyl results in increased expression of NFKBIA protein
Fentanyl results in increased expression of NFKBIA mRNA 		CTD PMID:22258905 PMID:36032789 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nid2 nidogen 2 decreases expression EXP Fentanyl results in decreased expression of NID2 mRNA CTD PMID:36032789 NCBI chr15:4,458,082...4,513,808
Ensembl chr15:4,506,756...4,562,949 		JBrowse link
G Nppc natriuretic peptide C affects expression EXP Fentanyl affects the expression of NPPC mRNA CTD PMID:36032789 NCBI chr 9:94,767,986...94,772,186
Ensembl chr 9:94,767,986...94,772,186 		JBrowse link
G Nts neurotensin decreases expression EXP Fentanyl results in decreased expression of NTS mRNA CTD PMID:36032789 NCBI chr 7:39,451,484...39,460,888
Ensembl chr 7:39,451,073...39,460,961 		JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like increases expression EXP Fentanyl results in increased expression of OASL mRNA CTD PMID:36032789 NCBI chr12:47,343,551...47,356,509
Ensembl chr12:47,343,551...47,356,483 		JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP Fentanyl binds to OPRD1 protein CTD PMID:35477798 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:149,590,244...149,624,999 		JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Fentanyl binds to OPRK1 protein CTD PMID:35477798 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671 		JBrowse link
G Oprm1 opioid receptor, mu 1 increases phosphorylation
multiple interactions 		ISO
EXP 		Fentanyl results in increased phosphorylation of OPRM1 protein
[Fentanyl binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein; Fentanyl binds to and results in increased activity of OPRM1 protein 		CTD PMID:17240843 PMID:21957251 PMID:23300227 PMID:35477798 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756 		JBrowse link
G P4ha2 prolyl 4-hydroxylase subunit alpha 2 decreases expression EXP Fentanyl results in decreased expression of P4HA2 mRNA CTD PMID:36032789 NCBI chr10:38,243,136...38,271,983
Ensembl chr10:38,743,894...38,772,993 		JBrowse link
G Pdyn prodynorphin increases expression EXP Fentanyl results in increased expression of PDYN protein CTD PMID:19200067 NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:137,354,161...137,366,503 		JBrowse link
G Pf4 platelet factor 4 increases expression EXP Fentanyl results in increased expression of PF4 mRNA CTD PMID:36032789 NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,582,477...17,583,392 		JBrowse link
G Pld2 phospholipase D2 increases activity ISO Fentanyl results in increased activity of PLD2 protein CTD PMID:23965172 NCBI chr10:55,754,957...55,772,819
Ensembl chr10:55,754,988...55,771,435 		JBrowse link
G Pomc proopiomelanocortin decreases expression
multiple interactions 		ISO Fentanyl results in decreased expression of POMC protein alternative form
[Fentanyl co-treated with Morphine] results in decreased expression of POMC protein alternative form 		CTD PMID:20084599 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173 		JBrowse link
G Prlhr prolactin releasing hormone receptor decreases expression EXP Fentanyl results in decreased expression of PRLHR mRNA CTD PMID:36032789 NCBI chr 1:259,606,704...259,608,391
Ensembl chr 1:269,585,611...269,594,909 		JBrowse link
G Psmb9 proteasome 20S subunit beta 9 increases expression EXP Fentanyl results in increased expression of PSMB9 mRNA CTD PMID:36032789 NCBI chr20:4,668,952...4,674,421
Ensembl chr20:4,668,739...4,674,421 		JBrowse link
G Pthlh parathyroid hormone-like hormone affects expression EXP Fentanyl affects the expression of PTHLH mRNA CTD PMID:36032789 NCBI chr 4:181,919,400...181,930,454
Ensembl chr 4:181,919,400...181,930,454 		JBrowse link
G Ptx3 pentraxin 3 increases expression EXP Fentanyl results in increased expression of PTX3 mRNA CTD PMID:36032789 NCBI chr 2:152,797,563...152,803,372
Ensembl chr 2:152,781,955...152,803,372 		JBrowse link
G Reln reelin increases expression EXP Fentanyl results in increased expression of RELN mRNA CTD PMID:36032789 NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:13,628,399...14,055,162 		JBrowse link
