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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thiopental
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Accession:CHEBI:102166 term browser browse the term
Definition:A barbiturate, the structure of which is that of 2-thiobarbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Synonyms:exact_synonym: 5-ethyl-5-(pentan-2-yl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
 related_synonym: 2-Thio-5-ethyl-5-sec-pentylbarbituric acid;   5-Ethyl-5-(1-methyl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione;   Formula=C11H18N2O2S;   InChI=1S/C11H18N2O2S/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16);   InChIKey=IUJDSEJGGMCXSG-UHFFFAOYSA-N;   Penthiobarbital;   Pentothiobarbital;   SMILES=CCCC(C)C1(CC)C(=O)NC(=S)NC1=O;   Thiopentobarbital;   Thiopentobarbitone;   Thiopentobarbituric acid;   Thiopentone
 alt_id: CHEBI:9560
 xref: Beilstein:209361;   CAS:76-75-5;   DrugBank:DB00599;   Drug_Central:2633;   KEGG:C07521
 xref_mesh: MESH:D013874
 xref: PMID:10666006;   PMID:10841799;   PMID:15857133;   PMID:16166909;   PMID:16897573;   PMID:18484074;   PMID:20488867;   PMID:2215478;   PMID:23305916;   PMID:23422796;   PMID:23490495;   PMID:23542731;   PMID:23644730;   PMID:23879844;   PMID:3654008;   PMID:6864729;   PMID:9171876;   PMID:9699097;   Reaxys:209361
 cyclic_relationship: is_conjugate_acid_of CHEBI:61485


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thiopental term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases expression ISO Thiopental results in increased expression of AGT protein CTD PMID:6349867 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I affects response to substance EXP CACNA1I protein affects the susceptibility to Thiopental CTD PMID:15644869 NCBI chr 7:121,521,787...121,619,300
Ensembl chr 7:121,511,097...121,619,283
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Thiopental results in increased activity of CASP3 protein
Thiopental inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]
CTD PMID:16129983 PMID:18218830 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions ISO Thiopental binds to and results in decreased activity of CHRM3 protein; Thiopental inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein] CTD PMID:12456425 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Thiopental affects the reaction [TNF protein results in increased activity of CHUK protein] CTD PMID:12883408 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 affects response to substance ISO GRIA2 protein affects the susceptibility to Thiopental CTD PMID:10551584 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
JBrowse link
G Hsf1 heat shock transcription factor 1 increases phosphorylation
increases activity
ISO Thiopental results in increased phosphorylation of HSF1 protein
Thiopental results in increased activity of HSF1 protein
CTD PMID:18218830 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression ISO Thiopental results in increased expression of HSP90AA1 mRNA CTD PMID:18218830 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO Thiopental results in increased expression of HSPB1 mRNA CTD PMID:18218830 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Thiopental promotes the reaction [IL1B protein results in increased abundance of Nitrites]; Thiopental promotes the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Thiopental promotes the reaction [IL1B protein results in increased expression of NOS2 protein] CTD PMID:9436821 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases secretion ISO Thiopental results in decreased secretion of IL2RA protein CTD PMID:16119599 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thiopental inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of JUN mRNA] CTD PMID:15263067 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases degradation
multiple interactions
ISO Thiopental results in decreased degradation of NFKBIA protein
TNF protein affects the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Thiopental] affects the phosphorylation of NFKBIA protein]
CTD PMID:12883408 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Bicuculline inhibits the reaction [Thiopental inhibits the reaction [Vincristine results in decreased susceptibility to NGF protein]]; Thiopental inhibits the reaction [Vincristine results in decreased susceptibility to NGF protein] CTD PMID:11991087 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Thiopental promotes the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Thiopental promotes the reaction [IL1B protein results in increased expression of NOS2 protein] CTD PMID:9436821 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Npy neuropeptide Y multiple interactions EXP Thiopental inhibits the reaction [Kainic Acid results in increased expression of NPY mRNA] CTD PMID:9427505 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Penk proenkephalin multiple interactions EXP Thiopental inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA] CTD PMID:9427505 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Thiopental affects the reaction [TNF protein results in increased activity of CHUK protein]; TNF protein affects the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Thiopental] affects the phosphorylation of NFKBIA protein] CTD PMID:12883408 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      biological role 19723
        xenobiotic 18396
          thiopental 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19583
                        carbon atom 19573
                          organic molecular entity 19573
                            organic molecule 19505
                              organic cyclic compound 19332
                                organic heterocyclic compound 18519
                                  organic heteromonocyclic compound 16987
                                    diazines 12208
                                      pyrimidines 12030
                                        pyrimidone 8848
                                          barbiturates 4391
                                            2-thiobarbituric acid 18
                                              thiopental 18
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