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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:clodronic acid
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Accession:CHEBI:110423 term browser browse the term
Definition:An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.
Synonyms:exact_synonym: (dichloromethanediyl)bis(phosphonic acid)
 related_synonym: (Dichloro-phosphono-methyl)-phosphonic acid;   (dichloromethylene)bisphosphonic acid;   (dichloromethylene)diphosphonic acid;   Formula=CH4Cl2O6P2;   InChI=1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9);   InChIKey=ACSIXWWBWUQEHA-UHFFFAOYSA-N;   SMILES=OP(O)(=O)C(Cl)(Cl)P(O)(O)=O;   acide clodronique;   acido clodronico;   acidum clodronicum;   clodronate;   clodronsaeure;   dichloromethylene-1,1-bisphosphonic acid;   dichloromethylene-1,1-diphosphonic acid;   dichloromethylidene diphosphonate
 xref: Beilstein:1876367;   CAS:10596-23-3;   DrugBank:DB00720;   Drug_Central:690;   KEGG:D03545;   LINCS:LSM-5802
 xref_mesh: MESH:D004002
 xref: PMID:15658873;   PMID:7818726;   PMID:8421279;   Patent:BE672205
 cyclic_relationship: is_conjugate_acid_of CHEBI:59585


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clodronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars1 alanyl-tRNA synthetase 1 decreases expression ISO Clodronic Acid results in decreased expression of AARS1 mRNA CTD PMID:25596134 NCBI chr19:55,906,694...55,930,499
Ensembl chr19:55,906,702...55,930,497 		JBrowse link
G Abcb9 ATP binding cassette subfamily B member 9 increases expression ISO Clodronic Acid results in increased expression of ABCB9 mRNA CTD PMID:25596134 NCBI chr12:38,146,659...38,192,862
Ensembl chr12:38,159,904...38,192,860 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO Clodronic Acid results in increased expression of ABCC3 mRNA CTD PMID:25596134 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression ISO Clodronic Acid results in decreased expression of ABCG1 mRNA CTD PMID:25596134 NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,127,803...9,186,563 		JBrowse link
G Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B increases expression ISO Clodronic Acid results in increased expression of ABHD4 mRNA CTD PMID:25596134 NCBI chr15:31,674,090...31,686,051
Ensembl chr15:31,674,143...31,687,007 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression ISO Clodronic Acid results in decreased expression of ACSL1 mRNA CTD PMID:25596134 NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP [Clodronic Acid co-treated with Thioacetamide] results in increased expression of ACTA2 protein CTD PMID:26957569 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Agrn agrin increases expression ISO Clodronic Acid results in increased expression of AGRN mRNA CTD PMID:25596134 NCBI chr 5:172,031,528...172,064,429
Ensembl chr 5:172,031,528...172,064,539 		JBrowse link
G Ahr aryl hydrocarbon receptor affects activity ISO Clodronic Acid affects the activity of AHR protein CTD PMID:25596134 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Aifm2 AIF family member 2 affects expression ISO Clodronic Acid affects the expression of AIFM2 mRNA CTD PMID:25596134 NCBI chr20:30,195,781...30,222,014
Ensembl chr20:30,193,829...30,220,957 		JBrowse link
G Ak3 adenylate kinase 3 increases expression ISO Clodronic Acid results in increased expression of AK3 mRNA CTD PMID:25596134 NCBI chr 1:236,151,012...236,178,689
Ensembl chr 1:236,151,012...236,178,183 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO Clodronic Acid results in increased expression of AKR1C2 mRNA CTD PMID:25596134 NCBI chr17:70,669,684...70,717,935
Ensembl chr17:70,669,710...70,685,686 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 increases expression ISO Clodronic Acid results in increased expression of ALDH1A3 mRNA CTD PMID:25596134 NCBI chr 1:129,392,516...129,436,552
Ensembl chr 1:129,392,516...129,427,777 		JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression ISO Clodronic Acid results in increased expression of ALDOA mRNA CTD PMID:25596134 NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:190,832,820...190,838,211 		JBrowse link
G Als2cl ALS2 C-terminal like affects expression ISO Clodronic Acid affects the expression of ALS2CL mRNA CTD PMID:25596134 NCBI chr 8:119,746,498...119,762,824
Ensembl chr 8:119,743,248...119,762,843 		JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression ISO Clodronic Acid results in decreased expression of ANGPTL4 mRNA CTD PMID:25596134 NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:15,252,473...15,258,681 		JBrowse link
G Ankra2 ankyrin repeat family A member 2 decreases expression ISO Clodronic Acid results in decreased expression of ANKRA2 mRNA CTD PMID:25596134 NCBI chr 2:31,347,158...31,358,002
Ensembl chr 2:31,347,090...31,364,394 		JBrowse link
G Arfgef2 ARF guanine nucleotide exchange factor 2 affects expression ISO Clodronic Acid affects the expression of ARFGEF2 mRNA CTD PMID:25596134 NCBI chr 3:175,966,575...176,052,715
Ensembl chr 3:175,966,579...176,052,713 		JBrowse link
G Arhgef10 Rho guanine nucleotide exchange factor 10 decreases expression ISO Clodronic Acid results in decreased expression of ARHGEF10 mRNA CTD PMID:25596134 NCBI chr16:81,349,429...81,440,439
Ensembl chr16:81,349,429...81,440,054 		JBrowse link
G Arl1 ARF like GTPase 1 increases expression ISO Clodronic Acid results in increased expression of ARL1 mRNA CTD PMID:25596134 NCBI chr 7:25,007,401...25,018,572
Ensembl chr 7:25,006,981...25,019,319 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO Clodronic Acid results in decreased expression of ASNS mRNA CTD PMID:25596134 NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050 		JBrowse link
G Astn2 astrotactin 2 increases expression ISO Clodronic Acid results in increased expression of ASTN2 mRNA CTD PMID:25596134 NCBI chr 5:83,772,988...84,759,439
Ensembl chr 5:83,773,633...84,759,485 		JBrowse link
G Atad2 ATPase family, AAA domain containing 2 increases expression ISO Clodronic Acid results in increased expression of ATAD2 mRNA CTD PMID:25596134 NCBI chr 7:91,523,626...91,566,238
Ensembl chr 7:91,523,626...91,566,238 		JBrowse link
G Atf3 activating transcription factor 3 decreases expression ISO Clodronic Acid results in decreased expression of ATF3 mRNA CTD PMID:25596134 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750 		JBrowse link
G Atf4 activating transcription factor 4 affects activity ISO Clodronic Acid affects the activity of ATF4 protein CTD PMID:25596134 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739 		JBrowse link
G Atosa atos homolog A decreases expression ISO Clodronic Acid results in decreased expression of ATOSA mRNA CTD PMID:25596134 NCBI chr 8:84,575,360...84,653,103
Ensembl chr 8:84,575,370...84,653,091 		JBrowse link
G Atxn1 ataxin 1 decreases expression ISO Clodronic Acid results in decreased expression of ATXN1 mRNA CTD PMID:25596134 NCBI chr17:18,943,397...19,354,751
