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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thiopental
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Accession:CHEBI:102166 term browser browse the term
Definition:A barbiturate, the structure of which is that of 2-thiobarbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Synonyms:exact_synonym: 5-ethyl-5-(pentan-2-yl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
 related_synonym: 2-Thio-5-ethyl-5-sec-pentylbarbituric acid;   5-Ethyl-5-(1-methyl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione;   Formula=C11H18N2O2S;   InChI=1S/C11H18N2O2S/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16);   InChIKey=IUJDSEJGGMCXSG-UHFFFAOYSA-N;   Penthiobarbital;   Pentothiobarbital;   SMILES=CCCC(C)C1(CC)C(=O)NC(=S)NC1=O;   Thiopentobarbital;   Thiopentobarbitone;   Thiopentobarbituric acid;   Thiopentone
 alt_id: CHEBI:9560
 xref: Beilstein:209361;   CAS:76-75-5;   DrugBank:DB00599;   Drug_Central:2633;   KEGG:C07521
 xref_mesh: MESH:D013874
 xref: PMID:10666006;   PMID:10841799;   PMID:15857133;   PMID:16166909;   PMID:16897573;   PMID:18484074;   PMID:20488867;   PMID:2215478;   PMID:23305916;   PMID:23422796;   PMID:23490495;   PMID:23542731;   PMID:23644730;   PMID:23879844;   PMID:3654008;   PMID:6864729;   PMID:9171876;   PMID:9699097;   Reaxys:209361
 cyclic_relationship: is_conjugate_acid_of CHEBI:61485



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thiopental term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases expression ISO Thiopental results in increased expression of AGT protein CTD PMID:6349867 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I affects response to substance EXP CACNA1I protein affects the susceptibility to Thiopental CTD PMID:15644869 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Thiopental results in increased activity of CASP3 protein
Thiopental inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]
CTD PMID:16129983 PMID:18218830 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions ISO Thiopental binds to and results in decreased activity of CHRM3 protein; Thiopental inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein] CTD PMID:12456425 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Thiopental affects the reaction [TNF protein results in increased activity of CHUK protein] CTD PMID:12883408 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 affects response to substance ISO GRIA2 protein affects the susceptibility to Thiopental CTD PMID:10551584 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
JBrowse link
G Hsf1 heat shock transcription factor 1 increases phosphorylation
increases activity
ISO Thiopental results in increased phosphorylation of HSF1 protein
Thiopental results in increased activity of HSF1 protein
CTD PMID:18218830 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression ISO Thiopental results in increased expression of HSP90AA1 mRNA CTD PMID:18218830 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO Thiopental results in increased expression of HSPB1 mRNA CTD PMID:18218830 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Thiopental promotes the reaction [IL1B protein results in increased abundance of Nitrites]; Thiopental promotes the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Thiopental promotes the reaction [IL1B protein results in increased expression of NOS2 protein] CTD PMID:9436821 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases secretion ISO Thiopental results in decreased secretion of IL2RA protein CTD PMID:16119599 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thiopental inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of JUN mRNA] CTD PMID:15263067 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases degradation
multiple interactions
ISO Thiopental results in decreased degradation of NFKBIA protein
TNF protein affects the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Thiopental] affects the phosphorylation of NFKBIA protein]
CTD PMID:12883408 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Bicuculline inhibits the reaction [Thiopental inhibits the reaction [Vincristine results in decreased susceptibility to NGF protein]]; Thiopental inhibits the reaction [Vincristine results in decreased susceptibility to NGF protein] CTD PMID:11991087 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Thiopental promotes the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Thiopental promotes the reaction [IL1B protein results in increased expression of NOS2 protein] CTD PMID:9436821 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Npy neuropeptide Y multiple interactions EXP Thiopental inhibits the reaction [Kainic Acid results in increased expression of NPY mRNA] CTD PMID:9427505 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Penk proenkephalin multiple interactions EXP Thiopental inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA] CTD PMID:9427505 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Thiopental affects the reaction [TNF protein results in increased activity of CHUK protein]; TNF protein affects the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Thiopental] affects the phosphorylation of NFKBIA protein] CTD PMID:12883408 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        xenobiotic 18436
          thiopental 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organic heteromonocyclic compound 17120
                                    diazines 12333
                                      pyrimidines 12163
                                        pyrimidone 8879
                                          barbiturates 4394
                                            2-thiobarbituric acid 18
                                              thiopental 18
paths to the root