|
G
|
Ache
|
acetylcholinesterase
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [3-nitropropionic acid results in increased activity of ACHE protein]; thymoquinone inhibits the reaction [Cytarabine results in increased activity of ACHE protein]
|
CTD |
PMID:27206696 PMID:36419121 |
|
NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651
|
|
G
|
Acta2
|
actin alpha 2, smooth muscle
|
multiple interactions
|
ISO
|
thymoquinone inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]; thymoquinone inhibits the reaction [Paraquat results in increased expression of ACTA2 mRNA]; thymoquinone inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]; thymoquinone inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein] thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of ACTA2 protein]; thymoquinone inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
|
CTD |
PMID:27375216 PMID:27688165 PMID:31935363 |
|
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554
|
|
G
|
Actg2
|
actin gamma 2, smooth muscle
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Thioacetamide results in increased expression of ACTG2 mRNA]
|
CTD |
PMID:38504479 |
|
NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465
|
|
G
|
Ada
|
adenosine deaminase
|
multiple interactions
|
ISO
|
thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased activity of ADA protein]
|
CTD |
PMID:36193556 |
|
NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:152,398,747...152,447,088
|
|
G
|
Adam17
|
ADAM metallopeptidase domain 17
|
decreases expression
|
ISO
|
thymoquinone results in decreased expression of ADAM17 protein
|
CTD |
PMID:36558177 |
|
NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:40,872,856...40,920,639
|
|
G
|
Afp
|
alpha-fetoprotein
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]; thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein alternative form]; thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]
|
CTD |
PMID:24012840 PMID:29923357 PMID:35437842 |
|
NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,573,412...17,591,480
|
|
G
|
Aifm1
|
apoptosis inducing factor, mitochondria associated 1
|
increases expression
|
ISO
|
thymoquinone results in increased expression of AIFM1 protein
|
CTD |
PMID:29981725 |
|
NCBI chr X:132,528,107...132,567,237
Ensembl chr X:127,650,226...127,689,256
|
|
G
|
Akt1
|
AKT serine/threonine kinase 1
|
decreases phosphorylation multiple interactions
|
ISO
|
thymoquinone results in decreased phosphorylation of AKT1 protein thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of AKT1 protein]
|
CTD |
PMID:31298468 PMID:36193556 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
|
|
G
|
Akt2
|
AKT serine/threonine kinase 2
|
multiple interactions
|
ISO
|
thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of AKT2 protein]
|
CTD |
PMID:36193556 |
|
NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817
|
|
G
|
Alpl
|
alkaline phosphatase, biomineralization associated
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Malathion results in increased activity of ALPL protein]
|
CTD |
PMID:33510276 |
|
NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:149,951,409...150,006,446
|
|
G
|
App
|
amyloid beta precursor protein
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APP protein alternative form]; thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APP protein]
|
CTD |
PMID:28734741 |
|
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
|
|
G
|
Ar
|
androgen receptor
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Propylthiouracil results in decreased expression of AR protein]
|
CTD |
PMID:36506574 |
|
NCBI chr X:67,135,317...67,304,476
Ensembl chr X:63,104,771...63,273,925
|
|
G
|
Atf4
|
activating transcription factor 4
|
increases expression
|
ISO
|
thymoquinone results in increased expression of ATF4 mRNA; thymoquinone results in increased expression of ATF4 protein
|
CTD |
PMID:29981725 |
|
NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446
|
|
G
|
Atf6
|
activating transcription factor 6
|
increases expression
|
ISO
|
thymoquinone results in increased expression of ATF6 mRNA; thymoquinone results in increased expression of ATF6 protein
|
CTD |
PMID:29981725 |
|
NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
|
|
G
|
Atg12
|
autophagy related 12
|
decreases expression
|
ISO
|
thymoquinone results in decreased expression of ATG12 protein
|
CTD |
PMID:31298468 |
|
NCBI chr18:41,638,841...41,649,311
Ensembl chr18:39,452,191...39,462,418
|
|
G
|
Atg5
|
autophagy related 5
|
decreases expression
|
ISO
|
thymoquinone results in decreased expression of ATG5 protein
|
CTD |
PMID:31298468 |
|
NCBI chr20:49,380,835...49,471,826
Ensembl chr20:47,798,290...47,889,209
|
|
G
|
Atg7
|
autophagy related 7
|
decreases expression
|
ISO
|
thymoquinone results in decreased expression of ATG7 protein
|
CTD |
PMID:31298468 |
|
NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:147,718,752...147,925,593
|
|
G
|
Bad
|
BCL2-associated agonist of cell death
|
decreases expression
|
ISO
|
thymoquinone results in decreased expression of BAD protein
|
CTD |
PMID:34173702 |
|
NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823
|
|
G
|
Bax
|
BCL2 associated X, apoptosis regulator
|
multiple interactions increases expression
|
EXP ISO
|
thymoquinone affects the reaction [Ethanol affects the expression of BAX mRNA]; thymoquinone inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX mRNA]; thymoquinone inhibits the reaction [Ethanol results in increased expression of BAX protein]; thymoquinone inhibits the reaction [sodium arsenate results in increased expression of BAX mRNA]; thymoquinone inhibits the reaction [sodium arsenate results in increased expression of BAX protein]; thymoquinone inhibits the reaction [sodium arsenite results in increased expression of BAX protein] thymoquinone results in increased expression of BAX protein [Benzo(a)pyrene co-treated with thymoquinone] results in increased expression of BAX mRNA; thymoquinone results in increased expression of and affects the localization of BAX protein thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein]
|
CTD |
PMID:24289642 PMID:29085585 PMID:29710533 PMID:29981725 PMID:30558456 PMID:31433961 PMID:34627931 PMID:35437842 PMID:36193556 More...
|
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
decreases expression multiple interactions
|
ISO EXP
|
thymoquinone results in decreased expression of BCL2 protein thymoquinone affects the reaction [Ethanol affects the expression of BCL2 mRNA]; thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of BCL2 mRNA]; thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA]; thymoquinone inhibits the reaction [Ethanol results in decreased expression of BCL2 protein]; thymoquinone inhibits the reaction [sodium arsenate results in decreased expression of BCL2 mRNA]; thymoquinone inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein] [Benzo(a)pyrene co-treated with thymoquinone] results in decreased expression of BCL2 mRNA; DDIT3 protein affects the reaction [thymoquinone results in decreased expression of BCL2 protein] thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein]
|
CTD |
PMID:21609759 PMID:24289642 PMID:29085585 PMID:29710533 PMID:29923357 PMID:29981725 PMID:30558456 PMID:31298468 PMID:31433961 PMID:35437842 PMID:36193556 More...