Ensembl chr17:19,208,200...19,356,790 		JBrowse link
G Aurkb aurora kinase B increases expression ISO Clodronic Acid results in increased expression of AURKB mRNA CTD PMID:25596134 NCBI chr10:54,243,116...54,249,675
Ensembl chr10:54,242,850...54,252,285 		JBrowse link
G Axl Axl receptor tyrosine kinase increases expression ISO Clodronic Acid results in increased expression of AXL mRNA CTD PMID:25596134 NCBI chr 1:90,392,864...90,424,123
Ensembl chr 1:90,392,864...90,424,009 		JBrowse link
G Batf basic leucine zipper ATF-like transcription factor decreases expression ISO Clodronic Acid results in decreased expression of BATF mRNA CTD PMID:25596134 NCBI chr 6:111,084,717...111,107,052
Ensembl chr 6:111,084,717...111,107,052 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Clodronic Acid results in increased expression of BAX mRNA CTD PMID:25596134 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcat1 branched chain amino acid transaminase 1 increases expression ISO Clodronic Acid results in increased expression of BCAT1 mRNA CTD PMID:25596134 NCBI chr 4:179,695,662...179,777,973
Ensembl chr 4:179,695,662...179,777,288 		JBrowse link
G Bcat2 branched chain amino acid transaminase 2 increases expression ISO Clodronic Acid results in increased expression of BCAT2 mRNA CTD PMID:25596134 NCBI chr 1:105,175,157...105,196,474
Ensembl chr 1:105,176,977...105,196,463 		JBrowse link
G Bcl3 BCL3, transcription coactivator decreases expression ISO Clodronic Acid results in decreased expression of BCL3 mRNA CTD PMID:25596134 NCBI chr 1:88,599,321...88,613,555
Ensembl chr 1:88,599,321...88,614,368 		JBrowse link
G Bend5 BEN domain containing 5 increases expression ISO Clodronic Acid results in increased expression of BEND5 mRNA CTD PMID:25596134 NCBI chr 5:131,519,214...131,565,228
Ensembl chr 5:131,519,214...131,762,906 		JBrowse link
G Bnip3 BCL2 interacting protein 3 decreases expression ISO Clodronic Acid results in decreased expression of BNIP3 mRNA CTD PMID:25596134 NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962 		JBrowse link
G Brd2 bromodomain containing 2 decreases expression ISO Clodronic Acid results in decreased expression of BRD2 mRNA CTD PMID:25596134 NCBI chr20:4,728,282...4,737,286
Ensembl chr20:4,728,951...4,737,290 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Clodronic Acid results in increased expression of BTG2 mRNA CTD PMID:25596134 NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 increases expression ISO Clodronic Acid results in increased expression of CAMKK2 mRNA CTD PMID:25596134 NCBI chr12:39,451,828...39,505,719
Ensembl chr12:39,451,834...39,514,964 		JBrowse link
G Cars1 cysteinyl-tRNA synthetase 1 decreases expression ISO Clodronic Acid results in decreased expression of CARS1 mRNA CTD PMID:25596134 NCBI chr 1:208,183,092...208,225,425
Ensembl chr 1:208,182,788...208,225,407 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions 		ISO Clodronic Acid results in increased expression of CASP3
Suramin inhibits the reaction [Clodronic Acid results in increased expression of CASP3] 		CTD PMID:19448140 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Ccdc90b coiled-coil domain containing 90B decreases expression ISO Clodronic Acid results in decreased expression of CCDC90B mRNA CTD PMID:25596134 NCBI chr 1:156,045,192...156,058,750
Ensembl chr 1:156,045,138...156,061,403 		JBrowse link
G Ccne2 cyclin E2 increases expression ISO Clodronic Acid results in increased expression of CCNE2 mRNA CTD PMID:25596134 NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882 		JBrowse link
G Ccng2 cyclin G2 decreases expression ISO Clodronic Acid results in decreased expression of CCNG2 mRNA CTD PMID:25596134 NCBI chr14:15,088,694...15,097,190
Ensembl chr14:15,088,695...15,096,206 		JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of CD68 mRNA] CTD PMID:27022031 NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,880,563...54,882,540 		JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO Clodronic Acid inhibits the reaction [Streptozocin results in increased expression of CD80 protein] CTD PMID:15892581 NCBI chr11:75,760,073...75,798,978
Ensembl chr11:75,760,147...75,797,540 		JBrowse link
G Cd86 CD86 molecule multiple interactions ISO Clodronic Acid inhibits the reaction [Streptozocin results in increased expression of CD86 protein] CTD PMID:15892581 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 affects expression ISO Clodronic Acid affects the expression of CDK6 mRNA CTD PMID:25596134 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Clodronic Acid results in increased expression of CDKN1A mRNA CTD PMID:25596134 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cers5 ceramide synthase 5 increases expression ISO Clodronic Acid results in increased expression of CERS5 mRNA CTD PMID:25596134 NCBI chr 7:132,738,834...132,776,920
Ensembl chr 7:132,738,834...132,776,786 		JBrowse link
G Clip4 CAP-GLY domain containing linker protein family, member 4 increases expression ISO Clodronic Acid results in increased expression of CLIP4 mRNA CTD PMID:25596134 NCBI chr 6:29,359,628...29,449,365
NCBI chr 6:29,349,245...29,351,890
Ensembl chr 6:29,348,918...29,449,271 		JBrowse link
G Cmbl carboxymethylenebutenolidase homolog increases expression ISO Clodronic Acid results in increased expression of CMBL mRNA CTD PMID:25596134 NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:84,242,512...84,301,880 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of COL1A1 mRNA] CTD PMID:27022031 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Crispld2 cysteine-rich secretory protein LCCL domain containing 2 increases expression ISO Clodronic Acid results in increased expression of CRISPLD2 mRNA CTD PMID:25596134 NCBI chr19:64,961,764...65,020,099
Ensembl chr19:64,961,771...65,020,349 		JBrowse link
G Ctdp1 CTD phosphatase subunit 1 decreases expression ISO Clodronic Acid results in decreased expression of CTDP1 mRNA CTD PMID:25596134 NCBI chr18:76,129,243...76,193,404
Ensembl chr18:76,129,243...76,190,578 		JBrowse link
G Cth cystathionine gamma-lyase decreases expression ISO Clodronic Acid results in decreased expression of CTH mRNA CTD PMID:25596134 NCBI chr 2:249,634,731...249,661,066
Ensembl chr 2:249,634,731...249,661,066 		JBrowse link
G Ctsc cathepsin C increases expression ISO Clodronic Acid results in increased expression of CTSC mRNA CTD PMID:25596134 NCBI chr 1:151,440,860...151,472,430
Ensembl chr 1:151,441,032...151,474,082 		JBrowse link
G Cttn cortactin increases expression ISO Clodronic Acid results in increased expression of CTTN mRNA CTD PMID:25596134 NCBI chr 1:209,029,048...209,064,577
Ensembl chr 1:209,029,048...209,058,211 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 multiple interactions ISO Clodronic Acid inhibits the reaction [Acetaminophen results in increased expression of CXCR2 protein]; IL10 protein inhibits the reaction [Clodronic Acid inhibits the reaction [Acetaminophen results in increased expression of CXCR2 protein]] CTD PMID:34724096 NCBI chr 9:83,178,645...83,185,017
