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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:beta-thujaplicin
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Accession:CHEBI:10447 term browser browse the term
Definition:A monoterpenoid that is cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2 and an isopropyl group at position 4. Isolated from Thuja plicata and Chamaecyparis obtusa, it exhibits antimicrobial activities.
Synonyms:exact_synonym: 2-hydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one
 related_synonym: 2-hydroxy-4-isopropyl-cyclohepta2,4,6-trien-1-one;   4-Isopropyltropolone;   Formula=C10H12O2;   Hinokitiol;   InChI=1S/C10H12O2/c1-7(2)8-4-3-5-9(11)10(12)6-8/h3-7H,1-2H3,(H,11,12);   InChIKey=FUWUEFKEXZQKKA-UHFFFAOYSA-N;   SMILES=CC(C)c1cccc(=O)c(O)c1
 alt_id: CHEBI:66015
 xref: CAS:499-44-5;   HMDB:HMDB0035213;   KEGG:C09904;   KEGG:D04876;   KNApSAcK:C00003062;   LINCS:LSM-2835
 xref_mesh: MESH:C009479
 xref: PMID:10973816;   PMID:15917561;   PMID:17927050;   PMID:18118412;   PMID:18379073;   PMID:23312825;   Reaxys:2045206;   Wikipedia:Hinokitiol


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beta-thujaplicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 increases expression ISO beta-thujaplicin results in increased expression of BECN1 protein CTD PMID:25044443 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO beta-thujaplicin results in decreased phosphorylation of MTOR protein CTD PMID:25044443 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO beta-thujaplicin results in decreased phosphorylation of RPS6KB1 protein CTD PMID:25044443 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO beta-thujaplicin results in decreased expression of SQSTM1 protein CTD PMID:25044443 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        antimicrobial agent 17400
          antibacterial agent 13566
            beta-thujaplicin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    main group molecular entity 19708
                      s-block molecular entity 19493
                        hydrogen molecular entity 19488
                          hydrides 18845
                            organic hydride 18354
                              organic fundamental parent 18354
                                hydrocarbon 18065
                                  olefin 5478
                                    cyclic olefin 108
                                      monocyclic olefin 105
                                        cycloalkatriene 5
                                          cycloheptatriene 5
                                            cyclohepta-1,3,5-triene 5
                                              beta-thujaplicin 4
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