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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:thymoquinone
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Accession:CHEBI:113532 term browser browse the term
Definition:A member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity.
Synonyms:exact_synonym: 2-methyl-5-(propan-2-yl)cyclohexa-2,5-diene-1,4-dione
 related_synonym: 2-isopropyl-5-methyl-1,4-benzoquinone;   2-isopropyl-5-methyl-p-benzoquinone;   2-methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione;   5-isopropyl-2-methyl-2,5-cyclohexadiene-1,4-dione;   Formula=C10H12O2;   InChI=1S/C10H12O2/c1-6(2)8-5-9(11)7(3)4-10(8)12/h4-6H,1-3H3;   InChIKey=KEQHJBNSCLWCAE-UHFFFAOYSA-N;   SMILES=CC(C)C1=CC(=O)C(C)=CC1=O;   TQ;   p-cymene-2,5-dione;   p-mentha-3,6-diene-2,5-dione;   thymoquinon
 xref: CAS:490-91-5;   FooDB:FDB013274;   HMDB:HMDB0034732;   KNApSAcK:C00010876;   LINCS:LSM-24947
 xref_mesh: MESH:C003466
 xref: PDBeChem:IMW;   PMID:23135290;   PMID:29519737;   PMID:30422744;   PMID:32074066;   PMID:32133061;   PMID:32560283;   PMID:32588453;   PMID:32596711;   PMID:32608003;   PMID:32610056;   PMID:32618005;   PMID:32620860;   PMID:32637881;   PMID:32652915;   PMID:32767958;   PMID:32774669;   PMID:32774804;   PMID:32793594;   PMID:32843585;   PMID:32860490;   PMID:32867015;   PMID:32901987;   PMID:32920292;   Reaxys:1939047;   Wikipedia:Thymoquinone


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thymoquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP thymoquinone inhibits the reaction [3-nitropropionic acid results in increased activity of ACHE protein]; thymoquinone inhibits the reaction [Cytarabine results in increased activity of ACHE protein] CTD PMID:27206696 PMID:36419121 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO thymoquinone inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]; thymoquinone inhibits the reaction [Paraquat results in increased expression of ACTA2 mRNA]; thymoquinone inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]; thymoquinone inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]
thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of ACTA2 protein]; thymoquinone inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]		 CTD PMID:27375216 PMID:27688165 PMID:31935363 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Ada adenosine deaminase multiple interactions ISO thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased activity of ADA protein] CTD PMID:36193556 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Afp alpha-fetoprotein multiple interactions EXP thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]; thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein alternative form]; thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] CTD PMID:24012840 PMID:29923357 PMID:35437842 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO thymoquinone results in increased expression of AIFM1 protein CTD PMID:29981725 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO thymoquinone results in decreased phosphorylation of AKT1 protein
thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of AKT1 protein]		 CTD PMID:31298468 PMID:36193556 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions ISO thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of AKT2 protein] CTD PMID:36193556 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APP protein alternative form]; thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APP protein] CTD PMID:28734741 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Ar androgen receptor multiple interactions EXP thymoquinone inhibits the reaction [Propylthiouracil results in decreased expression of AR protein] CTD PMID:36506574 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO thymoquinone results in increased expression of ATF4 mRNA; thymoquinone results in increased expression of ATF4 protein CTD PMID:29981725 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO thymoquinone results in increased expression of ATF6 mRNA; thymoquinone results in increased expression of ATF6 protein CTD PMID:29981725 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Atg12 autophagy related 12 decreases expression ISO thymoquinone results in decreased expression of ATG12 protein CTD PMID:31298468 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418 		JBrowse link
G Atg5 autophagy related 5 decreases expression ISO thymoquinone results in decreased expression of ATG5 protein CTD PMID:31298468 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atg7 autophagy related 7 decreases expression ISO thymoquinone results in decreased expression of ATG7 protein CTD PMID:31298468 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression ISO thymoquinone results in decreased expression of BAD protein CTD PMID:34173702 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 EXP
ISO		 thymoquinone affects the reaction [Ethanol affects the expression of BAX mRNA]; thymoquinone inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX mRNA]; thymoquinone inhibits the reaction [Ethanol results in increased expression of BAX protein]; thymoquinone inhibits the reaction [sodium arsenate results in increased expression of BAX mRNA]; thymoquinone inhibits the reaction [sodium arsenate results in increased expression of BAX protein]; thymoquinone inhibits the reaction [sodium arsenite results in increased expression of BAX protein]
thymoquinone results in increased expression of BAX protein
[Benzo(a)pyrene co-treated with thymoquinone] results in increased expression of BAX mRNA; thymoquinone results in increased expression of and affects the localization of BAX protein
thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein]		 CTD PMID:24289642 PMID:29085585 PMID:29710533 PMID:29981725 PMID:30558456 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO
EXP		 thymoquinone results in decreased expression of BCL2 protein