Ensembl chr 9:83,183,808...83,188,602 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Clodronic Acid results in increased expression of CYP1A2 mRNA CTD PMID:25596134 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO Clodronic Acid results in increased expression of CYP1B1 mRNA CTD PMID:25596134 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Ddb2 damage specific DNA binding protein 2 decreases expression ISO Clodronic Acid results in decreased expression of DDB2 mRNA CTD PMID:25596134 NCBI chr 3:97,640,923...97,667,617
Ensembl chr 3:97,640,579...97,664,066 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects expression ISO Clodronic Acid affects the expression of DDIT3 mRNA CTD PMID:25596134 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Clodronic Acid results in increased expression of DDIT4 mRNA CTD PMID:25596134 NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037 		JBrowse link
G Ddx17 DEAD-box helicase 17 decreases expression ISO Clodronic Acid results in decreased expression of DDX17 mRNA CTD PMID:25596134 NCBI chr 7:112,971,522...112,989,747
Ensembl chr 7:112,971,523...112,989,747 		JBrowse link
G Des desmin multiple interactions EXP [Clodronic Acid co-treated with Thioacetamide] results in increased expression of DES protein CTD PMID:26957569 NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:84,298,447...84,307,347 		JBrowse link
G Dgka diacylglycerol kinase, alpha increases expression ISO Clodronic Acid results in increased expression of DGKA mRNA CTD PMID:25596134 NCBI chr 7:1,733,247...1,761,181
Ensembl chr 7:1,733,248...1,759,569 		JBrowse link
G Dhx37 DEAH-box helicase 37 decreases expression ISO Clodronic Acid results in decreased expression of DHX37 mRNA CTD PMID:25596134 NCBI chr12:36,856,119...36,876,245
Ensembl chr12:36,849,701...36,876,240 		JBrowse link
G Dlgap5 DLG associated protein 5 increases expression ISO Clodronic Acid results in increased expression of DLGAP5 mRNA CTD PMID:25596134 NCBI chr15:23,113,678...23,144,281
Ensembl chr15:23,113,678...23,144,176 		JBrowse link
G Dnai3 dynein axonemal intermediate chain 3 decreases expression ISO Clodronic Acid results in decreased expression of DNAI3 mRNA CTD PMID:25596134 NCBI chr 2:237,608,202...237,666,465
Ensembl chr 2:237,604,068...237,666,465 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO Clodronic Acid results in increased expression of DNAJB9 mRNA CTD PMID:25596134 NCBI chr 6:66,997,842...67,007,371
Ensembl chr 6:66,997,842...67,009,344 		JBrowse link
G Dpm3 dolichyl-phosphate mannosyltransferase subunit 3, regulatory increases expression ISO Clodronic Acid results in increased expression of DPM3 mRNA CTD PMID:25596134 NCBI chr 2:174,676,532...174,677,047
Ensembl chr15:52,612,418...52,612,696 		JBrowse link
G Dpysl3 dihydropyrimidinase-like 3 increases expression ISO Clodronic Acid results in increased expression of DPYSL3 mRNA CTD PMID:25596134 NCBI chr18:35,625,357...35,731,152
Ensembl chr18:35,625,357...35,731,152 		JBrowse link
G Dusp22 dual specificity phosphatase 22 increases expression ISO Clodronic Acid results in increased expression of DUSP22 mRNA CTD PMID:25596134 NCBI chr17:33,989,637...34,040,021
Ensembl chr17:33,989,637...34,039,895 		JBrowse link
G Efna1 ephrin A1 decreases expression ISO Clodronic Acid results in decreased expression of EFNA1 mRNA CTD PMID:25596134 NCBI chr 2:176,979,434...176,988,675
Ensembl chr 2:176,979,434...176,988,726 		JBrowse link
G Eif1 eukaryotic translation initiation factor 1 increases expression ISO Clodronic Acid results in increased expression of EIF1 mRNA CTD PMID:25596134 NCBI chr10:85,747,064...85,749,447
Ensembl chr 5:25,895,968...25,896,654
Ensembl chr10:25,895,968...25,896,654 		JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2 subunit beta increases expression ISO Clodronic Acid results in increased expression of EIF2S2 mRNA CTD PMID:25596134 NCBI chr 3:163,834,846...163,855,733
Ensembl chr 3:163,834,851...163,855,570 		JBrowse link
G Eif3c eukaryotic translation initiation factor 3, subunit C decreases expression ISO Clodronic Acid results in decreased expression of EIF3C mRNA CTD PMID:25596134 NCBI chr 1:190,565,183...190,583,067
Ensembl chr 1:190,565,184...190,583,067 		JBrowse link
G Elf4 E74 like ETS transcription factor 4 decreases expression ISO Clodronic Acid results in decreased expression of ELF4 mRNA CTD PMID:25596134 NCBI chr  X:132,465,290...132,508,175
Ensembl chr  X:132,468,539...132,478,689 		JBrowse link
G Elk4 ETS transcription factor ELK4 decreases expression ISO Clodronic Acid results in decreased expression of ELK4 mRNA CTD PMID:25596134 NCBI chr13:46,004,145...46,027,206
Ensembl chr13:46,004,182...46,027,199 		JBrowse link
G Eno2 enolase 2 increases expression ISO Clodronic Acid results in increased expression of ENO2 mRNA CTD PMID:25596134 NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:159,258,371...159,267,220 		JBrowse link
G Ep400 E1A binding protein p400 decreases expression ISO Clodronic Acid results in decreased expression of EP400 mRNA CTD PMID:25596134 NCBI chr12:51,551,665...51,658,635
Ensembl chr12:51,551,695...51,658,634 		JBrowse link
G Eprs1 glutamyl-prolyl-tRNA synthetase 1 decreases expression ISO Clodronic Acid results in decreased expression of EPRS1 mRNA CTD PMID:25596134 NCBI chr13:99,431,955...99,503,510
Ensembl chr13:99,433,130...99,503,509 		JBrowse link
G Fam162a family with sequence similarity 162, member A decreases expression ISO Clodronic Acid results in decreased expression of FAM162A mRNA CTD PMID:25596134 NCBI chr11:78,186,260...78,215,186
Ensembl chr11:78,185,852...78,216,560 		JBrowse link
G Fam210a family with sequence similarity 210, member A affects expression ISO Clodronic Acid affects the expression of FAM210A mRNA CTD PMID:25596134 NCBI chr18:61,846,447...61,886,123
Ensembl chr18:64,116,274...64,155,949 		JBrowse link
G Fam89a family with sequence similarity 89, member A increases expression ISO Clodronic Acid results in increased expression of FAM89A mRNA CTD PMID:25596134 NCBI chr19:69,607,391...69,620,019
Ensembl chr19:69,607,391...69,620,019 		JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO Clodronic Acid results in decreased expression of FAS mRNA CTD PMID:25596134 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Fbxo22 F-box protein 22 increases expression ISO Clodronic Acid results in increased expression of FBXO22 mRNA CTD PMID:25596134 NCBI chr 8:64,476,034...64,492,063
Ensembl chr 8:64,475,957...64,492,062 		JBrowse link
G Fbxo30 F-box protein 30 decreases expression ISO Clodronic Acid results in decreased expression of FBXO30 mRNA CTD PMID:25596134 NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:7,475,575...7,493,199 		JBrowse link
G Fech ferrochelatase decreases expression ISO Clodronic Acid results in decreased expression of FECH mRNA CTD PMID:25596134 NCBI chr18:60,215,325...60,248,525
