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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:omega-hydroxy fatty acid
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Accession:CHEBI:10615 term browser browse the term
Definition:Any member of the class of naturally-occurring straight-chain fatty acids n carbon atoms long with a carboxyl group at position 1 and a hydroxyl at position n (omega).
Synonyms:related_synonym: Formula=CH2O3(CH2)n;   omega-hydroxy fatty acids
 xref: KEGG:C03547;   PMID:13771448;   PMID:16660004
 cyclic_relationship: is_conjugate_acid_of CHEBI:76307

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12-hydroxylauric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide increases oxidation
affects binding		 ISO ADH5 protein results in increased oxidation of 12-hydroxydodecanoic acid
12-hydroxydodecanoic acid binds to ADH5 protein		 CTD PMID:12196016 PMID:12604204 PMID:19428350 NCBI chr 2:243,728,500...243,740,907
Ensembl chr 2:243,700,784...243,740,899 		JBrowse link
G Cyp4v3 cytochrome P450, family 4, subfamily v, polypeptide 3 multiple interactions
increases chemical synthesis		 ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [CYP4V2 protein results in increased chemical synthesis of 12-hydroxydodecanoic acid] CTD PMID:28729181 NCBI chr16:50,111,803...50,136,741
Ensembl chr16:50,111,306...50,136,727 		JBrowse link
8-hydroxyoctanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide increases oxidation ISO ADH5 protein results in increased oxidation of 8-hydroxyoctanoic acid CTD PMID:19428350 NCBI chr 2:243,728,500...243,740,907
Ensembl chr 2:243,700,784...243,740,899 		JBrowse link
beta-propiolactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases response to substance ISO NFE2L2 protein results in decreased susceptibility to Propiolactone CTD PMID:20932822 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
royal jelly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in decreased expression of BCL2 mRNA] CTD PMID:30896085 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA] CTD PMID:30896085 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cat catalase multiple interactions EXP
ISO		 royal jelly inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
royal jelly inhibits the reaction [Nicotine results in decreased activity of CAT protein]		 CTD PMID:20369241 PMID:30896085 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
affects binding		 ISO Estradiol inhibits the reaction [royal jelly binds to ESR1 protein]; royal jelly binds to and results in increased activity of ESR1 protein; royal jelly inhibits the reaction [Estradiol binds to ESR1 protein]
royal jelly results in increased activity of ESR1 protein		 CTD PMID:15946813 PMID:17287592 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding		 ISO Estradiol inhibits the reaction [royal jelly binds to ESR2 protein]; royal jelly binds to and results in increased activity of ESR2 protein; royal jelly inhibits the reaction [Estradiol binds to ESR2 protein] CTD PMID:15946813 PMID:17287592 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in decreased expression of PCNA protein] CTD PMID:30896085 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO royal jelly results in increased expression of TFF1 mRNA CTD PMID:15946813 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in increased expression of TRP53 mRNA] CTD PMID:30896085 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO
EXP		 royal jelly results in increased expression of VEGFA mRNA CTD PMID:15946813 PMID:17287592 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    chemical entity 19883
      molecular entity 19880
        polyatomic entity 19794
          heteroatomic molecular entity 19719
            hydroxides 19147
              organic hydroxy compound 18696
                alcohol 15040
                  primary alcohol 13941
                    omega-hydroxy fatty acid 12
                      (2E)-11-hydroxy-2-dodecenoic acid 0
                      (2E)-11-hydroxyundec-2-enoic acid + 0
                      (2E)-12-hydroxydodec-2-enoic acid + 0
                      (2E)-13-hydroxytridec-2-enoic acid + 0
                      (2E)-14-hydroxytetradec-2-enoic acid + 0
                      (2E)-15-hydroxypentadec-2-enoic acid + 0
                      (2E)-16-hydroxyhexadec-2-enoic acid + 0
                      (2E)-17-hydroxyheptadec-2-enoic acid + 0
                      (2E)-18-hydroxyoctadec-2-enoic acid + 0
                      (2E)-19-hydroxynonadec-2-enoic acid + 0
                      (2E)-20-hydroxyicos-2-enoic acid + 0
                      (2E)-21-hydroxyhenicos-2-enoic acid + 0
                      (2E)-7-hydroxyhept-2-enoic acid + 0
                      (2E)-9-hydroxynon-2-enoic acid + 0
                      (3R)-3,10-dihydroxydecanoic acid + 0
                      (3R)-3,11-dihydroxyundecanoic acid + 0
                      (3R)-3,12-dihydroxylauric acid + 0
                      (3R)-3,13-dihydroxytridecanoic acid + 0
                      (3R)-3,14-dihydroxymyristic acid + 0
                      (3R)-3,15-dihydroxypentadecanoic acid + 0