thymoquinone affects the reaction [Ethanol affects the expression of BCL2 mRNA]; thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of BCL2 mRNA]; thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA]; thymoquinone inhibits the reaction [Ethanol results in decreased expression of BCL2 protein]; thymoquinone inhibits the reaction [sodium arsenate results in decreased expression of BCL2 mRNA]; thymoquinone inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]
[Benzo(a)pyrene co-treated with thymoquinone] results in decreased expression of BCL2 mRNA; DDIT3 protein affects the reaction [thymoquinone results in decreased expression of BCL2 protein]
thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein]		 CTD PMID:21609759 PMID:24289642 PMID:29085585 PMID:29710533 PMID:29923357 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO thymoquinone results in decreased expression of BCL2L1 protein CTD PMID:29981725 PMID:31433961 PMID:34627931 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO thymoquinone results in decreased expression of BID protein CTD PMID:31298468 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions		 ISO thymoquinone results in decreased expression of BIRC5 protein
Doxorubicin promotes the reaction [thymoquinone results in decreased expression of BIRC5 protein]; thymoquinone promotes the reaction [Doxorubicin results in decreased expression of BIRC5 protein]		 CTD PMID:31433961 PMID:34605108 PMID:34627931 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of CASP1 protein] CTD PMID:31935363 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp12 caspase 12 decreases expression ISO thymoquinone results in decreased expression of CASP12 protein CTD PMID:29981725 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
increases cleavage
increases activity		 ISO
EXP		 thymoquinone results in increased expression of CASP3 protein modified form
4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased cleavage of CASP3 protein]; [[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone] which results in increased cleavage of CASP3 protein; [Temozolomide results in decreased susceptibility to Temozolomide] inhibits the reaction [thymoquinone results in increased cleavage of CASP3 protein]; [Temozolomide results in decreased susceptibility to Temozolomide] promotes the reaction [thymoquinone results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of CASP3 protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [thymoquinone results in increased activity of CASP3 protein]; DDIT3 protein affects the reaction [thymoquinone results in increased activity of and results in increased cleavage of CASP3 protein]; MAPK14 protein promotes the reaction [[[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone] which results in increased cleavage of CASP3 protein]; MAPK3 protein inhibits the reaction [thymoquinone results in increased expression of CASP3 protein modified form]; thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of CASP3 protein]; thymoquinone results in increased activity of and results in increased cleavage of CASP3 protein
thymoquinone inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 mRNA]; thymoquinone inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein]; thymoquinone inhibits the reaction [Propylthiouracil results in increased expression of CASP3 protein]; thymoquinone inhibits the reaction [sodium arsenate results in increased cleavage of CASP3 protein]; thymoquinone inhibits the reaction [sodium arsenate results in increased expression of CASP3 mRNA]; thymoquinone inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]
Doxorubicin promotes the reaction [thymoquinone results in increased activity of CASP3 protein]; thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased expression of CASP3 protein]; thymoquinone promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]		 CTD PMID:29085585 PMID:29710533 PMID:29981725 PMID:30558456 PMID:31298468 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases expression
increases cleavage
multiple interactions		 ISO thymoquinone results in increased expression of CASP7 protein modified form
thymoquinone results in increased cleavage of CASP7 protein
Acetylcysteine inhibits the reaction [thymoquinone results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of CASP7 protein modified form]		 CTD PMID:29981725 PMID:31433961 PMID:34627931 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions EXP thymoquinone inhibits the reaction [Ethanol results in increased cleavage of CASP8 protein] CTD PMID:29085585 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases expression
multiple interactions
increases cleavage
increases activity		 ISO
EXP		 thymoquinone results in increased expression of CASP9 protein modified form
Acetylcysteine inhibits the reaction [thymoquinone results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of CASP9 protein modified form]
thymoquinone inhibits the reaction [Ethanol results in increased cleavage of CASP9 protein]
Doxorubicin promotes the reaction [thymoquinone results in increased activity of CASP9 protein]; thymoquinone promotes the reaction [Doxorubicin results in increased activity of CASP9 protein]		 CTD PMID:29085585 PMID:29981725 PMID:31298468 PMID:31433961 PMID:34605108 More... NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase increases activity
multiple interactions		 EXP
ISO		 thymoquinone results in increased activity of CAT protein
thymoquinone analog inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of CAT mRNA]; thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [cyhalothrin results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [Diethylnitrosamine results in decreased expression of CAT mRNA]; thymoquinone inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [Propylthiouracil results in decreased expression of CAT mRNA]; thymoquinone inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]		 CTD PMID:10755708 PMID:20957680 PMID:20972371 PMID:21382363 PMID:22450443 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO thymoquinone results in decreased expression of CCNB1 protein CTD PMID:32112862 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions		 ISO
