CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: fentanyl
Accession: CHEBI:119915
browse the term
Definition: A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Synonyms: exact_synonym: N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
related_synonym: 1-phenethyl-4-(N-phenylpropionamido)piperidine; 1-phenethyl-4-N-propionylanilinopiperidine; Duragesic; Formula=C22H28N2O; InChI=1S/C22H28N2O/c1-2-22(25)24(20-11-7-4-8-12-20)21-14-17-23(18-15-21)16-13-19-9-5-3-6-10-19/h3-12,21H,2,13-18H2,1H3; InChIKey=PJMPHNIQZUBGLI-UHFFFAOYSA-N; N-(1-Phenethyl-piperidin-4-yl)-N-phenyl-propionamide; N-(1-phenethyl-4-piperidinyl)-N-phenylpropionamide; N-(1-phenethyl-4-piperidyl)propionanilide; N-(1-phenethylpiperidin-4-yl)-N-phenylpropionamide; N-phenethyl-4-(N-propionylanilino)piperidine; N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide; SMILES=CCC(=O)N(C1CCN(CC1)CCc1ccccc1)c1ccccc1; fentanilo; fentanylum; phentanyl
alt_id: CHEBI:310077; CHEBI:5012
xref: CAS:437-38-7; DrugBank:DB00813; Drug_Central:1164; KEGG:D00320
xref_mesh: MESH:D005283
xref: PMID:10669565; PMID:10987438; PMID:11585443; PMID:14698188; PMID:16621415; PMID:18462178; PMID:18728103; PMID:30176422; PMID:30305277; Patent:FR1344366; Patent:US3164600; Reaxys:494484; VSDB:1864; Wikipedia:Fentanyl
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Abcb1a
ATP binding cassette subfamily B member 1A
increases transport increases response to substance multiple interactions
ISO EXP
ABCB1 protein results in increased transport of Fentanyl ABCB1 protein results in increased susceptibility to Fentanyl tariquidar inhibits the reaction [ABCB1 protein results in increased transport of Fentanyl]
CTD
PMID:29669042
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
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Acan
aggrecan
decreases expression
EXP
Fentanyl results in decreased expression of ACAN mRNA
CTD
PMID:36032789
NCBI chr 1:142,390,951...142,453,779
Ensembl chr 1:142,390,951...142,453,779
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Adamts14
ADAM metallopeptidase with thrombospondin type 1 motif, 14
decreases expression
EXP
Fentanyl results in decreased expression of ADAMTS14 mRNA
CTD
PMID:36032789
NCBI chr20:29,143,029...29,219,846
Ensembl chr20:29,685,876...29,762,682
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Adamtsl3
ADAMTS-like 3
affects expression
EXP
Fentanyl affects the expression of ADAMTSL3 mRNA
CTD
PMID:36032789
NCBI chr 1:145,698,004...146,006,195
Ensembl chr 1:145,698,004...146,006,195
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Akap5
A-kinase anchoring protein 5
increases expression
EXP
Fentanyl results in increased expression of AKAP5 mRNA
CTD
PMID:36032789
NCBI chr 6:100,787,169...100,796,712
Ensembl chr 6:100,790,148...100,796,620
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Apln
apelin
decreases expression
EXP
Fentanyl results in decreased expression of APLN mRNA
CTD
PMID:36032789
NCBI chr X:127,180,801...127,213,567
Ensembl chr X:132,081,759...132,091,246
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Arrb2
arrestin, beta 2
affects localization multiple interactions
ISO EXP
Fentanyl affects the localization of ARRB2 protein [Fentanyl binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein
CTD
PMID:27030709 PMID:35477798
NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,645,357...55,653,487
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Bdnf
brain-derived neurotrophic factor
affects expression
EXP
Fentanyl affects the expression of BDNF mRNA
CTD
PMID:36032789
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
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Bgn
biglycan
affects expression
EXP
Fentanyl affects the expression of BGN mRNA
CTD
PMID:36032789
NCBI chr X:156,348,633...156,360,797
Ensembl chr X:156,348,615...156,360,799
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Birc3
baculoviral IAP repeat-containing 3
increases expression
EXP
Fentanyl results in increased expression of BIRC3 mRNA
CTD
PMID:36032789
NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590
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Bst2
bone marrow stromal cell antigen 2
increases expression
EXP
Fentanyl results in increased expression of BST2 mRNA
CTD
PMID:36032789
NCBI chr16:18,250,593...18,254,967
Ensembl chr16:18,251,847...18,254,967
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C3
complement C3
increases expression
EXP
Fentanyl results in increased expression of C3 mRNA
CTD
PMID:36032789
NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339
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Cacna1e
calcium voltage-gated channel subunit alpha1 E
affects expression
EXP
Fentanyl affects the expression of CACNA1E mRNA
CTD
PMID:36032789
NCBI chr13:69,125,048...69,613,795
Ensembl chr13:69,132,305...69,612,983
