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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:clodronic acid
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Accession:CHEBI:110423 term browser browse the term
Definition:An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.
Synonyms:exact_synonym: (dichloromethanediyl)bis(phosphonic acid)
 related_synonym: (Dichloro-phosphono-methyl)-phosphonic acid;   (dichloromethylene)bisphosphonic acid;   (dichloromethylene)diphosphonic acid;   Formula=CH4Cl2O6P2;   InChI=1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9);   InChIKey=ACSIXWWBWUQEHA-UHFFFAOYSA-N;   SMILES=OP(O)(=O)C(Cl)(Cl)P(O)(O)=O;   acide clodronique;   acido clodronico;   acidum clodronicum;   clodronate;   clodronsaeure;   dichloromethylene-1,1-bisphosphonic acid;   dichloromethylene-1,1-diphosphonic acid;   dichloromethylidene diphosphonate
 xref: Beilstein:1876367;   CAS:10596-23-3;   DrugBank:DB00720;   Drug_Central:690;   KEGG:D03545;   LINCS:LSM-5802
 xref_mesh: MESH:D004002
 xref: PMID:15658873;   PMID:7818726;   PMID:8421279;   Patent:BE672205
 cyclic_relationship: is_conjugate_acid_of CHEBI:59585


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clodronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars1 alanyl-tRNA synthetase 1 decreases expression ISO Clodronic Acid results in decreased expression of AARS1 mRNA CTD PMID:25596134 NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147 		JBrowse link
G Abcb9 ATP binding cassette subfamily B member 9 increases expression ISO Clodronic Acid results in increased expression of ABCB9 mRNA CTD PMID:25596134 NCBI chr12:32,499,213...32,531,932
Ensembl chr12:32,499,225...32,531,931 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO Clodronic Acid results in increased expression of ABCC3 mRNA CTD PMID:25596134 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression ISO Clodronic Acid results in decreased expression of ABCG1 mRNA CTD PMID:25596134 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948 		JBrowse link
G Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B increases expression ISO Clodronic Acid results in increased expression of ABHD4 mRNA CTD PMID:25596134 NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression ISO Clodronic Acid results in decreased expression of ACSL1 mRNA CTD PMID:25596134 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP [Clodronic Acid co-treated with Thioacetamide] results in increased expression of ACTA2 protein CTD PMID:26957569 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Agrn agrin increases expression ISO Clodronic Acid results in increased expression of AGRN mRNA CTD PMID:25596134 NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003 		JBrowse link
G Ahr aryl hydrocarbon receptor affects activity ISO Clodronic Acid affects the activity of AHR protein CTD PMID:25596134 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aifm2 AIF family member 2 affects expression ISO Clodronic Acid affects the expression of AIFM2 mRNA CTD PMID:25596134 NCBI chr20:29,654,283...29,679,239
Ensembl chr20:29,652,927...29,679,236 		JBrowse link
G Ak3 adenylate kinase 3 increases expression ISO Clodronic Acid results in increased expression of AK3 mRNA CTD PMID:25596134 NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO Clodronic Acid results in increased expression of AKR1C2 mRNA CTD PMID:25596134 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 increases expression ISO Clodronic Acid results in increased expression of ALDH1A3 mRNA CTD PMID:25596134 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436 		JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression ISO Clodronic Acid results in increased expression of ALDOA mRNA CTD PMID:25596134 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182 		JBrowse link
G Als2cl ALS2 C-terminal like affects expression ISO Clodronic Acid affects the expression of ALS2CL mRNA CTD PMID:25596134 NCBI chr 8:110,863,753...110,884,434
Ensembl chr 8:110,864,975...110,884,419 		JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression ISO Clodronic Acid results in decreased expression of ANGPTL4 mRNA CTD PMID:25596134 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519 		JBrowse link
G Ankra2 ankyrin repeat family A member 2 decreases expression ISO Clodronic Acid results in decreased expression of ANKRA2 mRNA CTD PMID:25596134 NCBI chr 2:29,612,867...29,623,748
Ensembl chr 2:29,612,925...29,623,730 		JBrowse link
G Arfgef2 ARF guanine nucleotide exchange factor 2 affects expression ISO Clodronic Acid affects the expression of ARFGEF2 mRNA CTD PMID:25596134 NCBI chr 3:155,547,504...155,633,652
Ensembl chr 3:155,547,538...155,630,856 		JBrowse link
G Arhgef10 Rho guanine nucleotide exchange factor 10 decreases expression ISO Clodronic Acid results in decreased expression of ARHGEF10 mRNA CTD PMID:25596134 NCBI chr16:74,647,147...74,738,784
Ensembl chr16:74,647,153...74,738,173 		JBrowse link
G Arl1 ARF like GTPase 1 increases expression ISO Clodronic Acid results in increased expression of ARL1 mRNA CTD PMID:25596134 NCBI chr 7:23,120,004...23,131,173
Ensembl chr 7:23,119,589...23,131,898 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO Clodronic Acid results in decreased expression of ASNS mRNA CTD PMID:25596134 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Astn2 astrotactin 2 increases expression ISO Clodronic Acid results in increased expression of ASTN2 mRNA CTD PMID:25596134 NCBI chr 5:78,758,142...79,744,021
Ensembl chr 5:78,758,142...79,748,273 		JBrowse link
G Atad2 ATPase family, AAA domain containing 2 increases expression ISO Clodronic Acid results in increased expression of ATAD2 mRNA CTD PMID:25596134 NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738 		JBrowse link
G Atf3 activating transcription factor 3 decreases expression ISO Clodronic Acid results in decreased expression of ATF3 mRNA CTD PMID:25596134 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atf4 activating transcription factor 4 affects activity ISO Clodronic Acid affects the activity of ATF4 protein CTD PMID:25596134 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atosa atos homolog A decreases expression ISO Clodronic Acid results in decreased expression of ATOSA mRNA CTD PMID:25596134 NCBI chr 8:75,694,828...75,772,565
Ensembl chr 8:75,695,022...75,772,549 		JBrowse link
G Atxn1 ataxin 1 decreases expression ISO Clodronic Acid results in decreased expression of ATXN1 mRNA CTD PMID:25596134 NCBI chr17:18,737,491...19,142,360
Ensembl chr17:18,737,533...19,142,360 		JBrowse link
