Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Genetic Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS
Term:beta-lapachone
go back to main search page
Accession:CHEBI:10429 term browser browse the term
Definition:A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.
Synonyms:exact_synonym: 2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione
 related_synonym: 3,4-dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione;   ARQ 501;   Formula=C15H14O3;   InChI=1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6H,7-8H2,1-2H3;   InChIKey=QZPQTZZNNJUOLS-UHFFFAOYSA-N;   SMILES=CC1(C)CCC2=C(O1)c1ccccc1C(=O)C2=O;   beta-lap
 alt_id: CHEBI:66546
 xref: CAS:4707-32-8 "ChemIDplus";   CAS:4707-32-8 "KEGG COMPOUND";   KEGG:C10367;   KNApSAcK:C00002836
 xref_mesh: MESH:C014638
 xref: PMID:16822200 "Europe PMC";   PMID:16891723 "Europe PMC";   PMID:18180274 "Europe PMC";   PMID:18227145 "Europe PMC";   PMID:18424157 "Europe PMC";   PMID:18706870 "Europe PMC";   PMID:19051226 "Europe PMC";   PMID:22560628 "Europe PMC";   PMID:22736525 "Europe PMC";   PMID:23010281 "Europe PMC";   PMID:23071729 "Europe PMC";   PMID:23865001 "Europe PMC";   PMID:25448047 "Europe PMC";   PMID:26328485 "Europe PMC";   PMID:3652040 "Europe PMC";   PMID:6704108 "Europe PMC";   Reaxys:181499 "Reaxys"

show annotations for term's descendants       view all columns           Sort by:
 
beta-lapachone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atg7 autophagy related 7 JBrowse link 4 146,570,113 146,777,093 RGD:6480464
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Map1lc3b microtubule-associated protein 1 light chain 3 beta JBrowse link 19 53,635,449 53,643,970 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        anti-inflammatory agent 14907
          beta-lapachone 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      ketone 15789
                                        cyclic ketone 13094
                                          quinone 8224
                                            orthoquinones 83
                                              beta-lapachone 6
paths to the root

Contact Us |  About Us |  License CC BY 4.0 |  Legal Disclaimer |  © Medical College of Wisconsin
NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.