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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-methoxyestrone
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Accession:CHEBI:1189 term browser browse the term
Definition:A 17-oxo steroid that is estrone in which the hydrogen at position 2 has been replaced by a methoxy group.
Synonyms:exact_synonym: 3=hydroxy-2-methoxyestra-1,3,5(10)-trien-17-one
 related_synonym: Formula=C19H24O3;   InChI=1S/C19H24O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,20H,3-8H2,1-2H3/t12-,13+,15-,19-/m0/s1;   InChIKey=WHEUWNKSCXYKBU-QPWUGHHJSA-N;   SMILES=[H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])[C@]1([H])CCc1cc(O)c(OC)cc21
 xref: CAS:362-08-3;   KEGG:C05299;   LIPID_MAPS_instance:LMST02010033
 xref_mesh: MESH:C003655
 xref: PMID:14577664;   PMID:21488127



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2-methoxyestrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 multiple interactions ISO [HSD17B2 protein results in increased metabolism of and results in decreased activity of 2-methoxyestradiol] which results in increased chemical synthesis of 2-methoxyestrone CTD PMID:16397246 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    role 19810
      application 19679
        pharmaceutical 19495
          drug 19520
            antineoplastic agent 17820
              estrone 128
                2-methoxyestrone 1
                  2-methoxyestrone 3-O-(beta-D-glucuronide) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19722
                        carbon atom 19719
                          organic molecular entity 19719
                            organic molecule 19670
                              organic cyclic compound 19481
                                organic polycyclic compound 17242
                                  steroid 14704
                                    hydroxy steroid 14453
                                      3-hydroxy steroid 12796
                                        phenolic steroid 11305
                                          estrone 128
                                            2-methoxyestrone 1
                                              2-methoxyestrone 3-O-(beta-D-glucuronide) 0
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