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Calca
calcitonin-related polypeptide alpha
multiple interactions
EXP
Fentanyl inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]; Naloxone inhibits the reaction [Fentanyl inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]]
CTD
PMID:27030709
NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529
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Cckbr
cholecystokinin B receptor
decreases expression
EXP
Fentanyl results in decreased expression of CCKBR mRNA
CTD
PMID:36032789
NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:169,183,194...169,193,745
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Ccl2
C-C motif chemokine ligand 2
increases expression
EXP
Fentanyl results in increased expression of CCL2 mRNA
CTD
PMID:36032789
NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
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Ccl20
C-C motif chemokine ligand 20
increases expression
EXP
Fentanyl results in increased expression of CCL20 mRNA
CTD
PMID:36032789
NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736
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Ccl7
C-C motif chemokine ligand 7
increases expression
EXP
Fentanyl results in increased expression of CCL7 mRNA
CTD
PMID:36032789
NCBI chr10:67,514,095...67,515,945
Ensembl chr10:67,514,091...67,515,947
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Cfb
complement factor B
increases expression
EXP
Fentanyl results in increased expression of CFB mRNA
CTD
PMID:36032789
NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,955,776...3,981,740
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Chi3l1
chitinase 3 like 1
increases expression
EXP
Fentanyl results in increased expression of CHI3L1 mRNA
CTD
PMID:36032789
NCBI chr13:48,193,839...48,201,822
Ensembl chr13:48,193,800...48,201,825
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Clstn2
calsyntenin 2
affects expression
EXP
Fentanyl affects the expression of CLSTN2 mRNA
CTD
PMID:36032789
NCBI chr 8:98,020,406...98,637,232
Ensembl chr 8:106,899,894...107,040,053
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Cntf
ciliary neurotrophic factor
increases expression
EXP
Fentanyl results in increased expression of CNTF mRNA
CTD
PMID:36032789
NCBI chr 1:219,312,512...219,314,535
Ensembl chr 1:219,312,512...219,314,488
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Col15a1
collagen type XV alpha 1 chain
increases expression
EXP
Fentanyl results in increased expression of COL15A1 mRNA
CTD
PMID:36032789
NCBI chr 5:66,297,546...66,403,172
Ensembl chr 5:66,297,461...66,403,170
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Col26a1
collagen type XXVI alpha 1 chain
increases expression
EXP
Fentanyl results in increased expression of COL26A1 mRNA
CTD
PMID:36032789
NCBI chr12:19,792,693...19,938,556
Ensembl chr12:25,429,387...25,575,206
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Col3a1
collagen type III alpha 1 chain
affects expression
EXP
Fentanyl affects the expression of COL3A1 mRNA
CTD
PMID:36032789
NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232
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Crh
corticotropin releasing hormone
affects expression increases expression
EXP
Fentanyl affects the expression of CRH mRNA Fentanyl results in increased expression of CRH mRNA
CTD
PMID:18819432 PMID:36032789
NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386
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Crlf1
cytokine receptor-like factor 1
affects expression
EXP
Fentanyl affects the expression of CRLF1 mRNA
CTD
PMID:36032789
NCBI chr16:18,924,722...18,936,049
Ensembl chr16:18,957,956...18,969,970
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Csf1
colony stimulating factor 1
increases expression
EXP
Fentanyl results in increased expression of CSF1 mRNA
CTD
PMID:36032789
NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:198,065,405...198,084,468
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Cxcl1
C-X-C motif chemokine ligand 1
increases expression
EXP
Fentanyl results in increased expression of CXCL1 mRNA
CTD
PMID:36032789
NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811
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Cxcl10
C-X-C motif chemokine ligand 10
increases expression
EXP
Fentanyl results in increased expression of CXCL10 mRNA
CTD
PMID:36032789
NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261
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Cxcl11
C-X-C motif chemokine ligand 11
increases expression
EXP
Fentanyl results in increased expression of CXCL11 mRNA
CTD
PMID:36032789
NCBI chr14:15,973,728...15,976,503
Ensembl chr14:15,973,720...15,976,567
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Cxcl12
C-X-C motif chemokine ligand 12
increases expression
