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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sodium benzoate
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Accession:CHEBI:113455 term browser browse the term
Definition:An organic sodium salt resulting from the replacement of the proton from the carboxy group of benzoic acid by a sodium ion.
Synonyms:related_synonym: Benzoic acid, sodium salt;   E211;   Formula=C7H5NaO2;   InChI=1S/C7H6O2.Na/c8-7(9)6-4-2-1-3-5-6;/h1-5H,(H,8,9);/q;+1/p-1;   InChIKey=WXMKPNITSTVMEF-UHFFFAOYSA-M;   SMILES=C(C=1C=CC=CC1)([O-])=O.[Na+]
 xref: CAS:532-32-1;   KEGG:D02277
 xref_mesh: MESH:D020160
 xref: PMID:25377186;   PMID:25582668;   PMID:26585641;   PMID:26706697;   PMID:26749113;   PMID:26870932;   PMID:26875563;   PMID:26907495;   PMID:26951541;   PMID:26989415;   PMID:27000017;   Reaxys:1100243;   Wikipedia:Sodium_benzoate


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sodium benzoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA] CTD PMID:19860415 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP Sodium Benzoate promotes the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein] CTD PMID:17609678 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased activity of CASP3 protein] CTD PMID:11329530 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein] CTD PMID:12540492 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA] CTD PMID:19860415 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dao D-amino-acid oxidase multiple interactions
decreases activity
ISO
EXP
Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]
Sodium Benzoate results in decreased activity of DAO protein
CTD PMID:19860415, PMID:20952482 NCBI chr12:48,353,691...48,373,647
Ensembl chr12:48,354,196...48,365,784
JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO Sodium Benzoate results in decreased activity of ESR1 protein CTD PMID:22562034 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Ifng interferon gamma multiple interactions ISO Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein] CTD PMID:26706697 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:26706697 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO Sodium Benzoate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA alternative form]; Sodium Benzoate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA] CTD PMID:9614211 NCBI chr16:56,817,714...56,900,025
Ensembl chr16:56,813,791...56,900,052
JBrowse link
G Otc ornithine carbamoyltransferase multiple interactions ISO Sodium Benzoate affects the reaction [OTC gene mutant form affects the abundance of Hydroxyindoleacetic Acid]; Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Glycine]; Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Serotonin]; Sodium Benzoate affects the reaction [OTC gene mutant form results in increased abundance of Ammonium Compounds] CTD PMID:3091026, PMID:3374991 NCBI chr  X:13,524,804...13,601,074
Ensembl chr  X:13,524,607...13,601,069
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:26706697 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 mRNA] CTD PMID:16357363 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        antimicrobial agent 17309
          antimicrobial food preservative 11603
            sodium benzoate 13
              sodium caffeine benzoate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic ion 8320
                              organic anion 3011
                                carboxylic acid anion 2385
                                  monocarboxylic acid anion 1486
                                    benzoates 1265
                                      benzoate 18
                                        sodium benzoate 13
                                          sodium caffeine benzoate 0
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