|
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G
|
Bcl2l1
|
Bcl2-like 1
|
decreases expression multiple interactions
|
ISO
|
thymoquinone results in decreased expression of BCL2L1 protein thymoquinone inhibits the reaction [Bleomycin results in decreased expression of BCL2L1 mRNA]
|
CTD |
PMID:29981725 PMID:31433961 PMID:34627931 PMID:34818114 |
|
NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
|
|
G
|
Bid
|
BH3 interacting domain death agonist
|
decreases expression
|
ISO
|
thymoquinone results in decreased expression of BID protein
|
CTD |
PMID:31298468 |
|
NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720
|
|
G
|
Birc5
|
baculoviral IAP repeat-containing 5
|
decreases expression multiple interactions
|
ISO EXP
|
thymoquinone results in decreased expression of BIRC5 protein Doxorubicin promotes the reaction [thymoquinone results in decreased expression of BIRC5 protein]; thymoquinone promotes the reaction [Doxorubicin results in decreased expression of BIRC5 protein] thymoquinone inhibits the reaction [Malathion results in increased expression of BIRC5 protein]
|
CTD |
PMID:31433961 PMID:33510276 PMID:34605108 PMID:34627931 |
|
NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380
|
|
G
|
Casp1
|
caspase 1
|
multiple interactions
|
ISO
|
thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of CASP1 protein]
|
CTD |
PMID:31935363 |
|
NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383
|
|
G
|
Casp12
|
caspase 12
|
decreases expression
|
ISO
|
thymoquinone results in decreased expression of CASP12 protein
|
CTD |
PMID:29981725 |
|
NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:2,642,434...2,674,037
|
|
G
|
Casp3
|
caspase 3
|
increases expression multiple interactions increases cleavage increases activity
|
ISO EXP
|
thymoquinone results in increased expression of CASP3 protein modified form 4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased cleavage of CASP3 protein]; [[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone] which results in increased cleavage of CASP3 protein; [Temozolomide results in decreased susceptibility to Temozolomide] inhibits the reaction [thymoquinone results in increased cleavage of CASP3 protein]; [Temozolomide results in decreased susceptibility to Temozolomide] promotes the reaction [thymoquinone results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of CASP3 protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [thymoquinone results in increased activity of CASP3 protein]; DDIT3 protein affects the reaction [thymoquinone results in increased activity of and results in increased cleavage of CASP3 protein]; MAPK14 protein promotes the reaction [[[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone] which results in increased cleavage of CASP3 protein]; MAPK3 protein inhibits the reaction [thymoquinone results in increased expression of CASP3 protein modified form]; thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of CASP3 protein]; thymoquinone results in increased activity of and results in increased cleavage of CASP3 protein thymoquinone inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 mRNA]; thymoquinone inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; thymoquinone inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein]; thymoquinone inhibits the reaction [nonylphenol results in increased expression of CASP3 protein]; thymoquinone inhibits the reaction [Propylthiouracil results in increased expression of CASP3 protein]; thymoquinone inhibits the reaction [sodium arsenate results in increased cleavage of CASP3 protein]; thymoquinone inhibits the reaction [sodium arsenate results in increased expression of CASP3 mRNA]; thymoquinone inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein] Doxorubicin promotes the reaction [thymoquinone results in increased activity of CASP3 protein]; thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased expression of CASP3 protein]; thymoquinone promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]
|
CTD |
PMID:29085585 PMID:29710533 PMID:29981725 PMID:30558456 PMID:31298468 PMID:31433961 PMID:31935363 PMID:32394736 PMID:34173702 PMID:34234489 PMID:34605108 PMID:34627931 PMID:35437842 PMID:36176197 PMID:36193556 PMID:37466128 More...
|
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
|
|
G
|
Casp7
|
caspase 7
|
increases expression increases cleavage multiple interactions
|
ISO
|
thymoquinone results in increased expression of CASP7 protein modified form thymoquinone results in increased cleavage of CASP7 protein Acetylcysteine inhibits the reaction [thymoquinone results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of CASP7 protein modified form]
|
CTD |
PMID:29981725 PMID:31433961 PMID:34627931 |
|
NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729
|
|
G
|
Casp8
|
caspase 8
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Ethanol results in increased cleavage of CASP8 protein]
|
CTD |
PMID:29085585 |
|
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
|
|
G
|
Casp9
|
caspase 9
|
increases expression multiple interactions increases cleavage increases activity
|
ISO EXP
|
thymoquinone results in increased expression of CASP9 protein modified form Acetylcysteine inhibits the reaction [thymoquinone results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of CASP9 protein modified form] thymoquinone inhibits the reaction [Ethanol results in increased cleavage of CASP9 protein] Doxorubicin promotes the reaction [thymoquinone results in increased activity of CASP9 protein]; thymoquinone promotes the reaction [Doxorubicin results in increased activity of CASP9 protein]
|
CTD |
PMID:29085585 PMID:29981725 PMID:31298468 PMID:31433961 PMID:34605108 PMID:34627931 More...
|
|
Ensembl chr 5:154,109,046...154,126,626
|
|
G
|
Cat
|
catalase
|
increases activity multiple interactions
|
EXP ISO
|
thymoquinone results in increased activity of CAT protein thymoquinone analog inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of CAT mRNA]; thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [cyhalothrin results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [Diethylnitrosamine results in decreased expression of CAT mRNA]; thymoquinone inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [Propylthiouracil results in decreased expression of CAT mRNA]; thymoquinone inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [Thioacetamide results in decreased activity of CAT protein] thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]
|
CTD |
PMID:10755708 PMID:20957680 PMID:20972371 PMID:21382363 PMID:22450443 PMID:26645134 PMID:27206696 PMID:28734741 PMID:29923357 PMID:30558456 PMID:33832332 PMID:34234489 PMID:35437842 PMID:36193556 PMID:38504479 More...
|
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
|
|
G
|
Ccnb1
|
cyclin B1
|
decreases expression
|
ISO
|
thymoquinone results in decreased expression of CCNB1 protein
|
CTD |
PMID:32112862 |
|
NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172
|
|
G
|
Ccnd1
|
cyclin D1
|
decreases expression multiple interactions
|
ISO EXP
|
thymoquinone results in decreased expression of CCND1 mRNA; thymoquinone results in decreased expression of CCND1 protein [Benzo(a)pyrene co-treated with thymoquinone] results in decreased expression of CCND1 mRNA; Acetylcysteine inhibits the reaction [thymoquinone results in decreased expression of CCND1 protein] thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 protein] Doxorubicin promotes the reaction [thymoquinone results in decreased expression of CCND1 protein]; thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased expression of CCND1 protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased expression of CCND1 protein]
|
CTD |
PMID:24012840 PMID:24289642 PMID:31433961 PMID:32112862 PMID:34605108 PMID:34627931 PMID:36193556 More...
