Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:clodronic acid
go back to main search page
Accession:CHEBI:110423 term browser browse the term
Definition:An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.
Synonyms:exact_synonym: (dichloromethanediyl)bis(phosphonic acid)
 related_synonym: (Dichloro-phosphono-methyl)-phosphonic acid;   (dichloromethylene)bisphosphonic acid;   (dichloromethylene)diphosphonic acid;   Formula=CH4Cl2O6P2;   InChI=1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9);   InChIKey=ACSIXWWBWUQEHA-UHFFFAOYSA-N;   SMILES=OP(O)(=O)C(Cl)(Cl)P(O)(O)=O;   acide clodronique;   acido clodronico;   acidum clodronicum;   clodronate;   clodronsaeure;   dichloromethylene-1,1-bisphosphonic acid;   dichloromethylene-1,1-diphosphonic acid;   dichloromethylidene diphosphonate
 xref: Beilstein:1876367;   CAS:10596-23-3;   DrugBank:DB00720;   Drug_Central:690;   KEGG:D03545;   LINCS:LSM-5802
 xref_mesh: MESH:D004002
 xref: PMID:15658873;   PMID:7818726;   PMID:8421279;   Patent:BE672205
 cyclic_relationship: is_conjugate_acid_of CHEBI:59585


show annotations for term's descendants           Sort by:
 
clodronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars1 alanyl-tRNA synthetase 1 decreases expression ISO Clodronic Acid results in decreased expression of AARS1 mRNA CTD PMID:25596134 NCBI chr19:43,193,264...43,215,281
Ensembl chr19:43,193,257...43,215,281
JBrowse link
G Abcb9 ATP binding cassette subfamily B member 9 increases expression ISO Clodronic Acid results in increased expression of ABCB9 mRNA CTD PMID:25596134 NCBI chr12:37,923,974...37,956,678
Ensembl chr12:37,923,528...37,958,363
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO Clodronic Acid results in increased expression of ABCC3 mRNA CTD PMID:25596134 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression ISO Clodronic Acid results in decreased expression of ABCG1 mRNA CTD PMID:25596134 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
JBrowse link
G Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B increases expression ISO Clodronic Acid results in increased expression of ABHD4 mRNA CTD PMID:25596134 NCBI chr15:32,888,233...32,906,861
Ensembl chr15:32,894,938...32,906,850
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression ISO Clodronic Acid results in decreased expression of ACSL1 mRNA CTD PMID:25596134 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP [Clodronic Acid co-treated with Thioacetamide] results in increased expression of ACTA2 protein CTD PMID:26957569 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Agrn agrin increases expression ISO Clodronic Acid results in increased expression of AGRN mRNA CTD PMID:25596134 NCBI chr 5:173,589,910...173,622,813
Ensembl chr 5:173,589,819...173,622,645
JBrowse link
G Ahr aryl hydrocarbon receptor affects activity ISO Clodronic Acid affects the activity of AHR protein CTD PMID:25596134 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aifm2 apoptosis inducing factor, mitochondria associated 2 affects expression ISO Clodronic Acid affects the expression of AIFM2 mRNA CTD PMID:25596134 NCBI chr20:31,329,047...31,353,548
Ensembl chr20:31,339,787...31,352,906
JBrowse link
G Ak3 adenylate kinase 3 increases expression ISO Clodronic Acid results in increased expression of AK3 mRNA CTD PMID:25596134 NCBI chr 1:247,144,486...247,169,690
Ensembl chr 1:247,144,491...247,169,693
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO Clodronic Acid results in increased expression of AKR1C2 mRNA CTD PMID:25596134 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 increases expression ISO Clodronic Acid results in increased expression of ALDH1A3 mRNA CTD PMID:25596134 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression ISO Clodronic Acid results in increased expression of ALDOA mRNA CTD PMID:25596134 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
JBrowse link
G Als2cl ALS2 C-terminal like affects expression ISO Clodronic Acid affects the expression of ALS2CL mRNA CTD PMID:25596134 NCBI chr 8:119,156,081...119,176,680
Ensembl chr 8:119,160,731...119,174,830
JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression ISO Clodronic Acid results in decreased expression of ANGPTL4 mRNA CTD PMID:25596134 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Ankra2 ankyrin repeat family A member 2 decreases expression ISO Clodronic Acid results in decreased expression of ANKRA2 mRNA CTD PMID:25596134 NCBI chr  X:82,407,601...82,418,229
Ensembl chr  X:82,407,598...82,418,425
JBrowse link
G Arfgef2 ADP ribosylation factor guanine nucleotide exchange factor 2 affects expression ISO Clodronic Acid affects the expression of ARFGEF2 mRNA CTD PMID:25596134 NCBI chr 3:163,570,435...163,656,612
Ensembl chr 3:163,570,532...163,656,626
JBrowse link
G Arhgef10 Rho guanine nucleotide exchange factor 10 decreases expression ISO Clodronic Acid results in decreased expression of ARHGEF10 mRNA CTD PMID:25596134 NCBI chr16:79,725,629...79,817,065
Ensembl chr16:79,725,643...79,793,619
JBrowse link
G Arl1 ADP-ribosylation factor like GTPase 1 increases expression ISO Clodronic Acid results in increased expression of ARL1 mRNA CTD PMID:25596134 NCBI chr 7:29,282,411...29,293,455
Ensembl chr 7:29,282,305...29,293,399
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO Clodronic Acid results in decreased expression of ASNS mRNA CTD PMID:25596134 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Astn2 astrotactin 2 increases expression ISO Clodronic Acid results in increased expression of ASTN2 mRNA CTD PMID:25596134 NCBI chr 5:81,179,614...82,168,528
Ensembl chr 5:81,179,605...82,168,427
JBrowse link
G Atad2 ATPase family, AAA domain containing 2 increases expression ISO Clodronic Acid results in increased expression of ATAD2 mRNA CTD PMID:25596134 NCBI chr 7:97,984,754...98,027,379
Ensembl chr 7:97,984,862...98,026,052
JBrowse link
G Atf3 activating transcription factor 3 decreases expression ISO Clodronic Acid results in decreased expression of ATF3 mRNA CTD PMID:25596134 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf4 activating transcription factor 4 affects activity ISO Clodronic Acid affects the activity of ATF4 protein CTD PMID:25596134 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atxn1 ataxin 1 decreases expression ISO Clodronic Acid results in decreased expression of ATXN1 mRNA CTD PMID:25596134 NCBI chr17:19,160,986...19,533,814
Ensembl chr17:19,249,952...19,533,814
JBrowse link
G Aurkb aurora kinase B increases expression ISO Clodronic Acid results in increased expression of AURKB mRNA CTD PMID:25596134 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link
