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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:beta-thujaplicin
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Accession:CHEBI:10447 term browser browse the term
Definition:A monoterpenoid that is cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2 and an isopropyl group at position 4. Isolated from Thuja plicata and Chamaecyparis obtusa, it exhibits antimicrobial activities.
Synonyms:exact_synonym: 2-hydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one
 related_synonym: 2-hydroxy-4-isopropyl-cyclohepta2,4,6-trien-1-one;   4-Isopropyltropolone;   Formula=C10H12O2;   Hinokitiol;   InChI=1S/C10H12O2/c1-7(2)8-4-3-5-9(11)10(12)6-8/h3-7H,1-2H3,(H,11,12);   InChIKey=FUWUEFKEXZQKKA-UHFFFAOYSA-N;   SMILES=CC(C)c1cccc(=O)c(O)c1
 alt_id: CHEBI:66015
 xref: CAS:499-44-5;   HMDB:HMDB0035213;   KEGG:C09904;   KEGG:D04876;   KNApSAcK:C00003062;   LINCS:LSM-2835
 xref_mesh: MESH:C009479
 xref: PMID:10973816;   PMID:15917561;   PMID:17927050;   PMID:18118412;   PMID:18379073;   PMID:23312825;   Reaxys:2045206;   Wikipedia:Hinokitiol


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beta-thujaplicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 increases expression ISO beta-thujaplicin results in increased expression of BECN1 protein CTD PMID:25044443 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO beta-thujaplicin results in decreased phosphorylation of MTOR protein CTD PMID:25044443 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO beta-thujaplicin results in decreased phosphorylation of RPS6KB1 protein CTD PMID:25044443 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO beta-thujaplicin results in decreased expression of SQSTM1 protein CTD PMID:25044443 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          antibacterial agent 13021
            beta-thujaplicin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            organic hydride 18249
                              organic fundamental parent 18249
                                hydrocarbon 17969
                                  olefin 7183
                                    cyclic olefin 105
                                      monocyclic olefin 102
                                        cycloalkatriene 5
                                          cycloheptatriene 5
                                            cyclohepta-1,3,5-triene 5
                                              beta-thujaplicin 4
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