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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:beta-lapachone
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Accession:CHEBI:10429 term browser browse the term
Definition:A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.
Synonyms:exact_synonym: 2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione
 related_synonym: 3,4-dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione;   ARQ 501;   Formula=C15H14O3;   InChI=1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6H,7-8H2,1-2H3;   InChIKey=QZPQTZZNNJUOLS-UHFFFAOYSA-N;   SMILES=CC1(C)CCC2=C(O1)c1ccccc1C(=O)C2=O;   beta-lap
 alt_id: CHEBI:66546
 xref: CAS:4707-32-8;   KEGG:C10367;   KNApSAcK:C00002836
 xref_mesh: MESH:C014638
 xref: PMID:16822200;   PMID:16891723;   PMID:18180274;   PMID:18227145;   PMID:18424157;   PMID:18706870;   PMID:19051226;   PMID:22560628;   PMID:22736525;   PMID:23010281;   PMID:23071729;   PMID:23865001;   PMID:25448047;   PMID:26328485;   PMID:3652040;   PMID:6704108;   Reaxys:181499


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beta-lapachone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg7 autophagy related 7 affects response to substance ISO ATG7 protein affects the susceptibility to beta-lapachone CTD PMID:21035436 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Becn1 beclin 1 affects response to substance ISO BECN1 protein affects the susceptibility to beta-lapachone CTD PMID:21035436 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO beta-lapachone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GSTP1 mRNA]; beta-lapachone inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] CTD PMID:15313406 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO beta-lapachone affects the localization of and results in increased metabolism of MAP1LC3B protein CTD PMID:21035436 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases reduction ISO NQO1 protein results in increased reduction of beta-lapachone CTD PMID:24552538 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO beta-lapachone inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] CTD PMID:15313406 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        anti-inflammatory agent 14950
          beta-lapachone 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      ketone 16144
                                        cyclic ketone 13813
                                          quinone 8338
                                            orthoquinones 84
                                              beta-lapachone 6
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