G Axl Axl receptor tyrosine kinase increases expression ISO Clodronic Acid results in increased expression of AXL mRNA CTD PMID:25596134 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761
JBrowse link
G Batf basic leucine zipper ATF-like transcription factor decreases expression ISO Clodronic Acid results in decreased expression of BATF mRNA CTD PMID:25596134 NCBI chr 6:109,562,415...109,584,541
Ensembl chr 6:109,562,587...109,584,545
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Clodronic Acid results in increased expression of BAX mRNA CTD PMID:25596134 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcat1 branched chain amino acid transaminase 1 increases expression ISO Clodronic Acid results in increased expression of BCAT1 mRNA CTD PMID:25596134 NCBI chr 4:179,259,305...179,340,021
Ensembl chr 4:179,259,308...179,339,795
JBrowse link
G Bcat2 branched chain amino acid transaminase 2 increases expression ISO Clodronic Acid results in increased expression of BCAT2 mRNA CTD PMID:25596134 NCBI chr 1:101,553,900...101,572,103
Ensembl chr 1:101,554,642...101,572,080
JBrowse link
G Bcl3 BCL3, transcription coactivator decreases expression ISO Clodronic Acid results in decreased expression of BCL3 mRNA CTD PMID:25596134 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831
JBrowse link
G Bend5 BEN domain containing 5 increases expression ISO Clodronic Acid results in increased expression of BEND5 mRNA CTD PMID:25596134 NCBI chr 5:131,257,127...131,312,335
Ensembl chr 5:131,257,127...131,312,335
JBrowse link
G Bnip3 BCL2 interacting protein 3 decreases expression ISO Clodronic Acid results in decreased expression of BNIP3 mRNA CTD PMID:25596134 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Brd2 bromodomain containing 2 decreases expression ISO Clodronic Acid results in decreased expression of BRD2 mRNA CTD PMID:25596134 NCBI chr20:3,910,555...3,921,074
Ensembl chr20:3,910,555...3,917,426
Ensembl chr20:3,910,555...3,917,426
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Clodronic Acid results in increased expression of BTG2 mRNA CTD PMID:25596134 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 increases expression ISO Clodronic Acid results in increased expression of CAMKK2 mRNA CTD PMID:25596134 NCBI chr12:39,253,409...39,302,601
Ensembl chr12:39,253,409...39,302,601
JBrowse link
G Cars cysteinyl-tRNA synthetase decreases expression ISO Clodronic Acid results in decreased expression of CARS1 mRNA CTD PMID:25596134 NCBI chr 1:216,759,367...216,801,652
Ensembl chr 1:216,759,366...216,801,656
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
ISO Clodronic Acid results in increased expression of CASP3
Suramin inhibits the reaction [Clodronic Acid results in increased expression of CASP3]
CTD PMID:19448140 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccdc90b coiled-coil domain containing 90B decreases expression ISO Clodronic Acid results in decreased expression of CCDC90B mRNA CTD PMID:25596134 NCBI chr 1:157,403,595...157,417,153
Ensembl chr 1:157,403,595...157,417,147
JBrowse link
G Ccne2 cyclin E2 increases expression ISO Clodronic Acid results in increased expression of CCNE2 mRNA CTD PMID:25596134 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Ccng2 cyclin G2 decreases expression ISO Clodronic Acid results in decreased expression of CCNG2 mRNA CTD PMID:25596134 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of CD68 mRNA] CTD PMID:27022031 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO Clodronic Acid inhibits the reaction [Streptozocin results in increased expression of CD80 protein] CTD PMID:15892581 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cd86 CD86 molecule multiple interactions ISO Clodronic Acid inhibits the reaction [Streptozocin results in increased expression of CD86 protein] CTD PMID:15892581 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdk6 cyclin-dependent kinase 6 affects expression ISO Clodronic Acid affects the expression of CDK6 mRNA CTD PMID:25596134 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Clodronic Acid results in increased expression of CDKN1A mRNA CTD PMID:25596134 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cers5 ceramide synthase 5 increases expression ISO Clodronic Acid results in increased expression of CERS5 mRNA CTD PMID:25596134 NCBI chr 7:141,386,391...141,424,375
Ensembl chr 7:141,386,391...141,424,343
JBrowse link
G Clip4 CAP-GLY domain containing linker protein family, member 4 increases expression ISO Clodronic Acid results in increased expression of CLIP4 mRNA CTD PMID:25596134 NCBI chr 6:23,222,020...23,316,962
Ensembl chr 6:23,222,021...23,316,962
JBrowse link
G Cmbl carboxymethylenebutenolidase homolog increases expression ISO Clodronic Acid results in increased expression of CMBL mRNA CTD PMID:25596134 NCBI chr 2:84,645,084...84,666,836
Ensembl chr 2:84,645,084...84,666,835
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of COL1A1 mRNA] CTD PMID:27022031 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Crispld2 cysteine-rich secretory protein LCCL domain containing 2 increases expression ISO Clodronic Acid results in increased expression of CRISPLD2 mRNA CTD PMID:25596134 NCBI chr19:52,647,038...52,705,118
Ensembl chr19:52,647,070...52,705,131
JBrowse link
G Ctdp1 CTD phosphatase subunit 1 decreases expression ISO Clodronic Acid results in decreased expression of CTDP1 mRNA CTD PMID:25596134 NCBI chr18:76,922,913...76,985,095
Ensembl chr18:76,922,934...76,984,203
JBrowse link
G Cth cystathionine gamma-lyase decreases expression ISO Clodronic Acid results in decreased expression of CTH mRNA CTD PMID:25596134 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Ctsc cathepsin C increases expression ISO Clodronic Acid results in increased expression of CTSC mRNA CTD PMID:25596134 NCBI chr 1:151,918,514...151,949,979
Ensembl chr 1:151,918,571...151,949,983
JBrowse link
G Cttn cortactin increases expression ISO Clodronic Acid results in increased expression of CTTN mRNA CTD PMID:25596134 NCBI chr 1:217,602,698...217,638,196
NCBI chr 1:215,255,385...215,290,882
Ensembl chr 1:217,602,698...217,638,152
Ensembl chr 1:217,602,698...217,638,152
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Clodronic Acid results in increased expression of CYP1A2 mRNA CTD PMID:25596134 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO Clodronic Acid results in increased expression of CYP1B1 mRNA CTD PMID:25596134 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Ddb2 damage specific DNA binding protein 2 decreases expression ISO Clodronic Acid results in decreased expression of DDB2 mRNA CTD PMID:25596134 NCBI chr 3:80,030,437...80,052,984
