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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
gingerol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] |
CTD |
PMID:18385293 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
ISO |
gingerol inhibits the reaction [TNF protein results in decreased expression of ADIPOQ mRNA]; gingerol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein] |
CTD |
PMID:18577375 PMID:21851089 |
|
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
gingerol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:27451028 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
increases expression |
ISO |
gingerol results in increased expression of APAF1 mRNA; gingerol results in increased expression of APAF1 protein |
CTD |
PMID:19481070 |
|
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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G |
Atf2 |
activating transcription factor 2 |
multiple interactions |
ISO |
gingerol inhibits the reaction [TNF protein results in increased phosphorylation of ATF2 protein] |
CTD |
PMID:18577375 |
|
NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [gingerol results in increased expression of BAX protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of BAX protein] gingerol results in increased expression of BAX mRNA; gingerol results in increased expression of BAX protein gingerol inhibits the reaction [hypoxia-reoxygenation increases expression of Bax protein in neural crest-derived cells] |
CTD RGD |
PMID:18030663 PMID:19481070 PMID:25034532 PMID:28249781 PMID:34962339 |
RGD:155882488 |
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO |
gingerol results in decreased expression of BCL2 mRNA; gingerol results in decreased expression of BCL2 protein [gingerol co-treated with Hydrogen Peroxide] results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BCL2 protein]; gingerol inhibits the reaction [Testosterone results in increased expression of BCL2 protein] gingerol inhibits the reaction [hypoxia-reoxygenation decreases expression of Bcl2 protein in neural crest-derived cells] |
CTD RGD |
PMID:18030663 PMID:19481070 PMID:25034532 PMID:27451028 PMID:28249781 PMID:34962339 More...
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RGD:155882488 |
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
ISO |
gingerol inhibits the reaction [hypoxia-reoxygenation decreases expression of Bdnf protein in neural crest-derived cells] |
RGD |
PMID:34962339 |
RGD:155882488 |
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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|
G |
Becn1 |
beclin 1 |
multiple interactions |
ISO |
[gingerol co-treated with Hydrogen Peroxide] results in increased expression of BECN1 protein |
CTD |
PMID:27451028 |
|
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Bid |
BH3 interacting domain death agonist |
multiple interactions decreases expression |
ISO |
Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BID protein] |
CTD |
PMID:25034532 |
|
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions decreases expression |
ISO |
Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BIRC5 protein]; gingerol inhibits the reaction [Testosterone results in increased expression of BIRC5 protein] |
CTD |
PMID:18030663 PMID:25034532 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Casp3 |
caspase 3 |
increases expression multiple interactions affects activity increases cleavage |
ISO EXP |
gingerol results in increased expression of CASP3 mRNA; gingerol results in increased expression of CASP3 protein [TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of CASP3 protein] gingerol affects the activity of CASP3 protein gingerol inhibits the reaction [Dextran Sulfate results in increased activity of CASP3 protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of CASP3 protein] gingerol inhibits the reaction [Chlorpyrifos results in increased activity of CASP3 protein] gingerol results in increased cleavage of CASP3 protein |
CTD |
PMID:17454143 PMID:18030663 PMID:19481070 PMID:25034532 PMID:28249781 PMID:28373059 PMID:28421826 More...
