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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sorbinil
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Accession:CHEBI:102029 term browser browse the term
Definition:An azaspiro compound having a monofluoro-substituted chromane skeleton spiro-linked to an imidazolidinedione ring.
Synonyms:exact_synonym: (4S)-6-fluoro-2,3-dihydro-2'H,5'H-spiro[chromene-4,4'-imidazolidine]-2',5'-dione
 related_synonym: (S)-6-Fluorospiro(chroman-4,4'-imidazolidine)-2',5'-dione;   Formula=C11H9FN2O3;   InChI=1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1;   InChIKey=LXANPKRCLVQAOG-NSHDSACASA-N;   SMILES=Fc1ccc2OCC[C@]3(NC(=O)NC3=O)c2c1;   sorbinilo;   sorbinilum;   sorbinol
 alt_id: CHEBI:45392
 xref: CAS:68367-52-2;   DrugBank:DB02712
 xref_mesh: MESH:C026411
 xref: PDBeChem:SBI;   PMID:10875546;   PMID:10933817;   PMID:11048957;   PMID:11900277;   PMID:18772236;   PMID:19821053;   PMID:20138035;   PMID:20308528;   PMID:20354121;   PMID:21129963;   PMID:29438107;   PMID:7564101;   PMID:7591626;   PMID:8159110;   PMID:8692029;   PMID:9007520;   PMID:9088040;   PMID:9195881;   PMID:9349546;   Patent:DE2821966;   Patent:US4130714;   Reaxys:4297401;   Wikipedia:Sorbinil


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sorbinil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO sorbinil inhibits the reaction [AKR1B1 protein results in increased expression of ACTA2 mRNA] CTD PMID:28137510 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B decreases activity
multiple interactions
ISO sorbinil results in decreased activity of AKR1B1 protein
[sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Reactive Oxygen Species]; [sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone]; [sorbinil results in decreased activity of AKR1B1 protein] which results in decreased susceptibility to Lipopolysaccharides; [sorbinil results in decreased activity of AKR1B1 protein] which results in decreased susceptibility to TNF protein; sorbinil inhibits the reaction [AKR1B1 protein results in decreased expression of CDH1 mRNA]; sorbinil inhibits the reaction [AKR1B1 protein results in increased expression of ACTA2 mRNA]; sorbinil inhibits the reaction [AKR1B1 protein results in increased expression of FN1 mRNA]; sorbinil inhibits the reaction [AKR1B1 protein results in increased expression of FN1 protein]; sorbinil inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK1 protein]; sorbinil inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:21334316 PMID:28137510 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions
decreases activity
ISO sorbinil inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; sorbinil inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]
sorbinil results in decreased activity of AKR1B10 protein
CTD PMID:18325492 PMID:19028477 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 decreases activity EXP sorbinil results in decreased activity of AKR1B8 protein CTD PMID:18845131 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Alb albumin multiple interactions ISO sorbinil inhibits the reaction [[ALB protein binds to Fructosamine] which results in increased secretion of TNF protein] CTD PMID:30682331 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO sorbinil inhibits the reaction [AKR1B1 protein results in decreased expression of CDH1 mRNA] CTD PMID:28137510 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO sorbinil inhibits the reaction [AKR1B1 protein results in increased expression of FN1 mRNA]; sorbinil inhibits the reaction [AKR1B1 protein results in increased expression of FN1 protein] CTD PMID:28137510 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Il6 interleukin 6 multiple interactions ISO sorbinil inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; sorbinil inhibits the reaction [TNF protein results in increased secretion of IL6 protein] CTD PMID:21334316 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO sorbinil inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK1 protein] CTD PMID:28137510 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO sorbinil inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:28137510 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Ngf nerve growth factor multiple interactions EXP sorbinil inhibits the reaction [Streptozocin results in increased expression of NGF mRNA] CTD PMID:9748608 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO sorbinil inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; sorbinil inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] CTD PMID:24021941 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO sorbinil inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]; sorbinil inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein] CTD PMID:24021941 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO sorbinil inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]; sorbinil inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein] CTD PMID:24021941 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP sorbinil inhibits the reaction [Streptozocin results in increased expression of TAC1 mRNA] CTD PMID:9748608 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [sorbinil results in decreased activity of AKR1B1 protein] which results in decreased susceptibility to TNF protein; sorbinil inhibits the reaction [[ALB protein binds to Fructosamine] which results in increased secretion of TNF protein]; sorbinil inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; sorbinil inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; sorbinil inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; sorbinil inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
sorbinil inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; sorbinil inhibits the reaction [Oxygen deficiency results in increased expression of TNF protein]
CTD PMID:21334316 PMID:24021941 PMID:30682331 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO sorbinil inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein] CTD PMID:30682331 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

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  CHEBI ontology 19773
    role 19723
      chemical role 19262
        antioxidant 14255
          sorbinil 17
Path 2
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  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19583
                        carbon atom 19573
                          organic molecular entity 19573
                            organic molecule 19505
                              organic cyclic compound 19332
                                organic heterocyclic compound 18519
                                  oxacycle 17539
                                    benzopyran 10269
                                      1-benzopyran 9991
                                        chromanes 3925
                                          sorbinil 17
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