Ensembl chr 3:80,030,437...80,052,953
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects expression ISO Clodronic Acid affects the expression of DDIT3 mRNA CTD PMID:25596134 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Clodronic Acid results in increased expression of DDIT4 mRNA CTD PMID:25596134 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Ddx17 DEAD-box helicase 17 decreases expression ISO Clodronic Acid results in decreased expression of DDX17 mRNA CTD PMID:25596134 NCBI chr 7:120,761,843...120,765,012
Ensembl chr 7:120,761,826...120,780,641
JBrowse link
G Des desmin multiple interactions EXP [Clodronic Acid co-treated with Thioacetamide] results in increased expression of DES protein CTD PMID:26957569 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Dgka diacylglycerol kinase, alpha increases expression ISO Clodronic Acid results in increased expression of DGKA mRNA CTD PMID:25596134 NCBI chr 7:3,143,826...3,170,764
Ensembl chr 7:3,143,827...3,170,146
JBrowse link
G Dhx37 DEAH-box helicase 37 decreases expression ISO Clodronic Acid results in decreased expression of DHX37 mRNA CTD PMID:25596134 NCBI chr12:36,594,058...36,614,165
Ensembl chr12:36,594,047...36,614,210
JBrowse link
G Dlgap5 DLG associated protein 5 increases expression ISO Clodronic Acid results in increased expression of DLGAP5 mRNA CTD PMID:25596134 NCBI chr15:24,167,484...24,199,417
Ensembl chr15:24,167,486...24,199,341
JBrowse link
G Dnai3 dynein axonemal intermediate chain 3 decreases expression ISO Clodronic Acid results in decreased expression of DNAI3 mRNA CTD PMID:25596134 NCBI chr 2:251,912,432...251,970,699
Ensembl chr 2:251,912,368...251,970,768
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO Clodronic Acid results in increased expression of DNAJB9 mRNA CTD PMID:25596134 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151
JBrowse link
G Dpm3 dolichyl-phosphate mannosyltransferase subunit 3, regulatory increases expression ISO Clodronic Acid results in increased expression of DPM3 mRNA CTD PMID:25596134 NCBI chr 2:188,583,664...188,584,179
Ensembl chr 2:188,583,664...188,584,179
JBrowse link
G Dpysl3 dihydropyrimidinase-like 3 increases expression ISO Clodronic Acid results in increased expression of DPYSL3 mRNA CTD PMID:25596134 NCBI chr18:37,716,371...37,819,347
Ensembl chr18:37,716,143...37,819,097
JBrowse link
G Dusp22 dual specificity phosphatase 22 increases expression ISO Clodronic Acid results in increased expression of DUSP22 mRNA CTD PMID:25596134 NCBI chr17:34,986,589...35,037,297
Ensembl chr17:34,986,591...35,037,076
JBrowse link
G Efna1 ephrin A1 decreases expression ISO Clodronic Acid results in decreased expression of EFNA1 mRNA CTD PMID:25596134 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222
JBrowse link
G Eif1 eukaryotic translation initiation factor 1 increases expression ISO Clodronic Acid results in increased expression of EIF1 mRNA CTD PMID:25596134 NCBI chr10:88,227,455...88,229,546
Ensembl chr10:88,227,360...88,229,765
JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2 subunit beta increases expression ISO Clodronic Acid results in increased expression of EIF2S2 mRNA CTD PMID:25596134 NCBI chr 3:150,391,455...150,412,179
Ensembl chr 3:150,391,460...150,412,179
JBrowse link
G Eif3c eukaryotic translation initiation factor 3, subunit C decreases expression ISO Clodronic Acid results in decreased expression of EIF3C mRNA CTD PMID:25596134 NCBI chr 1:197,964,406...197,982,917
Ensembl chr 1:197,964,407...197,982,601
JBrowse link
G Elf4 E74 like ETS transcription factor 4 decreases expression ISO Clodronic Acid results in decreased expression of ELF4 mRNA CTD PMID:25596134 NCBI chr  X:135,239,626...135,284,330
Ensembl chr  X:135,240,451...135,250,519
JBrowse link
G Elk4 ETS transcription factor ELK4 decreases expression ISO Clodronic Acid results in decreased expression of ELK4 mRNA CTD PMID:25596134 NCBI chr13:48,788,262...48,813,267
Ensembl chr13:48,790,509...48,813,260
JBrowse link
G Eno2 enolase 2 increases expression ISO Clodronic Acid results in increased expression of ENO2 mRNA CTD PMID:25596134 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
JBrowse link
G Ep400 E1A binding protein p400 decreases expression ISO Clodronic Acid results in decreased expression of EP400 mRNA CTD PMID:25596134 NCBI chr12:51,948,650...52,055,274
Ensembl chr12:51,948,650...52,055,271
JBrowse link
G Eprs glutamyl-prolyl-tRNA synthetase decreases expression ISO Clodronic Acid results in decreased expression of EPRS1 mRNA CTD PMID:25596134 NCBI chr13:103,300,911...103,371,651
Ensembl chr13:103,300,932...103,371,577
JBrowse link
G Fam162a family with sequence similarity 162, member A decreases expression ISO Clodronic Acid results in decreased expression of FAM162A mRNA CTD PMID:25596134 NCBI chr11:67,618,683...67,646,253
Ensembl chr11:67,618,625...67,646,253
JBrowse link
G Fam210a family with sequence similarity 210, member A affects expression ISO Clodronic Acid affects the expression of FAM210A mRNA CTD PMID:25596134 NCBI chr18:64,045,023...64,084,594
Ensembl chr18:64,045,432...64,084,556
JBrowse link
G Fam214a family with sequence similarity 214, member A decreases expression ISO Clodronic Acid results in decreased expression of FAM214A mRNA CTD PMID:25596134 NCBI chr 8:81,863,619...81,941,548
Ensembl chr 8:81,863,619...81,941,536
JBrowse link
G Fam89a family with sequence similarity 89, member A increases expression ISO Clodronic Acid results in increased expression of FAM89A mRNA CTD PMID:25596134 NCBI chr19:57,502,308...57,514,896
Ensembl chr19:57,502,308...57,514,896
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO Clodronic Acid results in decreased expression of FAS mRNA CTD PMID:25596134 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fbxo22 F-box protein 22 increases expression ISO Clodronic Acid results in increased expression of FBXO22 mRNA CTD PMID:25596134 NCBI chr 8:59,770,032...59,786,061
Ensembl chr 8:59,769,994...59,786,065
JBrowse link
G Fbxo30 F-box protein 30 decreases expression ISO Clodronic Acid results in decreased expression of FBXO30 mRNA CTD PMID:25596134 NCBI chr 1:5,366,119...5,389,774
Ensembl chr 1:5,366,379...5,388,069
JBrowse link
G Fech ferrochelatase decreases expression ISO Clodronic Acid results in decreased expression of FECH mRNA CTD PMID:25596134 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Flvcr2 FLVCR heme transporter 2 increases expression ISO Clodronic Acid results in increased expression of FLVCR2 mRNA CTD PMID:25596134 NCBI chr 6:109,617,348...109,681,495