EXP
Fentanyl results in increased expression of CXCL12 mRNA
CTD
PMID:36032789
NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627
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Cxcl13
C-X-C motif chemokine ligand 13
increases expression
EXP
Fentanyl results in increased expression of CXCL13 mRNA
CTD
PMID:36032789
NCBI chr14:13,912,858...13,917,920
Ensembl chr14:13,912,858...13,917,920
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Cxcl16
C-X-C motif chemokine ligand 16
increases expression
EXP
Fentanyl results in increased expression of CXCL16 mRNA
CTD
PMID:36032789
NCBI chr10:55,665,355...55,669,950
Ensembl chr10:55,664,742...55,670,226
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases activity
ISO
Fentanyl results in increased activity of CYP2B6 protein
CTD
PMID:35914676
NCBI chr 1:90,780,468...90,859,852
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases metabolic processing
ISO
CYP3A4 protein results in increased metabolism of Fentanyl
CTD
PMID:11811955
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
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Dcn
decorin
increases expression
EXP
Fentanyl results in increased expression of DCN mRNA
CTD
PMID:36032789
NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:34,163,011...34,218,926
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Ednrb
endothelin receptor type B
decreases expression
EXP
Fentanyl results in decreased expression of EDNRB mRNA
CTD
PMID:36032789
NCBI chr15:87,055,490...87,086,765
Ensembl chr15:87,057,691...87,086,765
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Fbln5
fibulin 5
decreases expression
EXP
Fentanyl results in decreased expression of FBLN5 mRNA
CTD
PMID:36032789
NCBI chr 6:120,899,219...120,977,829
Ensembl chr 6:126,664,100...126,746,296
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Fgr
FGR proto-oncogene, Src family tyrosine kinase
increases expression
EXP
Fentanyl results in increased expression of FGR mRNA
CTD
PMID:36032789
NCBI chr 5:150,473,767...150,503,524
Ensembl chr 5:150,473,792...150,503,169
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
EXP
Fentanyl results in increased expression of FOS protein
CTD
PMID:7970238
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
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Gast
gastrin
multiple interactions
EXP
[fluanisone co-treated with Fentanyl co-treated with Midazolam] inhibits the reaction [GAST protein results in increased secretion of Histamine]
CTD
PMID:10864877
NCBI chr10:85,765,216...85,767,881
Ensembl chr10:85,765,216...85,767,880
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Gbp2
guanylate binding protein 2
increases expression
EXP
Fentanyl results in increased expression of GBP2 mRNA
CTD
PMID:36032789
NCBI chr 2:234,005,727...234,021,812
Ensembl chr 2:234,008,590...234,021,810
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Grem1
gremlin 1, DAN family BMP antagonist
decreases expression
EXP
Fentanyl results in decreased expression of GREM1 mRNA
CTD
PMID:36032789
NCBI chr 3:120,966,639...120,978,319
Ensembl chr 3:120,966,623...120,979,089
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Grin2a
glutamate ionotropic receptor NMDA type subunit 2A
affects expression
EXP
Fentanyl affects the expression of GRIN2A mRNA
CTD
PMID:36032789
NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378
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Grin2b
glutamate ionotropic receptor NMDA type subunit 2B
affects expression
EXP
Fentanyl affects the expression of GRIN2B mRNA
CTD
PMID:36032789
NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570
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Grm1
glutamate metabotropic receptor 1
affects expression
EXP
Fentanyl affects the expression of GRM1 mRNA
CTD
PMID:36032789
NCBI chr 1:6,878,542...7,273,447
Ensembl chr 1:6,878,545...7,273,443
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Grm3
glutamate metabotropic receptor 3
affects expression
EXP
Fentanyl affects the expression of GRM3 mRNA
CTD
PMID:36032789
NCBI chr 4:25,319,218...25,600,721
Ensembl chr 4:25,319,942...25,564,764
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Has1
hyaluronan synthase 1
decreases expression
EXP
Fentanyl results in decreased expression of HAS1 mRNA
CTD
PMID:36032789
NCBI chr 1:67,366,460...67,378,686
Ensembl chr 1:67,366,460...67,378,444
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Hcrtr1
hypocretin receptor 1
decreases expression
EXP
Fentanyl results in decreased expression of HCRTR1 mRNA
CTD
PMID:36032789
NCBI chr 5:142,477,214...142,486,674
Ensembl chr 5:147,760,145...147,770,850
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Htr2a
5-hydroxytryptamine receptor 2A
affects expression
EXP
Fentanyl affects the expression of HTR2A mRNA
CTD
PMID:36032789
NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619