Ensembl chr18:60,215,325...60,249,546 		JBrowse link
G Flvcr2 FLVCR choline and putative heme transporter 2 increases expression ISO Clodronic Acid results in increased expression of FLVCR2 mRNA CTD PMID:25596134 NCBI chr 6:111,139,352...111,203,345
Ensembl chr 6:111,139,295...111,203,345 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Clodronic Acid results in increased expression of FOSL1 mRNA CTD PMID:25596134 NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit decreases expression ISO Clodronic Acid results in decreased expression of FOSL2 mRNA CTD PMID:25596134 NCBI chr 6:30,017,952...30,039,269
Ensembl chr 6:30,021,916...30,039,406 		JBrowse link
G Frem2 FRAS1 related extracellular matrix 2 decreases expression ISO Clodronic Acid results in decreased expression of FREM2 mRNA CTD PMID:25596134 NCBI chr 2:139,753,055...139,891,046
Ensembl chr 2:139,753,055...139,891,046 		JBrowse link
G Fth1 ferritin heavy chain 1 decreases expression ISO Clodronic Acid results in decreased expression of FTH1 mRNA CTD PMID:25596134 NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214 		JBrowse link
G Gabarapl1 GABA type A receptor associated protein like 1 increases expression ISO Clodronic Acid results in increased expression of GABARAPL1 mRNA CTD PMID:25596134 NCBI chr 4:164,666,332...164,675,474
Ensembl chr 4:164,666,246...164,674,578 		JBrowse link
G Gars1 glycyl-tRNA synthetase 1 increases expression ISO Clodronic Acid results in increased expression of GARS1 mRNA CTD PMID:25596134 NCBI chr 4:85,484,939...85,542,876
Ensembl chr 4:85,493,753...85,542,876 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression ISO Clodronic Acid results in decreased expression of GCLC mRNA CTD PMID:25596134 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Clodronic Acid results in increased expression of GCLM mRNA CTD PMID:25596134 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003 		JBrowse link
G Gdf15 growth differentiation factor 15 decreases expression ISO Clodronic Acid results in decreased expression of GDF15 mRNA CTD PMID:25596134 NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022 		JBrowse link
G Golim4 golgi integral membrane protein 4 increases expression ISO Clodronic Acid results in increased expression of GOLIM4 mRNA CTD PMID:25596134 NCBI chr 2:160,640,837...160,733,475
Ensembl chr 2:162,939,429...163,031,901 		JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO Clodronic Acid results in increased expression of GPAT3 mRNA CTD PMID:25596134 NCBI chr14:9,018,762...9,072,552 JBrowse link
G Gpnmb glycoprotein nmb increases expression ISO Clodronic Acid results in increased expression of GPNMB mRNA CTD PMID:25596134 NCBI chr 4:79,341,128...79,362,366
Ensembl chr 4:79,341,021...79,380,240 		JBrowse link
G Gpr87 G protein-coupled receptor 87 decreases expression ISO Clodronic Acid results in decreased expression of GPR87 mRNA CTD PMID:25596134 NCBI chr 2:143,439,741...143,440,901
Ensembl chr 2:145,589,569...145,604,442 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO
EXP 		Clodronic Acid inhibits the reaction [Acetaminophen results in increased expression of GPT protein]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased secretion of GPT protein]; Clodronic Acid promotes the reaction [Acetaminophen results in increased activity of GPT protein]
Clodronic Acid promotes the reaction [Thioacetamide results in increased expression of GPT protein] 		CTD PMID:26957569 PMID:27022031 PMID:34724096 PMID:38825056 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO Clodronic Acid results in increased expression of GSR mRNA CTD PMID:25596134 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
affects activity 		EXP
ISO 		Clodronic Acid inhibits the reaction [Dopamine results in decreased expression of HIF1A protein]
Clodronic Acid affects the activity of HIF1A protein 		CTD PMID:25596134 PMID:25818600 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
increases expression 		ISO Clodronic Acid results in decreased expression of HMOX1 mRNA
Clodronic Acid results in increased expression of HMOX1 mRNA 		CTD PMID:21690482 PMID:25596134 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Iars1 isoleucyl-tRNA synthetase 1 affects expression ISO Clodronic Acid affects the expression of IARS1 mRNA CTD PMID:25596134 NCBI chr17:15,147,357...15,193,716
Ensembl chr17:15,147,357...15,193,652 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Clodronic Acid inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein] CTD PMID:15892581 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ids iduronate 2-sulfatase decreases expression ISO Clodronic Acid results in decreased expression of IDS mRNA CTD PMID:25596134 NCBI chr  X:154,070,781...154,093,681
Ensembl chr  X:154,070,781...154,091,444 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Clodronic Acid inhibits the reaction [Streptozocin results in increased expression of IFNG protein] CTD PMID:15892581 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor increases expression ISO Clodronic Acid results in increased expression of IGF1R mRNA CTD PMID:25596134 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Clodronic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL10 protein]; IL10 protein inhibits the reaction [Clodronic Acid inhibits the reaction [Acetaminophen results in increased expression of CXCR2 protein]] CTD PMID:32385136 PMID:34724096 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression 		ISO Clodronic Acid inhibits the reaction [Alendronate results in increased expression of IL1B protein]
Clodronic Acid results in increased expression of IL1B mRNA 		CTD PMID:20804833 PMID:25187657 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO 		Clodronic Acid inhibits the reaction [Taurocholic Acid results in increased expression of IL6 protein]
Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of IL6 mRNA] 		CTD PMID:20382593 PMID:27022031 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Kdm3a lysine demethylase 3A decreases expression ISO Clodronic Acid results in decreased expression of KDM3A mRNA CTD PMID:25596134 NCBI chr 4:105,189,208...105,233,526
Ensembl chr 4:105,189,208...105,233,370 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO Clodronic Acid results in increased expression of KEAP1 mRNA CTD PMID:25596134 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042 		JBrowse link
G Lama3 laminin subunit alpha 3 increases expression ISO Clodronic Acid results in increased expression of LAMA3 mRNA CTD PMID:25596134 NCBI chr18:3,797,898...4,033,021
Ensembl chr18:3,797,939...4,026,449 		JBrowse link
G Ltn1 listerin E3 ubiquitin protein ligase 1 decreases expression ISO Clodronic Acid results in decreased expression of LTN1 mRNA CTD PMID:25596134 NCBI chr11:40,090,169...40,147,159
Ensembl chr11:40,090,169...40,147,303 		JBrowse link
G Mafg MAF bZIP transcription factor G increases expression ISO Clodronic Acid results in increased expression of MAFG mRNA CTD PMID:25596134 NCBI chr10:106,401,633...106,410,159 JBrowse link