Ensembl chr 6:109,617,355...109,681,495
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Clodronic Acid results in increased expression of FOSL1 mRNA CTD PMID:25596134 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit decreases expression ISO Clodronic Acid results in decreased expression of FOSL2 mRNA CTD PMID:25596134 NCBI chr 6:25,598,936...25,616,995
Ensembl chr 6:25,598,936...25,616,995
JBrowse link
G Frem2 FRAS1 related extracellular matrix 2 decreases expression ISO Clodronic Acid results in decreased expression of FREM2 mRNA CTD PMID:25596134 NCBI chr 2:142,747,501...142,885,604
Ensembl chr 2:142,747,501...142,885,604
JBrowse link
G Fth1 ferritin heavy chain 1 decreases expression ISO Clodronic Acid results in decreased expression of FTH1 mRNA CTD PMID:25596134 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Gabarapl1 GABA type A receptor associated protein like 1 increases expression ISO Clodronic Acid results in increased expression of GABARAPL1 mRNA CTD PMID:25596134 NCBI chr 4:163,293,724...163,302,866
Ensembl chr 4:163,293,724...163,302,858
JBrowse link
G Gars glycyl-tRNA synthetase increases expression ISO Clodronic Acid results in increased expression of GARS1 mRNA CTD PMID:25596134 NCBI chr 4:85,235,122...85,276,085
Ensembl chr 4:85,235,172...85,276,044
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression ISO Clodronic Acid results in decreased expression of GCLC mRNA CTD PMID:25596134 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Clodronic Acid results in increased expression of GCLM mRNA CTD PMID:25596134 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gdf15 growth differentiation factor 15 decreases expression ISO Clodronic Acid results in decreased expression of GDF15 mRNA CTD PMID:25596134 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Golim4 golgi integral membrane protein 4 increases expression ISO Clodronic Acid results in increased expression of GOLIM4 mRNA CTD PMID:25596134 NCBI chr 2:174,321,303...174,413,847
Ensembl chr 2:174,322,673...174,413,236
JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO Clodronic Acid results in increased expression of GPAT3 mRNA CTD PMID:25596134 NCBI chr14:10,343,287...10,396,565
Ensembl chr14:10,343,282...10,395,047
JBrowse link
G Gpnmb glycoprotein nmb increases expression ISO Clodronic Acid results in increased expression of GPNMB mRNA CTD PMID:25596134 NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
JBrowse link
G Gpr87 G protein-coupled receptor 87 decreases expression ISO Clodronic Acid results in decreased expression of GPR87 mRNA CTD PMID:25596134 NCBI chr 2:149,398,949...149,418,041
Ensembl chr 2:149,398,949...149,417,212
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO
EXP
Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased secretion of GPT protein]
Clodronic Acid promotes the reaction [Thioacetamide results in increased expression of GPT protein]
CTD PMID:26957569, PMID:27022031 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO Clodronic Acid results in increased expression of GSR mRNA CTD PMID:25596134 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
affects activity
EXP
ISO
Clodronic Acid inhibits the reaction [Dopamine results in decreased expression of HIF1A protein]
Clodronic Acid affects the activity of HIF1A protein
CTD PMID:25596134, PMID:25818600 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
increases expression
ISO Clodronic Acid results in decreased expression of HMOX1 mRNA
Clodronic Acid results in increased expression of HMOX1 mRNA
CTD PMID:21690482, PMID:25596134 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Iars1 isoleucyl-tRNA synthetase 1 affects expression ISO Clodronic Acid affects the expression of IARS1 mRNA CTD PMID:25596134 NCBI chr17:15,356,016...15,402,680
Ensembl chr17:15,355,529...15,402,649
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Clodronic Acid inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein] CTD PMID:15892581 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ids iduronate 2-sulfatase decreases expression ISO Clodronic Acid results in decreased expression of IDS mRNA CTD PMID:25596134 NCBI chr 8:69,447,971...69,466,708
Ensembl chr 8:69,449,801...69,466,618
JBrowse link
G Ifng interferon gamma multiple interactions ISO Clodronic Acid inhibits the reaction [Streptozocin results in increased expression of IFNG protein] CTD PMID:15892581 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1r insulin-like growth factor 1 receptor increases expression ISO Clodronic Acid results in increased expression of IGF1R mRNA CTD PMID:25596134 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO Clodronic Acid inhibits the reaction [Alendronate results in increased expression of IL1B protein]
Clodronic Acid results in increased expression of IL1B mRNA
CTD PMID:20804833, PMID:25187657 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
Clodronic Acid inhibits the reaction [Taurocholic Acid results in increased expression of IL6 protein]
Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of IL6 mRNA]
CTD PMID:20382593, PMID:27022031 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kdm3a lysine demethylase 3A decreases expression ISO Clodronic Acid results in decreased expression of KDM3A mRNA CTD PMID:25596134 NCBI chr 4:99,503,160...99,547,315
Ensembl chr 4:99,503,176...99,546,905
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO Clodronic Acid results in increased expression of KEAP1 mRNA CTD PMID:25596134 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Lama3 laminin subunit alpha 3 increases expression ISO Clodronic Acid results in increased expression of LAMA3 mRNA CTD PMID:25596134 NCBI chr18:3,704,866...3,941,215
Ensembl chr18:3,705,916...3,940,838
JBrowse link
G Ltn1 listerin E3 ubiquitin protein ligase 1 decreases expression ISO Clodronic Acid results in decreased expression of LTN1 mRNA CTD PMID:25596134 NCBI chr11:27,023,328...27,080,575
Ensembl chr11:27,022,986...27,080,701
JBrowse link
G Mafg MAF bZIP transcription factor G increases expression ISO Clodronic Acid results in increased expression of MAFG mRNA CTD PMID:25596134 NCBI chr10:109,802,877...109,811,476
Ensembl chr10:109,806,159...109,811,323
JBrowse link
G Mapre2 microtubule-associated protein, RP/EB family, member 2 increases expression ISO Clodronic Acid results in increased expression of MAPRE2 mRNA CTD PMID:25596134 NCBI chr18:14,814,149...15,780,290 JBrowse link
G Mcoln2 mucolipin 2 decreases expression ISO Clodronic Acid results in decreased expression of MCOLN2 mRNA CTD PMID:25596134 NCBI chr 2:252,018,594...252,068,209