                      (3R)-3,17-dihydroxymargaric acid + 0
                      (3R)-3,18-dihydroxyoctadecanoic acid + 0
                      (3R)-3,19-dihydroxynonadecanoic acid + 0
                      (3R)-3,20-dihydroxyicosanoic acid + 0
                      (3R)-3,21-dihydroxyhenicosanoic acid + 0
                      (3R)-3,22-dihydroxybehenic acid + 0
                      (3R)-3,22-dihydroxytricosanoic acid + 0
                      (3R)-3,9-dihydroxynonanoic acid + 0
                      (4Z,7Z,10Z,12E,14R,16Z,19Z)-14,22-dihydroxydocosahexaenoic acid 0
                      (4Z,7Z,10Z,12E,14S,16Z,19Z)-14,22-dihydroxydocosahexaenoic acid 0
                      (9Z,12R)-12,18-dihydroxyoctadecenoic acid 0
                      (E)-10-hydroxydec-2-enoic acid + 9
                      10-hydroxycapric acid + 0
                      11,12-epoxy-20-hydroxy-(5Z,8Z,14Z)-icosatrienoic acid 0
                      11-hydroxyundecanoic acid + 0
                      12,13-epoxy-18-hydroxy-(9Z)-octadecenoic acid 0
                      12,18-dihydroxyoctadecanoic acid 0
                      12,20-DiHETE 0
                      12-hydroxylauric acid + 2
                      14,15-epoxy-20-hydroxy-(5Z,8Z,11Z)-icosatrienoic acid 0
                      18-hydroxylinoleic acid 0
                      18-hydroxyoleic acid + 0
                      2,4-dihydroxybutanoic acid 0
                      20-HETrE 0
                      20-hydroxy-6-trans-leukotriene B4 0
                      20-hydroxylipoxin A4 0
                      20-hydroxylipoxin B4 0
                      22-hydroxyprotectin D1 0
                      26-hydroxyhexacosanoic acid 0
                      3,12-dihydroxylauric acid 0
                      3,18-dihydroxyoctadecanoic acid 0
                      3,4-dihydroxybutyric acid 0
                      3-hydroxypropionic acid + 1
                      5,20-DiHETE 0
                      5,20-diHEPE 0
                      5,6-epoxy-20-hydroxy-(8Z,11Z,14Z)-icosatrienoic acid 0
                      5-hydroxypentanoic acid + 0
                      6-hydroxyhexanoic acid + 0
                      7-hydroxyheptanoic acid + 0
                      8,20-DiHETE 0
                      8,9-epoxy-20-hydroxy-(5Z,11Z,14Z)-icosatrienoic acid 0
                      8-hydroxyoctanoic acid + 1
                      9,10,18-trihydroxyoctadecanoic acid 0
                      9,10-epoxy-18-hydroxy-(12Z)-octadecenoic acid 0
                      9,10-epoxy-18-hydroxyoctadecanoic acid + 0
                      9-hydroxynonanoic acid + 0
                      omega-hydroxy fatty acid ascaroside + 0
                      omega-hydroxy fatty acyl-CoA + 0
                      omega-hydroxy fatty ester + 0
                      omega-hydroxy-long-chain fatty acid + 0
                      omega-hydroxy-ultra-long-chain fatty acid + 0
                      omega-hydroxyhentriacontanoic acid 0
                      omega-hydroxyheptacosanoic acid 0
                      omega-hydroxynonacosanoic acid 0
                      omega-hydroxyoctacosanoic acid 0
                      omega-hydroxytetracosanoic acid 0
                      omega-hydroxytritriacontanoic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic group 18580
                              organic divalent group 18571
                                organodiyl group 18571
                                  carbonyl group 18479
                                    carbonyl compound 18479
                                      carboxylic acid 18153
                                        monocarboxylic acid 17519
                                          fatty acid 16025
                                            hydroxy fatty acid 191
                                              omega-hydroxy fatty acid 12
                                                (2E)-11-hydroxy-2-dodecenoic acid 0
                                                (2E)-11-hydroxyundec-2-enoic acid + 0
                                                (2E)-12-hydroxydodec-2-enoic acid + 0
                                                (2E)-13-hydroxytridec-2-enoic acid + 0
                                                (2E)-14-hydroxytetradec-2-enoic acid + 0
                                                (2E)-15-hydroxypentadec-2-enoic acid + 0
                                                (2E)-16-hydroxyhexadec-2-enoic acid + 0
                                                (2E)-17-hydroxyheptadec-2-enoic acid + 0
                                                (2E)-18-hydroxyoctadec-2-enoic acid + 0
                                                (2E)-19-hydroxynonadec-2-enoic acid + 0
                                                (2E)-20-hydroxyicos-2-enoic acid + 0
                                                (2E)-21-hydroxyhenicos-2-enoic acid + 0
                                                (2E)-7-hydroxyhept-2-enoic acid + 0
                                                (2E)-9-hydroxynon-2-enoic acid + 0
                                                (3R)-3,10-dihydroxydecanoic acid + 0
