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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:[6]-Shogaol
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Accession:CHEBI:10138 term browser browse the term
Definition:A monomethoxybenzene that has formula C17H24O3.
Synonyms:related_synonym: Formula=C17H24O3;   InChI=1S/C17H24O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h7-8,10,12-13,19H,3-6,9,11H2,1-2H3/b8-7+;   InChIKey=OQWKEEOHDMUXEO-BQYQJAHWSA-N;   SMILES=CCCCC\\C=C\\C(=O)CCc1ccc(O)c(OC)c1
 xref: CAS:555-66-8;   HMDB:HMDB0137236;   KEGG:C10494;   KNApSAcK:C00002774
 xref_mesh: MESH:C040115


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[6]-Shogaol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression
ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [shogaol results in increased expression of ADIPOQ mRNA]; shogaol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein] CTD PMID:18577375 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO shogaol metabolite results in increased expression of AKR1B10 protein; shogaol results in increased expression of AKR1B10 mRNA; shogaol results in increased expression of AKR1B10 protein CTD PMID:25148906 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein] CTD PMID:18683823 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
affects folding
ISO shogaol results in increased expression of BAX protein
shogaol promotes the reaction [BAX protein binds to BAX protein binds to BAX protein]; shogaol promotes the reaction [BAX protein binds to BAX protein]
shogaol affects the folding of BAX protein
CTD PMID:18384088, PMID:25619640 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO shogaol results in decreased expression of BCL2 protein CTD PMID:18384088 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO shogaol results in decreased expression of BCL2L1 protein CTD PMID:18384088 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression
ISO [shogaol co-treated with Hydrogen Peroxide] results in increased expression of BDNF mRNA; [shogaol co-treated with Hydrogen Peroxide] results in increased expression of BDNF protein; shogaol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BDNF mRNA]
[shogaol results in increased expression of BDNF protein] which results in increased expression of CHAT protein; [shogaol results in increased expression of BDNF protein] which results in increased expression of SLC5A7 protein
CTD PMID:22381256 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [shogaol co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[shogaol co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein]; shogaol results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:18384088, PMID:25619640 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions ISO shogaol results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:18384088 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [shogaol results in decreased expression of CFLAR protein modified form]; CFLAR protein modified form inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]; shogaol promotes the reaction [Cycloheximide results in decreased expression of CFLAR protein modified form]; shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form] CTD PMID:25619640 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Chat choline O-acetyltransferase multiple interactions
increases expression
ISO [shogaol co-treated with Hydrogen Peroxide] results in increased expression of CHAT protein; shogaol inhibits the reaction [Hydrogen Peroxide results in decreased expression of CHAT protein]; staurosporine aglycone inhibits the reaction [[shogaol co-treated with Hydrogen Peroxide] results in increased expression of CHAT protein]
[shogaol results in increased expression of BDNF protein] which results in increased expression of CHAT protein; shogaol results in increased expression of CHAT protein
CTD PMID:22381256 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased expression of CHUK protein] CTD PMID:23899529 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO shogaol results in decreased expression of CTNNB1 mRNA; shogaol results in decreased expression of CTNNB1 protein CTD PMID:27645308 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [shogaol results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [shogaol results in increased expression of DDIT3 protein]
shogaol results in increased expression of DDIT3 mRNA; shogaol results in increased expression of DDIT3 protein
CTD PMID:18384088 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dffa DNA fragmentation factor subunit alpha increases degradation ISO shogaol results in increased degradation of DFFA protein CTD PMID:18384088 NCBI chr 5:165,922,893...165,935,822
Ensembl chr 5:165,922,915...165,935,821
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
increases expression
ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [shogaol results in increased expression of FABP4 mRNA] CTD PMID:18577375 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO shogaol results in increased expression of FAS protein CTD PMID:18384088 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand increases expression ISO shogaol results in increased expression of FASLG protein CTD PMID:18384088 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO shogaol metabolite results in increased expression of FTL protein; shogaol results in increased expression of FTL mRNA; shogaol results in increased expression of FTL protein CTD PMID:25148906 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO shogaol metabolite results in increased expression of GCLC protein; shogaol results in increased expression of GCLC protein
shogaol results in increased expression of GCLC mRNA
NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of GCLC mRNA]
CTD PMID:25148906 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO shogaol metabolite results in increased expression of GCLM protein; shogaol results in increased expression of GCLM protein CTD PMID:25148906 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO shogaol results in increased expression of GDF15 mRNA CTD PMID:25148906 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO shogaol results in increased expression of and results in increased phosphorylation of GSK3B protein CTD PMID:27645308 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO shogaol analog inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AX protein] CTD PMID:23899529 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite results in increased expression of HMOX1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol results in increased expression of HMOX1 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol metabolite results in increased expression of HMOX1 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol results in increased expression of HMOX1 protein]
shogaol analog results in increased expression of HMOX1 protein; shogaol results in increased expression of HMOX1 protein
KEAP1 protein affects the reaction [shogaol analog results in increased expression of HMOX1 protein]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of HMOX1 protein]
shogaol analog results in increased expression of HMOX1 protein; shogaol metabolite results in increased expression of HMOX1 protein; shogaol results in increased expression of HMOX1 mRNA; shogaol results in increased expression of HMOX1 protein
