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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sodium benzoate
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Accession:CHEBI:113455 term browser browse the term
Definition:An organic sodium salt resulting from the replacement of the proton from the carboxy group of benzoic acid by a sodium ion.
Synonyms:related_synonym: Benzoic acid, sodium salt;   E211;   Formula=C7H5NaO2;   InChI=1S/C7H6O2.Na/c8-7(9)6-4-2-1-3-5-6;/h1-5H,(H,8,9);/q;+1/p-1;   InChIKey=WXMKPNITSTVMEF-UHFFFAOYSA-M;   SMILES=C(C=1C=CC=CC1)([O-])=O.[Na+]
 xref: CAS:532-32-1;   KEGG:D02277
 xref_mesh: MESH:D020160
 xref: PMID:25377186;   PMID:25582668;   PMID:26585641;   PMID:26706697;   PMID:26749113;   PMID:26870932;   PMID:26875563;   PMID:26907495;   PMID:26951541;   PMID:26989415;   PMID:27000017;   Reaxys:1100243;   Wikipedia:Sodium_benzoate


show annotations for term's descendants           Sort by:
sodium benzoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
increases activity		 EXP Ascorbic Acid inhibits the reaction [Sodium Benzoate results in increased activity of ACHE protein] CTD PMID:35187746 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA] CTD PMID:19860415 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP Sodium Benzoate promotes the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein] CTD PMID:17609678 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression		 ISO
EXP		 Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased activity of CASP3 protein]
Sodium Benzoate results in increased activity of CASP3 protein
Ascorbic Acid inhibits the reaction [Sodium Benzoate results in increased expression of CASP3 protein]		 CTD PMID:11329530 PMID:32911041 PMID:35187746 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein] CTD PMID:12540492 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases activity
multiple interactions		 EXP Sodium Benzoate results in decreased activity of CAT protein
Ascorbic Acid inhibits the reaction [Sodium Benzoate results in decreased activity of CAT protein]		 CTD PMID:32911041 PMID:35187746 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA] CTD PMID:19860415 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Dao D-amino-acid oxidase multiple interactions
decreases activity		 ISO
EXP		 Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]
Sodium Benzoate results in decreased activity of DAO protein		 CTD PMID:19860415 PMID:20952482 NCBI chr12:42,592,342...42,613,046
Ensembl chr12:42,592,343...42,612,741 		JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO Sodium Benzoate results in decreased activity of ESR1 protein CTD PMID:22562034 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression EXP Sodium Benzoate results in increased expression of FSHB protein CTD PMID:32911041 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP		 Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein]
[Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IFNG mRNA		 CTD PMID:26706697 PMID:32179172 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP [Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IL10 mRNA CTD PMID:32179172 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IL1B mRNA CTD PMID:32179172 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO
EXP		 Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Sodium Benzoate results in increased expression of IL6 protein
[Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IL6 mRNA		 CTD PMID:26706697 PMID:32179172 PMID:32911041 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP Sodium Benzoate results in increased expression of LHB protein CTD PMID:32911041 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO Sodium Benzoate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA alternative form]; Sodium Benzoate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA] CTD PMID:9614211 NCBI chr16:52,717,775...52,802,890
Ensembl chr16:52,717,732...52,799,676 		JBrowse link
G Otc ornithine transcarbamylase multiple interactions ISO Sodium Benzoate affects the reaction [OTC gene mutant form affects the abundance of Hydroxyindoleacetic Acid]; Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Glycine]; Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Serotonin]; Sodium Benzoate affects the reaction [OTC gene mutant form results in increased abundance of Ammonium Compounds] CTD PMID:3091026 PMID:3374991 NCBI chr  X:12,453,834...12,529,954
Ensembl chr  X:12,453,834...12,566,918 		JBrowse link
G Tfam transcription factor A, mitochondrial increases expression EXP Sodium Benzoate results in increased expression of TFAM protein CTD PMID:32911041 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO
EXP		 Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Sodium Benzoate results in increased expression of TNF protein
[Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of TNF mRNA; Ascorbic Acid inhibits the reaction [Sodium Benzoate results in increased expression of TNF protein]		 CTD PMID:26706697 PMID:32179172 PMID:32911041 PMID:35187746 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO
EXP		 Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 mRNA]
Sodium Benzoate results in increased expression of TP53 protein		 CTD PMID:16357363 PMID:32911041 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ucp2 uncoupling protein 2 increases expression EXP Sodium Benzoate results in increased expression of UCP2 protein CTD PMID:32911041 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Xdh xanthine dehydrogenase increases activity EXP Sodium Benzoate results in increased activity of XDH protein CTD PMID:32911041 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19784
      biological role 19782
        antimicrobial agent 17941
          antimicrobial food preservative 11982
            sodium benzoate 22
              sodium caffeine benzoate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19810
      composite particle 19810
        hadron 19810
          baryon 19810
            nucleon 19810
              atomic nucleus 19810
                atom 19810
                  main group element atom 19755
                    p-block element atom 19755
                      carbon group element atom 19698
                        carbon atom 19693
                          organic molecular entity 19693
                            organic ion 9270
                              organic anion 3130
                                carboxylic acid anion 2462
                                  monocarboxylic acid anion 1580
                                    benzoates 1275
                                      benzoate 27
                                        sodium benzoate 22
                                          sodium caffeine benzoate 0
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