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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulfisoxazole
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Accession:CHEBI:102484 term browser browse the term
Definition:A sulfonamide antibacterial with an oxazole substituent. It has antibiotic activity against a wide range of gram-negative and gram-positive organisms.
Synonyms:exact_synonym: 4-amino-N-(3,4-dimethylisoxazol-5-yl)benzenesulfonamide
 related_synonym: 3,4-Dimethyl-5-sulfanilamidoisoxazole;   3,4-Dimethyl-5-sulfonamidoisoxazole;   3,4-Dimethyl-5-sulphanilamidoisoxazole;   3,4-Dimethyl-5-sulphonamidoisoxazole;   3,4-Dimethylisoxazole-5-sulfanilamide;   3,4-Dimethylisoxazole-5-sulphanilamide;   4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide;   4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulphonamide;   5-(4-Aminophenylsulfonamido)-3,4-dimethylisoxazole;   5-(p-Aminobenzenesulfonamido)-3,4-dimethylisoxazole;   5-(p-Aminobenzenesulphonamido)-3,4-dimethylisoxazole;   5-Sulfanilamido-3,4-dimethylisoxazole;   5-Sulphanilamido-3,4-dimethyl-isoxazole;   Formula=C11H13N3O3S;   InChI=1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6,14H,12H2,1-2H3;   InChIKey=NHUHCSRWZMLRLA-UHFFFAOYSA-N;   N'-(3,4)Dimethylisoxazol-5-yl-sulphanilamide;   N(1)-(3,4-dimethyl-5-isoxazolyl)sulfanilamide;   N(1)-(3,4-dimethyl-5-isoxazolyl)sulphanilamide;   SMILES=Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C;   Sulfadimethylisoxazole;   Sulfafurazol;   Sulfaisoxazole;   Sulfasoxazole;   Sulfisonazole;   Sulfisoxasole;   Sulfisoxazol;   Sulfofurazole;   Sulphadimethylisoxazole;   Sulphafurazol;   Sulphafurazole;   Sulphaisoxazole;   Sulphisoxazol;   Sulphofurazole;   sulfafurazole;   sulfafurazolum
 alt_id: CHEBI:9343
 xref: Beilstein:263871;   CAS:127-69-5;   DrugBank:DB00263;   Drug_Central:2529;   Gmelin:864477;   KEGG:C07318;   KEGG:D00450;   LINCS:LSM-3120
 xref_mesh: MESH:D013444
 xref: PMID:1861917;   PMID:4960234;   PMID:7356572;   Patent:US2430094;   Wikipedia:Sulfisoxazole


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sulfisoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO Sulfisoxazole inhibits the reaction [Bilirubin binds to ALB protein] CTD PMID:21280114 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases expression
multiple interactions
ISO Sulfisoxazole results in increased expression of CYP3A4 mRNA
Sulfisoxazole results in increased expression of and results in increased activity of CYP3A4 protein
CTD PMID:18505790 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Hmbs hydroxymethylbilane synthase decreases activity EXP Sulfisoxazole decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Sulfisoxazole results in decreased activity of PON1 protein CTD PMID:28665493 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Sulfisoxazole results in increased expression of SRXN1 mRNA CTD PMID:22003191 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      biological role 19825
        antimicrobial agent 17409
          sulfonamide antibiotic 251
            sulfisoxazole 5
              sulfisoxazole diolamine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    main group molecular entity 19763
                      s-block molecular entity 19511
                        hydrogen molecular entity 19503
                          hydrides 18775
                            inorganic hydride 17505
                              pnictogen hydride 17478
                                nitrogen hydride 17323
                                  azane 17040
                                    ammonia 17039
                                      organic amino compound 17038
                                        aromatic amine 13691
                                          anilines 12362
                                            substituted aniline 11857
                                              sulfanilamide 246
                                                sulfisoxazole 5
                                                  sulfisoxazole diolamine 0
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