G Aurkb aurora kinase B increases expression ISO Clodronic Acid results in increased expression of AURKB mRNA CTD PMID:25596134 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G Axl Axl receptor tyrosine kinase increases expression ISO Clodronic Acid results in increased expression of AXL mRNA CTD PMID:25596134 NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Batf basic leucine zipper ATF-like transcription factor decreases expression ISO Clodronic Acid results in decreased expression of BATF mRNA CTD PMID:25596134 NCBI chr 6:105,353,715...105,376,051
Ensembl chr 6:105,353,715...105,376,051 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Clodronic Acid results in increased expression of BAX mRNA CTD PMID:25596134 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcat1 branched chain amino acid transaminase 1 increases expression ISO Clodronic Acid results in increased expression of BCAT1 mRNA CTD PMID:25596134 NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597 		JBrowse link
G Bcat2 branched chain amino acid transaminase 2 increases expression ISO Clodronic Acid results in increased expression of BCAT2 mRNA CTD PMID:25596134 NCBI chr 1:96,040,407...96,060,008
Ensembl chr 1:96,042,625...96,060,007 		JBrowse link
G Bcl3 BCL3, transcription coactivator decreases expression ISO Clodronic Acid results in decreased expression of BCL3 mRNA CTD PMID:25596134 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607 		JBrowse link
G Bend5 BEN domain containing 5 increases expression ISO Clodronic Acid results in increased expression of BEND5 mRNA CTD PMID:25596134 NCBI chr 5:126,290,648...126,336,662
Ensembl chr 5:125,254,956...126,534,367 		JBrowse link
G Bnip3 BCL2 interacting protein 3 decreases expression ISO Clodronic Acid results in decreased expression of BNIP3 mRNA CTD PMID:25596134 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Brd2 bromodomain containing 2 decreases expression ISO Clodronic Acid results in decreased expression of BRD2 mRNA CTD PMID:25596134 NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Clodronic Acid results in increased expression of BTG2 mRNA CTD PMID:25596134 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 increases expression ISO Clodronic Acid results in increased expression of CAMKK2 mRNA CTD PMID:25596134 NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279 		JBrowse link
G Cars1 cysteinyl-tRNA synthetase 1 decreases expression ISO Clodronic Acid results in decreased expression of CARS1 mRNA CTD PMID:25596134 NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions		 ISO Clodronic Acid results in increased expression of CASP3
Suramin inhibits the reaction [Clodronic Acid results in increased expression of CASP3]		 CTD PMID:19448140 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccdc90b coiled-coil domain containing 90B decreases expression ISO Clodronic Acid results in decreased expression of CCDC90B mRNA CTD PMID:25596134 NCBI chr 1:146,632,756...146,646,314
Ensembl chr 1:146,633,036...146,647,338 		JBrowse link
G Ccne2 cyclin E2 increases expression ISO Clodronic Acid results in increased expression of CCNE2 mRNA CTD PMID:25596134 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Ccng2 cyclin G2 decreases expression ISO Clodronic Acid results in decreased expression of CCNG2 mRNA CTD PMID:25596134 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830 		JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of CD68 mRNA] CTD PMID:27022031 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO Clodronic Acid inhibits the reaction [Streptozocin results in increased expression of CD80 protein] CTD PMID:15892581 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cd86 CD86 molecule multiple interactions ISO Clodronic Acid inhibits the reaction [Streptozocin results in increased expression of CD86 protein] CTD PMID:15892581 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 affects expression ISO Clodronic Acid affects the expression of CDK6 mRNA CTD PMID:25596134 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Clodronic Acid results in increased expression of CDKN1A mRNA CTD PMID:25596134 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cers5 ceramide synthase 5 increases expression ISO Clodronic Acid results in increased expression of CERS5 mRNA CTD PMID:25596134 NCBI chr 7:130,859,993...130,897,979
Ensembl chr 7:130,859,990...130,897,947 		JBrowse link
G Clip4 CAP-GLY domain containing linker protein family, member 4 increases expression ISO Clodronic Acid results in increased expression of CLIP4 mRNA CTD PMID:25596134 NCBI chr 6:23,616,280...23,697,625
NCBI chr 6:23,718,580...23,729,231
NCBI chr 6:23,597,729...23,601,000
Ensembl chr 6:23,616,281...23,677,874 		JBrowse link
G Cmbl carboxymethylenebutenolidase homolog increases expression ISO Clodronic Acid results in increased expression of CMBL mRNA CTD PMID:25596134 NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of COL1A1 mRNA] CTD PMID:27022031 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Crispld2 cysteine-rich secretory protein LCCL domain containing 2 increases expression ISO Clodronic Acid results in increased expression of CRISPLD2 mRNA CTD PMID:25596134 NCBI chr19:48,053,153...48,111,485
Ensembl chr19:48,053,287...48,110,465 		JBrowse link
G Ctdp1 CTD phosphatase subunit 1 decreases expression ISO Clodronic Acid results in decreased expression of CTDP1 mRNA CTD PMID:25596134 NCBI chr18:73,854,277...73,916,232
Ensembl chr18:73,854,282...73,916,457 		JBrowse link
G Cth cystathionine gamma-lyase decreases expression ISO Clodronic Acid results in decreased expression of CTH mRNA CTD PMID:25596134 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
G Ctsc cathepsin C increases expression ISO Clodronic Acid results in increased expression of CTSC mRNA CTD PMID:25596134 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387 		JBrowse link