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Ifit3
interferon-induced protein with tetratricopeptide repeats 3
increases expression
EXP
Fentanyl results in increased expression of IFIT3 mRNA
CTD
PMID:36032789
NCBI chr 1:241,527,326...241,532,469
Ensembl chr 1:241,526,880...241,532,521
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Il1a
interleukin 1 alpha
increases expression
EXP
Fentanyl results in increased expression of IL1A mRNA
CTD
PMID:36032789
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013
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Il2
interleukin 2
decreases expression
ISO
Fentanyl results in decreased expression of IL2 mRNA
CTD
PMID:23965172
NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672
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Il4
interleukin 4
increases expression
ISO
Fentanyl results in increased expression of IL4 mRNA
CTD
PMID:23965172
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
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Il7
interleukin 7
increases expression
EXP
Fentanyl results in increased expression of IL7 mRNA
CTD
PMID:36032789
NCBI chr 2:96,142,523...96,186,282
Ensembl chr 2:96,142,092...96,187,389
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Irf7
interferon regulatory factor 7
increases expression
EXP
Fentanyl results in increased expression of IRF7 mRNA
CTD
PMID:36032789
NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:205,796,959...205,800,023
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Isg15
ISG15 ubiquitin-like modifier
increases expression
EXP
Fentanyl results in increased expression of ISG15 mRNA
CTD
PMID:36032789
NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:172,066,369...172,067,656
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Itga11
integrin subunit alpha 11
increases expression
EXP
Fentanyl results in increased expression of ITGA11 mRNA
CTD
PMID:36032789
NCBI chr 8:72,041,432...72,150,137
Ensembl chr 8:72,016,652...72,150,137
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Itgal
integrin subunit alpha L
increases expression
EXP
Fentanyl results in increased expression of ITGAL mRNA
CTD
PMID:36032789
NCBI chr 1:191,348,424...191,386,228
Ensembl chr 1:191,348,542...191,386,225
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
Fentanyl results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421
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Lamb3
laminin subunit beta 3
decreases expression
EXP
Fentanyl results in decreased expression of LAMB3 mRNA
CTD
PMID:36032789
NCBI chr13:107,362,514...107,404,081
Ensembl chr13:107,322,526...107,404,081
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Lamc2
laminin subunit gamma 2
affects expression
EXP
Fentanyl affects the expression of LAMC2 mRNA
CTD
PMID:36032789
NCBI chr13:67,835,199...67,894,694
Ensembl chr13:67,835,199...67,895,102
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Lcn2
lipocalin 2
increases expression
EXP
Fentanyl results in increased expression of LCN2 mRNA
CTD
PMID:36032789
NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842
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Lox
lysyl oxidase
decreases expression
EXP
Fentanyl results in decreased expression of LOX mRNA
CTD
PMID:36032789
NCBI chr18:48,162,889...48,175,640
Ensembl chr18:48,165,688...48,239,810
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Loxl1
lysyl oxidase-like 1
increases expression
EXP
Fentanyl results in increased expression of LOXL1 mRNA
CTD
PMID:36032789
NCBI chr 8:67,587,636...67,612,224
Ensembl chr 8:67,587,636...67,612,224
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Loxl2
lysyl oxidase-like 2
decreases expression
EXP
Fentanyl results in decreased expression of LOXL2 mRNA
CTD
PMID:36032789
NCBI chr15:44,683,449...44,773,067
Ensembl chr15:51,069,997...51,182,842
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Ltb
lymphotoxin beta
increases expression
EXP
Fentanyl results in increased expression of LTB mRNA
CTD
PMID:36032789
NCBI chr20:3,632,209...3,634,054
Ensembl chr20:3,632,210...3,634,054
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Mapk1
mitogen activated protein kinase 1
increases phosphorylation
ISO
Fentanyl results in increased phosphorylation of MAPK1 protein
CTD
PMID:23965172
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
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Mapk3
mitogen activated protein kinase 3
increases phosphorylation
ISO
Fentanyl results in increased phosphorylation of MAPK3 protein
CTD
PMID:23965172
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
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Mas1
MAS1 proto-oncogene, G protein-coupled receptor
decreases expression
EXP
Fentanyl results in decreased expression of MAS1 mRNA
CTD
PMID:36032789