|
|
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
|
|
G
|
Ccnd2
|
cyclin D2
|
multiple interactions decreases expression
|
ISO
|
Acetylcysteine inhibits the reaction [thymoquinone results in decreased expression of CCND2 protein]
|
CTD |
PMID:34627931 |
|
NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:159,962,363...159,989,495
|
|
G
|
Ccnd3
|
cyclin D3
|
decreases expression multiple interactions
|
ISO
|
thymoquinone results in decreased expression of CCND3 protein Acetylcysteine inhibits the reaction [thymoquinone results in decreased expression of CCND3 protein]
|
CTD |
PMID:32112862 PMID:34627931 |
|
NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:13,394,169...13,489,371
|
|
G
|
Ccne1
|
cyclin E1
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of CCNE1 protein]
|
CTD |
PMID:24012840 |
|
NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101
|
|
G
|
Cd14
|
CD14 molecule
|
multiple interactions
|
ISO
|
thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein]
|
CTD |
PMID:31935363 |
|
NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,335,340...28,337,261
|
|
G
|
Cd44
|
CD44 molecule
|
decreases expression
|
ISO
|
thymoquinone results in decreased expression of CD44 protein
|
CTD |
PMID:31298468 |
|
NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620
|
|
G
|
Cdh1
|
cadherin 1
|
increases expression multiple interactions
|
ISO
|
thymoquinone results in increased expression of CDH1 protein CTNNB1 protein inhibits the reaction [thymoquinone results in increased expression of CDH1 protein]; Lithium Chloride inhibits the reaction [thymoquinone results in increased expression of CDH1 protein]; thymoquinone promotes the reaction [cordycepin results in increased expression of CDH1 protein]; XAV939 promotes the reaction [thymoquinone results in increased expression of CDH1 protein]
|
CTD |
PMID:32112862 PMID:35774120 |
|
NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775
|
|
G
|
Cdh2
|
cadherin 2
|
decreases expression multiple interactions
|
ISO
|
thymoquinone results in decreased expression of CDH2 protein CTNNB1 protein inhibits the reaction [thymoquinone results in decreased expression of CDH2 protein]; Lithium Chloride inhibits the reaction [thymoquinone results in decreased expression of CDH2 protein]; thymoquinone promotes the reaction [cordycepin results in decreased expression of CDH2 protein]; XAV939 promotes the reaction [thymoquinone results in decreased expression of CDH2 protein]
|
CTD |
PMID:32112862 PMID:35774120 |
|
NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167
|
|
G
|
Cdk2
|
cyclin dependent kinase 2
|
decreases expression
|
ISO
|
thymoquinone results in decreased expression of CDK2 protein
|
CTD |
PMID:32112862 |
|
NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
|
|
G
|
Cdk4
|
cyclin-dependent kinase 4
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of CDK4 protein]
|
CTD |
PMID:24012840 |
|
NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403
|
|
G
|
Cdkn1a
|
cyclin-dependent kinase inhibitor 1A
|
multiple interactions
|
EXP ISO
|
thymoquinone inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein] [Benzo(a)pyrene co-treated with thymoquinone] results in increased expression of CDKN1A mRNA
|
CTD |
PMID:24012840 PMID:24289642 |
|
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
|
|
G
|
Ceacam20
|
CEA cell adhesion molecule 20
|
decreases expression multiple interactions
|
ISO
|
thymoquinone results in decreased expression of CEACAM20 protein Doxorubicin promotes the reaction [thymoquinone results in decreased expression of CEACAM20 protein]; thymoquinone promotes the reaction [Doxorubicin results in decreased expression of CEACAM20 protein]
|
CTD |
PMID:34605108 |
|
NCBI chr 1:79,622,077...79,643,782
Ensembl chr 1:79,622,077...79,643,782
|
|
G
|
Chuk
|
component of inhibitor of nuclear factor kappa B kinase complex
|
multiple interactions
|
ISO
|
[Benzo(a)pyrene co-treated with thymoquinone] results in decreased expression of CHUK mRNA
|
CTD |
PMID:24289642 |
|
NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:242,959,760...242,995,065
|
|
G
|
Col1a1
|
collagen type I alpha 1 chain
|
multiple interactions
|
ISO EXP
|
thymoquinone inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] thymoquinone inhibits the reaction [Ethanol results in increased expression of COL1A1 protein]; thymoquinone inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA]; thymoquinone inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]
|
CTD |
PMID:27375216 PMID:27688165 PMID:31935363 PMID:38504479 |
|
NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624
|
|
G
|
Col4a1
|
collagen type IV alpha 1 chain
|
multiple interactions
|
ISO
|
thymoquinone inhibits the reaction [Paraquat results in increased expression of COL4A1 mRNA]
|
CTD |
PMID:27375216 |
|
NCBI chr16:84,885,597...84,996,482
Ensembl chr16:78,183,533...78,294,412
|
|
G
|
Ctnnb1
|
catenin beta 1
|
decreases expression multiple interactions
|
ISO EXP
|
thymoquinone results in decreased expression of CTNNB1 protein thymoquinone results in decreased expression of CTNNB1 mRNA CTNNB1 protein inhibits the reaction [thymoquinone results in decreased expression of CDH2 protein]; CTNNB1 protein inhibits the reaction [thymoquinone results in decreased expression of MMP2 protein]; CTNNB1 protein inhibits the reaction [thymoquinone results in decreased expression of VIM protein]; CTNNB1 protein inhibits the reaction [thymoquinone results in increased expression of CDH1 protein]; Lithium Chloride inhibits the reaction [thymoquinone results in decreased expression of and results in increased phosphorylation of CTNNB1 protein]; thymoquinone inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of CTNNB1 protein]; thymoquinone results in decreased expression of and results in increased phosphorylation of and results in decreased activity of CTNNB1 protein; XAV939 promotes the reaction [thymoquinone results in decreased expression of and results in increased phosphorylation of CTNNB1 protein] thymoquinone inhibits the reaction [Propylthiouracil results in decreased expression of CTNNB1 mRNA]
|
CTD |
PMID:32112862 PMID:34234489 |
|
NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
|
|
G
|
Cxcr4
|
C-X-C motif chemokine receptor 4
|
increases expression
|
ISO
|
thymoquinone results in increased expression of CXCR4 mRNA
|
CTD |
PMID:31812774 |
|
NCBI chr13:42,630,383...42,634,288
Ensembl chr13:40,077,976...40,081,883
|
|
G
|
Cycs
|
cytochrome c, somatic
|
increases expression multiple interactions
|
ISO
|
thymoquinone results in increased expression of CYCS protein thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased expression of CYCS protein]
|
CTD |
PMID:31433961 PMID:36193556 |
|
NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
|
|
G
|
Cyp1a1
|
cytochrome P450, family 1, subfamily a, polypeptide 1
|
multiple interactions
|
ISO
|
thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]
|
CTD |
PMID:36193556 |
|
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
|
|
G
|
Cyp2e1
|
cytochrome P450, family 2, subfamily e, polypeptide 1
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Diethylnitrosamine results in decreased expression of CYP2E1 protein]
|
CTD |
PMID:35437842 |
|
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
|
|
G
|
Ddit3
|
DNA-damage inducible transcript 3
|
multiple interactions increases expression
|
ISO EXP
|
4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased expression of DDIT3 protein]; DDIT3 protein affects the reaction [thymoquinone results in decreased expression of BCL2 protein]; DDIT3 protein affects the reaction [thymoquinone results in increased activity of and results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [thymoquinone results in increased cleavage of PARP1 protein] thymoquinone results in increased expression of DDIT3 mRNA; thymoquinone results in increased expression of DDIT3 protein thymoquinone inhibits the reaction [Doxorubicin results in increased expression of DDIT3 protein]
|
CTD |
PMID:29981725 PMID:34392583 |
|
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
|
|
G
|
Dnm1l
|
dynamin 1-like
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Rotenone results in increased expression of DNM1L protein]
|
CTD |
PMID:28526446 |
|
NCBI chr11:98,084,049...98,135,663
Ensembl chr11:84,581,216...84,631,482
|
|
G
|
Eif2ak3
|
eukaryotic translation initiation factor 2 alpha kinase 3
|
increases expression
|
ISO
|
thymoquinone results in increased expression of EIF2AK3 protein
|
CTD |
PMID:29981725 |
|
NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911
|
|
G
|
Ephx1
|
epoxide hydrolase 1
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Carbon Tetrachloride results in decreased expression of EPHX1 mRNA]
|
CTD |
PMID:21994235 |
|
NCBI chr13:95,246,079...95,275,852
Ensembl chr13:92,714,315...92,790,235
|
|
G
|
Ern1
|
endoplasmic reticulum to nucleus signaling 1
|
increases expression
|
ISO
|
thymoquinone results in increased expression of ERN1 mRNA; thymoquinone results in increased expression of ERN1 protein
|
CTD |
PMID:29981725 |
|
NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029
|
|
G
|
Fos
|
Fos proto-oncogene, AP-1 transcription factor subunit
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of FOS mRNA]
|
CTD |
PMID:29923357 |
|
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
|
|
G
|
Fshb
|
follicle stimulating hormone subunit beta
|
multiple interactions
|
ISO
|
thymoquinone inhibits the reaction [Bleomycin results in increased expression of FSHB protein]