G Cttn cortactin increases expression ISO Clodronic Acid results in increased expression of CTTN mRNA CTD PMID:25596134 NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 multiple interactions ISO Clodronic Acid inhibits the reaction [Acetaminophen results in increased expression of CXCR2 protein]; IL10 protein inhibits the reaction [Clodronic Acid inhibits the reaction [Acetaminophen results in increased expression of CXCR2 protein]] CTD PMID:34724096 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Clodronic Acid results in increased expression of CYP1A2 mRNA CTD PMID:25596134 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO Clodronic Acid results in increased expression of CYP1B1 mRNA CTD PMID:25596134 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Ddb2 damage specific DNA binding protein 2 decreases expression ISO Clodronic Acid results in decreased expression of DDB2 mRNA CTD PMID:25596134 NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects expression ISO Clodronic Acid affects the expression of DDIT3 mRNA CTD PMID:25596134 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Clodronic Acid results in increased expression of DDIT4 mRNA CTD PMID:25596134 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Ddx17 DEAD-box helicase 17 decreases expression ISO Clodronic Acid results in decreased expression of DDX17 mRNA CTD PMID:25596134 NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193 		JBrowse link
G Des desmin multiple interactions EXP [Clodronic Acid co-treated with Thioacetamide] results in increased expression of DES protein CTD PMID:26957569 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699 		JBrowse link
G Dgka diacylglycerol kinase, alpha increases expression ISO Clodronic Acid results in increased expression of DGKA mRNA CTD PMID:25596134 NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110 		JBrowse link
G Dhx37 DEAH-box helicase 37 decreases expression ISO Clodronic Acid results in decreased expression of DHX37 mRNA CTD PMID:25596134 NCBI chr12:31,194,782...31,214,890
Ensembl chr12:31,194,859...31,216,802 		JBrowse link
G Dlgap5 DLG associated protein 5 increases expression ISO Clodronic Acid results in increased expression of DLGAP5 mRNA CTD PMID:25596134 NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518 		JBrowse link
G Dnai3 dynein axonemal intermediate chain 3 decreases expression ISO Clodronic Acid results in decreased expression of DNAI3 mRNA CTD PMID:25596134 NCBI chr 2:234,947,910...235,006,173
Ensembl chr 2:234,929,677...235,006,173 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO Clodronic Acid results in increased expression of DNAJB9 mRNA CTD PMID:25596134 NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063 		JBrowse link
G Dpm3 dolichyl-phosphate mannosyltransferase subunit 3, regulatory increases expression ISO Clodronic Acid results in increased expression of DPM3 mRNA CTD PMID:25596134 NCBI chr 2:174,676,532...174,677,047
Ensembl chr 2:174,676,363...174,677,668
Ensembl chr15:174,676,363...174,677,668 		JBrowse link
G Dpysl3 dihydropyrimidinase-like 3 increases expression ISO Clodronic Acid results in increased expression of DPYSL3 mRNA CTD PMID:25596134 NCBI chr18:35,374,427...35,480,228
Ensembl chr18:35,377,181...35,480,157 		JBrowse link
G Dusp22 dual specificity phosphatase 22 increases expression ISO Clodronic Acid results in increased expression of DUSP22 mRNA CTD PMID:25596134 NCBI chr17:33,780,980...33,831,241
Ensembl chr17:33,780,981...33,831,321 		JBrowse link
G Efna1 ephrin A1 decreases expression ISO Clodronic Acid results in decreased expression of EFNA1 mRNA CTD PMID:25596134 NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866 		JBrowse link
G Eif1 eukaryotic translation initiation factor 1 increases expression ISO Clodronic Acid results in increased expression of EIF1 mRNA CTD PMID:25596134 NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327
Ensembl chr 5:85,246,764...85,427,327 		JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2 subunit beta increases expression ISO Clodronic Acid results in increased expression of EIF2S2 mRNA CTD PMID:25596134 NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432 		JBrowse link
G Eif3c eukaryotic translation initiation factor 3, subunit C decreases expression ISO Clodronic Acid results in decreased expression of EIF3C mRNA CTD PMID:25596134 NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493 		JBrowse link
G Elf4 E74 like ETS transcription factor 4 decreases expression ISO Clodronic Acid results in decreased expression of ELF4 mRNA CTD PMID:25596134 NCBI chr  X:127,587,401...127,639,063
Ensembl chr  X:127,590,650...127,630,200 		JBrowse link
G Elk4 ETS transcription factor ELK4 decreases expression ISO Clodronic Acid results in decreased expression of ELK4 mRNA CTD PMID:25596134 NCBI chr13:43,451,130...43,475,035
Ensembl chr13:43,435,843...43,475,035 		JBrowse link
G Eno2 enolase 2 increases expression ISO Clodronic Acid results in increased expression of ENO2 mRNA CTD PMID:25596134 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980 		JBrowse link
G Ep400 E1A binding protein p400 decreases expression ISO Clodronic Acid results in decreased expression of EP400 mRNA CTD PMID:25596134 NCBI chr12:45,891,886...46,002,523
Ensembl chr12:45,891,916...45,998,861 		JBrowse link
G Eprs1 glutamyl-prolyl-tRNA synthetase 1 decreases expression ISO Clodronic Acid results in decreased expression of EPRS1 mRNA CTD PMID:25596134 NCBI chr13:96,901,548...96,971,966
Ensembl chr13:96,901,575...96,971,966 		JBrowse link
G Fam162a family with sequence similarity 162, member A decreases expression ISO Clodronic Acid results in decreased expression of FAM162A mRNA CTD PMID:25596134 NCBI chr11:64,680,978...64,709,865
Ensembl chr11:64,680,323...64,711,239 		JBrowse link
G Fam210a family with sequence similarity 210, member A affects expression ISO Clodronic Acid affects the expression of FAM210A mRNA CTD PMID:25596134 NCBI chr18:61,846,447...61,886,123
Ensembl chr18:61,852,907...61,886,171 		JBrowse link
G Fam89a family with sequence similarity 89, member A increases expression ISO Clodronic Acid results in increased expression of FAM89A mRNA CTD PMID:25596134 NCBI chr19:52,710,002...52,722,630
Ensembl chr19:52,710,019...52,722,631 		JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO Clodronic Acid results in decreased expression of FAS mRNA CTD PMID:25596134 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fbxo22 F-box protein 22 increases expression ISO Clodronic Acid results in increased expression of FBXO22 mRNA CTD PMID:25596134 NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148 		JBrowse link
G Fbxo30 F-box protein 30 decreases expression ISO Clodronic Acid results in decreased expression of FBXO30 mRNA CTD PMID:25596134 NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:5,655,339...5,672,441 		JBrowse link
G Fech ferrochelatase decreases expression ISO Clodronic Acid results in decreased expression of FECH mRNA CTD PMID:25596134 NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348 		JBrowse link
G Flvcr2 FLVCR choline and putative heme transporter 2 increases expression ISO Clodronic Acid results in increased expression of FLVCR2 mRNA CTD PMID:25596134 NCBI chr 6:105,408,355...105,472,355