G Mapre2 microtubule-associated protein, RP/EB family, member 2 increases expression ISO Clodronic Acid results in increased expression of MAPRE2 mRNA CTD PMID:25596134 NCBI chr18:15,303,502...15,444,306
Ensembl chr18:15,303,533...15,442,796 		JBrowse link
G Mcoln2 mucolipin TRP cation channel 2 decreases expression ISO Clodronic Acid results in decreased expression of MCOLN2 mRNA CTD PMID:25596134 NCBI chr 2:237,714,100...237,762,979
Ensembl chr 2:237,714,084...237,762,978 		JBrowse link
G Me1 malic enzyme 1 decreases expression ISO Clodronic Acid results in decreased expression of ME1 mRNA CTD PMID:25596134 NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:96,429,057...96,540,275 		JBrowse link
G Mtdh metadherin decreases expression ISO Clodronic Acid results in decreased expression of MTDH mRNA CTD PMID:25596134 NCBI chr 7:67,192,592...67,250,819
Ensembl chr 7:67,192,393...67,249,584 		JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming decreases expression ISO Clodronic Acid results in decreased expression of MUC2 mRNA CTD PMID:25187657 NCBI chr 1:206,225,775...206,261,280
Ensembl chr 1:206,229,035...206,261,280 		JBrowse link
G Mxi1 MAX interactor 1, dimerization protein decreases expression ISO Clodronic Acid results in decreased expression of MXI1 mRNA CTD PMID:25596134 NCBI chr 1:262,329,274...262,389,037
Ensembl chr 1:262,328,875...262,389,036 		JBrowse link
G Nars1 asparaginyl-tRNA synthetase 1 decreases expression ISO Clodronic Acid results in decreased expression of NARS1 mRNA CTD PMID:25596134 NCBI chr18:60,259,506...60,275,782
Ensembl chr18:60,259,516...60,275,782 		JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 decreases expression ISO Clodronic Acid results in decreased expression of NEDD9 mRNA CTD PMID:25596134 NCBI chr17:23,495,531...23,673,780
Ensembl chr17:23,495,492...23,675,668 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects activity ISO Clodronic Acid affects the activity of NFE2L2 protein CTD PMID:25596134 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nin ninein decreases expression ISO Clodronic Acid results in decreased expression of NIN mRNA CTD PMID:25596134 NCBI chr 6:94,261,382...94,363,679
Ensembl chr 6:94,263,206...94,363,610 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression ISO Clodronic Acid results in decreased expression of NQO1 mRNA CTD PMID:25596134 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression ISO Clodronic Acid results in decreased expression of NR3C1 mRNA CTD PMID:25596134 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843 		JBrowse link
G Nrep neuronal regeneration related protein increases expression ISO Clodronic Acid results in increased expression of NREP mRNA CTD PMID:25596134 NCBI chr18:25,291,219...25,320,742
Ensembl chr18:25,291,219...25,320,742 		JBrowse link
G Ntpcr nucleoside-triphosphatase, cancer-related increases expression ISO Clodronic Acid results in increased expression of NTPCR mRNA CTD PMID:25596134 NCBI chr19:53,701,496...53,715,260
Ensembl chr19:70,593,274...70,613,197 		JBrowse link
G Nuak1 NUAK family kinase 1 decreases expression ISO Clodronic Acid results in decreased expression of NUAK1 mRNA CTD PMID:25596134 NCBI chr 7:21,217,729...21,289,608
Ensembl chr 7:21,217,681...21,289,354 		JBrowse link
G Orai3 ORAI calcium release-activated calcium modulator 3 decreases expression ISO Clodronic Acid results in decreased expression of ORAI3 mRNA CTD PMID:25596134 NCBI chr 1:191,811,671...191,816,530
Ensembl chr 1:191,811,424...191,816,530 		JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 decreases expression ISO Clodronic Acid results in decreased expression of OSGIN1 mRNA CTD PMID:25596134 NCBI chr19:64,380,336...64,409,165
Ensembl chr19:64,401,173...64,409,162 		JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 decreases expression ISO Clodronic Acid results in decreased expression of P4HA1 mRNA CTD PMID:25596134 NCBI chr20:27,784,696...27,895,785
Ensembl chr20:27,845,141...27,895,404 		JBrowse link
G Pde8a phosphodiesterase 8A decreases expression ISO Clodronic Acid results in decreased expression of PDE8A mRNA CTD PMID:25596134 NCBI chr 1:144,575,203...144,698,216
Ensembl chr 1:144,575,428...144,698,215 		JBrowse link
G Pdia5 protein disulfide isomerase family A, member 5 increases expression ISO Clodronic Acid results in increased expression of PDIA5 mRNA CTD PMID:25596134 NCBI chr11:78,777,436...78,892,370
Ensembl chr11:78,777,419...78,864,329 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases expression ISO Clodronic Acid results in decreased expression of PDK1 mRNA CTD PMID:25596134 NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:77,113,473...77,144,145 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO Clodronic Acid results in increased expression of PDK4 mRNA CTD PMID:25596134 NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:34,556,330...34,568,381 		JBrowse link
G Pdlim1 PDZ and LIM domain 1 increases expression ISO Clodronic Acid results in increased expression of PDLIM1 mRNA CTD PMID:25596134 NCBI chr 1:248,991,818...249,040,409
Ensembl chr 1:248,991,818...249,047,379 		JBrowse link
G Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 decreases expression ISO Clodronic Acid results in decreased expression of PFKFB4 mRNA CTD PMID:25596134 NCBI chr 8:118,522,371...118,565,478
Ensembl chr 8:118,522,365...118,565,468 		JBrowse link
G Phgdh phosphoglycerate dehydrogenase decreases expression ISO Clodronic Acid results in decreased expression of PHGDH mRNA CTD PMID:25596134 NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:188,595,700...188,624,789 		JBrowse link
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma affects expression ISO Clodronic Acid affects the expression of PIP5K1C mRNA CTD PMID:25596134 NCBI chr 7:9,048,135...9,076,751
Ensembl chr 7:9,048,146...9,076,716 		JBrowse link
G Pir pirin increases expression ISO Clodronic Acid results in increased expression of PIR mRNA CTD PMID:25596134 NCBI chr  X:33,740,428...33,851,049
Ensembl chr  X:33,740,429...33,851,049 		JBrowse link
G Plec plectin decreases expression ISO Clodronic Acid results in decreased expression of PLEC mRNA CTD PMID:25596134 NCBI chr 7:109,768,447...109,829,798
Ensembl chr 7:109,768,447...109,828,089 		JBrowse link
G Plk3 polo-like kinase 3 increases expression ISO Clodronic Acid results in increased expression of PLK3 mRNA CTD PMID:25596134 NCBI chr 5:135,843,725...135,848,900
Ensembl chr 5:135,843,725...135,848,900 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 decreases expression ISO Clodronic Acid results in decreased expression of PMAIP1 mRNA CTD PMID:25596134 NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382 		JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 affects expression ISO Clodronic Acid affects the expression of PMEPA1 mRNA CTD PMID:25596134 NCBI chr 3:182,430,193...182,478,649