|
CTD |
PMID:34818114 |
|
NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370
|
|
G
|
G6pd
|
glucose-6-phosphate dehydrogenase
|
increases activity multiple interactions
|
EXP
|
thymoquinone results in increased activity of G6PD protein thymoquinone inhibits the reaction [Cisplatin results in decreased activity of G6PD protein]
|
CTD |
PMID:33832332 |
|
NCBI chr X:157,352,364...157,372,144
Ensembl chr X:152,201,098...152,220,801
|
|
G
|
Gfap
|
glial fibrillary acidic protein
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [nonylphenol results in increased expression of GFAP protein]
|
CTD |
PMID:37466128 |
|
NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589
|
|
G
|
Ggt1
|
gamma-glutamyltransferase 1
|
multiple interactions
|
ISO EXP
|
thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased activity of GGT1 protein] thymoquinone inhibits the reaction [Thioacetamide results in increased activity of GGT1 protein]
|
CTD |
PMID:36193556 PMID:38504479 |
|
NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,700...13,108,442
|
|
G
|
Got1
|
glutamic-oxaloacetic transaminase 1
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Malathion results in increased activity of GOT1 protein]
|
CTD |
PMID:33510276 |
|
NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:242,357,306...242,380,633
|
|
G
|
Gpc3
|
glypican 3
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of GPC3 protein]
|
CTD |
PMID:35437842 |
|
NCBI chr X:136,789,770...137,157,598
Ensembl chr X:131,868,990...132,236,798
|
|
G
|
Gpt
|
glutamic--pyruvic transaminase
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased activity of GPT protein]; thymoquinone inhibits the reaction [Cisplatin results in increased activity of GPT protein]; thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of GPT protein]; thymoquinone inhibits the reaction [Ethanol results in increased activity of GPT protein]; thymoquinone inhibits the reaction [Malathion results in increased activity of GPT protein]; thymoquinone inhibits the reaction [Thioacetamide results in increased activity of GPT protein]
|
CTD |
PMID:29085585 PMID:29923357 PMID:33510276 PMID:33832332 PMID:35437842 PMID:38504479 More...
|
|
NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
|
|
G
|
Gpx1
|
glutathione peroxidase 1
|
multiple interactions
|
EXP ISO
|
thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA] thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased activity of GPX1 protein]
|
CTD |
PMID:28734741 PMID:36193556 |
|
NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024
|
|
G
|
Gsk3b
|
glycogen synthase kinase 3 beta
|
decreases phosphorylation multiple interactions
|
ISO EXP
|
thymoquinone results in decreased phosphorylation of GSK3B protein Lithium Chloride inhibits the reaction [thymoquinone results in decreased phosphorylation of GSK3B protein]; XAV939 promotes the reaction [thymoquinone results in decreased phosphorylation of GSK3B protein] thymoquinone inhibits the reaction [bisphenol A results in decreased phosphorylation of GSK3B protein]
|
CTD |
PMID:32112862 PMID:33315269 |
|
NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
|
|
G
|
Gsr
|
glutathione-disulfide reductase
|
multiple interactions
|
EXP
|
thymoquinone analog inhibits the reaction [3-nitropropionic acid results in decreased activity of GSR protein]; thymoquinone inhibits the reaction [3-nitropropionic acid results in decreased activity of GSR protein]; thymoquinone inhibits the reaction [Cisplatin results in decreased activity of GSR protein]; thymoquinone inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; thymoquinone inhibits the reaction [Thioacetamide results in decreased activity of GSR protein]
|
CTD |
PMID:27206696 PMID:30558456 PMID:33832332 PMID:38504479 |
|
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
|
|
G
|
Gstp1
|
glutathione S-transferase pi 1
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of GSTP1 protein]
|
CTD |
PMID:35437842 |
|
NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
|
|
G
|
H2ax
|
H2A.X variant histone
|
increases phosphorylation
|
ISO
|
thymoquinone results in increased phosphorylation of H2AX protein
|
CTD |
PMID:31298468 |
|
NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
|
|
G
|
Hif1a
|
hypoxia inducible factor 1 subunit alpha
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Doxorubicin results in increased expression of HIF1A protein]
|
CTD |
PMID:34392583 |
|
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261
|
|
G
|
Hk1
|
hexokinase 1
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Cisplatin results in increased activity of HK1 protein]
|
CTD |
PMID:33832332 |
|
NCBI chr20:30,773,222...30,874,814
Ensembl chr20:30,230,486...30,332,131
|
|
G
|
Hmox1
|
heme oxygenase 1
|
multiple interactions increases expression
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [thymoquinone results in increased expression of HMOX1 protein]; [thymoquinone affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of HMOX1 protein]; dorsomorphin inhibits the reaction [thymoquinone results in increased expression of HMOX1 protein] thymoquinone results in increased expression of HMOX1 mRNA; thymoquinone results in increased expression of HMOX1 protein
|
CTD |
PMID:24355171 |
|
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
|
|
G
|
Hnf1a
|
HNF1 homeobox A
|
decreases expression
|
ISO
|
thymoquinone results in decreased expression of HNF1A mRNA
|
CTD |
PMID:32112862 |
|
NCBI chr12:47,299,171...47,333,457
Ensembl chr12:41,645,587...41,672,104
|
|
G
|
Hspa5
|
heat shock protein family A (Hsp70) member 5
|
multiple interactions increases expression
|
ISO EXP
|
4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased expression of HSPA5 protein] thymoquinone results in increased expression of HSPA5 mRNA; thymoquinone results in increased expression of HSPA5 protein thymoquinone inhibits the reaction [Doxorubicin results in increased expression of HSPA5 protein]
|
CTD |
PMID:29981725 PMID:34392583 |
|
NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
|
|
G
|
Ifng
|
interferon gamma
|
multiple interactions decreases expression
|
EXP ISO
|
thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IFNG mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IFNG protein] thymoquinone results in decreased expression of IFNG mRNA; thymoquinone results in decreased expression of IFNG protein [Benzo(a)pyrene co-treated with thymoquinone] results in decreased expression of IFNG protein
|
CTD |
PMID:22450443 PMID:24289642 PMID:26645134 |
|
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
|
|
G
|
Il10
|
interleukin 10
|
increases expression multiple interactions
|
EXP
|
thymoquinone results in increased expression of IL10 mRNA; thymoquinone results in increased expression of IL10 protein thymoquinone inhibits the reaction [cyhalothrin results in decreased expression of IL10 mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in decreased expression of IL10 protein]; thymoquinone inhibits the reaction [Doxorubicin results in decreased expression of IL10 protein]; thymoquinone inhibits the reaction [Propylthiouracil results in decreased expression of IL10 mRNA]
|
CTD |
PMID:22450443 PMID:25268985 PMID:26645134 PMID:34234489 |
|
NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
|
|
G
|
Il17a
|
interleukin 17A
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Doxorubicin results in increased expression of IL17A protein]
|
CTD |
PMID:34392583 |
|
NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889
|
|
G
|
Il1b
|
interleukin 1 beta
|
multiple interactions decreases expression increases expression
|
EXP ISO
|
thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL1B protein]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IL1B mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IL1B protein]; thymoquinone inhibits the reaction [Thioacetamide results in increased expression of IL1B protein] thymoquinone results in decreased expression of IL1B mRNA; thymoquinone results in decreased expression of IL1B protein thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] thymoquinone results in increased expression of IL1B protein
|
CTD |
PMID:22450443 PMID:26645134 PMID:29405769 PMID:31935363 PMID:38504479 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
|
|
G
|
Il4
|
interleukin 4
|
increases expression multiple interactions
|
EXP
|
thymoquinone results in increased expression of IL4 mRNA; thymoquinone results in increased expression of IL4 protein thymoquinone inhibits the reaction [cyhalothrin results in decreased expression of IL4 mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in decreased expression of IL4 protein]
|
CTD |
PMID:26645134 |
|
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions decreases expression
|
EXP ISO
|
thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IL6 mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IL6 protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased expression of IL6 protein]; thymoquinone inhibits the reaction [Ethanol results in increased expression of IL6 protein]; thymoquinone inhibits the reaction [sodium arsenite results in increased expression of IL6 protein] thymoquinone results in decreased expression of IL6 mRNA; thymoquinone results in decreased expression of IL6 protein Doxorubicin promotes the reaction [thymoquinone results in decreased expression of IL6 protein]
|
CTD |
PMID:22450443 PMID:25268985 PMID:26645134 PMID:29085585 PMID:30558456 PMID:34605108 More...
