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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:omega-hydroxy fatty acid
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Accession:CHEBI:10615 term browser browse the term
Definition:Any member of the class of naturally-occurring straight-chain fatty acids n carbon atoms long with a carboxyl group at position 1 and a hydroxyl at position n (omega).
Synonyms:related_synonym: Formula=CH2O3(CH2)n;   omega-hydroxy fatty acids
 xref: KEGG:C03547;   PMID:13771448;   PMID:16660004
 cyclic_relationship: is_conjugate_acid_of CHEBI:76307


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12-hydroxylauric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide affects binding
increases oxidation		 ISO 12-hydroxydodecanoic acid binds to ADH5 protein
ADH5 protein results in increased oxidation of 12-hydroxydodecanoic acid		 CTD PMID:12196016 PMID:12604204 PMID:19428350 NCBI chr 2:226,975,184...226,987,591 JBrowse link
G Cyp4v3 cytochrome P450, family 4, subfamily v, polypeptide 3 multiple interactions
increases chemical synthesis		 ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [CYP4V2 protein results in increased chemical synthesis of 12-hydroxydodecanoic acid] CTD PMID:28729181 NCBI chr16:46,917,929...46,958,735
Ensembl chr16:46,918,401...46,943,395 		JBrowse link
8-hydroxyoctanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide increases oxidation ISO ADH5 protein results in increased oxidation of 8-hydroxyoctanoic acid CTD PMID:19428350 NCBI chr 2:226,975,184...226,987,591 JBrowse link
beta-propiolactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases response to substance ISO NFE2L2 protein results in decreased susceptibility to Propiolactone CTD PMID:20932822 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
royal jelly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in decreased expression of BCL2 mRNA] CTD PMID:30896085 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA] CTD PMID:30896085 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP
ISO		 royal jelly inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
royal jelly inhibits the reaction [Nicotine results in decreased activity of CAT protein]		 CTD PMID:20369241 PMID:30896085 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
affects binding		 ISO Estradiol inhibits the reaction [royal jelly binds to ESR1 protein]; royal jelly binds to and results in increased activity of ESR1 protein; royal jelly inhibits the reaction [Estradiol binds to ESR1 protein]
royal jelly results in increased activity of ESR1 protein		 CTD PMID:15946813 PMID:17287592 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding		 ISO Estradiol inhibits the reaction [royal jelly binds to ESR2 protein]; royal jelly binds to and results in increased activity of ESR2 protein; royal jelly inhibits the reaction [Estradiol binds to ESR2 protein] CTD PMID:15946813 PMID:17287592 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in decreased expression of PCNA protein] CTD PMID:30896085 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO royal jelly results in increased expression of TFF1 mRNA CTD PMID:15946813 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in increased expression of TRP53 mRNA] CTD PMID:30896085 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO
EXP		 royal jelly results in increased expression of VEGFA mRNA CTD PMID:15946813 PMID:17287592 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      molecular entity 19799
        polyatomic entity 19721
          heteroatomic molecular entity 19662
            hydroxides 19158
              organic hydroxy compound 18656
                alcohol 15085
                  primary alcohol 14005
                    omega-hydroxy fatty acid 12
                      (2E)-11-hydroxy-2-dodecenoic acid 0
                      (2E)-11-hydroxyundec-2-enoic acid + 0
                      (2E)-12-hydroxydodec-2-enoic acid + 0
                      (2E)-13-hydroxytridec-2-enoic acid + 0
                      (2E)-14-hydroxytetradec-2-enoic acid + 0
                      (2E)-15-hydroxypentadec-2-enoic acid + 0
                      (2E)-16-hydroxyhexadec-2-enoic acid + 0
                      (2E)-17-hydroxyheptadec-2-enoic acid + 0
                      (2E)-18-hydroxyoctadec-2-enoic acid + 0
                      (2E)-19-hydroxynonadec-2-enoic acid + 0
                      (2E)-20-hydroxyicos-2-enoic acid + 0
                      (2E)-21-hydroxyhenicos-2-enoic acid + 0
                      (2E)-7-hydroxyhept-2-enoic acid + 0
                      (2E)-9-hydroxynon-2-enoic acid + 0
                      (3R)-3,10-dihydroxydecanoic acid + 0
                      (3R)-3,11-dihydroxyundecanoic acid + 0
                      (3R)-3,12-dihydroxylauric acid + 0
                      (3R)-3,13-dihydroxytridecanoic acid + 0
                      (3R)-3,14-dihydroxymyristic acid + 0
                      (3R)-3,15-dihydroxypentadecanoic acid + 0