Ensembl chr 3:182,430,193...182,478,649 		JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases expression ISO Clodronic Acid results in decreased expression of PNPLA6 mRNA CTD PMID:25596134 NCBI chr12:6,372,284...6,401,632
Ensembl chr12:6,372,293...6,401,631 		JBrowse link
G Polr3f RNA polymerase III subunit F decreases expression ISO Clodronic Acid results in decreased expression of POLR3F mRNA CTD PMID:25596134 NCBI chr 3:152,361,798...152,378,169
Ensembl chr 3:152,361,798...152,378,168 		JBrowse link
G Pon1 paraoxonase 1 decreases activity
multiple interactions 		EXP Clodronic Acid results in decreased activity of PON1 protein
[Clodronic Acid results in decreased activity of PON1 protein] which results in decreased metabolism of homocysteine thiolactone; [Clodronic Acid results in decreased activity of PON1 protein] which results in decreased metabolism of Paraoxon; [Clodronic Acid results in decreased activity of PON1 protein] which results in decreased metabolism of phenyl acetate 		CTD PMID:27387541 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects activity ISO Clodronic Acid affects the activity of PPARG protein CTD PMID:25596134 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ppfibp1 PPFIA binding protein 1 affects expression ISO Clodronic Acid affects the expression of PPFIBP1 mRNA CTD PMID:25596134 NCBI chr 4:181,538,249...181,682,079
Ensembl chr 4:181,539,450...181,682,076 		JBrowse link
G Ppig peptidylprolyl isomerase G decreases expression ISO Clodronic Acid results in decreased expression of PPIG mRNA CTD PMID:25596134 NCBI chr 3:74,891,846...74,923,010
Ensembl chr 3:74,891,846...74,920,750 		JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D decreases expression ISO Clodronic Acid results in decreased expression of PPM1D mRNA CTD PMID:25596134 NCBI chr10:70,670,026...70,706,030
Ensembl chr10:70,670,020...70,706,256 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A decreases expression ISO Clodronic Acid results in decreased expression of PPP1R15A mRNA CTD PMID:25596134 NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:105,136,525...105,139,774 		JBrowse link
G Ppp4r2 protein phosphatase 4, regulatory subunit 2 decreases expression ISO Clodronic Acid results in decreased expression of PPP4R2 mRNA CTD PMID:25596134 NCBI chr 4:135,010,919...135,051,844
Ensembl chr 4:135,010,919...135,051,844 		JBrowse link
G Prc1 protein regulator of cytokinesis 1 increases expression ISO Clodronic Acid results in increased expression of PRC1 mRNA CTD PMID:25596134 NCBI chr 1:143,659,312...143,681,019
Ensembl chr 1:143,659,481...143,681,012 		JBrowse link
G Prdm1 PR/SET domain 1 decreases expression ISO Clodronic Acid results in decreased expression of PRDM1 mRNA CTD PMID:25596134 NCBI chr20:49,542,465...49,564,088
Ensembl chr20:49,542,465...49,564,088 		JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 increases expression ISO Clodronic Acid results in increased expression of PRKAB1 mRNA CTD PMID:25596134 NCBI chr12:46,248,971...46,259,487
Ensembl chr12:46,249,010...46,259,482 		JBrowse link
G Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 decreases expression ISO Clodronic Acid results in decreased expression of PRKAB2 mRNA CTD PMID:25596134 NCBI chr 2:187,946,008...187,961,615
Ensembl chr 2:187,945,982...187,961,608 		JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression ISO Clodronic Acid results in increased expression of PSAT1 mRNA CTD PMID:25596134 NCBI chr 1:222,623,553...222,646,187
Ensembl chr 1:222,623,556...222,655,693 		JBrowse link
G Pspc1 paraspeckle component 1 decreases expression ISO Clodronic Acid results in decreased expression of PSPC1 mRNA CTD PMID:25596134 NCBI chr15:34,941,445...35,027,460
Ensembl chr15:34,967,477...35,026,828 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of CD68 mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of COL1A1 mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of IL6 mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TGFB1 mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TIMP1 mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TNF mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased secretion of GPT protein] CTD PMID:27022031 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330 		JBrowse link
G Pycr1 pyrroline-5-carboxylate reductase 1 increases expression ISO Clodronic Acid results in increased expression of PYCR1 mRNA CTD PMID:25596134 NCBI chr10:106,416,056...106,420,982
Ensembl chr10:106,412,576...106,423,393 		JBrowse link
G Rab26 RAB26, member RAS oncogene family increases expression ISO Clodronic Acid results in increased expression of RAB26 mRNA CTD PMID:25596134 NCBI chr10:14,057,942...14,062,602
Ensembl chr10:14,057,942...14,062,577 		JBrowse link
G Rab31 RAB31, member RAS oncogene family increases expression ISO Clodronic Acid results in increased expression of RAB31 mRNA CTD PMID:25596134 NCBI chr 9:112,693,596...112,828,104
Ensembl chr 9:112,693,597...112,828,092 		JBrowse link
G Rara retinoic acid receptor, alpha decreases expression ISO Clodronic Acid results in decreased expression of RARA mRNA CTD PMID:25596134 NCBI chr10:84,379,780...84,424,371
Ensembl chr10:84,389,622...84,425,160 		JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase increases expression ISO Clodronic Acid results in increased expression of RFFL mRNA CTD PMID:25596134 NCBI chr10:68,238,273...68,301,225
Ensembl chr10:68,238,273...68,321,902 		JBrowse link
G Rit1 Ras-like without CAAX 1 increases expression ISO Clodronic Acid results in increased expression of RIT1 mRNA CTD PMID:25596134 NCBI chr 2:176,478,616...176,493,269
Ensembl chr 2:176,478,596...176,494,684 		JBrowse link
G Rnd3 Rho family GTPase 3 affects expression ISO Clodronic Acid affects the expression of RND3 mRNA CTD PMID:25596134 NCBI chr 3:55,981,142...55,998,494
Ensembl chr 3:55,980,355...55,998,536 		JBrowse link
G Ro60 Ro60, Y RNA binding protein decreases expression ISO Clodronic Acid results in decreased expression of RO60 mRNA CTD PMID:25596134 NCBI chr13:58,049,838...58,070,828
Ensembl chr13:58,049,858...58,076,264 		JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B decreases expression ISO Clodronic Acid results in decreased expression of RRM2B mRNA CTD PMID:25596134 NCBI chr 7:70,962,008...70,993,726
Ensembl chr 7:70,965,590...70,993,670 		JBrowse link
G Rrp12 ribosomal RNA processing 12 decreases expression ISO Clodronic Acid results in decreased expression of RRP12 mRNA CTD PMID:25596134 NCBI chr 1:250,621,707...250,655,318
Ensembl chr 1:250,621,707...250,655,318 		JBrowse link
G Rsrc2 arginine and serine rich coiled-coil 2 affects expression ISO Clodronic Acid affects the expression of RSRC2 mRNA CTD PMID:25596134 NCBI chr12:38,500,709...38,520,715
Ensembl chr12:38,500,770...38,520,707 		JBrowse link
G Runx1 RUNX family transcription factor 1 increases expression ISO Clodronic Acid results in increased expression of RUNX1 mRNA CTD PMID:25596134 NCBI chr11:45,325,778...45,560,300