|
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
|
|
G
|
Il6r
|
interleukin 6 receptor
|
decreases expression multiple interactions
|
ISO
|
thymoquinone results in decreased expression of IL6R mRNA Doxorubicin promotes the reaction [thymoquinone results in decreased expression of IL6R mRNA]
|
CTD |
PMID:34605108 |
|
NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:175,298,686...175,347,536
|
|
G
|
Ins1
|
insulin 1
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of INS1 protein]; thymoquinone inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased secretion of INS1 protein]
|
CTD |
PMID:21382363 |
|
NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536
|
|
G
|
Irf3
|
interferon regulatory factor 3
|
multiple interactions increases expression
|
EXP
|
thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IRF3 mRNA] thymoquinone results in increased expression of IRF3 mRNA
|
CTD |
PMID:29405769 |
|
NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
|
|
G
|
Irs1
|
insulin receptor substrate 1
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [bisphenol A results in decreased phosphorylation of IRS1 protein]
|
CTD |
PMID:33315269 |
|
NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:83,548,944...83,606,122
|
|
G
|
Jak2
|
Janus kinase 2
|
multiple interactions decreases phosphorylation
|
ISO
|
Doxorubicin promotes the reaction [thymoquinone results in decreased phosphorylation of JAK2 protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased phosphorylation of JAK2 protein] Acetylcysteine inhibits the reaction [thymoquinone results in decreased phosphorylation of JAK2 protein]
|
CTD |
PMID:34605108 PMID:34627931 |
|
NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189
|
|
G
|
Kit
|
KIT proto-oncogene receptor tyrosine kinase
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Malathion results in increased expression of KIT protein]
|
CTD |
PMID:33510276 |
|
NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,548,877...32,624,652
|
|
G
|
Lap3
|
leucine aminopeptidase 3
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Cisplatin results in decreased activity of LAP3 protein]
|
CTD |
PMID:33832332 |
|
NCBI chr14:65,608,375...65,627,359
Ensembl chr14:65,608,376...65,627,359
|
|
G
|
Lef1
|
lymphoid enhancer binding factor 1
|
decreases expression
|
ISO
|
thymoquinone results in decreased expression of LEF1 mRNA
|
CTD |
PMID:32112862 |
|
NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:219,666,592...219,779,794
|
|
G
|
Lhb
|
luteinizing hormone subunit beta
|
multiple interactions
|
ISO
|
thymoquinone inhibits the reaction [Bleomycin results in increased expression of LHB protein]
|
CTD |
PMID:34818114 |
|
NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
|
|
G
|
Map1lc3a
|
microtubule-associated protein 1 light chain 3 alpha
|
increases lipidation
|
ISO
|
thymoquinone results in increased lipidation of MAP1LC3A protein
|
CTD |
PMID:31298468 |
|
NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
|
|
G
|
Mapk1
|
mitogen activated protein kinase 1
|
decreases phosphorylation increases phosphorylation multiple interactions
|
ISO
|
thymoquinone results in decreased phosphorylation of MAPK1 protein thymoquinone results in increased phosphorylation of MAPK1 protein [Temozolomide results in decreased susceptibility to Temozolomide] inhibits the reaction [thymoquinone results in increased phosphorylation of MAPK1 protein]; [Temozolomide results in decreased susceptibility to Temozolomide] promotes the reaction [[thymoquinone co-treated with SB 203580] results in increased phosphorylation of MAPK1 protein]; [Temozolomide results in decreased susceptibility to Temozolomide] promotes the reaction [thymoquinone results in increased phosphorylation of MAPK1 protein]; [thymoquinone co-treated with SB 203580] results in increased phosphorylation of MAPK1 protein; Anisomycin promotes the reaction [thymoquinone results in increased phosphorylation of MAPK1 protein]; MAPK3 protein inhibits the reaction [thymoquinone results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [thymoquinone results in increased phosphorylation of MAPK1 protein]
|
CTD |
PMID:27060453 PMID:34173702 PMID:36176197 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
|
|
G
|
Mapk14
|
mitogen activated protein kinase 14
|
multiple interactions
|
ISO
|
MAPK14 protein promotes the reaction [[[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone] which results in increased cleavage of CASP3 protein]; MAPK14 protein promotes the reaction [[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone]
|
CTD |
PMID:36176197 |
|
NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589
|
|
G
|
Mapk3
|
mitogen activated protein kinase 3
|
multiple interactions decreases phosphorylation increases phosphorylation decreases response to substance
|
EXP ISO
|
thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased phosphorylation of MAPK3 protein] thymoquinone results in decreased phosphorylation of MAPK3 protein [Temozolomide results in decreased susceptibility to Temozolomide] inhibits the reaction [thymoquinone results in increased phosphorylation of MAPK3 protein]; [Temozolomide results in decreased susceptibility to Temozolomide] promotes the reaction [[thymoquinone co-treated with SB 203580] results in increased phosphorylation of MAPK3 protein]; [Temozolomide results in decreased susceptibility to Temozolomide] promotes the reaction [thymoquinone results in increased phosphorylation of MAPK3 protein]; [thymoquinone co-treated with SB 203580] results in increased phosphorylation of MAPK3 protein; Anisomycin promotes the reaction [thymoquinone results in increased phosphorylation of MAPK3 protein]; MAPK3 protein inhibits the reaction [thymoquinone results in increased expression of CASP3 protein modified form]; MAPK3 protein inhibits the reaction [thymoquinone results in increased phosphorylation of MAPK1 protein]; MAPK3 protein inhibits the reaction [thymoquinone results in increased phosphorylation of MAPK3 protein]; MAPK3 protein promotes the reaction [[[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone] which results in increased expression of MGMT protein]; MAPK3 protein promotes the reaction [[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone]; U 0126 inhibits the reaction [thymoquinone results in increased phosphorylation of MAPK3 protein] MAPK3 protein results in decreased susceptibility to thymoquinone
|
CTD |
PMID:27060453 PMID:29923357 PMID:34173702 PMID:36176197 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
|
|
G
|
Mdm2
|
MDM2 proto-oncogene
|
decreases expression
|
ISO
|
thymoquinone results in decreased expression of MDM2 protein
|
CTD |
PMID:31433961 PMID:34627931 |
|
NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915
|
|
G
|
Met
|
MET proto-oncogene, receptor tyrosine kinase
|
decreases expression increases expression
|
ISO
|
thymoquinone results in decreased expression of MET mRNA thymoquinone results in increased expression of MET mRNA
|
CTD |
PMID:31812774 PMID:32112862 |
|
NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:45,790,791...45,897,876
|
|
G
|
Mgmt
|
O-6-methylguanine-DNA methyltransferase
|
multiple interactions
|
ISO
|
[[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone] which results in increased expression of MGMT protein; [Temozolomide results in decreased susceptibility to Temozolomide] inhibits the reaction [thymoquinone results in decreased expression of MGMT protein]; MAPK3 protein promotes the reaction [[[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone] which results in increased expression of MGMT protein]
|
CTD |
PMID:36176197 |
|
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
|
|
G
|
Mir125a
|
microRNA 125a
|
increases expression
|
ISO
|
thymoquinone results in increased expression of MIR125A mRNA
|
CTD |
PMID:34605108 |
|
NCBI chr 1:58,677,626...58,677,710
Ensembl chr 1:58,677,626...58,677,710
|
|
G
|
Mki67
|
marker of proliferation Ki-67
|
decreases expression
|
ISO
|
thymoquinone results in decreased expression of MKI67 protein
|
CTD |
PMID:31298468 |
|
NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762
|
|
G
|
Mmp13
|
matrix metallopeptidase 13
|
multiple interactions
|
ISO
|
thymoquinone inhibits the reaction [TGFB1 protein results in decreased expression of MMP13 protein]
|
CTD |
PMID:27688165 |
|
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
|
|
G
|
Mmp2
|
matrix metallopeptidase 2
|
multiple interactions decreases expression
|
ISO
|
CTNNB1 protein inhibits the reaction [thymoquinone results in decreased expression of MMP2 protein]; pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of MMP2 protein]; thymoquinone results in decreased expression of and results in decreased activity of MMP2 protein
|
CTD |
PMID:27060453 PMID:32112862 |
|
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
|
|
G
|
Mmp7
|
matrix metallopeptidase 7
|
decreases expression
|
ISO
|
thymoquinone results in decreased expression of MMP7 mRNA
|
CTD |
PMID:32112862 |
|
NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:4,848,186...4,855,902
|
|
G
|
Mmp9
|
matrix metallopeptidase 9
|
multiple interactions decreases expression
|
ISO
|
pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of MMP9 protein]; SB 203580 inhibits the reaction [thymoquinone results in decreased expression of MMP9 protein]; thymoquinone results in decreased expression of and results in decreased activity of MMP9 protein
|
CTD |
PMID:27060453 PMID:32112862 |
|
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
|
|
G
|
Mpo
