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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulfisoxazole
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Accession:CHEBI:102484 term browser browse the term
Definition:A sulfonamide antibacterial with an oxazole substituent. It has antibiotic activity against a wide range of gram-negative and gram-positive organisms.
Synonyms:exact_synonym: 4-amino-N-(3,4-dimethylisoxazol-5-yl)benzenesulfonamide
 related_synonym: 3,4-Dimethyl-5-sulfanilamidoisoxazole;   3,4-Dimethyl-5-sulfonamidoisoxazole;   3,4-Dimethyl-5-sulphanilamidoisoxazole;   3,4-Dimethyl-5-sulphonamidoisoxazole;   3,4-Dimethylisoxazole-5-sulfanilamide;   3,4-Dimethylisoxazole-5-sulphanilamide;   4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide;   4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulphonamide;   5-(4-Aminophenylsulfonamido)-3,4-dimethylisoxazole;   5-(p-Aminobenzenesulfonamido)-3,4-dimethylisoxazole;   5-(p-Aminobenzenesulphonamido)-3,4-dimethylisoxazole;   5-Sulfanilamido-3,4-dimethylisoxazole;   5-Sulphanilamido-3,4-dimethyl-isoxazole;   Formula=C11H13N3O3S;   InChI=1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6,14H,12H2,1-2H3;   InChIKey=NHUHCSRWZMLRLA-UHFFFAOYSA-N;   N'-(3,4)Dimethylisoxazol-5-yl-sulphanilamide;   N(1)-(3,4-dimethyl-5-isoxazolyl)sulfanilamide;   N(1)-(3,4-dimethyl-5-isoxazolyl)sulphanilamide;   SMILES=Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C;   Sulfadimethylisoxazole;   Sulfafurazol;   Sulfaisoxazole;   Sulfasoxazole;   Sulfisonazole;   Sulfisoxasole;   Sulfisoxazol;   Sulfofurazole;   Sulphadimethylisoxazole;   Sulphafurazol;   Sulphafurazole;   Sulphaisoxazole;   Sulphisoxazol;   Sulphofurazole;   sulfafurazole;   sulfafurazolum
 alt_id: CHEBI:9343
 xref: Beilstein:263871;   CAS:127-69-5;   DrugBank:DB00263;   Drug_Central:2529;   Gmelin:864477;   KEGG:C07318;   KEGG:D00450;   LINCS:LSM-3120
 xref_mesh: MESH:D013444
 xref: PMID:1861917;   PMID:4960234;   PMID:7356572;   Patent:US2430094;   Wikipedia:Sulfisoxazole



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sulfisoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO Sulfisoxazole inhibits the reaction [Bilirubin binds to ALB protein] CTD PMID:21280114 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO Sulfisoxazole results in increased expression of CYP3A4 mRNA
Sulfisoxazole results in increased expression of and results in increased activity of CYP3A4 protein
CTD PMID:18505790 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Hmbs hydroxymethylbilane synthase decreases activity EXP Sulfisoxazole decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Sulfisoxazole results in decreased activity of PON1 protein CTD PMID:28665493 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Sulfisoxazole results in increased expression of SRXN1 mRNA CTD PMID:22003191 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        antimicrobial agent 17472
          sulfonamide antibiotic 253
            sulfisoxazole 5
              sulfisoxazole diolamine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    main group molecular entity 19698
                      s-block molecular entity 19479
                        hydrogen molecular entity 19471
                          hydrides 18834
                            inorganic hydride 17691
                              pnictogen hydride 17671
                                nitrogen hydride 17543
                                  azane 17278
                                    ammonia 17277
                                      organic amino compound 17277
                                        aromatic amine 13710
                                          anilines 12382
                                            substituted aniline 11855
                                              sulfanilamide 248
                                                sulfisoxazole 5
                                                  sulfisoxazole diolamine 0
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