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ONTOLOGY REPORT - ANNOTATIONS


Term:methohexital
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Accession:CHEBI:102216 term browser browse the term
Definition:A barbiturate, the structure of which is that of barbituric acid substituted at N-1 by a methyl group and at C-5 by allyl and 1-methylpent-2-ynyl groups.
Synonyms:exact_synonym: 1-methyl-5-(1-methylpent-2-yn-1-yl)-5-(prop-2-en-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione
 related_synonym: (+-)-5-allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric acid;   5-Allyl-1-methyl-5-(1-methyl-pent-2-ynyl)-pyrimidine-2,4,6-trione;   5-Allyl-5-(3-hexyn-2-yl)-1-methylbarbituric acid;   5-allyl-1-methyl-5-(1-methyl-2-pentynyl)-2,4,6(1H,3H,5H)-pyrimidinetrione;   Formula=C14H18N2O3;   InChI=1S/C14H18N2O3/c1-5-7-8-10(3)14(9-6-2)11(17)15-13(19)16(4)12(14)18/h6,10H,2,5,9H2,1,3-4H3,(H,15,17,19);   InChIKey=NZXKDOXHBHYTKP-UHFFFAOYSA-N;   Methohexitalum;   Methohexitone;   Metohexital;   SMILES=CCC#CC(C)C1(CC=C)C(=O)NC(=O)N(C)C1=O;   alpha-DL-1-methyl-5-allyl-5-(1'-methylpentyn-2-yl)barbituric acid
 alt_id: CHEBI:6833
 xref: Beilstein:89964 "Beilstein";   CAS:151-83-7 "ChemIDplus";   CAS:151-83-7 "KEGG COMPOUND";   CAS:151-83-7 "NIST Chemistry WebBook";   DrugBank:DB00474;   Drug_Central:1748 "DrugCentral";   KEGG:C07844;   KEGG:D04985
 xref_mesh: MESH:D008723
 xref: PMID:13919899 "Europe PMC";   PMID:20045848 "Europe PMC";   PMID:22330701 "Europe PMC";   PMID:22914630 "Europe PMC";   PMID:22914634 "Europe PMC";   PMID:23164727 "Europe PMC";   PMID:23399487 "Europe PMC";   PMID:23422530 "Europe PMC";   PMID:23813116 "Europe PMC";   PMID:3654008 "Europe PMC";   PMID:6864729 "ChEMBL";   Reaxys:89964 "Reaxys";   Wikipedia:Methohexital
 cyclic_relationship: is_conjugate_acid_of CHEBI:60792


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methohexital term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19764
    role 19711
      application 19362
        pharmaceutical 19231
          drug 19231
            drug allergen 9766
              methohexital 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19764
    subatomic particle 19762
      composite particle 19762
        hadron 19762
          baryon 19762
            nucleon 19762
              atomic nucleus 19762
                atom 19762
                  main group element atom 19646
                    p-block element atom 19646
                      carbon group element atom 19540
                        carbon atom 19529
                          organic molecular entity 19529
                            organic molecule 19447
                              organic cyclic compound 19207
                                organic heterocyclic compound 18276
                                  organic heteromonocyclic compound 16370
                                    diazines 12138
                                      pyrimidines 11956
                                        pyrimidone 8746
                                          barbiturates 4377
                                            methohexital 5
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.