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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nordazepam
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Accession:CHEBI:111762 term browser browse the term
Definition:A 1,4-benzodiazepinone having phenyl and chloro substituents at positions 5 and 7 respectively; it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties but is used primarily in the treatment of anxiety.
Synonyms:related_synonym: 1-Demethyldiazepam;   7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one;   Chlordesmethyldiazepam;   Dealkylprazepam;   Desmethyldiazepam;   Formula=C15H11ClN2O;   InChI=1S/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19);   InChIKey=AKPLHCDWDRPJGD-UHFFFAOYSA-N;   N-Demethyldiazepam;   N-Deoxydemoxepam;   N-Desmethyldiazepam;   N1-Desmethyldiazepam;   Nordiazepam;   Norprazepam;   SMILES=Clc1ccc2NC(=O)CN=C(c3ccccc3)c2c1;   nordazepamum
 alt_id: CHEBI:7624
 xref: CAS:1088-11-5;   Drug_Central:816;   KEGG:C07486;   KEGG:D08283
 xref_mesh: MESH:D003708
 xref: PMID:16622;   PMID:19604;   PMID:360230;   PMID:364005;   PMID:367407;   PMID:4953859;   Patent:BE620020;   Patent:DE1136709;   Patent:US3051701;   Patent:US3202699;   Reaxys:751823;   Wikipedia:Desmethyldiazepam


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nordazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of Nordazepam CTD PMID:18846481 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20845
    role 20805
      biological role 20803
        biophysical role 14956
          membrane transport modulator 14821
            GABA modulator 5151
              nordazepam 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20845
    subatomic particle 20843
      composite particle 20843
        hadron 20843
          baryon 20843
            nucleon 20843
              atomic nucleus 20843
                atom 20843
                  main group element atom 20766
                    p-block element atom 20766
                      carbon group element atom 20699
                        carbon atom 20693
                          organic molecular entity 20693
                            organic molecule 20637
                              organic cyclic compound 20387
                                organic heterocyclic compound 19369
                                  organonitrogen heterocyclic compound 18513
                                    benzodiazepine 941
                                      1,4-benzodiazepinone 127
                                        nordazepam 1
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