                      (3R)-3,17-dihydroxymargaric acid + 0
                      (3R)-3,18-dihydroxyoctadecanoic acid + 0
                      (3R)-3,19-dihydroxynonadecanoic acid + 0
                      (3R)-3,20-dihydroxyicosanoic acid + 0
                      (3R)-3,21-dihydroxyhenicosanoic acid + 0
                      (3R)-3,22-dihydroxybehenic acid + 0
                      (3R)-3,22-dihydroxytricosanoic acid + 0
                      (3R)-3,9-dihydroxynonanoic acid + 0
                      (4Z,7Z,10Z,12E,14R,16Z,19Z)-14,22-dihydroxydocosahexaenoic acid 0
                      (4Z,7Z,10Z,12E,14S,16Z,19Z)-14,22-dihydroxydocosahexaenoic acid 0
                      (9Z,12R)-12,18-dihydroxyoctadecenoic acid 0
                      (E)-10-hydroxydec-2-enoic acid + 9
                      10-hydroxycapric acid + 0
                      11,12-epoxy-20-hydroxy-(5Z,8Z,14Z)-icosatrienoic acid 0
                      11-hydroxyundecanoic acid + 0
                      12,13-epoxy-18-hydroxy-(9Z)-octadecenoic acid 0
                      12,18-dihydroxyoctadecanoic acid 0
                      12,20-DiHETE 0
                      12-hydroxylauric acid + 2
                      14,15-epoxy-20-hydroxy-(5Z,8Z,11Z)-icosatrienoic acid 0
                      18-hydroxylinoleic acid 0
                      18-hydroxyoleic acid + 0
                      2,4-dihydroxybutanoic acid 0
                      20-HETrE 0
                      20-hydroxy-6-trans-leukotriene B4 0
                      20-hydroxylipoxin A4 0
                      20-hydroxylipoxin B4 0
                      22-hydroxyprotectin D1 0
                      26-hydroxyhexacosanoic acid 0
                      3,12-dihydroxylauric acid 0
                      3,18-dihydroxyoctadecanoic acid 0
                      3,4-dihydroxybutyric acid 0
                      3-hydroxypropionic acid + 1
                      5,20-DiHETE 0
                      5,20-diHEPE 0
                      5,6-epoxy-20-hydroxy-(8Z,11Z,14Z)-icosatrienoic acid 0
                      5-hydroxypentanoic acid + 0
                      6-hydroxyhexanoic acid + 0
                      7-hydroxyheptanoic acid + 0
                      8,20-DiHETE 0
                      8,9-epoxy-20-hydroxy-(5Z,11Z,14Z)-icosatrienoic acid 0
                      8-hydroxyoctanoic acid + 1
                      9,10,18-trihydroxyoctadecanoic acid 0
                      9,10-epoxy-18-hydroxy-(12Z)-octadecenoic acid 0
                      9,10-epoxy-18-hydroxyoctadecanoic acid + 0
                      9-hydroxynonanoic acid + 0
                      omega-hydroxy fatty acid ascaroside + 0
                      omega-hydroxy fatty acyl-CoA + 0
                      omega-hydroxy fatty ester + 0
                      omega-hydroxy-long-chain fatty acid + 0
                      omega-hydroxy-ultra-long-chain fatty acid + 0
                      omega-hydroxyhentriacontanoic acid 0
                      omega-hydroxyheptacosanoic acid 0
                      omega-hydroxynonacosanoic acid 0
                      omega-hydroxyoctacosanoic acid 0
                      omega-hydroxytetracosanoic acid 0
                      omega-hydroxytritriacontanoic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        monocarboxylic acid 17622
                                          fatty acid 16011
                                            hydroxy fatty acid 192
                                              omega-hydroxy fatty acid 12
                                                (2E)-11-hydroxy-2-dodecenoic acid 0
                                                (2E)-11-hydroxyundec-2-enoic acid + 0
                                                (2E)-12-hydroxydodec-2-enoic acid + 0
                                                (2E)-13-hydroxytridec-2-enoic acid + 0
                                                (2E)-14-hydroxytetradec-2-enoic acid + 0
                                                (2E)-15-hydroxypentadec-2-enoic acid + 0
                                                (2E)-16-hydroxyhexadec-2-enoic acid + 0
                                                (2E)-17-hydroxyheptadec-2-enoic acid + 0
                                                (2E)-18-hydroxyoctadec-2-enoic acid + 0
                                                (2E)-19-hydroxynonadec-2-enoic acid + 0
                                                (2E)-20-hydroxyicos-2-enoic acid + 0
                                                (2E)-21-hydroxyhenicos-2-enoic acid + 0
                                                (2E)-7-hydroxyhept-2-enoic acid + 0
                                                (2E)-9-hydroxynon-2-enoic acid + 0
                                                (3R)-3,10-dihydroxydecanoic acid + 0
                                                (3R)-3,11-dihydroxyundecanoic acid + 0
                                                (3R)-3,12-dihydroxylauric acid + 0
