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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nomifensine
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Accession:CHEBI:116225 term browser browse the term
Definition:An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.
Synonyms:exact_synonym: 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine
 related_synonym: 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine;   8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline;   D,L-nomifensine;   Formula=C16H18N2;   InChI=1S/C16H18N2/c1-18-10-14(12-6-3-2-4-7-12)13-8-5-9-16(17)15(13)11-18/h2-9,14H,10-11,17H2,1H3;   InChIKey=XXPANQJNYNUNES-UHFFFAOYSA-N;   Nomifenison;   Nomifensin;   Nomiphensine;   R/S-nomifensine;   SMILES=CN1CC(c2ccccc2)c2cccc(N)c2C1;   nomifensina;   nomifensinum
 xref: Beilstein:484561;   CAS:24526-64-5;   DrugBank:DB04821;   Drug_Central:1958;   LINCS:LSM-4388
 xref_mesh: MESH:D009627
 xref: PMID:1502708;   PMID:24766210;   PMID:7189402;   Reaxys:484561


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nomifensine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Nomifensine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Nomifensine results in increased expression of FOS protein CTD PMID:10904129 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Il24 interleukin 24 increases expression ISO Nomifensine results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO Nomifensine results in decreased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Nomifensine results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Nomifensine results in decreased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 affects binding ISO Nomifensine binds to SLC18A2 protein CTD PMID:7912402 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions EXP
ISO		 Nomifensine inhibits the reaction [Rotenone results in decreased expression of SLC6A3 protein]
[Nomifensine results in decreased activity of SLC6A3 protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium; Nomifensine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]		 CTD PMID:18206288 PMID:18289173 PMID:20875051 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO Nomifensine binds to and results in decreased activity of SLC6A4 protein CTD PMID:16272152 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Nomifensine results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        pharmacological role 19054
          neurotransmitter agent 16734
            dopaminergic agent 5492
              dopamine uptake inhibitor 4676
                nomifensine 10
                  (R)-nomifensine 0
                  (S)-nomifensine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            organic molecule 19677
                              organic cyclic compound 19490
                                organic heterocyclic compound 18852
                                  organonitrogen heterocyclic compound 18148
                                    isoquinolines 530
                                      nomifensine 10
                                        (R)-nomifensine 0
                                        (S)-nomifensine 0
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