Ensembl chr 6:105,408,339...105,472,353 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Clodronic Acid results in increased expression of FOSL1 mRNA CTD PMID:25596134 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit decreases expression ISO Clodronic Acid results in decreased expression of FOSL2 mRNA CTD PMID:25596134 NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034 		JBrowse link
G Frem2 FRAS1 related extracellular matrix 2 decreases expression ISO Clodronic Acid results in decreased expression of FREM2 mRNA CTD PMID:25596134 NCBI chr 2:137,602,784...137,740,785
Ensembl chr 2:137,602,784...137,740,785 		JBrowse link
G Fth1 ferritin heavy chain 1 decreases expression ISO Clodronic Acid results in decreased expression of FTH1 mRNA CTD PMID:25596134 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Gabarapl1 GABA type A receptor associated protein like 1 increases expression ISO Clodronic Acid results in increased expression of GABARAPL1 mRNA CTD PMID:25596134 NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450 		JBrowse link
G Gars1 glycyl-tRNA synthetase 1 increases expression ISO Clodronic Acid results in increased expression of GARS1 mRNA CTD PMID:25596134 NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression ISO Clodronic Acid results in decreased expression of GCLC mRNA CTD PMID:25596134 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Clodronic Acid results in increased expression of GCLM mRNA CTD PMID:25596134 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gdf15 growth differentiation factor 15 decreases expression ISO Clodronic Acid results in decreased expression of GDF15 mRNA CTD PMID:25596134 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Golim4 golgi integral membrane protein 4 increases expression ISO Clodronic Acid results in increased expression of GOLIM4 mRNA CTD PMID:25596134 NCBI chr 2:160,640,837...160,733,475
Ensembl chr 2:160,640,938...160,733,253 		JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO Clodronic Acid results in increased expression of GPAT3 mRNA CTD PMID:25596134 NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490 		JBrowse link
G Gpnmb glycoprotein nmb increases expression ISO Clodronic Acid results in increased expression of GPNMB mRNA CTD PMID:25596134 NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367 		JBrowse link
G Gpr87 G protein-coupled receptor 87 decreases expression ISO Clodronic Acid results in decreased expression of GPR87 mRNA CTD PMID:25596134 NCBI chr 2:143,439,741...143,440,901
Ensembl chr 2:143,439,735...143,458,190 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO
EXP		 Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased secretion of GPT protein]; Clodronic Acid promotes the reaction [Acetaminophen results in increased activity of GPT protein]
Clodronic Acid promotes the reaction [Thioacetamide results in increased expression of GPT protein]		 CTD PMID:26957569 PMID:27022031 PMID:34724096 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO Clodronic Acid results in increased expression of GSR mRNA CTD PMID:25596134 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
affects activity		 EXP
ISO		 Clodronic Acid inhibits the reaction [Dopamine results in decreased expression of HIF1A protein]
Clodronic Acid affects the activity of HIF1A protein		 CTD PMID:25596134 PMID:25818600 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
increases expression		 ISO Clodronic Acid results in decreased expression of HMOX1 mRNA
Clodronic Acid results in increased expression of HMOX1 mRNA		 CTD PMID:21690482 PMID:25596134 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Iars1 isoleucyl-tRNA synthetase 1 affects expression ISO Clodronic Acid affects the expression of IARS1 mRNA CTD PMID:25596134 NCBI chr17:14,940,919...14,987,277
Ensembl chr17:14,940,924...14,987,237 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Clodronic Acid inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein] CTD PMID:15892581 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ids iduronate 2-sulfatase decreases expression ISO Clodronic Acid results in decreased expression of IDS mRNA CTD PMID:25596134 NCBI chr  X:149,025,976...149,046,641
Ensembl chr  X:149,025,976...149,046,663 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Clodronic Acid inhibits the reaction [Streptozocin results in increased expression of IFNG protein] CTD PMID:15892581 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor increases expression ISO Clodronic Acid results in increased expression of IGF1R mRNA CTD PMID:25596134 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Clodronic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL10 protein]; IL10 protein inhibits the reaction [Clodronic Acid inhibits the reaction [Acetaminophen results in increased expression of CXCR2 protein]] CTD PMID:32385136 PMID:34724096 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO Clodronic Acid inhibits the reaction [Alendronate results in increased expression of IL1B protein]
Clodronic Acid results in increased expression of IL1B mRNA		 CTD PMID:20804833 PMID:25187657 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 Clodronic Acid inhibits the reaction [Taurocholic Acid results in increased expression of IL6 protein]
Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of IL6 mRNA]		 CTD PMID:20382593 PMID:27022031 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kdm3a lysine demethylase 3A decreases expression ISO Clodronic Acid results in decreased expression of KDM3A mRNA CTD PMID:25596134 NCBI chr 4:103,630,907...103,675,073
Ensembl chr 4:103,630,908...103,675,073 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO Clodronic Acid results in increased expression of KEAP1 mRNA CTD PMID:25596134 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Lama3 laminin subunit alpha 3 increases expression ISO Clodronic Acid results in increased expression of LAMA3 mRNA CTD PMID:25596134 NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353 		JBrowse link
G Ltn1 listerin E3 ubiquitin protein ligase 1 decreases expression ISO Clodronic Acid results in decreased expression of LTN1 mRNA CTD PMID:25596134 NCBI chr11:26,603,903...26,660,871
Ensembl chr11:26,603,903...26,660,886 		JBrowse link
G Mafg MAF bZIP transcription factor G increases expression ISO Clodronic Acid results in increased expression of MAFG mRNA CTD PMID:25596134 NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026 		JBrowse link
