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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-hydroxyestrone
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Accession:CHEBI:1156 term browser browse the term
Definition:A 2-hydroxy steroid that is estrone substituted by a hydroxy group at position 2.
Synonyms:related_synonym: 2,3-Dihydroxyestra-1,3,5(10)-trien-17-one;   Formula=C18H22O3;   InChI=1S/C18H22O3/c1-18-7-6-11-12(14(18)4-5-17(18)21)3-2-10-8-15(19)16(20)9-13(10)11/h8-9,11-12,14,19-20H,2-7H2,1H3/t11-,12+,14-,18-/m0/s1;   InChIKey=SWINWPBPEKHUOD-JPVZDGGYSA-N;   SMILES=[H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])[C@]1([H])CCc1cc(O)c(O)cc21
 xref: CAS:362-06-1;   HMDB:HMDB0000343;   KEGG:C05298;   LIPID_MAPS_instance:LMST02010032
 xref_mesh: MESH:C024980
 xref: PMID:11054642;   PMID:29713726;   PMID:8337235;   Reaxys:2221833


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2-hydroxyestrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ckb creatine kinase B multiple interactions EXP 2-hydroxyestrone inhibits the reaction [Estradiol results in increased expression of CKB] CTD PMID:10030690 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837
JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions
ISO 2-hydroxyestrone binds to ESR1 protein
2-hydroxyestrone binds to and results in increased activity of ESR1 protein
CTD PMID:16728493, PMID:17713618 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO 2-hydroxyestrone binds to and results in increased activity of ESR2 protein CTD PMID:17713618 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression ISO 2-hydroxyestrone results in decreased expression of FSHB protein CTD PMID:6401747 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression ISO 2-hydroxyestrone results in decreased expression of LHB protein CTD PMID:6401747 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of 2-hydroxyestrone CTD PMID:15117964 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of 2-hydroxyestrone CTD PMID:15117964 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of 2-hydroxyestrone CTD PMID:15117964 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 2-hydroxyestrone CTD PMID:15117964 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      application 19385
        pharmaceutical 19255
          drug 19255
            antineoplastic agent 16999
              estrone 125
                2-hydroxyestrone 9
                  2-hydroxy-3-O-methyl estrone 0
                  2-hydroxyestrone 2-O-(beta-D-glucuronide) 0
                  2-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                  estra-1(10),4-diene-2,3,17-trione 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            organic group 18508
                              organic divalent group 18501
                                organodiyl group 18501
                                  carbonyl group 18404
                                    carbonyl compound 18404
                                      ketone 16152
                                        oxo steroid 9281
                                          17-oxo steroid 257
                                            estrone 125
                                              2-hydroxyestrone 9
                                                2-hydroxy-3-O-methyl estrone 0
                                                2-hydroxyestrone 2-O-(beta-D-glucuronide) 0
                                                2-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                                                estra-1(10),4-diene-2,3,17-trione 0
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