Ensembl chr11:45,329,044...45,564,925 		JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO Clodronic Acid results in increased expression of RUNX2 mRNA CTD PMID:25596134 NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027 		JBrowse link
G Scamp1 secretory carrier membrane protein 1 increases expression ISO Clodronic Acid results in increased expression of SCAMP1 mRNA CTD PMID:25596134 NCBI chr 2:27,168,863...27,251,637
Ensembl chr 2:27,168,864...27,251,742 		JBrowse link
G Sectm1b secreted and transmembrane 1B increases expression ISO Clodronic Acid results in increased expression of SECTM1 mRNA CTD PMID:25596134 NCBI chr10:106,822,397...106,832,105
Ensembl chr10:106,822,397...106,832,104 		JBrowse link
G Sertad1 SERTA domain containing 1 increases expression ISO Clodronic Acid results in increased expression of SERTAD1 mRNA CTD PMID:25596134 NCBI chr 1:91,903,297...91,906,565
Ensembl chr 1:91,891,814...91,907,001 		JBrowse link
G Setx senataxin decreases expression ISO Clodronic Acid results in decreased expression of SETX mRNA CTD PMID:25596134 NCBI chr 3:32,825,771...32,878,740
Ensembl chr 3:32,828,412...32,878,740 		JBrowse link
G Sfn stratifin increases expression ISO Clodronic Acid results in increased expression of SFN mRNA CTD PMID:25596134 NCBI chr 5:151,110,582...151,111,854
Ensembl chr 5:151,110,530...151,111,995 		JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 decreases expression ISO Clodronic Acid results in decreased expression of SHANK3 mRNA CTD PMID:25596134 NCBI chr 7:122,448,323...122,518,623
Ensembl chr 7:122,448,323...122,510,410 		JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 increases expression ISO Clodronic Acid results in increased expression of SIAH2 mRNA CTD PMID:25596134 NCBI chr 2:145,063,847...145,081,675
Ensembl chr 2:145,063,857...145,081,873 		JBrowse link
G Sipa1l2 signal-induced proliferation-associated 1 like 2 decreases expression ISO Clodronic Acid results in decreased expression of SIPA1L2 mRNA CTD PMID:25596134 NCBI chr19:53,389,792...53,540,466
Ensembl chr19:70,287,147...70,437,773 		JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor increases expression ISO Clodronic Acid results in increased expression of SIVA1 mRNA CTD PMID:25596134 NCBI chr 6:137,526,416...137,530,790
Ensembl chr 6:137,526,031...137,530,790 		JBrowse link
G Slc12a8 solute carrier family 12, member 8 decreases expression ISO Clodronic Acid results in decreased expression of SLC12A8 mRNA CTD PMID:25596134 NCBI chr11:80,622,000...80,771,674
Ensembl chr11:80,622,000...80,771,659 		JBrowse link
G Slc1a4 solute carrier family 1 member 4 decreases expression ISO Clodronic Acid results in decreased expression of SLC1A4 mRNA CTD PMID:25596134 NCBI chr14:98,718,646...98,761,672
Ensembl chr14:98,730,450...98,761,790 		JBrowse link
G Slc1a5 solute carrier family 1 member 5 decreases expression ISO Clodronic Acid results in decreased expression of SLC1A5 mRNA CTD PMID:25596134 NCBI chr 1:86,584,949...86,599,052
Ensembl chr 1:86,584,949...86,599,054 		JBrowse link
G Slc25a20 solute carrier family 25 member 20 increases expression ISO Clodronic Acid results in increased expression of SLC25A20 mRNA CTD PMID:25596134 NCBI chr 8:118,243,573...118,265,027
Ensembl chr 8:118,243,519...118,265,027 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 affects expression ISO Clodronic Acid affects the expression of SLC3A2 mRNA CTD PMID:25596134 NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064 		JBrowse link
G Slc6a9 solute carrier family 6 member 9 decreases expression ISO Clodronic Acid results in decreased expression of SLC6A9 mRNA CTD PMID:25596134 NCBI chr 5:136,660,022...136,694,173
Ensembl chr 5:136,659,948...136,694,172 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 affects expression ISO Clodronic Acid affects the expression of SLC7A5 mRNA CTD PMID:25596134 NCBI chr19:66,843,808...66,872,412
Ensembl chr19:66,843,808...66,872,412 		JBrowse link
G Smap1 small ArfGAP 1 increases expression ISO Clodronic Acid results in increased expression of SMAP1 mRNA CTD PMID:25596134 NCBI chr 9:33,746,489...33,838,488
Ensembl chr 9:33,746,489...33,838,734 		JBrowse link
G Son SON DNA and RNA binding protein decreases expression ISO Clodronic Acid results in decreased expression of SON mRNA CTD PMID:25596134 NCBI chr11:44,336,818...44,409,127
Ensembl chr11:44,377,976...44,409,127 		JBrowse link
G Sorl1 sortilin related receptor 1 increases expression ISO Clodronic Acid results in increased expression of SORL1 mRNA CTD PMID:25596134 NCBI chr 8:51,238,713...51,401,458
Ensembl chr 8:51,238,722...51,401,446 		JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 increases expression ISO Clodronic Acid results in increased expression of SPRY1 mRNA CTD PMID:25596134 NCBI chr 2:122,484,995...122,490,008
Ensembl chr 2:122,484,355...122,492,956 		JBrowse link
G Srd5a3 steroid 5 alpha-reductase 3 decreases expression ISO Clodronic Acid results in decreased expression of SRD5A3 mRNA CTD PMID:25596134 NCBI chr14:32,400,603...32,414,987
Ensembl chr14:32,400,603...32,415,117 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Clodronic Acid results in increased expression of SRXN1 mRNA CTD PMID:25596134 NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:161,059,931...161,088,765 		JBrowse link
G Sulf2 sulfatase 2 decreases expression ISO Clodronic Acid results in decreased expression of SULF2 mRNA CTD PMID:25596134 NCBI chr 3:175,241,322...175,323,808
Ensembl chr 3:175,241,322...175,323,651 		JBrowse link
G Taok1 TAO kinase 1 affects expression ISO Clodronic Acid affects the expression of TAOK1 mRNA CTD PMID:25596134 NCBI chr10:62,871,198...62,989,049
Ensembl chr10:62,871,198...62,957,595 		JBrowse link
G Tars1 threonyl-tRNA synthetase 1 decreases expression ISO Clodronic Acid results in decreased expression of TARS1 mRNA CTD PMID:25596134 NCBI chr 2:62,095,978...62,114,802
Ensembl chr 2:62,087,763...62,114,802 		JBrowse link
G Tbxas1 thromboxane A synthase 1 affects expression ISO Clodronic Acid affects the expression of TBXAS1 mRNA CTD PMID:25596134 NCBI chr 4:68,631,841...68,803,959
Ensembl chr 4:68,631,838...68,803,969 		JBrowse link
G Tfap2a transcription factor AP-2 alpha decreases expression ISO Clodronic Acid results in decreased expression of TFAP2A mRNA CTD PMID:25596134 NCBI chr17:24,230,064...24,253,219
Ensembl chr17:24,229,910...24,253,219 		JBrowse link
G Tfe3 transcription factor binding to IGHM enhancer 3 decreases expression ISO Clodronic Acid results in decreased expression of TFE3 mRNA CTD PMID:25596134 NCBI chr  X:17,401,466...17,414,829
Ensembl chr  X:17,401,466...17,414,685 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TGFB1 mRNA] CTD PMID:27022031 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase increases expression ISO Clodronic Acid results in increased expression of TIGAR mRNA CTD PMID:25596134 NCBI chr 4:161,613,306...161,632,248
Ensembl chr 4:161,613,306...161,632,229 		JBrowse link