                                                (3R)-3,13-dihydroxytridecanoic acid + 0
                                                (3R)-3,14-dihydroxymyristic acid + 0
                                                (3R)-3,15-dihydroxypentadecanoic acid + 0
                                                (3R)-3,17-dihydroxymargaric acid + 0
                                                (3R)-3,18-dihydroxyoctadecanoic acid + 0
                                                (3R)-3,19-dihydroxynonadecanoic acid + 0
                                                (3R)-3,20-dihydroxyicosanoic acid + 0
                                                (3R)-3,21-dihydroxyhenicosanoic acid + 0
                                                (3R)-3,22-dihydroxybehenic acid + 0
                                                (3R)-3,22-dihydroxytricosanoic acid + 0
                                                (3R)-3,9-dihydroxynonanoic acid + 0
                                                (4Z,7Z,10Z,12E,14R,16Z,19Z)-14,22-dihydroxydocosahexaenoic acid 0
                                                (4Z,7Z,10Z,12E,14S,16Z,19Z)-14,22-dihydroxydocosahexaenoic acid 0
                                                (9Z,12R)-12,18-dihydroxyoctadecenoic acid 0
                                                (E)-10-hydroxydec-2-enoic acid + 9
                                                10-hydroxycapric acid + 0
                                                11,12-epoxy-20-hydroxy-(5Z,8Z,14Z)-icosatrienoic acid 0
                                                11-hydroxyundecanoic acid + 0
                                                12,13-epoxy-18-hydroxy-(9Z)-octadecenoic acid 0
                                                12,18-dihydroxyoctadecanoic acid 0
                                                12,20-DiHETE 0
                                                12-hydroxylauric acid + 2
                                                14,15-epoxy-20-hydroxy-(5Z,8Z,11Z)-icosatrienoic acid 0
                                                18-hydroxylinoleic acid 0
                                                18-hydroxyoleic acid + 0
                                                2,4-dihydroxybutanoic acid 0
                                                20-HETrE 0
                                                20-hydroxy-6-trans-leukotriene B4 0
                                                20-hydroxylipoxin A4 0
                                                20-hydroxylipoxin B4 0
                                                22-hydroxyprotectin D1 0
                                                26-hydroxyhexacosanoic acid 0
                                                3,12-dihydroxylauric acid 0
                                                3,18-dihydroxyoctadecanoic acid 0
                                                3,4-dihydroxybutyric acid 0
                                                3-hydroxypropionic acid + 1
                                                5,20-DiHETE 0
                                                5,20-diHEPE 0
                                                5,6-epoxy-20-hydroxy-(8Z,11Z,14Z)-icosatrienoic acid 0
                                                5-hydroxypentanoic acid + 0
                                                6-hydroxyhexanoic acid + 0
                                                7-hydroxyheptanoic acid + 0
                                                8,20-DiHETE 0
                                                8,9-epoxy-20-hydroxy-(5Z,11Z,14Z)-icosatrienoic acid 0
                                                8-hydroxyoctanoic acid + 1
                                                9,10,18-trihydroxyoctadecanoic acid 0
                                                9,10-epoxy-18-hydroxy-(12Z)-octadecenoic acid 0
                                                9,10-epoxy-18-hydroxyoctadecanoic acid + 0
                                                9-hydroxynonanoic acid + 0
                                                omega-hydroxy fatty acid ascaroside + 0
                                                omega-hydroxy fatty acyl-CoA + 0
                                                omega-hydroxy fatty ester + 0
                                                omega-hydroxy-long-chain fatty acid + 0
                                                omega-hydroxy-ultra-long-chain fatty acid + 0
                                                omega-hydroxyhentriacontanoic acid 0
                                                omega-hydroxyheptacosanoic acid 0
                                                omega-hydroxynonacosanoic acid 0
                                                omega-hydroxyoctacosanoic acid 0
                                                omega-hydroxytetracosanoic acid 0
                                                omega-hydroxytritriacontanoic acid 0
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