Ensembl chr 2:252,018,597...252,068,271
JBrowse link
G Me1 malic enzyme 1 decreases expression ISO Clodronic Acid results in decreased expression of ME1 mRNA CTD PMID:25596134 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Mtdh metadherin decreases expression ISO Clodronic Acid results in decreased expression of MTDH mRNA CTD PMID:25596134 NCBI chr 7:72,771,018...72,830,599
Ensembl chr 7:72,772,440...72,827,908
JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming decreases expression ISO Clodronic Acid results in decreased expression of MUC2 mRNA CTD PMID:25187657 NCBI chr 1:214,663,929...214,693,197 JBrowse link
G Mxi1 MAX interactor 1, dimerization protein decreases expression ISO Clodronic Acid results in decreased expression of MXI1 mRNA CTD PMID:25596134 NCBI chr 1:274,030,748...274,090,071
Ensembl chr 1:274,030,978...274,090,071
JBrowse link
G Nars1 asparaginyl-tRNA synthetase 1 decreases expression ISO Clodronic Acid results in decreased expression of NARS1 mRNA CTD PMID:25596134 NCBI chr18:59,986,350...60,002,644
Ensembl chr18:59,986,360...60,002,569
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 decreases expression ISO Clodronic Acid results in decreased expression of NEDD9 mRNA CTD PMID:25596134 NCBI chr17:22,984,792...23,179,701
Ensembl chr17:22,984,844...23,179,701
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects activity ISO Clodronic Acid affects the activity of NFE2L2 protein CTD PMID:25596134 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nin ninein decreases expression ISO Clodronic Acid results in decreased expression of NIN mRNA CTD PMID:25596134 NCBI chr 6:92,423,412...92,527,776
Ensembl chr 6:92,433,381...92,527,711
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression ISO Clodronic Acid results in decreased expression of NQO1 mRNA CTD PMID:25596134 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression ISO Clodronic Acid results in decreased expression of NR3C1 mRNA CTD PMID:25596134 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nrep neuronal regeneration related protein increases expression ISO Clodronic Acid results in increased expression of NREP mRNA CTD PMID:25596134 NCBI chr18:26,183,753...26,212,796
Ensembl chr18:26,185,259...26,211,445
JBrowse link
G Ntpcr nucleoside-triphosphatase, cancer-related increases expression ISO Clodronic Acid results in increased expression of NTPCR mRNA CTD PMID:25596134 NCBI chr19:58,565,576...58,579,276
Ensembl chr19:58,565,576...58,579,265
JBrowse link
G Nuak1 NUAK family kinase 1 decreases expression ISO Clodronic Acid results in decreased expression of NUAK1 mRNA CTD PMID:25596134 NCBI chr 7:25,039,336...25,111,118
Ensembl chr 7:25,039,335...25,113,664
JBrowse link
G Orai3 ORAI calcium release-activated calcium modulator 3 decreases expression ISO Clodronic Acid results in decreased expression of ORAI3 mRNA CTD PMID:25596134 NCBI chr 1:199,217,504...199,222,363
Ensembl chr 1:199,217,016...199,222,851
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 decreases expression ISO Clodronic Acid results in decreased expression of OSGIN1 mRNA CTD PMID:25596134 NCBI chr19:52,056,808...52,085,491
Ensembl chr19:52,077,109...52,085,496
JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 decreases expression ISO Clodronic Acid results in decreased expression of P4HA1 mRNA CTD PMID:25596134 NCBI chr20:28,920,616...28,972,576
Ensembl chr20:28,920,616...28,971,966
JBrowse link
G Pde8a phosphodiesterase 8A decreases expression ISO Clodronic Acid results in decreased expression of PDE8A mRNA CTD PMID:25596134 NCBI chr 1:143,036,083...143,160,395
Ensembl chr 1:143,036,218...143,159,433
JBrowse link
G Pdia5 protein disulfide isomerase family A, member 5 increases expression ISO Clodronic Acid results in increased expression of PDIA5 mRNA CTD PMID:25596134 NCBI chr11:68,493,035...68,578,999
Ensembl chr11:68,493,035...68,578,995
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases expression ISO Clodronic Acid results in decreased expression of PDK1 mRNA CTD PMID:25596134 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO Clodronic Acid results in increased expression of PDK4 mRNA CTD PMID:25596134 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Pdlim1 PDZ and LIM domain 1 increases expression ISO Clodronic Acid results in increased expression of PDLIM1 mRNA CTD PMID:25596134 NCBI chr 1:259,308,326...259,357,006
Ensembl chr 1:259,308,296...259,357,056
JBrowse link
G Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 decreases expression ISO Clodronic Acid results in decreased expression of PFKFB4 mRNA CTD PMID:25596134 NCBI chr 8:117,733,347...117,776,525
Ensembl chr 8:117,737,117...117,775,386
JBrowse link
G Phgdh phosphoglycerate dehydrogenase decreases expression ISO Clodronic Acid results in decreased expression of PHGDH mRNA CTD PMID:25596134 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564
JBrowse link
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma affects expression ISO Clodronic Acid affects the expression of PIP5K1C mRNA CTD PMID:25596134 NCBI chr 7:11,267,207...11,294,291
Ensembl chr 7:11,267,218...11,294,249
JBrowse link
G Pir pirin increases expression ISO Clodronic Acid results in increased expression of PIR mRNA CTD PMID:25596134 NCBI chr  X:31,852,322...31,968,152
Ensembl chr  X:31,852,323...31,968,152
JBrowse link
G Plec plectin decreases expression ISO Clodronic Acid results in decreased expression of PLEC mRNA CTD PMID:25596134 NCBI chr 7:117,230,319...117,291,859
Ensembl chr 7:117,230,319...117,289,961
JBrowse link
G Plk3 polo-like kinase 3 increases expression ISO Clodronic Acid results in increased expression of PLK3 mRNA CTD PMID:25596134 NCBI chr 5:135,997,725...136,002,900
Ensembl chr 5:135,997,725...136,002,900
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 decreases expression ISO Clodronic Acid results in decreased expression of PMAIP1 mRNA CTD PMID:25596134 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 affects expression ISO Clodronic Acid affects the expression of PMEPA1 mRNA CTD PMID:25596134 NCBI chr 3:171,295,630...171,342,662
Ensembl chr 3:171,294,856...171,342,646
JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases expression ISO Clodronic Acid results in decreased expression of PNPLA6 mRNA CTD PMID:25596134 NCBI chr12:2,068,749...2,098,139
Ensembl chr12:2,069,959...2,097,904
JBrowse link
G Polr3f RNA polymerase III subunit F decreases expression ISO Clodronic Acid results in decreased expression of POLR3F mRNA CTD PMID:25596134 NCBI chr 3:138,684,685...138,701,055