G Ren renin multiple interactions ISO [Fentanyl co-treated with Isoflurane] results in decreased expression of REN protein CTD PMID:3284271 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP Fentanyl results in increased expression of S100A8 mRNA CTD PMID:36032789 NCBI chr 2:178,464,095...178,465,223
Ensembl chr 2:178,464,702...178,465,221 		JBrowse link
G Scg2 secretogranin II affects expression EXP Fentanyl affects the expression of SCG2 mRNA CTD PMID:36032789 NCBI chr 9:88,251,531...88,257,208
Ensembl chr 9:88,251,354...88,269,598 		JBrowse link
G Sema3a semaphorin 3A decreases expression EXP Fentanyl results in decreased expression of SEMA3A mRNA CTD PMID:36032789 NCBI chr 4:22,239,418...22,709,907
Ensembl chr 4:22,245,322...22,535,774 		JBrowse link
G Slc11a1 solute carrier family 11 member 1 increases expression EXP Fentanyl results in increased expression of SLC11A1 mRNA CTD PMID:36032789 NCBI chr 9:83,406,327...83,417,252
Ensembl chr 9:83,406,427...83,417,238 		JBrowse link
G Slc8a2 solute carrier family 8 member A2 affects expression EXP Fentanyl affects the expression of SLC8A2 mRNA CTD PMID:36032789 NCBI chr 1:85,944,752...85,982,900
Ensembl chr 1:85,947,204...85,981,889 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP Fentanyl results in increased expression of SOD2 mRNA CTD PMID:36032789 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Sorcs3 sortilin-related VPS10 domain containing receptor 3 decreases expression EXP Fentanyl results in decreased expression of SORCS3 mRNA CTD PMID:36032789 NCBI chr 1:247,099,178...247,734,027
Ensembl chr 1:257,040,473...257,675,259 		JBrowse link
G Spp1 secreted phosphoprotein 1 affects expression EXP Fentanyl affects the expression of SPP1 mRNA CTD PMID:36032789 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820 		JBrowse link
G Tlr2 toll-like receptor 2 increases expression EXP Fentanyl results in increased expression of TLR2 mRNA CTD PMID:36032789 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194 		JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 increases expression EXP Fentanyl results in increased expression of TNFRSF9 mRNA CTD PMID:36032789 NCBI chr 5:166,664,494...166,690,834
Ensembl chr 5:166,664,494...166,690,831 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression EXP Fentanyl results in increased expression of VCAM1 mRNA CTD PMID:36032789 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression EXP Fentanyl results in decreased expression of VEGFA mRNA CTD PMID:36032789 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Vgf VGF nerve growth factor inducible affects expression EXP Fentanyl affects the expression of VGF mRNA CTD PMID:36032789 NCBI chr12:25,274,004...25,281,803
Ensembl chr12:25,273,333...25,282,703 		JBrowse link
G Wnt10a Wnt family member 10A affects expression EXP Fentanyl affects the expression of WNT10A mRNA CTD PMID:36032789 NCBI chr 9:83,798,594...83,811,060
Ensembl chr 9:83,798,594...83,811,067 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        pharmaceutical 20416
          adjuvant 4864
            fentanyl 108
              fentanyl citrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            inorganic hydride 18602
                              pnictogen hydride 18589
                                nitrogen hydride 18502
                                  azane 18262
                                    ammonia 18261
                                      organic amino compound 18261
                                        primary amino compound 9437
                                          primary amine 6420
                                            primary arylamine 3716
                                              aniline 3555
                                                anilide 1191
                                                  fentanyl 108
                                                    fentanyl citrate 0
paths to the root