                                                (3R)-3,11-dihydroxyundecanoic acid + 0
                                                (3R)-3,12-dihydroxylauric acid + 0
                                                (3R)-3,13-dihydroxytridecanoic acid + 0
                                                (3R)-3,14-dihydroxymyristic acid + 0
                                                (3R)-3,15-dihydroxypentadecanoic acid + 0
                                                (3R)-3,17-dihydroxymargaric acid + 0
                                                (3R)-3,18-dihydroxyoctadecanoic acid + 0
                                                (3R)-3,19-dihydroxynonadecanoic acid + 0
                                                (3R)-3,20-dihydroxyicosanoic acid + 0
                                                (3R)-3,21-dihydroxyhenicosanoic acid + 0
                                                (3R)-3,22-dihydroxybehenic acid + 0
                                                (3R)-3,22-dihydroxytricosanoic acid + 0
                                                (3R)-3,9-dihydroxynonanoic acid + 0
                                                (4Z,7Z,10Z,12E,14R,16Z,19Z)-14,22-dihydroxydocosahexaenoic acid 0
                                                (4Z,7Z,10Z,12E,14S,16Z,19Z)-14,22-dihydroxydocosahexaenoic acid 0
                                                (9Z,12R)-12,18-dihydroxyoctadecenoic acid 0
                                                (E)-10-hydroxydec-2-enoic acid + 9
                                                10-hydroxycapric acid + 0
                                                11,12-epoxy-20-hydroxy-(5Z,8Z,14Z)-icosatrienoic acid 0
                                                11-hydroxyundecanoic acid + 0
                                                12,13-epoxy-18-hydroxy-(9Z)-octadecenoic acid 0
                                                12,18-dihydroxyoctadecanoic acid 0
                                                12,20-DiHETE 0
                                                12-hydroxylauric acid + 2
                                                14,15-epoxy-20-hydroxy-(5Z,8Z,11Z)-icosatrienoic acid 0
                                                18-hydroxylinoleic acid 0
                                                18-hydroxyoleic acid + 0
                                                2,4-dihydroxybutanoic acid 0
                                                20-HETrE 0
                                                20-hydroxy-6-trans-leukotriene B4 0
                                                20-hydroxylipoxin A4 0
                                                20-hydroxylipoxin B4 0
                                                22-hydroxyprotectin D1 0
                                                26-hydroxyhexacosanoic acid 0
                                                3,12-dihydroxylauric acid 0
                                                3,18-dihydroxyoctadecanoic acid 0
                                                3,4-dihydroxybutyric acid 0
                                                3-hydroxypropionic acid + 1
                                                5,20-DiHETE 0
                                                5,20-diHEPE 0
                                                5,6-epoxy-20-hydroxy-(8Z,11Z,14Z)-icosatrienoic acid 0
                                                5-hydroxypentanoic acid + 0
                                                6-hydroxyhexanoic acid + 0
                                                7-hydroxyheptanoic acid + 0
                                                8,20-DiHETE 0
                                                8,9-epoxy-20-hydroxy-(5Z,11Z,14Z)-icosatrienoic acid 0
                                                8-hydroxyoctanoic acid + 1
                                                9,10,18-trihydroxyoctadecanoic acid 0
                                                9,10-epoxy-18-hydroxy-(12Z)-octadecenoic acid 0
                                                9,10-epoxy-18-hydroxyoctadecanoic acid + 0
                                                9-hydroxynonanoic acid + 0
                                                omega-hydroxy fatty acid ascaroside + 0
                                                omega-hydroxy fatty acyl-CoA + 0
                                                omega-hydroxy fatty ester + 0
                                                omega-hydroxy-long-chain fatty acid + 0
                                                omega-hydroxy-ultra-long-chain fatty acid + 0
                                                omega-hydroxyhentriacontanoic acid 0
                                                omega-hydroxyheptacosanoic acid 0
                                                omega-hydroxynonacosanoic acid 0
                                                omega-hydroxyoctacosanoic acid 0
                                                omega-hydroxytetracosanoic acid 0
                                                omega-hydroxytritriacontanoic acid 0
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