G Mapre2 microtubule-associated protein, RP/EB family, member 2 increases expression ISO Clodronic Acid results in increased expression of MAPRE2 mRNA CTD PMID:25596134 NCBI chr18:15,028,675...15,169,553
Ensembl chr18:15,029,041...15,168,044 		JBrowse link
G Mcoln2 mucolipin TRP cation channel 2 decreases expression ISO Clodronic Acid results in decreased expression of MCOLN2 mRNA CTD PMID:25596134 NCBI chr 2:235,053,816...235,102,703
Ensembl chr 2:235,053,816...235,102,702 		JBrowse link
G Me1 malic enzyme 1 decreases expression ISO Clodronic Acid results in decreased expression of ME1 mRNA CTD PMID:25596134 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304 		JBrowse link
G Mtdh metadherin decreases expression ISO Clodronic Acid results in decreased expression of MTDH mRNA CTD PMID:25596134 NCBI chr 7:65,306,464...65,365,647
Ensembl chr 7:65,306,400...65,364,413 		JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming decreases expression ISO Clodronic Acid results in decreased expression of MUC2 mRNA CTD PMID:25187657 NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756 		JBrowse link
G Mxi1 MAX interactor 1, dimerization protein decreases expression ISO Clodronic Acid results in decreased expression of MXI1 mRNA CTD PMID:25596134 NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681 		JBrowse link
G Nars1 asparaginyl-tRNA synthetase 1 decreases expression ISO Clodronic Acid results in decreased expression of NARS1 mRNA CTD PMID:25596134 NCBI chr18:57,989,308...58,005,584
Ensembl chr18:57,989,308...58,005,622 		JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 decreases expression ISO Clodronic Acid results in decreased expression of NEDD9 mRNA CTD PMID:25596134 NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects activity ISO Clodronic Acid affects the activity of NFE2L2 protein CTD PMID:25596134 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nin ninein decreases expression ISO Clodronic Acid results in decreased expression of NIN mRNA CTD PMID:25596134 NCBI chr 6:88,525,405...88,627,710
Ensembl chr 6:88,525,742...88,627,639 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression ISO Clodronic Acid results in decreased expression of NQO1 mRNA CTD PMID:25596134 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression ISO Clodronic Acid results in decreased expression of NR3C1 mRNA CTD PMID:25596134 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nrep neuronal regeneration related protein increases expression ISO Clodronic Acid results in increased expression of NREP mRNA CTD PMID:25596134 NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591 		JBrowse link
G Ntpcr nucleoside-triphosphatase, cancer-related increases expression ISO Clodronic Acid results in increased expression of NTPCR mRNA CTD PMID:25596134 NCBI chr19:53,701,496...53,715,260
Ensembl chr19:53,695,976...53,715,202 		JBrowse link
G Nuak1 NUAK family kinase 1 decreases expression ISO Clodronic Acid results in decreased expression of NUAK1 mRNA CTD PMID:25596134 NCBI chr 7:19,330,034...19,401,918
Ensembl chr 7:19,329,933...19,401,913 		JBrowse link
G Orai3 ORAI calcium release-activated calcium modulator 3 decreases expression ISO Clodronic Acid results in decreased expression of ORAI3 mRNA CTD PMID:25596134 NCBI chr 1:182,381,196...182,386,055
Ensembl chr 1:182,344,293...182,386,052 		JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 decreases expression ISO Clodronic Acid results in decreased expression of OSGIN1 mRNA CTD PMID:25596134 NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516 		JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 decreases expression ISO Clodronic Acid results in decreased expression of P4HA1 mRNA CTD PMID:25596134 NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786 		JBrowse link
G Pde8a phosphodiesterase 8A decreases expression ISO Clodronic Acid results in decreased expression of PDE8A mRNA CTD PMID:25596134 NCBI chr 1:135,166,143...135,288,986
Ensembl chr 1:135,166,237...135,288,024 		JBrowse link
G Pdia5 protein disulfide isomerase family A, member 5 increases expression ISO Clodronic Acid results in increased expression of PDIA5 mRNA CTD PMID:25596134 NCBI chr11:65,272,152...65,359,087
Ensembl chr11:65,272,155...65,359,084 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases expression ISO Clodronic Acid results in decreased expression of PDK1 mRNA CTD PMID:25596134 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO Clodronic Acid results in increased expression of PDK4 mRNA CTD PMID:25596134 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Pdlim1 PDZ and LIM domain 1 increases expression ISO Clodronic Acid results in increased expression of PDLIM1 mRNA CTD PMID:25596134 NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076 		JBrowse link
G Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 decreases expression ISO Clodronic Acid results in decreased expression of PFKFB4 mRNA CTD PMID:25596134 NCBI chr 8:109,643,558...109,687,006
Ensembl chr 8:109,643,937...109,685,634 		JBrowse link
G Phgdh phosphoglycerate dehydrogenase decreases expression ISO Clodronic Acid results in decreased expression of PHGDH mRNA CTD PMID:25596134 NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944 		JBrowse link
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma affects expression ISO Clodronic Acid affects the expression of PIP5K1C mRNA CTD PMID:25596134 NCBI chr 7:8,397,406...8,426,030
Ensembl chr 7:8,397,406...8,425,988 		JBrowse link
G Pir pirin increases expression ISO Clodronic Acid results in increased expression of PIR mRNA CTD PMID:25596134 NCBI chr  X:30,108,536...30,219,269
Ensembl chr  X:30,108,538...30,219,218 		JBrowse link
G Plec plectin decreases expression ISO Clodronic Acid results in decreased expression of PLEC mRNA CTD PMID:25596134 NCBI chr 7:107,887,764...107,949,100
Ensembl chr 7:107,887,764...107,945,467 		JBrowse link
G Plk3 polo-like kinase 3 increases expression ISO Clodronic Acid results in increased expression of PLK3 mRNA CTD PMID:25596134 NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 decreases expression ISO Clodronic Acid results in decreased expression of PMAIP1 mRNA CTD PMID:25596134 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 affects expression ISO Clodronic Acid affects the expression of PMEPA1 mRNA CTD PMID:25596134 NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454 		JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases expression ISO Clodronic Acid results in decreased expression of PNPLA6 mRNA CTD PMID:25596134 NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734 		JBrowse link