Ensembl chr 3:138,684,685...138,701,055
JBrowse link
G Pon1 paraoxonase 1 decreases activity
multiple interactions
EXP Clodronic Acid results in decreased activity of PON1 protein
[Clodronic Acid results in decreased activity of PON1 protein] which results in decreased metabolism of homocysteine thiolactone; [Clodronic Acid results in decreased activity of PON1 protein] which results in decreased metabolism of Paraoxon; [Clodronic Acid results in decreased activity of PON1 protein] which results in decreased metabolism of phenyl acetate
CTD PMID:27387541 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects activity ISO Clodronic Acid affects the activity of PPARG protein CTD PMID:25596134 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppfibp1 PPFIA binding protein 1 affects expression ISO Clodronic Acid affects the expression of PPFIBP1 mRNA CTD PMID:25596134 NCBI chr 4:181,285,179...181,428,157
Ensembl chr 4:181,286,455...181,428,157
JBrowse link
G Ppig peptidylprolyl isomerase G decreases expression ISO Clodronic Acid results in decreased expression of PPIG mRNA CTD PMID:25596134 NCBI chr 3:55,959,756...55,990,040
Ensembl chr 3:55,960,067...55,988,968
JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D decreases expression ISO Clodronic Acid results in decreased expression of PPM1D mRNA CTD PMID:25596134 NCBI chr10:72,909,550...72,945,884
Ensembl chr10:72,909,550...72,945,884
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A decreases expression ISO Clodronic Acid results in decreased expression of PPP1R15A mRNA CTD PMID:25596134 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Ppp4r2 protein phosphatase 4, regulatory subunit 2 decreases expression ISO Clodronic Acid results in decreased expression of PPP4R2 mRNA CTD PMID:25596134 NCBI chr 4:133,285,552...133,323,755
Ensembl chr 4:133,285,552...133,323,755
JBrowse link
G Prc1 protein regulator of cytokinesis 1 increases expression ISO Clodronic Acid results in increased expression of PRC1 mRNA CTD PMID:25596134 NCBI chr 1:142,087,181...142,108,746
Ensembl chr 1:142,087,208...142,108,746
JBrowse link
G Prdm1 PR/SET domain 1 decreases expression ISO Clodronic Acid results in decreased expression of PRDM1 mRNA CTD PMID:25596134 NCBI chr20:49,464,921...49,556,623
Ensembl chr20:49,464,919...49,556,518
JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 increases expression ISO Clodronic Acid results in increased expression of PRKAB1 mRNA CTD PMID:25596134 NCBI chr12:46,316,298...46,326,789
Ensembl chr12:46,316,236...46,326,790
JBrowse link
G Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 decreases expression ISO Clodronic Acid results in decreased expression of PRKAB2 mRNA CTD PMID:25596134 NCBI chr 2:199,831,990...199,847,623
Ensembl chr 2:199,831,990...199,847,629
JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression ISO Clodronic Acid results in increased expression of PSAT1 mRNA CTD PMID:25596134 NCBI chr 1:233,124,089...233,145,941
Ensembl chr 1:233,124,092...233,145,941
JBrowse link
G Pspc1 paraspeckle component 1 decreases expression ISO Clodronic Acid results in decreased expression of PSPC1 mRNA CTD PMID:25596134 NCBI chr15:36,946,914...37,030,273
Ensembl chr15:36,950,257...37,030,281
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of CD68 mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of COL1A1 mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of IL6 mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TGFB1 mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TIMP1 mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TNF mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased secretion of GPT protein] CTD PMID:27022031 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Pycr1 pyrroline-5-carboxylate reductase 1 increases expression ISO Clodronic Acid results in increased expression of PYCR1 mRNA CTD PMID:25596134 NCBI chr10:109,817,300...109,822,218
Ensembl chr10:109,818,177...109,821,807
JBrowse link
G Rab26 RAB26, member RAS oncogene family increases expression ISO Clodronic Acid results in increased expression of RAB26 mRNA CTD PMID:25596134 NCBI chr10:13,894,271...13,898,578
Ensembl chr10:13,893,290...13,898,855
JBrowse link
G Rab31 RAB31, member RAS oncogene family increases expression ISO Clodronic Acid results in increased expression of RAB31 mRNA CTD PMID:25596134 NCBI chr 9:113,370,072...113,504,606
Ensembl chr 9:113,370,033...113,504,605
JBrowse link
G Rara retinoic acid receptor, alpha decreases expression ISO Clodronic Acid results in decreased expression of RARA mRNA CTD PMID:25596134 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase increases expression ISO Clodronic Acid results in increased expression of RFFL mRNA CTD PMID:25596134 NCBI chr10:70,157,621...70,220,618
Ensembl chr10:70,157,621...70,220,582
JBrowse link
G Rit1 Ras-like without CAAX 1 increases expression ISO Clodronic Acid results in increased expression of RIT1 mRNA CTD PMID:25596134 NCBI chr 2:188,087,486...188,099,444
Ensembl chr 2:188,087,486...188,099,444
JBrowse link
G Rnd3 Rho family GTPase 3 affects expression ISO Clodronic Acid affects the expression of RND3 mRNA CTD PMID:25596134 NCBI chr 3:36,643,374...36,660,727
Ensembl chr 3:36,642,587...36,660,758
JBrowse link
G Ro60 Ro60, Y RNA binding protein decreases expression ISO Clodronic Acid results in decreased expression of RO60 mRNA CTD PMID:25596134 NCBI chr13:60,546,892...60,567,882
Ensembl chr13:60,546,912...60,567,882
JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B decreases expression ISO Clodronic Acid results in decreased expression of RRM2B mRNA CTD PMID:25596134 NCBI chr 7:76,750,045...76,780,817
Ensembl chr 7:76,750,050...76,780,817
JBrowse link
G Rrp12 ribosomal RNA processing 12 homolog decreases expression ISO Clodronic Acid results in decreased expression of RRP12 mRNA CTD PMID:25596134 NCBI chr 1:261,106,768...261,140,416
Ensembl chr 1:261,106,760...261,140,389
JBrowse link
G Rsrc2 arginine and serine rich coiled-coil 2 affects expression ISO Clodronic Acid affects the expression of RSRC2 mRNA CTD PMID:25596134 NCBI chr12:38,274,290...38,294,294
Ensembl chr12:38,274,297...38,294,292
JBrowse link
G Runx1 RUNX family transcription factor 1 increases expression ISO Clodronic Acid results in increased expression of RUNX1 mRNA CTD PMID:25596134 NCBI chr11:32,765,147...33,003,061
Ensembl chr11:32,769,165...33,003,021
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO Clodronic Acid results in increased expression of RUNX2 mRNA CTD PMID:25596134 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Scamp1 secretory carrier membrane protein 1 increases expression ISO Clodronic Acid results in increased expression of SCAMP1 mRNA CTD PMID:25596134 NCBI chr 2:23,858,021...23,941,128