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|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
multiple interactions affects activity increases cleavage |
ISO |
[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein] gingerol affects the activity of CASP8 protein gingerol results in increased cleavage of CASP8 protein |
CTD |
PMID:17454143 PMID:25034532 PMID:28249781 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases expression affects activity multiple interactions increases cleavage |
ISO |
gingerol results in increased expression of CASP9 mRNA; gingerol results in increased expression of CASP9 protein gingerol affects the activity of CASP9 protein gingerol inhibits the reaction [Testosterone results in decreased expression of CASP9 protein] gingerol results in increased cleavage of CASP9 protein |
CTD |
PMID:17454143 PMID:18030663 PMID:19481070 PMID:28249781 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions |
ISO EXP |
gingerol inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]; gingerol inhibits the reaction [Dextran Sulfate results in decreased activity of CAT protein]; gingerol inhibits the reaction [sodium arsenite results in decreased activity of CAT protein] gingerol inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein] |
CTD |
PMID:22285432 PMID:28373059 PMID:28421826 PMID:31004597 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
gingerol results in decreased expression of CCNB1 mRNA; gingerol results in decreased expression of CCNB1 protein |
CTD |
PMID:28249781 |
|
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnd1 |
cyclin D1 |
multiple interactions decreases expression increases expression |
ISO |
[gingerol co-treated with Cycloheximide] results in increased degradation of CCND1 protein gingerol results in decreased expression of CCND1 mRNA; gingerol results in decreased expression of CCND1 protein gingerol results in increased expression of CCND1 mRNA; gingerol results in increased expression of CCND1 protein |
CTD |
PMID:18058799 PMID:26498061 PMID:28249781 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccne1 |
cyclin E1 |
decreases expression |
ISO |
gingerol results in decreased expression of CCNE1 mRNA; gingerol results in decreased expression of CCNE1 protein |
CTD |
PMID:28249781 |
|
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases expression |
ISO |
gingerol results in decreased expression of CDK1 mRNA |
CTD |
PMID:28249781 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdk4 |
cyclin-dependent kinase 4 |
decreases expression |
ISO |
gingerol results in decreased expression of CDK4 protein |
CTD |
PMID:18058799 |
|
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
decreases expression |
ISO |
gingerol results in decreased expression of CDKN1A mRNA |
CTD |
PMID:28249781 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
decreases expression |
ISO |
gingerol results in decreased expression of CDKN1B mRNA |
CTD |
PMID:28249781 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
decreases expression multiple interactions |
ISO |
gingerol results in decreased expression of CEBPA mRNA; gingerol results in decreased expression of CEBPA protein GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA protein] |
CTD |
PMID:26498061 |
|
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
multiple interactions decreases expression |
ISO |
Acetylcysteine inhibits the reaction [gingerol results in decreased expression of CFLAR protein] |
CTD |
PMID:25034532 |
|
NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
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G |
Chek2 |
checkpoint kinase 2 |
multiple interactions |
ISO |
gingerol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of CHEK2 protein] |
CTD |
PMID:28988496 |
|
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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G |
Ctnnb1 |
catenin beta 1 |
affects localization multiple interactions increases expression |
ISO |
gingerol affects the localization of CTNNB1 protein gingerol promotes the reaction [IL1B protein results in increased expression of CTNNB1 protein] gingerol results in increased expression of and affects the localization of CTNNB1 protein gingerol results in increased expression of CTNNB1 mRNA |
CTD |
PMID:18058799 PMID:26498061 PMID:27645308 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
increases response to substance |
ISO |
CYP2C19 mRNA results in increased susceptibility to gingerol |
CTD |
PMID:29555536 |
|
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
gingerol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] |
CTD |
PMID:18385293 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Dusp10 |
dual specificity phosphatase 10 |
increases expression |
ISO |
gingerol results in increased expression of DUSP10 mRNA |
CTD |
PMID:17151092 |
|
NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
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G |
Dvl2 |
dishevelled segment polarity protein 2 |
increases expression |
ISO |
gingerol results in increased expression of DVL2 mRNA |
CTD |
PMID:26498061 |
|
NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820
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G |
Fas |
Fas cell surface death receptor |
affects activity |
ISO |
gingerol affects the activity of FAS protein |
CTD |
PMID:17454143 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Fasn |
fatty acid synthase |
decreases expression |
ISO |
gingerol results in decreased expression of FASN mRNA; gingerol results in decreased expression of FASN protein |
CTD |
PMID:26498061 |
|
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
ISO |
gingerol inhibits the reaction [Glucose results in increased secretion of FN1 protein] |
CTD |
PMID:21829520 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
ISO |
gingerol inhibits the reaction [Dextran Sulfate results in decreased expression of FSHB protein] |
CTD |
PMID:28421826 |
|