G Polr3f RNA polymerase III subunit F decreases expression ISO Clodronic Acid results in decreased expression of POLR3F mRNA CTD PMID:25596134 NCBI chr 3:131,908,466...131,924,838
Ensembl chr 3:131,908,466...131,924,837 		JBrowse link
G Pon1 paraoxonase 1 decreases activity
multiple interactions		 EXP Clodronic Acid results in decreased activity of PON1 protein
[Clodronic Acid results in decreased activity of PON1 protein] which results in decreased metabolism of homocysteine thiolactone; [Clodronic Acid results in decreased activity of PON1 protein] which results in decreased metabolism of Paraoxon; [Clodronic Acid results in decreased activity of PON1 protein] which results in decreased metabolism of phenyl acetate		 CTD PMID:27387541 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects activity ISO Clodronic Acid affects the activity of PPARG protein CTD PMID:25596134 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppfibp1 PPFIA binding protein 1 affects expression ISO Clodronic Acid affects the expression of PPFIBP1 mRNA CTD PMID:25596134 NCBI chr 4:179,807,579...179,951,428
Ensembl chr 4:179,808,794...179,951,428 		JBrowse link
G Ppig peptidylprolyl isomerase G decreases expression ISO Clodronic Acid results in decreased expression of PPIG mRNA CTD PMID:25596134 NCBI chr 3:54,484,023...54,512,929
Ensembl chr 3:54,484,023...54,512,926 		JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D decreases expression ISO Clodronic Acid results in decreased expression of PPM1D mRNA CTD PMID:25596134 NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A decreases expression ISO Clodronic Acid results in decreased expression of PPP1R15A mRNA CTD PMID:25596134 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171 		JBrowse link
G Ppp4r2 protein phosphatase 4, regulatory subunit 2 decreases expression ISO Clodronic Acid results in decreased expression of PPP4R2 mRNA CTD PMID:25596134 NCBI chr 4:133,454,555...133,495,486
Ensembl chr 4:133,454,555...133,495,486 		JBrowse link
G Prc1 protein regulator of cytokinesis 1 increases expression ISO Clodronic Acid results in increased expression of PRC1 mRNA CTD PMID:25596134 NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765 		JBrowse link
G Prdm1 PR/SET domain 1 decreases expression ISO Clodronic Acid results in decreased expression of PRDM1 mRNA CTD PMID:25596134 NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488 		JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 increases expression ISO Clodronic Acid results in increased expression of PRKAB1 mRNA CTD PMID:25596134 NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661 		JBrowse link
G Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 decreases expression ISO Clodronic Acid results in decreased expression of PRKAB2 mRNA CTD PMID:25596134 NCBI chr 2:185,257,218...185,272,846
Ensembl chr 2:185,257,213...185,269,872 		JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression ISO Clodronic Acid results in increased expression of PSAT1 mRNA CTD PMID:25596134 NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682 		JBrowse link
G Pspc1 paraspeckle component 1 decreases expression ISO Clodronic Acid results in decreased expression of PSPC1 mRNA CTD PMID:25596134 NCBI chr15:30,828,617...30,911,315
Ensembl chr15:30,828,626...30,911,202 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of CD68 mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of COL1A1 mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of IL6 mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TGFB1 mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TIMP1 mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TNF mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased secretion of GPT protein] CTD PMID:27022031 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Pycr1 pyrroline-5-carboxylate reductase 1 increases expression ISO Clodronic Acid results in increased expression of PYCR1 mRNA CTD PMID:25596134 NCBI chr10:105,917,732...105,922,658
Ensembl chr10:105,917,680...105,922,549 		JBrowse link
G Rab26 RAB26, member RAS oncogene family increases expression ISO Clodronic Acid results in increased expression of RAB26 mRNA CTD PMID:25596134 NCBI chr10:13,553,395...13,558,063
Ensembl chr10:13,553,395...13,558,030 		JBrowse link
G Rab31 RAB31, member RAS oncogene family increases expression ISO Clodronic Acid results in increased expression of RAB31 mRNA CTD PMID:25596134 NCBI chr 9:105,246,712...105,382,973
Ensembl chr 9:105,246,709...105,381,253 		JBrowse link
G Rara retinoic acid receptor, alpha decreases expression ISO Clodronic Acid results in decreased expression of RARA mRNA CTD PMID:25596134 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase increases expression ISO Clodronic Acid results in increased expression of RFFL mRNA CTD PMID:25596134 NCBI chr10:67,740,711...67,803,669
Ensembl chr10:67,740,712...67,824,434 		JBrowse link
G Rit1 Ras-like without CAAX 1 increases expression ISO Clodronic Acid results in increased expression of RIT1 mRNA CTD PMID:25596134 NCBI chr 2:174,180,742...174,195,455
Ensembl chr 2:174,180,848...174,195,455 		JBrowse link
G Rnd3 Rho family GTPase 3 affects expression ISO Clodronic Acid affects the expression of RND3 mRNA CTD PMID:25596134 NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327 		JBrowse link
G Ro60 Ro60, Y RNA binding protein decreases expression ISO Clodronic Acid results in decreased expression of RO60 mRNA CTD PMID:25596134 NCBI chr13:55,499,514...55,520,504
Ensembl chr13:55,499,534...55,520,504 		JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B decreases expression ISO Clodronic Acid results in decreased expression of RRM2B mRNA CTD PMID:25596134 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633 		JBrowse link
G Rrp12 ribosomal RNA processing 12 decreases expression ISO Clodronic Acid results in decreased expression of RRP12 mRNA CTD PMID:25596134 NCBI chr 1:240,672,378...240,705,992
Ensembl chr 1:240,672,382...240,706,018 		JBrowse link
G Rsrc2 arginine and serine rich coiled-coil 2 affects expression ISO Clodronic Acid affects the expression of RSRC2 mRNA CTD PMID:25596134 NCBI chr12:32,839,840...32,859,820
Ensembl chr12:32,839,809...32,859,799 		JBrowse link
G Runx1 RUNX family transcription factor 1 increases expression ISO Clodronic Acid results in increased expression of RUNX1 mRNA CTD PMID:25596134 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542 		JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO Clodronic Acid results in increased expression of RUNX2 mRNA CTD PMID:25596134 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Scamp1 secretory carrier membrane protein 1 increases expression ISO Clodronic Acid results in increased expression of SCAMP1 mRNA CTD PMID:25596134 NCBI chr 2:25,433,958...25,516,734
