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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sodium benzoate
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Accession:CHEBI:113455 term browser browse the term
Definition:An organic sodium salt resulting from the replacement of the proton from the carboxy group of benzoic acid by a sodium ion.
Synonyms:related_synonym: Benzoic acid, sodium salt;   E211;   Formula=C7H5NaO2;   InChI=1S/C7H6O2.Na/c8-7(9)6-4-2-1-3-5-6;/h1-5H,(H,8,9);/q;+1/p-1;   InChIKey=WXMKPNITSTVMEF-UHFFFAOYSA-M;   SMILES=[Na+].[O-]C(=O)C1=CC=CC=C1
 xref: CAS:532-32-1;   KEGG:D02277
 xref_mesh: MESH:D020160
 xref: PMID:25377186;   PMID:25582668;   PMID:26585641;   PMID:26706697;   PMID:26749113;   PMID:26870932;   PMID:26875563;   PMID:26907495;   PMID:26951541;   PMID:26989415;   PMID:27000017;   Reaxys:1100243;   Wikipedia:Sodium_benzoate


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sodium benzoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
increases activity 		EXP Ascorbic Acid inhibits the reaction [Sodium Benzoate results in increased activity of ACHE protein] CTD PMID:35187746 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Sodium Benzoate inhibits the reaction [arsenite results in increased expression of ACTA2 protein] CTD PMID:38703806 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA] CTD PMID:19860415 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP Sodium Benzoate promotes the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein] CTD PMID:17609678 NCBI chr18:56,648,779...56,711,505
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression 		ISO
EXP 		Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased activity of CASP3 protein]
Sodium Benzoate results in increased activity of CASP3 protein
Ascorbic Acid inhibits the reaction [Sodium Benzoate results in increased expression of CASP3 protein] 		CTD PMID:11329530 PMID:32911041 PMID:35187746 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein] CTD PMID:12540492 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase decreases activity
multiple interactions 		EXP Sodium Benzoate results in decreased activity of CAT protein
Ascorbic Acid inhibits the reaction [Sodium Benzoate results in decreased activity of CAT protein] 		CTD PMID:32911041 PMID:35187746 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Sodium Benzoate inhibits the reaction [arsenite results in increased expression of COL1A1 protein] CTD PMID:38703806 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Sodium Benzoate inhibits the reaction [arsenite results in increased expression of COL3A1 protein] CTD PMID:38703806 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 multiple interactions ISO Sodium Benzoate inhibits the reaction [arsenite results in increased expression of CPS1 protein] CTD PMID:38703806 NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA] CTD PMID:19860415 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Dao D-amino-acid oxidase multiple interactions
decreases activity 		ISO
EXP 		Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]
Sodium Benzoate results in decreased activity of DAO protein 		CTD PMID:19860415 PMID:20952482 NCBI chr12:42,592,342...42,613,046
Ensembl chr12:42,592,343...42,612,741 		JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO Sodium Benzoate results in decreased activity of ESR1 protein CTD PMID:22562034 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression EXP Sodium Benzoate results in increased expression of FSHB protein CTD PMID:32911041 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP 		Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein]
[Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IFNG mRNA 		CTD PMID:26706697 PMID:32179172 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP [Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IL10 mRNA CTD PMID:32179172 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IL1B mRNA CTD PMID:32179172 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression 		ISO
EXP 		Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Sodium Benzoate results in increased expression of IL6 protein
[Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IL6 mRNA 		CTD PMID:26706697 PMID:32179172 PMID:32911041 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP Sodium Benzoate results in increased expression of LHB protein CTD PMID:32911041 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO Sodium Benzoate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA alternative form]; Sodium Benzoate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA] CTD PMID:9614211 NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676 		JBrowse link
G Otc ornithine transcarbamylase multiple interactions ISO Sodium Benzoate affects the reaction [OTC gene mutant form affects the abundance of Hydroxyindoleacetic Acid]; Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Glycine]; Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Serotonin]; Sodium Benzoate affects the reaction [OTC gene mutant form results in increased abundance of Ammonium Compounds] CTD PMID:3091026 PMID:3374991 NCBI chr  X:12,453,834...12,529,954
Ensembl chr  X:12,453,834...12,566,918 		JBrowse link
G Tfam transcription factor A, mitochondrial increases expression EXP Sodium Benzoate results in increased expression of TFAM protein CTD PMID:32911041 NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression 		ISO
EXP 		Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Sodium Benzoate results in increased expression of TNF protein
[Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of TNF mRNA; Ascorbic Acid inhibits the reaction [Sodium Benzoate results in increased expression of TNF protein] 		CTD PMID:26706697 PMID:32179172 PMID:32911041 PMID:35187746 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression 		ISO
EXP 		Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 mRNA]
Sodium Benzoate results in increased expression of TP53 protein 		CTD PMID:16357363 PMID:32911041 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ucp2 uncoupling protein 2 increases expression EXP Sodium Benzoate results in increased expression of UCP2 protein CTD PMID:32911041 NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Vim vimentin multiple interactions ISO Sodium Benzoate inhibits the reaction [arsenite results in increased expression of VIM protein] CTD PMID:38703806 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Xdh xanthine dehydrogenase increases activity EXP Sodium Benzoate results in increased activity of XDH protein CTD PMID:32911041 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      biological role 20814
        antimicrobial agent 18575
          antimicrobial food preservative 12656
            sodium benzoate 27
              sodium caffeine benzoate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            organic ion 11522
                              organic anion 6867
                                carboxylic acid anion 2513
                                  monocarboxylic acid anion 1606
                                    benzoates 1285
                                      benzoate 32
                                        sodium benzoate 27
                                          sodium caffeine benzoate 0
paths to the root