EXP		 thymoquinone results in decreased expression of CCND1 mRNA; thymoquinone results in decreased expression of CCND1 protein
[Benzo(a)pyrene co-treated with thymoquinone] results in decreased expression of CCND1 mRNA; Acetylcysteine inhibits the reaction [thymoquinone results in decreased expression of CCND1 protein]
thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 protein]
Doxorubicin promotes the reaction [thymoquinone results in decreased expression of CCND1 protein]; thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased expression of CCND1 protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased expression of CCND1 protein]		 CTD PMID:24012840 PMID:24289642 PMID:31433961 PMID:32112862 PMID:34605108 More... NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd2 cyclin D2 multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [thymoquinone results in decreased expression of CCND2 protein] CTD PMID:34627931 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ccnd3 cyclin D3 decreases expression
multiple interactions		 ISO thymoquinone results in decreased expression of CCND3 protein
Acetylcysteine inhibits the reaction [thymoquinone results in decreased expression of CCND3 protein]		 CTD PMID:32112862 PMID:34627931 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Ccne1 cyclin E1 multiple interactions EXP thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of CCNE1 protein] CTD PMID:24012840 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cd14 CD14 molecule multiple interactions ISO thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein] CTD PMID:31935363 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) decreases expression ISO thymoquinone results in decreased expression of CD44 protein CTD PMID:31298468 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions		 ISO thymoquinone results in increased expression of CDH1 protein
CTNNB1 protein inhibits the reaction [thymoquinone results in increased expression of CDH1 protein]; Lithium Chloride inhibits the reaction [thymoquinone results in increased expression of CDH1 protein]; XAV939 promotes the reaction [thymoquinone results in increased expression of CDH1 protein]		 CTD PMID:32112862 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 decreases expression
multiple interactions		 ISO thymoquinone results in decreased expression of CDH2 protein
CTNNB1 protein inhibits the reaction [thymoquinone results in decreased expression of CDH2 protein]; Lithium Chloride inhibits the reaction [thymoquinone results in decreased expression of CDH2 protein]; XAV939 promotes the reaction [thymoquinone results in decreased expression of CDH2 protein]		 CTD PMID:32112862 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO thymoquinone results in decreased expression of CDK2 protein CTD PMID:32112862 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions EXP thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of CDK4 protein] CTD PMID:24012840 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions EXP
ISO		 thymoquinone inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]
[Benzo(a)pyrene co-treated with thymoquinone] results in increased expression of CDKN1A mRNA		 CTD PMID:24012840 PMID:24289642 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ceacam20 CEA cell adhesion molecule 20 decreases expression
multiple interactions		 ISO thymoquinone results in decreased expression of CEACAM20 protein
Doxorubicin promotes the reaction [thymoquinone results in decreased expression of CEACAM20 protein]; thymoquinone promotes the reaction [Doxorubicin results in decreased expression of CEACAM20 protein]		 CTD PMID:34605108 NCBI chr 1:79,622,077...79,643,782
Ensembl chr 1:79,622,077...79,643,782 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO [Benzo(a)pyrene co-treated with thymoquinone] results in decreased expression of CHUK mRNA CTD PMID:24289642 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO thymoquinone inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]
thymoquinone inhibits the reaction [Ethanol results in increased expression of COL1A1 protein]; thymoquinone inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA]; thymoquinone inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]		 CTD PMID:27375216 PMID:27688165 PMID:31935363 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions ISO thymoquinone inhibits the reaction [Paraquat results in increased expression of COL4A1 mRNA] CTD PMID:27375216 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
multiple interactions		 ISO
EXP		 thymoquinone results in decreased expression of CTNNB1 protein
thymoquinone results in decreased expression of CTNNB1 mRNA
CTNNB1 protein inhibits the reaction [thymoquinone results in decreased expression of CDH2 protein]; CTNNB1 protein inhibits the reaction [thymoquinone results in decreased expression of MMP2 protein]; CTNNB1 protein inhibits the reaction [thymoquinone results in decreased expression of VIM protein]; CTNNB1 protein inhibits the reaction [thymoquinone results in increased expression of CDH1 protein]; Lithium Chloride inhibits the reaction [thymoquinone results in decreased expression of and results in increased phosphorylation of CTNNB1 protein]; thymoquinone inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of CTNNB1 protein]; thymoquinone results in decreased expression of and results in increased phosphorylation of and results in decreased activity of CTNNB1 protein; XAV939 promotes the reaction [thymoquinone results in decreased expression of and results in increased phosphorylation of CTNNB1 protein]
thymoquinone inhibits the reaction [Propylthiouracil results in decreased expression of CTNNB1 mRNA]		 CTD PMID:32112862 PMID:34234489 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO thymoquinone results in increased expression of CXCR4 mRNA CTD PMID:31812774 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cycs cytochrome c, somatic increases expression
multiple interactions		 ISO thymoquinone results in increased expression of CYCS protein
thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased expression of CYCS protein]		 CTD PMID:31433961 PMID:36193556 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein] CTD PMID:36193556 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP thymoquinone inhibits the reaction [Diethylnitrosamine results in decreased expression of CYP2E1 protein] CTD PMID:35437842 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO
EXP		 4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased expression of DDIT3 protein]; DDIT3 protein affects the reaction [thymoquinone results in decreased expression of BCL2 protein]; DDIT3 protein affects the reaction [thymoquinone results in increased activity of and results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [thymoquinone results in increased cleavage of PARP1 protein]
thymoquinone results in increased expression of DDIT3 mRNA; thymoquinone results in increased expression of DDIT3 protein
thymoquinone inhibits the reaction [Doxorubicin results in increased expression of DDIT3 protein]		 CTD PMID:29981725 PMID:34392583 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions EXP thymoquinone inhibits the reaction [Rotenone results in increased expression of DNM1L protein] CTD PMID:28526446 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression ISO thymoquinone results in increased expression of EIF2AK3 protein CTD PMID:29981725 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Ephx1 epoxide hydrolase 1 multiple interactions EXP thymoquinone inhibits the reaction [Carbon Tetrachloride results in decreased expression of EPHX1 mRNA] CTD PMID:21994235 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO thymoquinone results in increased expression of ERN1 mRNA; thymoquinone results in increased expression of ERN1 protein CTD PMID:29981725 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of FOS mRNA] CTD PMID:29923357 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions ISO thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased activity of GGT1 protein] CTD PMID:36193556 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Gpc3 glypican 3 multiple interactions EXP thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of GPC3 protein] CTD PMID:35437842 NCBI chr  X:131,868,986...132,236,824
Ensembl chr  X:131,868,990...132,236,798 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased activity of GPT protein]; thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of GPT protein]; thymoquinone inhibits the reaction [Ethanol results in increased activity of GPT protein] CTD PMID:29085585 PMID:29923357 PMID:35437842 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP
ISO		 thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA]
thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased activity of GPX1 protein]		 CTD PMID:28734741 PMID:36193556 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
multiple interactions		 ISO
EXP		 thymoquinone results in decreased phosphorylation of GSK3B protein
Lithium Chloride inhibits the reaction [thymoquinone results in decreased phosphorylation of GSK3B protein]; XAV939 promotes the reaction [thymoquinone results in decreased phosphorylation of GSK3B protein]
thymoquinone inhibits the reaction [bisphenol A results in decreased phosphorylation of GSK3B protein]		 CTD PMID:32112862 PMID:33315269 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP thymoquinone analog inhibits the reaction [3-nitropropionic acid results in decreased activity of GSR protein]; thymoquinone inhibits the reaction [3-nitropropionic acid results in decreased activity of GSR protein]; thymoquinone inhibits the reaction [sodium arsenite results in decreased activity of GSR protein] CTD PMID:27206696 PMID:30558456 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions EXP thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of GSTP1 protein] CTD PMID:35437842 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO thymoquinone results in increased phosphorylation of H2AX protein CTD PMID:31298468 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP thymoquinone inhibits the reaction [Doxorubicin results in increased expression of HIF1A protein] CTD PMID:34392583 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [thymoquinone results in increased expression of HMOX1 protein]; [thymoquinone affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of HMOX1 protein]; dorsomorphin inhibits the reaction [thymoquinone results in increased expression of HMOX1 protein]
thymoquinone results in increased expression of HMOX1 mRNA; thymoquinone results in increased expression of HMOX1 protein		 CTD PMID:24355171 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnf1a HNF1 homeobox A decreases expression ISO thymoquinone results in decreased expression of HNF1A mRNA CTD PMID:32112862 NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression		 ISO
EXP		 4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased expression of HSPA5 protein]
thymoquinone results in increased expression of HSPA5 mRNA; thymoquinone results in increased expression of HSPA5 protein
thymoquinone inhibits the reaction [Doxorubicin results in increased expression of HSPA5 protein]		 CTD PMID:29981725 PMID:34392583 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression		 EXP
ISO		 thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IFNG mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IFNG protein]
thymoquinone results in decreased expression of IFNG mRNA; thymoquinone results in decreased expression of IFNG protein
[Benzo(a)pyrene co-treated with thymoquinone] results in decreased expression of IFNG protein		 CTD PMID:22450443 PMID:24289642 PMID:26645134 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions		 EXP thymoquinone results in increased expression of IL10 mRNA; thymoquinone results in increased expression of IL10 protein