|
myeloperoxidase
|
decreases activity
|
EXP
|
thymoquinone results in decreased activity of MPO protein
|
CTD |
PMID:22450443 |
|
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
|
|
G
|
Mtor
|
mechanistic target of rapamycin kinase
|
decreases phosphorylation
|
ISO
|
thymoquinone results in decreased phosphorylation of MTOR protein
|
CTD |
PMID:31298468 |
|
NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
|
|
G
|
Myc
|
MYC proto-oncogene, bHLH transcription factor
|
decreases expression
|
ISO
|
thymoquinone results in decreased expression of MYC mRNA
|
CTD |
PMID:32112862 |
|
NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
|
|
G
|
Myd88
|
MYD88, innate immune signal transduction adaptor
|
increases expression multiple interactions
|
EXP
|
thymoquinone results in increased expression of MYD88 mRNA thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of MYD88 mRNA]
|
CTD |
PMID:29405769 |
|
NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415
|
|
G
|
Nanog
|
Nanog homeobox
|
decreases expression
|
ISO
|
thymoquinone results in decreased expression of NANOG protein
|
CTD |
PMID:31298468 |
|
NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:155,943,737...155,951,116
|
|
G
|
Nes
|
nestin
|
decreases expression
|
ISO
|
thymoquinone results in decreased expression of NES protein
|
CTD |
PMID:31298468 |
|
NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:173,438,734...173,447,777
|
|
G
|
Nfe2l2
|
NFE2 like bZIP transcription factor 2
|
multiple interactions
|
EXP ISO
|
thymoquinone inhibits the reaction [Doxorubicin results in decreased activity of NFE2L2 protein]; thymoquinone inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [thymoquinone affects the localization of and results in increased activity of NFE2L2 protein]; [thymoquinone affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [thymoquinone affects the localization of and results in increased activity of NFE2L2 protein]; dorsomorphin inhibits the reaction [thymoquinone affects the localization of and results in increased activity of NFE2L2 protein]; thymoquinone affects the localization of and results in increased activity of NFE2L2 protein
|
CTD |
PMID:24355171 PMID:25268985 |
|
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
|
|
G
|
Nfkb1
|
nuclear factor kappa B subunit 1
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Propylthiouracil results in increased expression of NFKB1 mRNA]
|
CTD |
PMID:36506574 |
|
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
|
|
G
|
Ngf
|
nerve growth factor
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [nonylphenol results in increased expression of NGF protein]
|
CTD |
PMID:37466128 |
|
NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452
|
|
G
|
Nos1
|
nitric oxide synthase 1
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Isoproterenol results in decreased expression of NOS1 protein]
|
CTD |
PMID:35940283 |
|
NCBI chr12:44,276,011...44,456,371
Ensembl chr12:38,626,714...38,710,945
|
|
G
|
Nos2
|
nitric oxide synthase 2
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Thioacetamide results in increased expression of NOS2 protein]
|
CTD |
PMID:38504479 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
|
|
G
|
Nos3
|
nitric oxide synthase 3
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Isoproterenol results in increased expression of NOS3 protein]
|
CTD |
PMID:35940283 |
|
NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
|
|
G
|
Notch1
|
notch receptor 1
|
multiple interactions
|
ISO
|
[cordycepin co-treated with thymoquinone] results in decreased expression of NOTCH1 protein
|
CTD |
PMID:35774120 |
|
NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531
|
|
G
|
Nox4
|
NADPH oxidase 4
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Doxorubicin results in increased expression of NOX4 protein]
|
CTD |
PMID:25268985 |
|
NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406
|
|
G
|
Nppa
|
natriuretic peptide A
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Isoproterenol results in decreased secretion of NPPA protein]
|
CTD |
PMID:35940283 |
|
NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351
|
|
G
|
Nppb
|
natriuretic peptide B
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Isoproterenol results in decreased secretion of NPPB protein modified form]
|
CTD |
PMID:35940283 |
|
NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168
|
|
G
|
Parp1
|
poly (ADP-ribose) polymerase 1
|
increases cleavage multiple interactions increases expression
|
ISO
|
thymoquinone results in increased cleavage of PARP1 protein 4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of PARP1 protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [thymoquinone results in increased activity of PARP1 protein]; DDIT3 protein affects the reaction [thymoquinone results in increased cleavage of PARP1 protein]
|
CTD |
PMID:29981725 PMID:31298468 PMID:31433961 PMID:34627931 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
|
|
G
|
Pcna
|
proliferating cell nuclear antigen
|
multiple interactions
|
EXP ISO
|
thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of PCNA mRNA] thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased expression of PCNA protein]
|
CTD |
PMID:29923357 PMID:36193556 |
|
NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995
|
|
G
|
Pou5f1
|
POU class 5 homeobox 1
|
decreases expression
|
ISO
|
thymoquinone results in decreased expression of POU5F1 protein
|
CTD |
PMID:31298468 |
|
NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,223,129...3,227,891
|
|
G
|
Pparg
|
peroxisome proliferator-activated receptor gamma
|
increases expression multiple interactions
|
ISO
|
thymoquinone results in increased expression of PPARG protein PRKAA1 protein promotes the reaction [thymoquinone results in increased expression of PPARG protein]; thymoquinone inhibits the reaction [TGFB1 protein results in decreased expression of PPARG protein]
|
CTD |
PMID:27688165 |
|
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
|
|
G
|
Prkaa1
|
protein kinase AMP-activated catalytic subunit alpha 1
|
multiple interactions
|
ISO
|
PRKAA1 protein promotes the reaction [thymoquinone results in increased expression of PPARG protein]
|
CTD |
PMID:27688165 |
|
NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:54,240,137...54,275,978
|
|
G
|
Pten
|
phosphatase and tensin homolog
|
multiple interactions
|
ISO
|
thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased expression of PTEN protein]
|
CTD |
PMID:36193556 |
|
NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838
|
|
G
|
Ptgs1
|
prostaglandin-endoperoxide synthase 1
|
multiple interactions
|
ISO
|
[thymoquinone co-treated with Diclofenac] results in decreased expression of PTGS1 protein
|
CTD |
PMID:32220568 |
|
NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:19,584,015...19,605,586
|
|
G
|
Rbfox3
|
RNA binding fox-1 homolog 3
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [nonylphenol results in decreased expression of RBFOX3 protein]
|
CTD |
PMID:37466128 |
|
NCBI chr10:103,720,355...104,157,277
Ensembl chr10:103,720,636...104,156,935
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Bleomycin results in increased expression of RELA protein]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of RELA mRNA]
|
CTD |
PMID:22982510 PMID:26645134 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
|
|
G
|
Ripk1
|
receptor interacting serine/threonine kinase 1
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Isoproterenol results in increased expression of RIPK1 protein]
|
CTD |
PMID:35940283 |
|
NCBI chr17:31,044,983...31,077,167
Ensembl chr17:30,839,650...30,871,824
|
|
G
|
Ripk3
|
receptor-interacting serine-threonine kinase 3
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Isoproterenol results in increased expression of RIPK3 protein]
|
CTD |
PMID:35940283 |
|
NCBI chr15:33,253,071...33,262,025
Ensembl chr15:29,283,145...29,292,121
|
|
G
|
Rorc
|
RAR-related orphan receptor C
|
increases expression
|
ISO
|
thymoquinone results in increased expression of RORC mRNA
|
CTD |
PMID:31812774 |
|
NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:182,009,286...182,034,907
|
|
G
|
Sftpb
|
surfactant protein B
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Malathion results in decreased expression of SFTPB mRNA]
|
CTD |
PMID:33510276 |
|
NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436
|
|
G
|
Sirt1
|
sirtuin 1
|
multiple interactions
|
ISO EXP
|
thymoquinone inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein] thymoquinone inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein] thymoquinone inhibits the reaction [Propylthiouracil results in decreased expression of SIRT1 mRNA]; thymoquinone inhibits the reaction [Propylthiouracil results in decreased expression of SIRT1 protein]
|
CTD |
PMID:27688165 PMID:36506574 |
|
NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260
|
|
G
|
Smad3
|
SMAD family member 3
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Thioacetamide results in increased expression of SMAD3 mRNA]
|
CTD |
PMID:38504479 |
|
NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960
|
|
G
|
Smad7
|
SMAD family member 7
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [Thioacetamide results in increased expression of SMAD7 mRNA]
|
CTD |
PMID:38504479 |
|
NCBI chr18:71,263,508...71,291,849
Ensembl chr18:68,988,429...69,016,765
|
|
G
|
Snai1
|
snail family transcriptional repressor 1
|
decreases expression multiple interactions
|
ISO
|