NCBI chr 1:50,428,064...50,459,537
Ensembl chr 1:50,425,257...50,500,561
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Mmp2
matrix metallopeptidase 2
increases expression
EXP
Fentanyl results in increased expression of MMP2 mRNA
CTD
PMID:36032789
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
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Mmp9
matrix metallopeptidase 9
decreases expression
EXP
Fentanyl results in decreased expression of MMP9 mRNA
CTD
PMID:36032789
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
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Mx1
MX dynamin like GTPase 1
increases expression
EXP
Fentanyl results in increased expression of MX1 mRNA
CTD
PMID:36032789
NCBI chr11:50,269,056...50,294,699
Ensembl chr11:50,269,057...50,292,904
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Mx2
MX dynamin like GTPase 2
increases expression
EXP
Fentanyl results in increased expression of MX2 mRNA
CTD
PMID:36032789
NCBI chr11:50,375,101...50,399,373
Ensembl chr11:50,375,191...50,402,478
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Nfkbia
NFKB inhibitor alpha
increases expression
ISO EXP
Fentanyl results in increased expression of NFKBIA protein Fentanyl results in increased expression of NFKBIA mRNA
CTD
PMID:22258905 PMID:36032789
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
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Nid2
nidogen 2
decreases expression
EXP
Fentanyl results in decreased expression of NID2 mRNA
CTD
PMID:36032789
NCBI chr15:4,458,082...4,513,808
Ensembl chr15:4,506,756...4,562,949
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Nppc
natriuretic peptide C
affects expression
EXP
Fentanyl affects the expression of NPPC mRNA
CTD
PMID:36032789
NCBI chr 9:94,767,986...94,772,186
Ensembl chr 9:94,767,986...94,772,186
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Nts
neurotensin
decreases expression
EXP
Fentanyl results in decreased expression of NTS mRNA
CTD
PMID:36032789
NCBI chr 7:39,451,484...39,460,888
Ensembl chr 7:39,451,073...39,460,961
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Oasl
2'-5'-oligoadenylate synthetase-like
increases expression
EXP
Fentanyl results in increased expression of OASL mRNA
CTD
PMID:36032789
NCBI chr12:47,343,551...47,356,509
Ensembl chr12:47,343,551...47,356,483
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Oprd1
opioid receptor, delta 1
affects binding
EXP
Fentanyl binds to OPRD1 protein
CTD
PMID:35477798
NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:149,590,244...149,624,999
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Oprk1
opioid receptor, kappa 1
affects binding
EXP
Fentanyl binds to OPRK1 protein
CTD
PMID:35477798
NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671
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Oprm1
opioid receptor, mu 1
increases phosphorylation multiple interactions
ISO EXP
Fentanyl results in increased phosphorylation of OPRM1 protein [Fentanyl binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein; Fentanyl binds to and results in increased activity of OPRM1 protein
CTD
PMID:17240843 PMID:21957251 PMID:23300227 PMID:35477798
NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
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P4ha2
prolyl 4-hydroxylase subunit alpha 2
decreases expression
EXP
Fentanyl results in decreased expression of P4HA2 mRNA
CTD
PMID:36032789
NCBI chr10:38,243,136...38,271,983
Ensembl chr10:38,743,894...38,772,993
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Pdyn
prodynorphin
increases expression
EXP
Fentanyl results in increased expression of PDYN protein
CTD
PMID:19200067
NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:137,354,161...137,366,503
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Pf4
platelet factor 4
increases expression
EXP
Fentanyl results in increased expression of PF4 mRNA
CTD
PMID:36032789
NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,582,477...17,583,392
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Pld2
phospholipase D2
increases activity
ISO
Fentanyl results in increased activity of PLD2 protein
CTD
PMID:23965172
NCBI chr10:55,754,957...55,772,819
Ensembl chr10:55,754,988...55,771,435
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Pomc
proopiomelanocortin
decreases expression multiple interactions
ISO
Fentanyl results in decreased expression of POMC protein alternative form [Fentanyl co-treated with Morphine] results in decreased expression of POMC protein alternative form
CTD
PMID:20084599
NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173
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Prlhr
prolactin releasing hormone receptor
decreases expression
EXP
Fentanyl results in decreased expression of PRLHR mRNA
CTD
PMID:36032789
NCBI chr 1:259,606,704...259,608,391