G Timm17b translocase of inner mitochondrial membrane 17b decreases expression ISO Clodronic Acid results in decreased expression of TIMM17B mRNA CTD PMID:25596134 NCBI chr  X:17,268,257...17,275,424
Ensembl chr  X:17,268,257...17,275,563 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TIMP1 mRNA] CTD PMID:27022031 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression ISO Clodronic Acid results in increased expression of TIPARP mRNA CTD PMID:25596134 NCBI chr 2:152,063,769...152,090,414
Ensembl chr 2:152,063,751...152,090,406 		JBrowse link
G Tmem45b transmembrane protein 45b decreases expression ISO Clodronic Acid results in decreased expression of TMEM45B mRNA CTD PMID:25596134 NCBI chr 8:38,123,423...38,168,599
Ensembl chr 8:38,123,423...38,168,599 		JBrowse link
G Tmem94 transmembrane protein 94 affects expression ISO Clodronic Acid affects the expression of TMEM94 mRNA CTD PMID:25596134 NCBI chr10:101,490,496...101,525,983
Ensembl chr10:101,490,481...101,525,975 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression 		EXP
ISO 		Clodronic Acid inhibits the reaction [Taurocholic Acid results in increased expression of TNF protein]
Clodronic Acid results in increased expression of TNF mRNA
Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TNF mRNA] 		CTD PMID:20382593 PMID:25187657 PMID:27022031 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfaip8 TNF alpha induced protein 8 increases expression ISO Clodronic Acid results in increased expression of TNFAIP8 mRNA CTD PMID:25596134 NCBI chr18:45,370,334...45,486,036
Ensembl chr18:45,370,406...45,486,036 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO Clodronic Acid affects the activity of TP53 protein CTD PMID:25596134 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO Clodronic Acid results in increased expression of TP53I3 mRNA CTD PMID:25596134 NCBI chr 6:33,537,779...33,545,204 JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO Clodronic Acid results in increased expression of TP53INP1 mRNA CTD PMID:25596134 NCBI chr 5:29,051,267...29,069,486
Ensembl chr 5:29,051,264...29,069,484 		JBrowse link
G Tpcn1 two pore segment channel 1 increases expression ISO Clodronic Acid results in increased expression of TPCN1 mRNA CTD PMID:25596134 NCBI chr12:41,633,399...41,690,200
Ensembl chr12:41,633,398...41,690,200 		JBrowse link
G Tpd52l1 TPD52 like 1 increases expression ISO Clodronic Acid results in increased expression of TPD52L1 mRNA CTD PMID:25596134 NCBI chr 1:27,991,114...28,109,767
Ensembl chr 1:27,991,131...28,110,158 		JBrowse link
G Trafd1 TRAF type zinc finger domain containing 1 affects expression ISO Clodronic Acid affects the expression of TRAFD1 mRNA CTD PMID:25596134 NCBI chr12:40,826,251...40,840,169
Ensembl chr12:40,825,851...40,841,320 		JBrowse link
G Tspan12 tetraspanin 12 decreases expression ISO Clodronic Acid results in decreased expression of TSPAN12 mRNA CTD PMID:25596134 NCBI chr 4:51,279,562...51,355,030
Ensembl chr 4:51,279,563...51,355,030 		JBrowse link
G Txn1 thioredoxin 1 increases expression ISO Clodronic Acid results in increased expression of TXN mRNA CTD PMID:25596134 NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Clodronic Acid results in increased expression of TXNRD1 mRNA CTD PMID:25596134 NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817 		JBrowse link
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 increases expression ISO Clodronic Acid results in increased expression of UBE2G2 mRNA CTD PMID:25596134 NCBI chr20:10,983,322...11,005,060
Ensembl chr20:10,983,325...11,005,187 		JBrowse link
G Ube2o ubiquitin-conjugating enzyme E2O decreases expression ISO Clodronic Acid results in decreased expression of UBE2O mRNA CTD PMID:25596134 NCBI chr10:102,264,418...102,311,578
Ensembl chr10:102,264,418...102,311,549 		JBrowse link
G Unkl unk like zinc finger increases expression ISO Clodronic Acid results in increased expression of UNKL mRNA CTD PMID:25596134 NCBI chr10:14,710,627...14,756,725
Ensembl chr10:14,710,563...14,756,724 		JBrowse link
G Vars1 valyl-tRNA synthetase 1 increases expression ISO Clodronic Acid results in increased expression of VARS1 mRNA CTD PMID:25596134 NCBI chr20:3,810,427...3,825,193
Ensembl chr20:3,810,429...3,824,951 		JBrowse link
G Vegfb vascular endothelial growth factor B decreases expression ISO Clodronic Acid results in decreased expression of VEGFB mRNA CTD PMID:25596134 NCBI chr 1:213,601,570...213,607,254
Ensembl chr 1:213,600,966...213,607,152 		JBrowse link
G Vim vimentin multiple interactions EXP [Clodronic Acid co-treated with Thioacetamide] results in increased expression of VIM protein CTD PMID:26957569 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746 		JBrowse link
G Vtcn1 V-set domain containing T cell activation inhibitor 1 increases expression ISO Clodronic Acid results in increased expression of VTCN1 mRNA CTD PMID:25596134 NCBI chr 2:190,942,224...191,010,280
Ensembl chr 2:190,942,224...191,010,280 		JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 affects expression ISO Clodronic Acid affects the expression of WARS1 mRNA CTD PMID:25596134 NCBI chr 6:133,540,463...133,571,645
Ensembl chr 6:133,539,744...133,571,645 		JBrowse link
G Wwc2 WW and C2 domain containing 2 decreases expression ISO Clodronic Acid results in decreased expression of WWC2 mRNA CTD PMID:25596134 NCBI chr16:50,991,096...51,154,529
Ensembl chr16:50,991,096...51,154,526 		JBrowse link
G Xbp1 X-box binding protein 1 affects activity
decreases expression 		ISO Clodronic Acid affects the activity of XBP1 protein
Clodronic Acid results in decreased expression of XBP1 mRNA 		CTD PMID:25596134 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706 		JBrowse link
G Yars1 tyrosyl-tRNA synthetase 1 decreases expression ISO Clodronic Acid results in decreased expression of YARS1 mRNA CTD PMID:25596134 NCBI chr 5:146,820,163...146,848,377
Ensembl chr 5:146,819,358...146,848,377 		JBrowse link
G Yeats2 YEATS domain containing 2 affects expression ISO Clodronic Acid affects the expression of YEATS2 mRNA CTD PMID:25596134 NCBI chr11:94,247,538...94,333,652
Ensembl chr11:94,247,538...94,333,292 		JBrowse link
G Ythdc2 YTH N6-methyladenosine RNA binding protein C2 affects expression ISO Clodronic Acid affects the expression of YTHDC2 mRNA CTD PMID:25596134 NCBI chr18:37,517,286...37,582,551
Ensembl chr18:37,517,248...37,582,550 		JBrowse link
G Zfx zinc finger protein X-linked increases expression ISO Clodronic Acid results in increased expression of ZFX mRNA CTD PMID:25596134 NCBI chr  X:62,798,483...62,847,068
Ensembl chr  X:62,798,483...62,875,309 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        pharmaceutical 20416
          drug 20416
            bone density conservation agent 6104
              clodronic acid 241
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organohalogen compound 18997
                                organochlorine compound 18749
                                  clodronic acid 241
paths to the root