Ensembl chr 2:23,857,995...23,941,084
JBrowse link
G Sectm1b secreted and transmembrane 1B increases expression ISO Clodronic Acid results in increased expression of SECTM1 mRNA CTD PMID:25596134 NCBI chr10:110,251,363...110,260,577
Ensembl chr10:110,251,363...110,259,985
JBrowse link
G Sertad1 SERTA domain containing 1 increases expression ISO Clodronic Acid results in increased expression of SERTAD1 mRNA CTD PMID:25596134 NCBI chr 1:84,293,102...84,296,370
Ensembl chr 1:84,293,102...84,296,367
JBrowse link
G Setx senataxin decreases expression ISO Clodronic Acid results in decreased expression of SETX mRNA CTD PMID:25596134 NCBI chr 3:7,680,430...7,731,815
Ensembl chr 3:7,686,503...7,730,539
JBrowse link
G Sfn stratifin increases expression ISO Clodronic Acid results in increased expression of SFN mRNA CTD PMID:25596134 NCBI chr 5:151,823,422...151,824,937
Ensembl chr 5:151,823,887...151,824,633
JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 decreases expression ISO Clodronic Acid results in decreased expression of SHANK3 mRNA CTD PMID:25596134 NCBI chr 7:130,474,278...130,534,679
Ensembl chr 7:130,474,279...130,534,679
JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 increases expression ISO Clodronic Acid results in increased expression of SIAH2 mRNA CTD PMID:25596134 NCBI chr 2:148,874,151...148,891,900
Ensembl chr 2:148,874,151...148,891,900
JBrowse link
G Sipa1l2 signal-induced proliferation-associated 1 like 2 decreases expression ISO Clodronic Acid results in decreased expression of SIPA1L2 mRNA CTD PMID:25596134 NCBI chr19:58,236,201...58,399,842
Ensembl chr19:58,236,214...58,399,816
JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor increases expression ISO Clodronic Acid results in increased expression of SIVA1 mRNA CTD PMID:25596134 NCBI chr 6:137,209,999...137,214,379
Ensembl chr 6:137,210,052...137,214,388
JBrowse link
G Slc12a8 solute carrier family 12, member 8 decreases expression ISO Clodronic Acid results in decreased expression of SLC12A8 mRNA CTD PMID:25596134 NCBI chr11:70,344,771...70,499,202
Ensembl chr11:70,344,797...70,499,200
JBrowse link
G Slc1a4 solute carrier family 1 member 4 decreases expression ISO Clodronic Acid results in decreased expression of SLC1A4 mRNA CTD PMID:25596134 NCBI chr14:104,582,884...104,612,417
Ensembl chr14:104,581,190...104,612,597
JBrowse link
G Slc1a5 solute carrier family 1 member 5 decreases expression ISO Clodronic Acid results in decreased expression of SLC1A5 mRNA CTD PMID:25596134 NCBI chr 1:78,710,686...78,724,789
Ensembl chr 1:78,710,539...78,724,794
JBrowse link
G Slc25a20 solute carrier family 25 member 20 increases expression ISO Clodronic Acid results in increased expression of SLC25A20 mRNA CTD PMID:25596134 NCBI chr 8:117,455,308...117,476,762
Ensembl chr 8:117,455,262...117,476,734
JBrowse link
G Slc3a2 solute carrier family 3 member 2 affects expression ISO Clodronic Acid affects the expression of SLC3A2 mRNA CTD PMID:25596134 NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092
JBrowse link
G Slc6a9 solute carrier family 6 member 9 decreases expression ISO Clodronic Acid results in decreased expression of SLC6A9 mRNA CTD PMID:25596134 NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697
JBrowse link
G Slc7a5 solute carrier family 7 member 5 affects expression ISO Clodronic Acid affects the expression of SLC7A5 mRNA CTD PMID:25596134 NCBI chr19:54,693,959...54,722,563
Ensembl chr19:54,693,959...54,722,563
JBrowse link
G Smap1 small ArfGAP 1 increases expression ISO Clodronic Acid results in increased expression of SMAP1 mRNA CTD PMID:25596134 NCBI chr 9:30,068,888...30,161,753
Ensembl chr 9:30,068,659...30,161,578
JBrowse link
G Son SON DNA and RNA binding protein decreases expression ISO Clodronic Acid results in decreased expression of SON mRNA CTD PMID:25596134 NCBI chr11:31,806,598...31,837,769
Ensembl chr11:31,806,618...31,837,763
JBrowse link
G Sorl1 sortilin related receptor 1 increases expression ISO Clodronic Acid results in increased expression of SORL1 mRNA CTD PMID:25596134 NCBI chr 8:46,228,077...46,287,171 JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 increases expression ISO Clodronic Acid results in increased expression of SPRY1 mRNA CTD PMID:25596134 NCBI chr 2:124,400,689...124,405,331
Ensembl chr 2:124,400,679...124,405,331
JBrowse link
G Srd5a3 steroid 5 alpha-reductase 3 decreases expression ISO Clodronic Acid results in decreased expression of SRD5A3 mRNA CTD PMID:25596134 NCBI chr14:34,554,769...34,570,423
Ensembl chr14:34,556,220...34,570,356
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Clodronic Acid results in increased expression of SRXN1 mRNA CTD PMID:25596134 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Sulf2 sulfatase 2 decreases expression ISO Clodronic Acid results in decreased expression of SULF2 mRNA CTD PMID:25596134 NCBI chr 3:162,791,349...162,872,984
Ensembl chr 3:162,791,355...162,872,831
JBrowse link
G Taok1 TAO kinase 1 affects expression ISO Clodronic Acid affects the expression of TAOK1 mRNA CTD PMID:25596134 NCBI chr10:62,542,870...62,630,341
Ensembl chr10:62,566,732...62,630,155
JBrowse link
G Tars1 threonyl-tRNA synthetase 1 decreases expression ISO Clodronic Acid results in decreased expression of TARS1 mRNA CTD PMID:25596134 NCBI chr 2:61,394,632...61,414,115
Ensembl chr 2:61,394,770...61,414,102
JBrowse link
G Tbxas1 thromboxane A synthase 1 affects expression ISO Clodronic Acid affects the expression of TBXAS1 mRNA CTD PMID:25596134 NCBI chr 4:66,624,181...66,846,745
Ensembl chr 4:66,670,618...66,846,805
JBrowse link
G Tfap2a transcription factor AP-2 alpha decreases expression ISO Clodronic Acid results in decreased expression of TFAP2A mRNA CTD PMID:25596134 NCBI chr17:24,653,342...24,670,457
Ensembl chr17:24,654,902...24,670,457
JBrowse link
G Tfe3 transcription factor binding to IGHM enhancer 3 decreases expression ISO Clodronic Acid results in decreased expression of TFE3 mRNA CTD PMID:25596134 NCBI chr  X:15,574,579...15,587,826
Ensembl chr  X:15,575,934...15,587,419
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TGFB1 mRNA] CTD PMID:27022031 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase increases expression ISO Clodronic Acid results in increased expression of TIGAR mRNA CTD PMID:25596134 NCBI chr 4:159,635,145...159,654,108
Ensembl chr 4:159,635,153...159,654,063
JBrowse link