thymoquinone inhibits the reaction [cyhalothrin results in decreased expression of IL10 mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in decreased expression of IL10 protein]; thymoquinone inhibits the reaction [Doxorubicin results in decreased expression of IL10 protein]; thymoquinone inhibits the reaction [Propylthiouracil results in decreased expression of IL10 mRNA]		 CTD PMID:22450443 PMID:25268985 PMID:26645134 PMID:34234489 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il17a interleukin 17A multiple interactions EXP thymoquinone inhibits the reaction [Doxorubicin results in increased expression of IL17A protein] CTD PMID:34392583 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
increases expression		 EXP
ISO		 thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL1B protein]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IL1B mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IL1B protein]
thymoquinone results in decreased expression of IL1B mRNA; thymoquinone results in decreased expression of IL1B protein
thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
thymoquinone results in increased expression of IL1B protein		 CTD PMID:22450443 PMID:26645134 PMID:29405769 PMID:31935363 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 increases expression
multiple interactions		 EXP thymoquinone results in increased expression of IL4 mRNA; thymoquinone results in increased expression of IL4 protein
thymoquinone inhibits the reaction [cyhalothrin results in decreased expression of IL4 mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in decreased expression of IL4 protein]		 CTD PMID:26645134 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 EXP
ISO		 thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IL6 mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IL6 protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased expression of IL6 protein]; thymoquinone inhibits the reaction [Ethanol results in increased expression of IL6 protein]; thymoquinone inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]
thymoquinone results in decreased expression of IL6 mRNA; thymoquinone results in decreased expression of IL6 protein
Doxorubicin promotes the reaction [thymoquinone results in decreased expression of IL6 protein]		 CTD PMID:22450443 PMID:25268985 PMID:26645134 PMID:29085585 PMID:30558456 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6r interleukin 6 receptor decreases expression
multiple interactions		 ISO thymoquinone results in decreased expression of IL6R mRNA
Doxorubicin promotes the reaction [thymoquinone results in decreased expression of IL6R mRNA]		 CTD PMID:34605108 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP thymoquinone inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of INS1 protein]; thymoquinone inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased secretion of INS1 protein] CTD PMID:21382363 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions
increases expression		 EXP thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IRF3 mRNA]
thymoquinone results in increased expression of IRF3 mRNA		 CTD PMID:29405769 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP thymoquinone inhibits the reaction [bisphenol A results in decreased phosphorylation of IRS1 protein] CTD PMID:33315269 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions
decreases phosphorylation		 ISO Doxorubicin promotes the reaction [thymoquinone results in decreased phosphorylation of JAK2 protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased phosphorylation of JAK2 protein]
Acetylcysteine inhibits the reaction [thymoquinone results in decreased phosphorylation of JAK2 protein]		 CTD PMID:34605108 PMID:34627931 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression ISO thymoquinone results in decreased expression of LEF1 mRNA CTD PMID:32112862 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases lipidation ISO thymoquinone results in increased lipidation of MAP1LC3A protein CTD PMID:31298468 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
increases phosphorylation
multiple interactions		 ISO thymoquinone results in decreased phosphorylation of MAPK1 protein
thymoquinone results in increased phosphorylation of MAPK1 protein
[Temozolomide results in decreased susceptibility to Temozolomide] inhibits the reaction [thymoquinone results in increased phosphorylation of MAPK1 protein]; [Temozolomide results in decreased susceptibility to Temozolomide] promotes the reaction [[thymoquinone co-treated with SB 203580] results in increased phosphorylation of MAPK1 protein]; [Temozolomide results in decreased susceptibility to Temozolomide] promotes the reaction [thymoquinone results in increased phosphorylation of MAPK1 protein]; [thymoquinone co-treated with SB 203580] results in increased phosphorylation of MAPK1 protein; Anisomycin promotes the reaction [thymoquinone results in increased phosphorylation of MAPK1 protein]; MAPK3 protein inhibits the reaction [thymoquinone results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [thymoquinone results in increased phosphorylation of MAPK1 protein]		 CTD PMID:27060453 PMID:34173702 PMID:36176197 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO MAPK14 protein promotes the reaction [[[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone] which results in increased cleavage of CASP3 protein]; MAPK14 protein promotes the reaction [[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone] CTD PMID:36176197 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation
decreases response to substance		 EXP
ISO		 thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased phosphorylation of MAPK3 protein]
thymoquinone results in decreased phosphorylation of MAPK3 protein