thymoquinone results in decreased expression of SNAI1 protein pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of SNAI1 protein]; SB 203580 inhibits the reaction [thymoquinone results in decreased expression of SNAI1 protein]; thymoquinone promotes the reaction [cordycepin results in decreased expression of SNAI1 protein]
|
CTD |
PMID:27060453 PMID:35774120 |
|
NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969
|
|
G
|
Snai2
|
snail family transcriptional repressor 2
|
multiple interactions decreases expression
|
ISO
|
thymoquinone promotes the reaction [cordycepin results in decreased expression of SNAI2 protein] thymoquinone results in decreased expression of SNAI2 protein
|
CTD |
PMID:35774120 |
|
NCBI chr11:99,686,934...99,690,349
Ensembl chr11:86,181,909...86,186,200
|
|
G
|
Sod1
|
superoxide dismutase 1
|
multiple interactions
|
EXP ISO
|
thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD1 mRNA] thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased activity of SOD1 protein]
|
CTD |
PMID:28734741 PMID:36193556 |
|
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
|
|
G
|
Sod2
|
superoxide dismutase 2
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD2 mRNA]
|
CTD |
PMID:28734741 |
|
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
|
|
G
|
Sod3
|
superoxide dismutase 3
|
multiple interactions
|
EXP
|
thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA]
|
CTD |
PMID:28734741 |
|
NCBI chr14:62,822,865...62,828,602
Ensembl chr14:58,609,958...58,615,990
|
|
G
|
Src
|
SRC proto-oncogene, non-receptor tyrosine kinase
|
decreases phosphorylation multiple interactions
|
ISO
|
thymoquinone results in decreased phosphorylation of SRC protein Acetylcysteine inhibits the reaction [thymoquinone results in decreased phosphorylation of SRC protein] Doxorubicin promotes the reaction [thymoquinone results in decreased phosphorylation of SRC protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased phosphorylation of SRC protein]
|
CTD |
PMID:31433961 PMID:34605108 |
|
NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476
|
|
G
|
Stat3
|
signal transducer and activator of transcription 3
|
multiple interactions decreases phosphorylation
|
ISO
|
Acetylcysteine inhibits the reaction [thymoquinone results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in decreased phosphorylation of STAT3 protein]; thymoquinone results in decreased phosphorylation of and results in decreased activity of STAT3 protein Doxorubicin promotes the reaction [thymoquinone results in decreased phosphorylation of STAT3 protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased phosphorylation of STAT3 protein]
|
CTD |
PMID:31433961 PMID:34605108 PMID:34627931 |
|
NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057
|
|
G
|
Stat6
|
signal transducer and activator of transcription 6
|
increases expression
|
ISO
|
thymoquinone results in increased expression of STAT6 mRNA
|
CTD |
PMID:31812774 |
|
NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:63,479,642...63,498,495
|
|
G
|
Stk11
|
serine/threonine kinase 11
|
multiple interactions
|
ISO
|
thymoquinone inhibits the reaction [Ethanol results in decreased expression of STK11 protein modified form]; thymoquinone inhibits the reaction [Ethanol results in decreased expression of STK11 protein] thymoquinone inhibits the reaction [TGFB1 protein results in decreased phosphorylation of STK11 protein]
|
CTD |
PMID:27688165 |
|
NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:9,575,269...9,591,315
|
|
G
|
Tgfb1
|
transforming growth factor, beta 1
|
multiple interactions
|
ISO
|
thymoquinone inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA] thymoquinone inhibits the reaction [TGFB1 protein results in decreased expression of MMP13 protein]; thymoquinone inhibits the reaction [TGFB1 protein results in decreased expression of PPARG protein]; thymoquinone inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein]; thymoquinone inhibits the reaction [TGFB1 protein results in decreased phosphorylation of STK11 protein]; thymoquinone inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; thymoquinone inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; thymoquinone inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 protein]
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CTD |
PMID:27375216 PMID:27688165 |
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NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
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G
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Tgfb1i1
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transforming growth factor beta 1 induced transcript 1
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multiple interactions
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EXP
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thymoquinone inhibits the reaction [Thioacetamide results in increased expression of TGFB1I1 mRNA]
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CTD |
PMID:38504479 |
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NCBI chr 1:192,258,992...192,265,903
Ensembl chr 1:182,828,544...182,837,080
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G
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Ticam1
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TIR domain containing adaptor molecule 1
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increases expression multiple interactions
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EXP
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thymoquinone results in increased expression of TICAM1 mRNA thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TICAM1 mRNA]
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CTD |
PMID:29405769 |
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NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,102,366...1,123,147
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G
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Timp1
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TIMP metallopeptidase inhibitor 1
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multiple interactions increases expression
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ISO
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thymoquinone inhibits the reaction [Thioacetamide results in increased expression of TIMP1 mRNA]; thymoquinone inhibits the reaction [Thioacetamide results in increased expression of TIMP1 protein] thymoquinone results in increased expression of TIMP1 protein pyrazolanthrone inhibits the reaction [thymoquinone results in increased expression of TIMP1 protein]; SB 203580 inhibits the reaction [thymoquinone results in increased expression of TIMP1 protein]; thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of TIMP1 protein]; thymoquinone inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 protein]
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CTD |
PMID:27060453 PMID:27688165 PMID:31935363 |
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NCBI chr X:3,766,509...3,772,578
Ensembl chr X:1,212,972...1,217,664
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G
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Timp2
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TIMP metallopeptidase inhibitor 2
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increases expression multiple interactions
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ISO
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thymoquinone results in increased expression of TIMP2 protein pyrazolanthrone inhibits the reaction [thymoquinone results in increased expression of TIMP2 protein]; SB 203580 inhibits the reaction [thymoquinone results in increased expression of TIMP2 protein]
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CTD |
PMID:27060453 |
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NCBI chr10:104,041,604...104,089,214
Ensembl chr10:103,531,505...103,590,611
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G
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Tlr2
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toll-like receptor 2
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multiple interactions increases expression
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EXP
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thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TLR2 mRNA] thymoquinone results in increased expression of TLR2 mRNA
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CTD |
PMID:29405769 |
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NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630
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G
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Tlr4
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toll-like receptor 4
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multiple interactions increases expression
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ISO EXP
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thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TLR4 mRNA] thymoquinone results in increased expression of TLR4 mRNA
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CTD |
PMID:29405769 PMID:31935363 |
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NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
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G
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Tnf
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tumor necrosis factor