CTD PMID:23899529, PMID:25148906 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased expression of IKBKB protein] CTD PMID:23899529 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO shogaol inhibits the reaction [IL1B protein results in increased expression of PTGES protein] CTD PMID:27645308 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions
increases alkylation
decreases expression
ISO KEAP1 protein affects the reaction [shogaol analog results in increased expression of HMOX1 protein]; KEAP1 protein affects the reaction [shogaol analog results in increased expression of NFE2L2 protein]; KEAP1 protein affects the reaction [shogaol analog results in increased expression of NQO1 protein]
shogaol results in increased alkylation of KEAP1 protein
shogaol metabolite results in decreased expression of KEAP1 protein; shogaol results in decreased expression of KEAP1 protein
CTD PMID:23899529, PMID:25148906 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:18683823 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:18683823 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased secretion of MMP9 protein]; shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA] CTD PMID:23899529 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mt1 metallothionein 1 multiple interactions
increases expression
ISO NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of MT1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of MT1 protein]
shogaol results in increased expression of MT1 mRNA; shogaol results in increased expression of MT1 protein
CTD PMID:25148906 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
affects localization
multiple interactions
ISO shogaol analog results in increased expression of NFE2L2 protein
shogaol affects the localization of NFE2L2 protein
KEAP1 protein affects the reaction [shogaol analog results in increased expression of NFE2L2 protein]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of GCLC mRNA]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of HMOX1 protein]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of MT1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of MT1 protein]
shogaol affects the localization of NFE2L2 protein; shogaol metabolite affects the localization of NFE2L2 protein; shogaol metabolite affects the localization of NFE2L2 protein modified form
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol affects the localization of and results in increased phosphorylation of NFE2L2 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein modified form]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol affects the localization of and results in increased phosphorylation of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein modified form]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol affects the localization of and results in increased phosphorylation of NFE2L2 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein modified form]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein]; shogaol metabolite results in increased expression of and results in increased phosphorylation of NFE2L2 protein; shogaol results in increased expression of and results in increased phosphorylation of NFE2L2 protein
CTD PMID:23899529, PMID:25148906 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO shogaol inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; shogaol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:18683823 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased expression of NFKBIA protein]
shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
CTD PMID:18683823, PMID:23899529 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein]
shogaol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; shogaol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; shogaol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein]
CTD PMID:18683823, PMID:23899529 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO KEAP1 protein affects the reaction [shogaol analog results in increased expression of NQO1 protein] CTD PMID:23899529 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; Acetylcysteine inhibits the reaction [shogaol results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; CFLAR protein modified form inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein] CTD PMID:18384088, PMID:25619640 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO shogaol results in increased activity of PPARG protein CTD PMID:18577375 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptges prostaglandin E synthase multiple interactions
decreases expression
ISO shogaol inhibits the reaction [IL1B protein results in increased expression of PTGES protein]
shogaol results in decreased expression of PTGES mRNA
CTD PMID:27645308 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO shogaol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; shogaol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; shogaol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
CTD PMID:18683823, PMID:23899529 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO shogaol inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; shogaol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]; shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]
shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein]
CTD PMID:18683823, PMID:23899529 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc5a7 solute carrier family 5 member 7 multiple interactions
increases expression
ISO [shogaol co-treated with Hydrogen Peroxide] results in increased expression of SLC5A7 protein; shogaol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SLC5A7 protein]; staurosporine aglycone inhibits the reaction [[shogaol co-treated with Hydrogen Peroxide] results in increased expression of SLC5A7 protein]
[shogaol results in increased expression of BDNF protein] which results in increased expression of SLC5A7 protein; shogaol results in increased expression of SLC5A7 protein
CTD PMID:22381256 NCBI chr 9:5,294,377...5,330,822
Ensembl chr 9:5,294,381...5,330,815
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO shogaol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein] CTD PMID:18577375 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases response to substance
ISO [shogaol co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]; Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[shogaol co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; CFLAR protein modified form inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]; shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]
shogaol results in increased susceptibility to TNFSF10 protein
CTD PMID:25619640 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      molecular entity 19782
        polyatomic entity 19695
          heteroatomic molecular entity 19620
            hydroxides 19066
              organic hydroxy compound 18630
                phenols 18109
                  [6]-Shogaol 45
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      ketone 16140
                                        alpha,beta-unsaturated ketone 8519
                                          enone 8519
                                            [6]-Shogaol 45
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.