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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benzocaine
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Accession:CHEBI:116735 term browser browse the term
Definition:A benzoate ester having 4-aminobenzoic acid as the acid component and ethanol as the alcohol component. A surface anaesthetic, it is used to suppress the gag reflex, and as a lubricant and topical anaesthetic on the larynx, mouth, nasal cavity, respiratory tract, oesophagus, rectum, urinary tract, and vagina.
Synonyms:exact_synonym: ethyl 4-aminobenzoate
 related_synonym: 4-aminobenzoic acid ethyl ester;   Amben ethyl ester;   Benzocaina;   Benzocainum;   Ethyl aminobenzoate;   Ethyl p-aminobenzoate;   Ethyl p-aminophenylcarboxylate;   Formula=C9H11NO2;   InChI=1S/C9H11NO2/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6H,2,10H2,1H3;   InChIKey=BLFLLBZGZJTVJG-UHFFFAOYSA-N;   SMILES=CCOC(=O)c1ccc(N)cc1;   p-(Ethoxycarbonyl)aniline;   p-Carbethoxyaniline;   p-Ethoxycarboxylic aniline
 alt_id: CHEBI:3030
 xref: Beilstein:638434;   CAS:94-09-7;   DrugBank:DB01086;   Drug_Central:323;   HMDB:HMDB0004992;   KEGG:C07527;   KEGG:D00552;   LINCS:LSM-5830
 xref_mesh: MESH:D001566
 xref: PMID:10866370;   PMID:1155304;   PMID:12574744;   PMID:12873507;   PMID:16640711;   PMID:18971079;   PMID:21616561;   PMID:22015737;   PMID:22105694;   PMID:22551703;   PMID:22556388;   PMID:23301559;   PMID:23565580;   PMID:23696166;   PMID:25097477;   PMID:2579237;   PMID:29079364;   Reaxys:638434;   Wikipedia:Benzocaine



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benzocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Benzocaine results in increased expression of CCL4 protein CTD PMID:18353026 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Benzocaine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG protein CTD PMID:15588918 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Benzocaine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL10 protein CTD PMID:15588918 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il18 interleukin 18 increases activity ISO Benzocaine results in increased activity of IL18 protein CTD PMID:15840424 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1a interleukin 1 alpha increases activity ISO Benzocaine results in increased activity of IL1A protein CTD PMID:15840424 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Benzocaine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 protein CTD PMID:15588918 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19905
    role 19881
      biological role 19879
        aetiopathogenetic role 19227
          sensitiser 9859
            benzocaine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19905
    subatomic particle 19903
      composite particle 19903
        hadron 19903
          baryon 19903
            nucleon 19903
              atomic nucleus 19903
                atom 19903
                  main group element atom 19853
                    p-block element atom 19853
                      carbon group element atom 19798
                        carbon atom 19793
                          organic molecular entity 19793
                            organic group 18983
                              organic divalent group 18958
                                organodiyl group 18958
                                  carbonyl group 18911
                                    carbonyl compound 18911
                                      carboxylic acid 18634
                                        aromatic carboxylic acid 12257
                                          benzoic acids 12232
                                            benzoate ester 5585
                                              benzocaine 6
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