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multiple interactions decreases expression increases expression
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EXP
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thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TNF protein]; thymoquinone inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of TNF mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of TNF protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; thymoquinone inhibits the reaction [Ethanol results in increased expression of TNF protein]; thymoquinone inhibits the reaction [Propylthiouracil results in increased expression of TNF mRNA]; thymoquinone inhibits the reaction [Propylthiouracil results in increased expression of TNF protein]; thymoquinone inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; thymoquinone inhibits the reaction [Thioacetamide results in increased expression of TNF protein] thymoquinone results in decreased expression of TNF mRNA; thymoquinone results in decreased expression of TNF protein thymoquinone results in increased expression of TNF protein
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CTD |
PMID:20957680 PMID:22450443 PMID:25268985 PMID:26645134 PMID:29085585 PMID:29405769 PMID:30558456 PMID:34392583 PMID:36506574 PMID:38504479 More...
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NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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G
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Tnfrsf10b
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TNF receptor superfamily member 10b
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multiple interactions
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ISO
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[Benzo(a)pyrene co-treated with thymoquinone] results in increased expression of TNFRSF10A mRNA
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CTD |
PMID:24289642 |
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NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
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G
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Tnfrsf25
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TNF receptor superfamily member 25
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multiple interactions
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ISO
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thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF25 protein]
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CTD |
PMID:31935363 |
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NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341
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G
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Tnni3
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troponin I3, cardiac type
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multiple interactions
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EXP
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thymoquinone inhibits the reaction [Isoproterenol results in increased secretion of TNNI3 protein]
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CTD |
PMID:35940283 |
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NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
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G
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Top2a
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DNA topoisomerase II alpha
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affects activity
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ISO
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thymoquinone affects the activity of TOP2A protein
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CTD |
PMID:24650156 |
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NCBI chr10:84,441,954...84,473,093
Ensembl chr10:83,945,735...83,976,874
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G
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Tp53
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tumor protein p53
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multiple interactions increases expression
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ISO
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Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of TP53 protein] thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased expression of TP53 protein]
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CTD |
PMID:21609759 PMID:31433961 PMID:34627931 PMID:36193556 |
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NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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G
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Twist1
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twist family bHLH transcription factor 1
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multiple interactions decreases expression
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ISO
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pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of TWIST1 protein]; SB 203580 inhibits the reaction [thymoquinone results in decreased expression of TWIST1 protein]; thymoquinone promotes the reaction [cordycepin results in decreased expression of TWIST1 protein]
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CTD |
PMID:27060453 PMID:35774120 |
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NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:50,674,678...50,677,653
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G
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Vegfa
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vascular endothelial growth factor A
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multiple interactions decreases expression
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ISO
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Doxorubicin promotes the reaction [thymoquinone results in decreased expression of VEGFA protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased expression of VEGFA protein]
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CTD |
PMID:34605108 |
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NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
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G
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Vim
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vimentin
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multiple interactions decreases expression
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ISO
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CTNNB1 protein inhibits the reaction [thymoquinone results in decreased expression of VIM protein]; Lithium Chloride inhibits the reaction [thymoquinone results in decreased expression of VIM protein]; pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of VIM protein]; XAV939 promotes the reaction [thymoquinone results in decreased expression of VIM protein]
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CTD |
PMID:27060453 PMID:32112862 |
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NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187
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G
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Wnt3a
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Wnt family member 3A
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decreases expression
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ISO
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thymoquinone results in decreased expression of WNT3A protein
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CTD |
PMID:32112862 |
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NCBI chr10:44,533,734...44,577,919
Ensembl chr10:44,034,194...44,078,324
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G
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Xiap
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X-linked inhibitor of apoptosis
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multiple interactions
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ISO
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thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of XIAP protein]
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CTD |
PMID:31935363 |
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NCBI chr X:125,756,107...125,803,979
Ensembl chr X:120,897,907...120,934,700
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G
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Zeb1
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zinc finger E-box binding homeobox 1
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decreases expression multiple interactions
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ISO
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thymoquinone results in decreased expression of ZEB1 protein thymoquinone promotes the reaction [cordycepin results in decreased expression of ZEB1 protein]
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CTD |
PMID:35774120 |
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NCBI chr17:56,644,397...56,811,155
Ensembl chr17:51,948,948...52,115,214
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