G Timm17b translocase of inner mitochondrial membrane 17b decreases expression ISO Clodronic Acid results in decreased expression of TIMM17B mRNA CTD PMID:25596134 NCBI chr  X:15,441,369...15,448,452
Ensembl chr  X:15,441,651...15,448,403
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TIMP1 mRNA] CTD PMID:27022031 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression ISO Clodronic Acid results in increased expression of TIPARP mRNA CTD PMID:25596134 NCBI chr 2:157,316,293...157,342,979
Ensembl chr 2:157,316,266...157,341,469
JBrowse link
G Tmem45b transmembrane protein 45b decreases expression ISO Clodronic Acid results in decreased expression of TMEM45B mRNA CTD PMID:25596134 NCBI chr 8:32,563,872...32,609,212
Ensembl chr 8:32,563,874...32,609,212
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP
ISO
Clodronic Acid inhibits the reaction [Taurocholic Acid results in increased expression of TNF protein]
Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TNF mRNA]
Clodronic Acid results in increased expression of TNF mRNA
CTD PMID:20382593, PMID:25187657, PMID:27022031 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip8 TNF alpha induced protein 8 increases expression ISO Clodronic Acid results in increased expression of TNFAIP8 mRNA CTD PMID:25596134 NCBI chr18:44,664,310...44,779,914
Ensembl chr18:44,716,226...44,779,914
JBrowse link
G Tp53 tumor protein p53 affects activity ISO Clodronic Acid affects the activity of TP53 protein CTD PMID:25596134 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO Clodronic Acid results in increased expression of TP53I3 mRNA CTD PMID:25596134 NCBI chr13:75,101,759...75,145,967
Ensembl chr13:75,105,615...75,143,441
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO Clodronic Acid results in increased expression of TP53INP1 mRNA CTD PMID:25596134 NCBI chr 5:24,402,895...24,419,651
Ensembl chr 5:24,410,863...24,416,888
JBrowse link
G Tpcn1 two pore segment channel 1 increases expression ISO Clodronic Acid results in increased expression of TPCN1 mRNA CTD PMID:25596134 NCBI chr12:41,507,784...41,566,847
Ensembl chr12:41,543,696...41,566,847
JBrowse link
G Tpd52l1 TPD52 like 1 increases expression ISO Clodronic Acid results in increased expression of TPD52L1 mRNA CTD PMID:25596134 NCBI chr 1:28,454,949...28,578,736
Ensembl chr 1:28,454,966...28,576,553
JBrowse link
G Trafd1 TRAF type zinc finger domain containing 1 affects expression ISO Clodronic Acid affects the expression of TRAFD1 mRNA CTD PMID:25596134 NCBI chr12:40,695,520...40,709,438
Ensembl chr12:40,695,520...40,709,462
JBrowse link
G Tspan12 tetraspanin 12 decreases expression ISO Clodronic Acid results in decreased expression of TSPAN12 mRNA CTD PMID:25596134 NCBI chr 4:48,852,823...48,953,240
Ensembl chr 4:48,852,827...48,928,372
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO Clodronic Acid results in increased expression of TXN mRNA CTD PMID:25596134 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Clodronic Acid results in increased expression of TXNRD1 mRNA CTD PMID:25596134 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 increases expression ISO Clodronic Acid results in increased expression of UBE2G2 mRNA CTD PMID:25596134 NCBI chr20:11,700,089...11,721,823
Ensembl chr20:11,700,089...11,721,838
JBrowse link
G Ube2o ubiquitin-conjugating enzyme E2O decreases expression ISO Clodronic Acid results in decreased expression of UBE2O mRNA CTD PMID:25596134 NCBI chr10:105,505,721...105,553,167
Ensembl chr10:105,506,955...105,552,986
JBrowse link
G Unkl unk like zinc finger increases expression ISO Clodronic Acid results in increased expression of UNKL mRNA CTD PMID:25596134 NCBI chr10:14,547,126...14,593,090
Ensembl chr10:14,547,172...14,590,762
JBrowse link
G Vars1 valyl-tRNA synthetase 1 increases expression ISO Clodronic Acid results in increased expression of VARS1 mRNA CTD PMID:25596134 NCBI chr20:4,993,539...5,008,259
Ensembl chr20:4,993,560...5,008,262
JBrowse link
G Vegfb vascular endothelial growth factor B decreases expression ISO Clodronic Acid results in decreased expression of VEGFB mRNA CTD PMID:25596134 NCBI chr 1:222,237,000...222,242,786
Ensembl chr 1:222,239,022...222,242,644
JBrowse link
G Vim vimentin multiple interactions EXP [Clodronic Acid co-treated with Thioacetamide] results in increased expression of VIM protein CTD PMID:26957569 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Vtcn1 V-set domain containing T cell activation inhibitor 1 increases expression ISO Clodronic Acid results in increased expression of VTCN1 mRNA CTD PMID:25596134 NCBI chr 2:203,200,435...203,274,264
Ensembl chr 2:203,200,427...203,276,142
JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 affects expression ISO Clodronic Acid affects the expression of WARS1 mRNA CTD PMID:25596134 NCBI chr 6:132,771,026...132,802,262
Ensembl chr 6:132,771,021...132,802,210
JBrowse link
G Wwc2 WW and C2 domain containing 2 decreases expression ISO Clodronic Acid results in decreased expression of WWC2 mRNA CTD PMID:25596134 NCBI chr16:47,368,768...47,533,816
Ensembl chr16:47,368,768...47,533,816
JBrowse link
G Xbp1 X-box binding protein 1 affects activity
decreases expression
ISO Clodronic Acid affects the activity of XBP1 protein
Clodronic Acid results in decreased expression of XBP1 mRNA
CTD PMID:25596134 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Yars1 tyrosyl-tRNA synthetase 1 decreases expression ISO Clodronic Acid results in decreased expression of YARS1 mRNA CTD PMID:25596134 NCBI chr 5:147,375,350...147,403,578
Ensembl chr 5:147,375,350...147,403,571
JBrowse link
G Yeats2 YEATS domain containing 2 affects expression ISO Clodronic Acid affects the expression of YEATS2 mRNA CTD PMID:25596134 NCBI chr11:84,330,064...84,595,296
Ensembl chr11:84,330,064...84,583,542
JBrowse link
G Ythdc2 YTH domain containing 2 affects expression ISO Clodronic Acid affects the expression of YTHDC2 mRNA CTD PMID:25596134 NCBI chr 1:182,072,386...182,141,399
Ensembl chr 1:182,085,899...182,140,570
JBrowse link
G Zfx zinc finger protein X-linked increases expression ISO Clodronic Acid results in increased expression of ZFX mRNA CTD PMID:25596134 NCBI chr  X:63,158,368...63,204,971
Ensembl chr  X:63,158,976...63,204,530
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            bone density conservation agent 5961
              clodronic acid 238
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            heteroorganic entity 19147
                              organohalogen compound 17713
                                organochlorine compound 17466
                                  clodronic acid 238
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.