Ensembl chr 2:25,433,959...25,516,673 		JBrowse link
G Sectm1b secreted and transmembrane 1B increases expression ISO Clodronic Acid results in increased expression of SECTM1 mRNA CTD PMID:25596134 NCBI chr10:106,324,070...106,333,779
Ensembl chr10:106,325,203...106,333,769 		JBrowse link
G Sertad1 SERTA domain containing 1 increases expression ISO Clodronic Acid results in increased expression of SERTAD1 mRNA CTD PMID:25596134 NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091 		JBrowse link
G Setx senataxin decreases expression ISO Clodronic Acid results in decreased expression of SETX mRNA CTD PMID:25596134 NCBI chr 3:12,428,091...12,480,801
Ensembl chr 3:12,427,635...12,480,803 		JBrowse link
G Sfn stratifin increases expression ISO Clodronic Acid results in increased expression of SFN mRNA CTD PMID:25596134 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 decreases expression ISO Clodronic Acid results in decreased expression of SHANK3 mRNA CTD PMID:25596134 NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374 		JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 increases expression ISO Clodronic Acid results in increased expression of SIAH2 mRNA CTD PMID:25596134 NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950 		JBrowse link
G Sipa1l2 signal-induced proliferation-associated 1 like 2 decreases expression ISO Clodronic Acid results in decreased expression of SIPA1L2 mRNA CTD PMID:25596134 NCBI chr19:53,389,792...53,540,466
Ensembl chr19:53,389,805...53,540,428 		JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor increases expression ISO Clodronic Acid results in increased expression of SIVA1 mRNA CTD PMID:25596134 NCBI chr 6:131,705,323...131,709,697
Ensembl chr 6:131,705,323...131,709,690 		JBrowse link
G Slc12a8 solute carrier family 12, member 8 decreases expression ISO Clodronic Acid results in decreased expression of SLC12A8 mRNA CTD PMID:25596134 NCBI chr11:67,116,876...67,266,548
Ensembl chr11:67,116,877...67,266,834 		JBrowse link
G Slc1a4 solute carrier family 1 member 4 decreases expression ISO Clodronic Acid results in decreased expression of SLC1A4 mRNA CTD PMID:25596134 NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418 		JBrowse link
G Slc1a5 solute carrier family 1 member 5 decreases expression ISO Clodronic Acid results in decreased expression of SLC1A5 mRNA CTD PMID:25596134 NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952 		JBrowse link
G Slc25a20 solute carrier family 25 member 20 increases expression ISO Clodronic Acid results in increased expression of SLC25A20 mRNA CTD PMID:25596134 NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 affects expression ISO Clodronic Acid affects the expression of SLC3A2 mRNA CTD PMID:25596134 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931 		JBrowse link
G Slc6a9 solute carrier family 6 member 9 decreases expression ISO Clodronic Acid results in decreased expression of SLC6A9 mRNA CTD PMID:25596134 NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 affects expression ISO Clodronic Acid affects the expression of SLC7A5 mRNA CTD PMID:25596134 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823 		JBrowse link
G Smap1 small ArfGAP 1 increases expression ISO Clodronic Acid results in increased expression of SMAP1 mRNA CTD PMID:25596134 NCBI chr 9:26,250,178...26,342,151
Ensembl chr 9:26,249,978...26,342,170 		JBrowse link
G Son SON DNA and RNA binding protein decreases expression ISO Clodronic Acid results in decreased expression of SON mRNA CTD PMID:25596134 NCBI chr11:30,850,890...30,923,167
Ensembl chr11:30,892,005...30,923,167 		JBrowse link
G Sorl1 sortilin related receptor 1 increases expression ISO Clodronic Acid results in increased expression of SORL1 mRNA CTD PMID:25596134 NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513 		JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 increases expression ISO Clodronic Acid results in increased expression of SPRY1 mRNA CTD PMID:25596134 NCBI chr 2:120,557,256...120,561,917
Ensembl chr 2:120,556,706...120,566,189 		JBrowse link
G Srd5a3 steroid 5 alpha-reductase 3 decreases expression ISO Clodronic Acid results in decreased expression of SRD5A3 mRNA CTD PMID:25596134 NCBI chr14:32,046,408...32,060,796
Ensembl chr14:32,046,408...32,060,747 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Clodronic Acid results in increased expression of SRXN1 mRNA CTD PMID:25596134 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Sulf2 sulfatase 2 decreases expression ISO Clodronic Acid results in decreased expression of SULF2 mRNA CTD PMID:25596134 NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415 		JBrowse link
G Taok1 TAO kinase 1 affects expression ISO Clodronic Acid affects the expression of TAOK1 mRNA CTD PMID:25596134 NCBI chr10:62,373,072...62,465,295
Ensembl chr10:62,381,404...62,465,766 		JBrowse link
G Tars1 threonyl-tRNA synthetase 1 decreases expression ISO Clodronic Acid results in decreased expression of TARS1 mRNA CTD PMID:25596134 NCBI chr 2:60,368,893...60,387,715
Ensembl chr 2:60,367,796...60,387,717 		JBrowse link
G Tbxas1 thromboxane A synthase 1 affects expression ISO Clodronic Acid affects the expression of TBXAS1 mRNA CTD PMID:25596134 NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096 		JBrowse link
G Tfap2a transcription factor AP-2 alpha decreases expression ISO Clodronic Acid results in decreased expression of TFAP2A mRNA CTD PMID:25596134 NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507 		JBrowse link
G Tfe3 transcription factor binding to IGHM enhancer 3 decreases expression ISO Clodronic Acid results in decreased expression of TFE3 mRNA CTD PMID:25596134 NCBI chr  X:14,729,547...14,742,830
Ensembl chr  X:14,729,550...14,742,571 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TGFB1 mRNA] CTD PMID:27022031 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase increases expression ISO Clodronic Acid results in increased expression of TIGAR mRNA CTD PMID:25596134 NCBI chr 4:159,927,136...159,946,077
Ensembl chr 4:159,927,139...159,946,029
Ensembl chr 6:159,927,139...159,946,029 		JBrowse link
G Timm17b translocase of inner mitochondrial membrane 17b decreases expression ISO Clodronic Acid results in decreased expression of TIMM17B mRNA CTD PMID:25596134 NCBI chr  X:14,596,330...14,603,491
