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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benzocaine
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Accession:CHEBI:116735 term browser browse the term
Definition:A benzoate ester having 4-aminobenzoic acid as the acid component and ethanol as the alcohol component. A surface anaesthetic, it is used to suppress the gag reflex, and as a lubricant and topical anaesthetic on the larynx, mouth, nasal cavity, respiratory tract, oesophagus, rectum, urinary tract, and vagina.
Synonyms:exact_synonym: ethyl 4-aminobenzoate
 related_synonym: 4-aminobenzoic acid ethyl ester;   Amben ethyl ester;   Benzocaina;   Benzocainum;   Ethyl aminobenzoate;   Ethyl p-aminobenzoate;   Ethyl p-aminophenylcarboxylate;   Formula=C9H11NO2;   InChI=1S/C9H11NO2/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6H,2,10H2,1H3;   InChIKey=BLFLLBZGZJTVJG-UHFFFAOYSA-N;   SMILES=CCOC(=O)c1ccc(N)cc1;   p-(Ethoxycarbonyl)aniline;   p-Carbethoxyaniline;   p-Ethoxycarboxylic aniline
 alt_id: CHEBI:3030
 xref: Beilstein:638434;   CAS:94-09-7;   DrugBank:DB01086;   Drug_Central:323;   HMDB:HMDB0004992;   KEGG:C07527;   KEGG:D00552;   LINCS:LSM-5830
 xref_mesh: MESH:D001566
 xref: PMID:10866370;   PMID:1155304;   PMID:12574744;   PMID:12873507;   PMID:16640711;   PMID:18971079;   PMID:21616561;   PMID:22015737;   PMID:22105694;   PMID:22551703;   PMID:22556388;   PMID:23301559;   PMID:23565580;   PMID:23696166;   PMID:25097477;   PMID:2579237;   PMID:29079364;   Reaxys:638434;   Wikipedia:Benzocaine


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benzocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Benzocaine results in increased expression of CCL4 protein CTD PMID:18353026 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Benzocaine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG protein CTD PMID:15588918 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Benzocaine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL10 protein CTD PMID:15588918 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il18 interleukin 18 increases activity ISO Benzocaine results in increased activity of IL18 protein CTD PMID:15840424 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1a interleukin 1 alpha increases activity ISO Benzocaine results in increased activity of IL1A protein CTD PMID:15840424 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Benzocaine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 protein CTD PMID:15588918 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19757
      biological role 19757
        aetiopathogenetic role 19032
          sensitiser 9823
            benzocaine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            organic group 18725
                              organic divalent group 18716
                                organodiyl group 18716
                                  carbonyl group 18664
                                    carbonyl compound 18664
                                      carboxylic acid 18361
                                        aromatic carboxylic acid 11710
                                          benzoic acids 11683
                                            benzoate ester 5033
                                              benzocaine 6
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