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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:10447 term browser browse the term
Definition:A monoterpenoid that is cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2 and an isopropyl group at position 4. Isolated from Thuja plicata and Chamaecyparis obtusa, it exhibits antimicrobial activities.
Synonyms:exact_synonym: 2-hydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one
 related_synonym: 2-hydroxy-4-isopropyl-cyclohepta2,4,6-trien-1-one;   4-Isopropyltropolone;   Formula=C10H12O2;   Hinokitiol;   InChI=1S/C10H12O2/c1-7(2)8-4-3-5-9(11)10(12)6-8/h3-7H,1-2H3,(H,11,12);   InChIKey=FUWUEFKEXZQKKA-UHFFFAOYSA-N;   SMILES=CC(C)c1cccc(=O)c(O)c1
 alt_id: CHEBI:66015
 xref: CAS:499-44-5;   HMDB:HMDB0035213;   KEGG:C09904;   KEGG:D04876;   KNApSAcK:C00003062;   LINCS:LSM-2835
 xref_mesh: MESH:C009479
 xref: PMID:10973816;   PMID:15917561;   PMID:17927050;   PMID:18118412;   PMID:18379073;   PMID:23312825;   Reaxys:2045206;   Wikipedia:Hinokitiol

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beta-thujaplicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1, autophagy related increases expression EXP beta-thujaplicin results in increased expression of BECN1 protein CTD PMID:25044443 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation EXP beta-thujaplicin results in decreased phosphorylation of MTOR protein CTD PMID:25044443 NCBI chr 4:148,448,582...148,557,685
Ensembl chr 4:148,448,611...148,557,683
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 decreases phosphorylation EXP beta-thujaplicin results in decreased phosphorylation of RPS6KB1 protein CTD PMID:25044443 NCBI chr11:86,498,869...86,544,885
Ensembl chr11:86,498,871...86,544,805
JBrowse link
G Sqstm1 sequestosome 1 decreases expression EXP beta-thujaplicin results in decreased expression of SQSTM1 protein CTD PMID:25044443 NCBI chr11:50,200,152...50,210,820
Ensembl chr11:50,199,366...50,210,827
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21802
    role 21781
      biological role 21779
        antimicrobial agent 18456
          antibacterial agent 14343
            beta-thujaplicin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 21802
    subatomic particle 21788
      composite particle 21788
        hadron 21788
          baryon 21788
            nucleon 21788
              atomic nucleus 21788
                atom 21788
                  main group element atom 21705
                    main group molecular entity 21705
                      s-block molecular entity 21229
                        hydrogen molecular entity 21165
                          hydrides 20390
                            organic hydride 19916
                              organic fundamental parent 19916
                                hydrocarbon 19763
                                  olefin 5679
                                    cyclic olefin 103
                                      monocyclic olefin 100
                                        cycloalkatriene 5
                                          cycloheptatriene 5
                                            cyclohepta-1,3,5-triene 5
                                              beta-thujaplicin 4
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