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
Gdf15 |
growth differentiation factor 15 |
increases expression multiple interactions |
ISO |
gingerol results in increased expression of GDF15 mRNA; gingerol results in increased expression of GDF15 protein GSK3B protein affects the reaction [gingerol results in increased expression of GDF15 protein]; PRKCE protein affects the reaction [gingerol results in increased expression of GDF15 protein]; Ro 31-8220 inhibits the reaction [gingerol results in increased expression of GDF15 protein] |
CTD |
PMID:18058799 |
|
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions increases expression increases phosphorylation increases response to substance |
ISO |
gingerol inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; gingerol inhibits the reaction [IL1B protein results in increased phosphorylation of GSK3B protein]; GSK3B protein affects the reaction [gingerol results in increased expression of GDF15 protein] gingerol results in increased expression of GSK3B protein gingerol results in increased phosphorylation of GSK3B protein GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA protein]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG protein] GSK3B protein results in increased susceptibility to gingerol |
CTD |
PMID:18058799 PMID:26498061 PMID:27645308 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of HIF1A mRNA] |
CTD |
PMID:21382473 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Htr3a |
5-hydroxytryptamine receptor 3A |
decreases activity |
ISO |
gingerol results in decreased activity of HTR3A protein |
CTD |
PMID:26456648 |
|
NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
gingerol inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; gingerol inhibits the reaction [IL1B protein results in increased phosphorylation of GSK3B protein]; gingerol promotes the reaction [IL1B protein results in increased expression of CTNNB1 protein] gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B protein]; gingerol inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein] |
CTD |
PMID:27645308 PMID:28421826 PMID:31004597 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
gingerol inhibits the reaction [sodium arsenite results in increased expression of IL6 mRNA] |
CTD |
PMID:22285432 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Ins1 |
insulin 1 |
multiple interactions |
ISO |
gingerol inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of INS1 protein]; gingerol inhibits the reaction [sodium arsenite results in decreased secretion of INS1 protein] |
CTD |
PMID:21851089 PMID:22285432 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Irs1 |
insulin receptor substrate 1 |
multiple interactions |
ISO |
gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 protein] |
CTD |
PMID:22285432 |
|
NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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G |
Irs2 |
insulin receptor substrate 2 |
multiple interactions |
ISO |
gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 protein] |
CTD |
PMID:22285432 |
|
NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
gingerol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein] |
CTD |
PMID:18577375 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Klkb1 |
kallikrein B1 |
multiple interactions decreases expression |
ISO |
gingerol inhibits the reaction [Testosterone results in increased expression of KLKB1 protein] gingerol results in decreased expression of KLKB1 protein |
CTD |
PMID:18030663 |
|
NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053
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G |
Lats1 |
large tumor suppressor kinase 1 |
increases expression |
ISO |
gingerol results in increased expression of LATS1 protein |
CTD |
PMID:32926756 |
|
NCBI chr 1:2,160,411...2,193,640
Ensembl chr 1:2,160,411...2,193,640
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G |
Ldhc |
lactate dehydrogenase C |
multiple interactions |
ISO |
gingerol inhibits the reaction [Dextran Sulfate results in increased activity of LDHC protein] |
CTD |
PMID:28421826 |
|
NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378
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G |
Lep |
leptin |
multiple interactions |
ISO |
gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA]; gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP protein] |
CTD |
PMID:21851089 |
|
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
ISO |
gingerol inhibits the reaction [Dextran Sulfate results in decreased expression of LHB protein] |
CTD |
PMID:28421826 |
|
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G |
Lrp6 |
LDL receptor related protein 6 |
increases expression |
ISO |
gingerol results in increased expression of LRP6 mRNA |
CTD |
PMID:26498061 |
|
NCBI chr 4:167,269,856...167,400,364
Ensembl chr 4:167,270,353...167,400,497
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions |
ISO |
[gingerol co-treated with Hydrogen Peroxide] results in increased expression of MAP1LC3B protein modified form |
CTD |
PMID:27451028 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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|
G |
Map2k4 |
mitogen activated protein kinase kinase 4 |
multiple interactions |
ISO |
gingerol inhibits the reaction [TNF protein results in increased phosphorylation of MAP2K4 protein] |
CTD |
PMID:18577375 |
|
NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
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|
G |
Mir210 |
microRNA 210 |
multiple interactions |
ISO |
gingerol inhibits the reaction [hypoxia-reoxygenation increases expression of Mir210 miRNA in neural crest-derived cells] |
RGD |
PMID:34962339 |
RGD:155882488 |
NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454
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|
G |
Mmp2 |
matrix metallopeptidase 2 |
decreases expression decreases activity multiple interactions |
ISO |