[Temozolomide results in decreased susceptibility to Temozolomide] inhibits the reaction [thymoquinone results in increased phosphorylation of MAPK3 protein]; [Temozolomide results in decreased susceptibility to Temozolomide] promotes the reaction [[thymoquinone co-treated with SB 203580] results in increased phosphorylation of MAPK3 protein]; [Temozolomide results in decreased susceptibility to Temozolomide] promotes the reaction [thymoquinone results in increased phosphorylation of MAPK3 protein]; [thymoquinone co-treated with SB 203580] results in increased phosphorylation of MAPK3 protein; Anisomycin promotes the reaction [thymoquinone results in increased phosphorylation of MAPK3 protein]; MAPK3 protein inhibits the reaction [thymoquinone results in increased expression of CASP3 protein modified form]; MAPK3 protein inhibits the reaction [thymoquinone results in increased phosphorylation of MAPK1 protein]; MAPK3 protein inhibits the reaction [thymoquinone results in increased phosphorylation of MAPK3 protein]; MAPK3 protein promotes the reaction [[[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone] which results in increased expression of MGMT protein]; MAPK3 protein promotes the reaction [[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone]; U 0126 inhibits the reaction [thymoquinone results in increased phosphorylation of MAPK3 protein]
MAPK3 protein results in decreased susceptibility to thymoquinone		 CTD PMID:27060453 PMID:29923357 PMID:34173702 PMID:36176197 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression ISO thymoquinone results in decreased expression of MDM2 protein CTD PMID:31433961 PMID:34627931 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression
increases expression		 ISO thymoquinone results in decreased expression of MET mRNA
thymoquinone results in increased expression of MET mRNA		 CTD PMID:31812774 PMID:32112862 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions ISO [[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone] which results in increased expression of MGMT protein; [Temozolomide results in decreased susceptibility to Temozolomide] inhibits the reaction [thymoquinone results in decreased expression of MGMT protein]; MAPK3 protein promotes the reaction [[[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone] which results in increased expression of MGMT protein] CTD PMID:36176197 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Mir125a microRNA 125a increases expression ISO thymoquinone results in increased expression of MIR125A mRNA CTD PMID:34605108 NCBI chr 1:58,677,626...58,677,710
Ensembl chr 1:58,677,626...58,677,710 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO thymoquinone results in decreased expression of MKI67 protein CTD PMID:31298468 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO thymoquinone inhibits the reaction [TGFB1 protein results in decreased expression of MMP13 protein] CTD PMID:27688165 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression		 ISO CTNNB1 protein inhibits the reaction [thymoquinone results in decreased expression of MMP2 protein]; pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of MMP2 protein]; thymoquinone results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:27060453 PMID:32112862 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO thymoquinone results in decreased expression of MMP7 mRNA CTD PMID:32112862 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression		 ISO pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of MMP9 protein]; SB 203580 inhibits the reaction [thymoquinone results in decreased expression of MMP9 protein]; thymoquinone results in decreased expression of and results in decreased activity of MMP9 protein CTD PMID:27060453 PMID:32112862 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase decreases activity EXP thymoquinone results in decreased activity of MPO protein CTD PMID:22450443 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO thymoquinone results in decreased phosphorylation of MTOR protein CTD PMID:31298468 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO thymoquinone results in decreased expression of MYC mRNA CTD PMID:32112862 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor increases expression
multiple interactions		 EXP thymoquinone results in increased expression of MYD88 mRNA
thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of MYD88 mRNA]		 CTD PMID:29405769 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nanog Nanog homeobox decreases expression ISO thymoquinone results in decreased expression of NANOG protein CTD PMID:31298468 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Nes nestin decreases expression ISO thymoquinone results in decreased expression of NES protein CTD PMID:31298468 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP
ISO		 thymoquinone inhibits the reaction [Doxorubicin results in decreased activity of NFE2L2 protein]; thymoquinone inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [thymoquinone affects the localization of and results in increased activity of NFE2L2 protein]; [thymoquinone affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [thymoquinone affects the localization of and results in increased activity of NFE2L2 protein]; dorsomorphin inhibits the reaction [thymoquinone affects the localization of and results in increased activity of NFE2L2 protein]; thymoquinone affects the localization of and results in increased activity of NFE2L2 protein		 CTD PMID:24355171 PMID:25268985 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP thymoquinone inhibits the reaction [Propylthiouracil results in increased expression of NFKB1 mRNA] CTD PMID:36506574 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP thymoquinone inhibits the reaction [Isoproterenol results in decreased expression of NOS1 protein] CTD PMID:35940283 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP thymoquinone inhibits the reaction [Isoproterenol results in increased expression of NOS3 protein] CTD PMID:35940283 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP thymoquinone inhibits the reaction [Doxorubicin results in increased expression of NOX4 protein] CTD PMID:25268985 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP thymoquinone inhibits the reaction [Isoproterenol results in decreased secretion of NPPA protein] CTD PMID:35940283 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP thymoquinone inhibits the reaction [Isoproterenol results in decreased secretion of NPPB protein modified form] CTD PMID:35940283 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
increases expression		 ISO thymoquinone results in increased cleavage of PARP1 protein
