CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: methohexital
Accession: CHEBI:102216
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Definition: A barbiturate, the structure of which is that of barbituric acid substituted at N-1 by a methyl group and at C-5 by allyl and 1-methylpent-2-ynyl groups.
Synonyms: exact_synonym: 1-methyl-5-(1-methylpent-2-yn-1-yl)-5-(prop-2-en-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione
related_synonym: (+-)-5-allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric acid; 5-Allyl-1-methyl-5-(1-methyl-pent-2-ynyl)-pyrimidine-2,4,6-trione; 5-Allyl-5-(3-hexyn-2-yl)-1-methylbarbituric acid; 5-allyl-1-methyl-5-(1-methyl-2-pentynyl)-2,4,6(1H,3H,5H)-pyrimidinetrione; Formula=C14H18N2O3; InChI=1S/C14H18N2O3/c1-5-7-8-10(3)14(9-6-2)11(17)15-13(19)16(4)12(14)18/h6,10H,2,5,9H2,1,3-4H3,(H,15,17,19); InChIKey=NZXKDOXHBHYTKP-UHFFFAOYSA-N; Methohexitalum; Methohexitone; Metohexital; SMILES=CCC#CC(C)C1(CC=C)C(=O)NC(=O)N(C)C1=O; alpha-DL-1-methyl-5-allyl-5-(1'-methylpentyn-2-yl)barbituric acid
alt_id: CHEBI:6833
xref: Beilstein:89964; CAS:151-83-7; DrugBank:DB00474; Drug_Central:1748; KEGG:C07844; KEGG:D04985
xref_mesh: MESH:D008723
xref: PMID:13919899; PMID:20045848; PMID:22330701; PMID:22914630; PMID:22914634; PMID:23164727; PMID:23399487; PMID:23422530; PMID:23813116; PMID:3654008; PMID:6864729; Reaxys:89964; Wikipedia:Methohexital
cyclic_relationship: is_conjugate_acid_of CHEBI:60792
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
Methohexital inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of JUN mRNA]
CTD
PMID:15263067
NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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Kras
KRAS proto-oncogene, GTPase
multiple interactions
ISO
Methohexital inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of KRAS protein]
CTD
PMID:15263067
NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
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Mapk1
mitogen activated protein kinase 1
decreases phosphorylation
ISO
Methohexital results in decreased phosphorylation of MAPK1 protein
CTD
PMID:15263067
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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Mapk3
mitogen activated protein kinase 3
decreases phosphorylation
ISO
Methohexital results in decreased phosphorylation of MAPK3 protein
CTD
PMID:15263067
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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Rac1
Rac family small GTPase 1
multiple interactions
ISO
Methohexital inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of RAC1 protein]
CTD
PMID:15263067
NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
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