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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sorbinil
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Accession:CHEBI:102029 term browser browse the term
Definition:An azaspiro compound having a monofluoro-substituted chromane skeleton spiro-linked to an imidazolidinedione ring.
Synonyms:exact_synonym: (4S)-6-fluoro-2,3-dihydro-2'H,5'H-spiro[chromene-4,4'-imidazolidine]-2',5'-dione
 related_synonym: (S)-6-Fluorospiro(chroman-4,4'-imidazolidine)-2',5'-dione;   Formula=C11H9FN2O3;   InChI=1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1;   InChIKey=LXANPKRCLVQAOG-NSHDSACASA-N;   SMILES=Fc1ccc2OCC[C@]3(NC(=O)NC3=O)c2c1;   sorbinilo;   sorbinilum;   sorbinol
 alt_id: CHEBI:45392
 xref: CAS:68367-52-2;   DrugBank:DB02712
 xref_mesh: MESH:C026411
 xref: PDBeChem:SBI;   PMID:10875546;   PMID:10933817;   PMID:11048957;   PMID:11900277;   PMID:18772236;   PMID:19821053;   PMID:20138035;   PMID:20308528;   PMID:20354121;   PMID:21129963;   PMID:29438107;   PMID:7564101;   PMID:7591626;   PMID:8159110;   PMID:8692029;   PMID:9007520;   PMID:9088040;   PMID:9195881;   PMID:9349546;   Patent:DE2821966;   Patent:US4130714;   Reaxys:4297401;   Wikipedia:Sorbinil



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sorbinil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO sorbinil inhibits the reaction [AKR1B1 protein results in increased expression of ACTA2 mRNA] CTD PMID:28137510 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B decreases activity
multiple interactions
ISO sorbinil results in decreased activity of AKR1B1 protein
[sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Reactive Oxygen Species]; [sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone]; [sorbinil results in decreased activity of AKR1B1 protein] which results in decreased susceptibility to Lipopolysaccharides; [sorbinil results in decreased activity of AKR1B1 protein] which results in decreased susceptibility to TNF protein; sorbinil inhibits the reaction [AKR1B1 protein results in decreased expression of CDH1 mRNA]; sorbinil inhibits the reaction [AKR1B1 protein results in increased expression of ACTA2 mRNA]; sorbinil inhibits the reaction [AKR1B1 protein results in increased expression of FN1 mRNA]; sorbinil inhibits the reaction [AKR1B1 protein results in increased expression of FN1 protein]; sorbinil inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK1 protein]; sorbinil inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:21334316 PMID:28137510 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions
decreases activity
ISO sorbinil inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; sorbinil inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]
sorbinil results in decreased activity of AKR1B10 protein
CTD PMID:18325492 PMID:19028477 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 decreases activity EXP sorbinil results in decreased activity of AKR1B8 protein CTD PMID:18845131 NCBI chr 4:62,997,241...63,009,815 JBrowse link
G Alb albumin multiple interactions ISO sorbinil inhibits the reaction [[ALB protein binds to Fructosamine] which results in increased secretion of TNF protein] CTD PMID:30682331 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO sorbinil inhibits the reaction [AKR1B1 protein results in decreased expression of CDH1 mRNA] CTD PMID:28137510 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO sorbinil inhibits the reaction [AKR1B1 protein results in increased expression of FN1 mRNA]; sorbinil inhibits the reaction [AKR1B1 protein results in increased expression of FN1 protein] CTD PMID:28137510 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Il6 interleukin 6 multiple interactions ISO sorbinil inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; sorbinil inhibits the reaction [TNF protein results in increased secretion of IL6 protein] CTD PMID:21334316 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO sorbinil inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK1 protein] CTD PMID:28137510 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO sorbinil inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:28137510 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Ngf nerve growth factor multiple interactions EXP sorbinil inhibits the reaction [Streptozocin results in increased expression of NGF mRNA] CTD PMID:9748608 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO sorbinil inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; sorbinil inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] CTD PMID:24021941 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO sorbinil inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]; sorbinil inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein] CTD PMID:24021941 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO sorbinil inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]; sorbinil inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein] CTD PMID:24021941 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP sorbinil inhibits the reaction [Streptozocin results in increased expression of TAC1 mRNA] CTD PMID:9748608 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [sorbinil results in decreased activity of AKR1B1 protein] which results in decreased susceptibility to TNF protein; sorbinil inhibits the reaction [[ALB protein binds to Fructosamine] which results in increased secretion of TNF protein]; sorbinil inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; sorbinil inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; sorbinil inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; sorbinil inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
sorbinil inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; sorbinil inhibits the reaction [Oxygen deficiency results in increased expression of TNF protein]
CTD PMID:21334316 PMID:24021941 PMID:30682331 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO sorbinil inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein] CTD PMID:30682331 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
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  CHEBI ontology 19800
    role 19751
      chemical role 19320
        antioxidant 14438
          sorbinil 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  oxacycle 17609
                                    benzopyran 11162
                                      1-benzopyran 10903
                                        chromanes 3935
                                          sorbinil 17
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