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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nordazepam
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Accession:CHEBI:111762 term browser browse the term
Definition:A 1,4-benzodiazepinone having phenyl and chloro substituents at positions 5 and 7 respectively; it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties but is used primarily in the treatment of anxiety.
Synonyms:related_synonym: 1-Demethyldiazepam;   7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one;   Chlordesmethyldiazepam;   Dealkylprazepam;   Desmethyldiazepam;   Formula=C15H11ClN2O;   InChI=1S/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19);   InChIKey=AKPLHCDWDRPJGD-UHFFFAOYSA-N;   N-Demethyldiazepam;   N-Deoxydemoxepam;   N-Desmethyldiazepam;   N1-Desmethyldiazepam;   Nordiazepam;   Norprazepam;   SMILES=Clc1ccc2NC(=O)CN=C(c3ccccc3)c2c1;   nordazepamum
 alt_id: CHEBI:7624
 xref: CAS:1088-11-5;   Drug_Central:816;   KEGG:C07486;   KEGG:D08283
 xref_mesh: MESH:D003708
 xref: PMID:16622;   PMID:19604;   PMID:360230;   PMID:364005;   PMID:367407;   PMID:4953859;   Patent:BE620020;   Patent:DE1136709;   Patent:US3051701;   Patent:US3202699;   Reaxys:751823;   Wikipedia:Desmethyldiazepam


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Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of Nordazepam CTD PMID:18846481 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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  CHEBI ontology 19812
    role 19761
      biological role 19761
        biophysical role 13092
          membrane transport modulator 12905
            GABA modulator 4665
              nordazepam 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic heterocyclic compound 18582
                                  organonitrogen heterocyclic compound 17639
                                    benzodiazepine 549
                                      1,4-benzodiazepinone 123
                                        nordazepam 1
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