Ensembl chr 1:269,585,611...269,594,909
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Psmb9
proteasome 20S subunit beta 9
increases expression
EXP
Fentanyl results in increased expression of PSMB9 mRNA
CTD
PMID:36032789
NCBI chr20:4,668,952...4,674,421
Ensembl chr20:4,668,739...4,674,421
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Pthlh
parathyroid hormone-like hormone
affects expression
EXP
Fentanyl affects the expression of PTHLH mRNA
CTD
PMID:36032789
NCBI chr 4:181,919,400...181,930,454
Ensembl chr 4:181,919,400...181,930,454
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Ptx3
pentraxin 3
increases expression
EXP
Fentanyl results in increased expression of PTX3 mRNA
CTD
PMID:36032789
NCBI chr 2:152,797,563...152,803,372
Ensembl chr 2:152,781,955...152,803,372
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Reln
reelin
increases expression
EXP
Fentanyl results in increased expression of RELN mRNA
CTD
PMID:36032789
NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:13,628,399...14,055,162
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Ren
renin
multiple interactions
ISO
[Fentanyl co-treated with Isoflurane] results in decreased expression of REN protein
CTD
PMID:3284271
NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543
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S100a8
S100 calcium binding protein A8
increases expression
EXP
Fentanyl results in increased expression of S100A8 mRNA
CTD
PMID:36032789
NCBI chr 2:178,464,095...178,465,223
Ensembl chr 2:178,464,702...178,465,221
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Scg2
secretogranin II
affects expression
EXP
Fentanyl affects the expression of SCG2 mRNA
CTD
PMID:36032789
NCBI chr 9:88,251,531...88,257,208
Ensembl chr 9:88,251,354...88,269,598
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Sema3a
semaphorin 3A
decreases expression
EXP
Fentanyl results in decreased expression of SEMA3A mRNA
CTD
PMID:36032789
NCBI chr 4:22,239,418...22,709,907
Ensembl chr 4:22,245,322...22,535,774
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Slc11a1
solute carrier family 11 member 1
increases expression
EXP
Fentanyl results in increased expression of SLC11A1 mRNA
CTD
PMID:36032789
NCBI chr 9:83,406,327...83,417,252
Ensembl chr 9:83,406,427...83,417,238
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Slc8a2
solute carrier family 8 member A2
affects expression
EXP
Fentanyl affects the expression of SLC8A2 mRNA
CTD
PMID:36032789
NCBI chr 1:85,944,752...85,982,900
Ensembl chr 1:85,947,204...85,981,889
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Sod2
superoxide dismutase 2
increases expression
EXP
Fentanyl results in increased expression of SOD2 mRNA
CTD
PMID:36032789
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
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Sorcs3
sortilin-related VPS10 domain containing receptor 3
decreases expression
EXP
Fentanyl results in decreased expression of SORCS3 mRNA
CTD
PMID:36032789
NCBI chr 1:247,099,178...247,734,027
Ensembl chr 1:257,040,473...257,675,259
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Spp1
secreted phosphoprotein 1
affects expression
EXP
Fentanyl affects the expression of SPP1 mRNA
CTD
PMID:36032789
NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820
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Tlr2
toll-like receptor 2
increases expression
EXP
Fentanyl results in increased expression of TLR2 mRNA
CTD
PMID:36032789
NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194
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Tnfrsf9
TNF receptor superfamily member 9
increases expression
EXP
Fentanyl results in increased expression of TNFRSF9 mRNA
CTD
PMID:36032789
NCBI chr 5:166,664,494...166,690,834
Ensembl chr 5:166,664,494...166,690,831
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Vcam1
vascular cell adhesion molecule 1
increases expression
EXP
Fentanyl results in increased expression of VCAM1 mRNA
CTD
PMID:36032789
NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801
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Vegfa
vascular endothelial growth factor A
decreases expression
EXP
Fentanyl results in decreased expression of VEGFA mRNA
CTD
PMID:36032789
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
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Vgf
VGF nerve growth factor inducible
affects expression
EXP
Fentanyl affects the expression of VGF mRNA
CTD
PMID:36032789
NCBI chr12:25,274,004...25,281,803
Ensembl chr12:25,273,333...25,282,703
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Wnt10a
Wnt family member 10A
affects expression
EXP
Fentanyl affects the expression of WNT10A mRNA
CTD
PMID:36032789
NCBI chr 9:83,798,594...83,811,060
Ensembl chr 9:83,798,594...83,811,067
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