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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:beta-lapachone
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Accession:CHEBI:10429 term browser browse the term
Definition:A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.
Synonyms:exact_synonym: 2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione
 related_synonym: 3,4-dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione;   ARQ 501;   Formula=C15H14O3;   InChI=1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6H,7-8H2,1-2H3;   InChIKey=QZPQTZZNNJUOLS-UHFFFAOYSA-N;   SMILES=CC1(C)CCC2=C(O1)c1ccccc1C(=O)C2=O;   beta-lap
 alt_id: CHEBI:66546
 xref: CAS:4707-32-8;   KEGG:C10367;   KNApSAcK:C00002836
 xref_mesh: MESH:C014638
 xref: PMID:16822200;   PMID:16891723;   PMID:18180274;   PMID:18227145;   PMID:18424157;   PMID:18706870;   PMID:19051226;   PMID:22560628;   PMID:22736525;   PMID:23010281;   PMID:23071729;   PMID:23865001;   PMID:25448047;   PMID:26328485;   PMID:3652040;   PMID:6704108;   Reaxys:181499



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beta-lapachone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg7 autophagy related 7 affects response to substance ISO ATG7 protein affects the susceptibility to beta-lapachone CTD PMID:21035436 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
G Becn1 beclin 1 affects response to substance ISO BECN1 protein affects the susceptibility to beta-lapachone CTD PMID:21035436 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO beta-lapachone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GSTP1 mRNA]; beta-lapachone inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] CTD PMID:15313406 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO beta-lapachone affects the localization of and results in increased metabolism of MAP1LC3B protein CTD PMID:21035436 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases reduction ISO NQO1 protein results in increased reduction of beta-lapachone CTD PMID:24552538 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO beta-lapachone inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] CTD PMID:15313406 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

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  CHEBI ontology 19808
    role 19757
      application 19467
        anti-inflammatory agent 15834
          beta-lapachone 6
Path 2
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  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            organic group 18725
                              organic divalent group 18716
                                organodiyl group 18716
                                  carbonyl group 18664
                                    carbonyl compound 18664
                                      ketone 16925
                                        cyclic ketone 15395
                                          quinone 8377
                                            orthoquinones 87
                                              beta-lapachone 6
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