4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of PARP1 protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [thymoquinone results in increased activity of PARP1 protein]; DDIT3 protein affects the reaction [thymoquinone results in increased cleavage of PARP1 protein]		 CTD PMID:29981725 PMID:31298468 PMID:31433961 PMID:34627931 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP
ISO		 thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of PCNA mRNA]
thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased expression of PCNA protein]		 CTD PMID:29923357 PMID:36193556 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO thymoquinone results in decreased expression of POU5F1 protein CTD PMID:31298468 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions		 ISO thymoquinone results in increased expression of PPARG protein
PRKAA1 protein promotes the reaction [thymoquinone results in increased expression of PPARG protein]; thymoquinone inhibits the reaction [TGFB1 protein results in decreased expression of PPARG protein]		 CTD PMID:27688165 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO PRKAA1 protein promotes the reaction [thymoquinone results in increased expression of PPARG protein] CTD PMID:27688165 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased expression of PTEN protein] CTD PMID:36193556 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO [thymoquinone co-treated with Diclofenac] results in decreased expression of PTGS1 protein CTD PMID:32220568 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP thymoquinone inhibits the reaction [Bleomycin results in increased expression of RELA protein]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of RELA mRNA] CTD PMID:22982510 PMID:26645134 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions EXP thymoquinone inhibits the reaction [Isoproterenol results in increased expression of RIPK1 protein] CTD PMID:35940283 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions EXP thymoquinone inhibits the reaction [Isoproterenol results in increased expression of RIPK3 protein] CTD PMID:35940283 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Rorc RAR-related orphan receptor C increases expression ISO thymoquinone results in increased expression of RORC mRNA CTD PMID:31812774 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO
EXP		 thymoquinone inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein]
thymoquinone inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein]
thymoquinone inhibits the reaction [Propylthiouracil results in decreased expression of SIRT1 mRNA]; thymoquinone inhibits the reaction [Propylthiouracil results in decreased expression of SIRT1 protein]		 CTD PMID:27688165 PMID:36506574 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression
multiple interactions		 ISO thymoquinone results in decreased expression of SNAI1 protein
pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of SNAI1 protein]; SB 203580 inhibits the reaction [thymoquinone results in decreased expression of SNAI1 protein]		 CTD PMID:27060453 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP
ISO		 thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD1 mRNA]
thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased activity of SOD1 protein]		 CTD PMID:28734741 PMID:36193556 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD2 mRNA] CTD PMID:28734741 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions EXP thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA] CTD PMID:28734741 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases phosphorylation
multiple interactions		 ISO thymoquinone results in decreased phosphorylation of SRC protein
Acetylcysteine inhibits the reaction [thymoquinone results in decreased phosphorylation of SRC protein]
Doxorubicin promotes the reaction [thymoquinone results in decreased phosphorylation of SRC protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased phosphorylation of SRC protein]		 CTD PMID:31433961 PMID:34605108 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation		 ISO Acetylcysteine inhibits the reaction [thymoquinone results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in decreased phosphorylation of STAT3 protein]; thymoquinone results in decreased phosphorylation of and results in decreased activity of STAT3 protein
Doxorubicin promotes the reaction [thymoquinone results in decreased phosphorylation of STAT3 protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased phosphorylation of STAT3 protein]		 CTD PMID:31433961 PMID:34605108 PMID:34627931 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 increases expression ISO thymoquinone results in increased expression of STAT6 mRNA CTD PMID:31812774 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO thymoquinone inhibits the reaction [Ethanol results in decreased expression of STK11 protein modified form]; thymoquinone inhibits the reaction [Ethanol results in decreased expression of STK11 protein]
thymoquinone inhibits the reaction [TGFB1 protein results in decreased phosphorylation of STK11 protein]		 CTD PMID:27688165 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO thymoquinone inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]
thymoquinone inhibits the reaction [TGFB1 protein results in decreased expression of MMP13 protein]; thymoquinone inhibits the reaction [TGFB1 protein results in decreased expression of PPARG protein]; thymoquinone inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein]; thymoquinone inhibits the reaction [TGFB1 protein results in decreased phosphorylation of STK11 protein]; thymoquinone inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; thymoquinone inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; thymoquinone inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 protein]		 CTD PMID:27375216 PMID:27688165 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 increases expression
multiple interactions		 EXP thymoquinone results in increased expression of TICAM1 mRNA
thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TICAM1 mRNA]		 CTD PMID:29405769 NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,102,366...1,123,147 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
increases expression		 ISO thymoquinone inhibits the reaction [Thioacetamide results in increased expression of TIMP1 mRNA]; thymoquinone inhibits the reaction [Thioacetamide results in increased expression of TIMP1 protein]
thymoquinone results in increased expression of TIMP1 protein
pyrazolanthrone inhibits the reaction [thymoquinone results in increased expression of TIMP1 protein]; SB 203580 inhibits the reaction [thymoquinone results in increased expression of TIMP1 protein]; thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of TIMP1 protein]; thymoquinone inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 protein]		 CTD PMID:27060453 PMID:27688165 PMID:31935363 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression
multiple interactions		 ISO thymoquinone results in increased expression of TIMP2 protein
pyrazolanthrone inhibits the reaction [thymoquinone results in increased expression of TIMP2 protein]; SB 203580 inhibits the reaction [thymoquinone results in increased expression of TIMP2 protein]		 CTD PMID:27060453 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions
increases expression		 EXP thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TLR2 mRNA]
thymoquinone results in increased expression of TLR2 mRNA		 CTD PMID:29405769 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
increases expression		 ISO
EXP		 thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]
thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TLR4 mRNA]
thymoquinone results in increased expression of TLR4 mRNA		 CTD PMID:29405769 PMID:31935363 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
increases expression		 EXP thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TNF protein]; thymoquinone inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of TNF mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of TNF protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; thymoquinone inhibits the reaction [Ethanol results in increased expression of TNF protein]; thymoquinone inhibits the reaction [Propylthiouracil results in increased expression of TNF mRNA]; thymoquinone inhibits the reaction [Propylthiouracil results in increased expression of TNF protein]; thymoquinone inhibits the reaction [sodium arsenite results in increased expression of TNF protein]
thymoquinone results in decreased expression of TNF mRNA; thymoquinone results in decreased expression of TNF protein
thymoquinone results in increased expression of TNF protein		 CTD PMID:20957680 PMID:22450443 PMID:25268985 PMID:26645134 PMID:29085585 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b multiple interactions ISO [Benzo(a)pyrene co-treated with thymoquinone] results in increased expression of TNFRSF10A mRNA CTD PMID:24289642 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 multiple interactions ISO thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF25 protein] CTD PMID:31935363 NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341 		JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP thymoquinone inhibits the reaction [Isoproterenol results in increased secretion of TNNI3 protein] CTD PMID:35940283 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580 		JBrowse link
G Top2a DNA topoisomerase II alpha affects activity ISO thymoquinone affects the activity of TOP2A protein CTD PMID:24650156 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of TP53 protein]
thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased expression of TP53 protein]		 CTD PMID:21609759 PMID:31433961 PMID:34627931 PMID:36193556 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 multiple interactions
decreases expression		 ISO pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of TWIST1 protein]; SB 203580 inhibits the reaction [thymoquinone results in decreased expression of TWIST1 protein] CTD PMID:27060453 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression		 ISO Doxorubicin promotes the reaction [thymoquinone results in decreased expression of VEGFA protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased expression of VEGFA protein] CTD PMID:34605108 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin multiple interactions
decreases expression		 ISO CTNNB1 protein inhibits the reaction [thymoquinone results in decreased expression of VIM protein]; Lithium Chloride inhibits the reaction [thymoquinone results in decreased expression of VIM protein]; pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of VIM protein]; XAV939 promotes the reaction [thymoquinone results in decreased expression of VIM protein] CTD PMID:27060453 PMID:32112862 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Wnt3a Wnt family member 3A decreases expression ISO thymoquinone results in decreased expression of WNT3A protein CTD PMID:32112862 NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of XIAP protein] CTD PMID:31935363 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19896
      chemical role 19512
        antioxidant 16051
          thymoquinone 141
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19867
                    p-block element atom 19867
                      carbon group element atom 19812
                        carbon atom 19807
                          organic molecular entity 19807
                            organic group 18971
                              organic divalent group 18952
                                organodiyl group 18952
                                  carbonyl group 18905
                                    carbonyl compound 18905
                                      ketone 17193
                                        cyclic ketone 15708
                                          quinone 8574
                                            benzoquinones 776
                                              1,4-benzoquinones 772
                                                thymoquinone 141
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