Ensembl chr  X:14,594,577...14,603,416 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TIMP1 mRNA] CTD PMID:27022031 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression ISO Clodronic Acid results in increased expression of TIPARP mRNA CTD PMID:25596134 NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327 		JBrowse link
G Tmem45b transmembrane protein 45b decreases expression ISO Clodronic Acid results in decreased expression of TMEM45B mRNA CTD PMID:25596134 NCBI chr 8:29,865,276...29,910,453
Ensembl chr 8:29,865,278...29,910,453 		JBrowse link
G Tmem94 transmembrane protein 94 affects expression ISO Clodronic Acid affects the expression of TMEM94 mRNA CTD PMID:25596134 NCBI chr10:100,991,523...101,027,046
Ensembl chr10:100,991,573...101,027,394 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 EXP
ISO		 Clodronic Acid inhibits the reaction [Taurocholic Acid results in increased expression of TNF protein]
Clodronic Acid results in increased expression of TNF mRNA
Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TNF mRNA]		 CTD PMID:20382593 PMID:25187657 PMID:27022031 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip8 TNF alpha induced protein 8 increases expression ISO Clodronic Acid results in increased expression of TNFAIP8 mRNA CTD PMID:25596134 NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO Clodronic Acid affects the activity of TP53 protein CTD PMID:25596134 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO Clodronic Acid results in increased expression of TP53I3 mRNA CTD PMID:25596134 NCBI chr 6:27,818,327...27,825,753 JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO Clodronic Acid results in increased expression of TP53INP1 mRNA CTD PMID:25596134 NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968 		JBrowse link
G Tpcn1 two pore segment channel 1 increases expression ISO Clodronic Acid results in increased expression of TPCN1 mRNA CTD PMID:25596134 NCBI chr12:35,972,813...36,029,632
Ensembl chr12:35,972,846...36,029,626 		JBrowse link
G Tpd52l1 TPD52 like 1 increases expression ISO Clodronic Acid results in increased expression of TPD52L1 mRNA CTD PMID:25596134 NCBI chr 1:26,172,038...26,290,704
Ensembl chr 1:26,172,170...26,291,109 		JBrowse link
G Trafd1 TRAF type zinc finger domain containing 1 affects expression ISO Clodronic Acid affects the expression of TRAFD1 mRNA CTD PMID:25596134 NCBI chr12:35,165,606...35,179,525
Ensembl chr12:35,165,606...35,179,525 		JBrowse link
G Tspan12 tetraspanin 12 decreases expression ISO Clodronic Acid results in decreased expression of TSPAN12 mRNA CTD PMID:25596134 NCBI chr 4:50,313,768...50,389,246
Ensembl chr 4:50,313,772...50,389,246 		JBrowse link
G Txn1 thioredoxin 1 increases expression ISO Clodronic Acid results in increased expression of TXN mRNA CTD PMID:25596134 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Clodronic Acid results in increased expression of TXNRD1 mRNA CTD PMID:25596134 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 increases expression ISO Clodronic Acid results in increased expression of UBE2G2 mRNA CTD PMID:25596134 NCBI chr20:10,983,734...11,005,468
Ensembl chr20:10,983,742...11,005,447 		JBrowse link
G Ube2o ubiquitin-conjugating enzyme E2O decreases expression ISO Clodronic Acid results in decreased expression of UBE2O mRNA CTD PMID:25596134 NCBI chr10:101,765,572...101,812,736
Ensembl chr10:101,766,005...101,812,899 		JBrowse link
G Unkl unk like zinc finger increases expression ISO Clodronic Acid results in increased expression of UNKL mRNA CTD PMID:25596134 NCBI chr10:14,206,125...14,252,226
Ensembl chr10:14,206,189...14,252,225 		JBrowse link
G Vars1 valyl-tRNA synthetase 1 increases expression ISO Clodronic Acid results in increased expression of VARS1 mRNA CTD PMID:25596134 NCBI chr20:3,805,774...3,820,468
Ensembl chr20:3,805,776...3,820,298 		JBrowse link
G Vegfb vascular endothelial growth factor B decreases expression ISO Clodronic Acid results in decreased expression of VEGFB mRNA CTD PMID:25596134 NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944 		JBrowse link
G Vim vimentin multiple interactions EXP [Clodronic Acid co-treated with Thioacetamide] results in increased expression of VIM protein CTD PMID:26957569 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Vtcn1 V-set domain containing T cell activation inhibitor 1 increases expression ISO Clodronic Acid results in increased expression of VTCN1 mRNA CTD PMID:25596134 NCBI chr 2:188,253,594...188,321,658
Ensembl chr 2:188,253,594...188,321,658 		JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 affects expression ISO Clodronic Acid affects the expression of WARS1 mRNA CTD PMID:25596134 NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269 		JBrowse link
G Wwc2 WW and C2 domain containing 2 decreases expression ISO Clodronic Acid results in decreased expression of WWC2 mRNA CTD PMID:25596134 NCBI chr16:44,258,372...44,421,815
Ensembl chr16:44,258,372...44,421,812 		JBrowse link
G Xbp1 X-box binding protein 1 affects activity
decreases expression		 ISO Clodronic Acid affects the activity of XBP1 protein
Clodronic Acid results in decreased expression of XBP1 mRNA		 CTD PMID:25596134 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Yars1 tyrosyl-tRNA synthetase 1 decreases expression ISO Clodronic Acid results in decreased expression of YARS1 mRNA CTD PMID:25596134 NCBI chr 5:141,535,815...141,564,029
Ensembl chr 5:141,535,759...141,563,833 		JBrowse link
G Yeats2 YEATS domain containing 2 affects expression ISO Clodronic Acid affects the expression of YEATS2 mRNA CTD PMID:25596134 NCBI chr11:80,743,134...80,829,253
Ensembl chr11:80,743,134...80,829,208 		JBrowse link
G Ythdc2 YTH N6-methyladenosine RNA binding protein C2 affects expression ISO Clodronic Acid affects the expression of YTHDC2 mRNA CTD PMID:25596134 NCBI chr18:37,266,559...37,331,681
Ensembl chr18:37,265,836...37,331,023 		JBrowse link
G Zfx zinc finger protein X-linked increases expression ISO Clodronic Acid results in increased expression of ZFX mRNA CTD PMID:25596134 NCBI chr  X:58,804,690...58,853,155
Ensembl chr  X:58,804,691...58,853,265 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        pharmaceutical 19525
          drug 19525
            bone density conservation agent 6065
              clodronic acid 241
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organohalogen compound 18523
                                organochlorine compound 18295
                                  clodronic acid 241
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