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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methohexital
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Accession:CHEBI:102216 term browser browse the term
Definition:A barbiturate, the structure of which is that of barbituric acid substituted at N-1 by a methyl group and at C-5 by allyl and 1-methylpent-2-ynyl groups.
Synonyms:exact_synonym: 1-methyl-5-(1-methylpent-2-yn-1-yl)-5-(prop-2-en-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione
 related_synonym: (+-)-5-allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric acid;   5-Allyl-1-methyl-5-(1-methyl-pent-2-ynyl)-pyrimidine-2,4,6-trione;   5-Allyl-5-(3-hexyn-2-yl)-1-methylbarbituric acid;   5-allyl-1-methyl-5-(1-methyl-2-pentynyl)-2,4,6(1H,3H,5H)-pyrimidinetrione;   Formula=C14H18N2O3;   InChI=1S/C14H18N2O3/c1-5-7-8-10(3)14(9-6-2)11(17)15-13(19)16(4)12(14)18/h6,10H,2,5,9H2,1,3-4H3,(H,15,17,19);   InChIKey=NZXKDOXHBHYTKP-UHFFFAOYSA-N;   Methohexitalum;   Methohexitone;   Metohexital;   SMILES=CCC#CC(C)C1(CC=C)C(=O)NC(=O)N(C)C1=O;   alpha-DL-1-methyl-5-allyl-5-(1'-methylpentyn-2-yl)barbituric acid
 alt_id: CHEBI:6833
 xref: Beilstein:89964;   CAS:151-83-7;   DrugBank:DB00474;   Drug_Central:1748;   KEGG:C07844;   KEGG:D04985
 xref_mesh: MESH:D008723
 xref: PMID:13919899;   PMID:20045848;   PMID:22330701;   PMID:22914630;   PMID:22914634;   PMID:23164727;   PMID:23399487;   PMID:23422530;   PMID:23813116;   PMID:3654008;   PMID:6864729;   Reaxys:89964;   Wikipedia:Methohexital
 cyclic_relationship: is_conjugate_acid_of CHEBI:60792


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methohexital term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Methohexital inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of JUN mRNA] CTD PMID:15263067 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO Methohexital inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of KRAS protein] CTD PMID:15263067 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Methohexital results in decreased phosphorylation of MAPK1 protein CTD PMID:15263067 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Methohexital results in decreased phosphorylation of MAPK3 protein CTD PMID:15263067 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO Methohexital inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of RAC1 protein] CTD PMID:15263067 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link

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  CHEBI ontology 19817
    role 19767
      application 19445
        pharmaceutical 19319
          drug 19319
            drug allergen 9932
              methohexital 5
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  CHEBI ontology 19817
    subatomic particle 19815
      composite particle 19815
        hadron 19815
          baryon 19815
            nucleon 19815
              atomic nucleus 19815
                atom 19815
                  main group element atom 19705
                    p-block element atom 19705
                      carbon group element atom 19614
                        carbon atom 19603
                          organic molecular entity 19603
                            organic molecule 19532
                              organic cyclic compound 19348
                                organic heterocyclic compound 18475
                                  organic heteromonocyclic compound 16598
                                    diazines 12207
                                      pyrimidines 12028
                                        pyrimidone 8849
                                          barbiturates 4392
                                            methohexital 5
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