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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:beta-carboline
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Accession:CHEBI:109895 term browser browse the term
Definition:The parent compound of the beta-carbolines, a tricyclic structure comprising an indole ring system ortho- fused to C-3 and C-4 of a pyridine ring.
Synonyms:related_synonym: 2,9-Diazafluorene;   2-Azacarbazole;   9H-beta-Carboline;   9H-pyrido[3,4-b]indole;   Carbazoline;   Formula=C11H8N2;   InChI=1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H;   InChIKey=AIFRHYZBTHREPW-UHFFFAOYSA-N;   Norharman;   Norharmane;   SMILES=c1ccc2c(c1)[nH]c1cnccc21
 xref: Beilstein:128414;   CAS:244-63-3;   HMDB:HMDB0012897;   KEGG:C20157;   LINCS:LSM-19021
 xref_mesh: MESH:C010262
 xref: MetaCyc:CPD-15304;   PDBeChem:NRH;   PMID:23600147;   PMID:8070089;   Reaxys:128414;   Wikipedia:Beta-Carboline

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beta-carboline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity		 ISO norharman inhibits the reaction [Lipids metabolite results in increased activity of AHR protein]
norharman results in increased activity of AHR protein		 CTD PMID:27020609 PMID:28336214 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO CYP1A1 protein affects the metabolism of [norharman co-treated with aniline]
norharman results in increased expression of CYP1A1 mRNA; norharman results in increased expression of CYP1A1 protein		 CTD PMID:15279827 PMID:28336214 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO CYP1A2 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO CYP1B1 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO CYP2B6 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO CYP2D6 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO CYP2E1 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO CYP3A4 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Maoa monoamine oxidase A decreases activity ISO norharman results in decreased activity of MAOA protein CTD PMID:28057462 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722 		JBrowse link
G Maob monoamine oxidase B multiple interactions
decreases activity		 ISO norharman inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]
norharman results in decreased activity of MAOB protein		 CTD PMID:21554916 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity
multiple interactions		 ISO norharman results in decreased activity of SLC22A1 protein
norharman inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]		 CTD PMID:30189235 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity
multiple interactions		 ISO norharman results in decreased activity of SLC22A2 protein
norharman inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]		 CTD PMID:30189235 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 decreases activity
multiple interactions		 ISO norharman results in decreased activity of SLC22A3 protein
norharman inhibits the reaction [SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]		 CTD PMID:30189235 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256 		JBrowse link
annomontine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases expression ISO annomontine results in increased expression of AHR mRNA CTD PMID:20449727 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression ISO annomontine results in increased expression of AHRR mRNA CTD PMID:20449727 NCBI chr 1:31,603,297...31,698,329
Ensembl chr 1:31,603,297...31,698,329 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO annomontine results in increased expression of CYP1A1 mRNA CTD PMID:20449727 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      biological role 19720
        biochemical role 19310
          metabolite 19292
            marine metabolite 5170
              beta-carboline 14
                annomontine 3
                cordysinin C 0
                cordysinin D 0
                cordysinin E 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic molecule 19504
                              organic cyclic compound 19331
                                organic heterocyclic compound 18519
                                  organic heteropolycyclic compound 17978
                                    organic heterotricyclic compound 14600
                                      pyridoindole 114
                                        beta-carbolines 97
                                          beta-carboline 14
                                            annomontine 3
                                            cordysinin C 0
                                            cordysinin D 0
                                            cordysinin E 0
paths to the root