gingerol results in decreased expression of MMP2 mRNA; gingerol results in decreased expression of MMP2 protein gingerol results in decreased activity of MMP2 protein gingerol inhibits the reaction [YAP1 protein results in increased expression of MMP2 protein] |
CTD |
PMID:17683926 PMID:32926756 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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|
G |
Mmp9 |
matrix metallopeptidase 9 |
decreases expression decreases activity |
ISO |
gingerol results in decreased expression of MMP9 mRNA gingerol results in decreased activity of MMP9 protein |
CTD |
PMID:17683926 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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|
G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP ISO |
gingerol inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein] gingerol inhibits the reaction [Benzo(a)pyrene results in increased activity of MPO protein]; gingerol inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein] |
CTD |
PMID:28373059 PMID:28421826 PMID:31004597 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions decreases expression |
ISO |
gingerol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MTOR protein] gingerol results in decreased expression of MTOR protein modified form |
CTD |
PMID:27451028 PMID:28249781 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
gingerol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] |
CTD |
PMID:18683823 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
gingerol affects the phosphorylation of and affects the activity of NFKBIA protein |
CTD |
PMID:17454143 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein]; gingerol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; gingerol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; gingerol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] |
CTD |
PMID:18683823 PMID:31004597 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
[TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein] |
CTD |
PMID:25034532 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions decreases expression |
ISO |
gingerol inhibits the reaction [sodium arsenite results in decreased expression of PPARG mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of PPARG protein]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG protein] gingerol results in decreased expression of PPARG mRNA; gingerol results in decreased expression of PPARG protein |
CTD |
PMID:22285432 PMID:26498061 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Prkce |
protein kinase C, epsilon |
multiple interactions |
ISO |
PRKCE protein affects the reaction [gingerol results in increased expression of GDF15 protein] |
CTD |
PMID:18058799 |
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NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
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G |
Ptges |
prostaglandin E synthase |
decreases expression increases expression |
ISO |
gingerol results in decreased expression of PTGES protein gingerol results in increased expression of PTGES mRNA |
CTD |
PMID:27645308 |
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NCBI chr 3:14,177,892...14,189,236
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
affects expression multiple interactions |
ISO |
gingerol affects the expression of PTGS2 mRNA; gingerol affects the expression of PTGS2 protein gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]; gingerol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] |
CTD |
PMID:17454143 PMID:18683823 PMID:31004597 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rb1 |
RB transcriptional corepressor 1 |
decreases phosphorylation |
ISO |
gingerol results in decreased phosphorylation of RB1 protein |
CTD |
PMID:18058799 |
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NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
affects expression affects localization multiple interactions |
ISO |
gingerol affects the expression of RELA protein gingerol affects the localization of RELA protein gingerol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] |
CTD |
PMID:17454143 PMID:18683823 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
decreases expression |
ISO |
gingerol results in decreased expression of RPS6KB1 protein modified form |
CTD |
PMID:28249781 |
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NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions |
ISO |
gingerol inhibits the reaction [sodium arsenite results in decreased expression of SLC2A4 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of SLC2A4 protein] |
CTD |
PMID:22285432 |
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NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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G |
Snai1 |
snail family transcriptional repressor 1 |
multiple interactions |
ISO |
gingerol inhibits the reaction [Glucose results in increased expression of SNAI1 mRNA] |
CTD |
PMID:21829520 |
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NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
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G |
Snai2 |
snail family transcriptional repressor 2 |
decreases expression multiple interactions |
ISO |
gingerol results in decreased expression of SNAI2 protein gingerol inhibits the reaction [YAP1 protein results in increased expression of SNAI2 protein] |
CTD |
PMID:32926756 |
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NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
gingerol inhibits the reaction [Oxygen deficiency results in decreased activity of SOD1 protein]; gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of SOD1 mRNA] |
CTD |
PMID:21382473 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
ISO |
gingerol inhibits the reaction [Oxygen deficiency results in decreased activity of SOD2 protein]; gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of SOD2 mRNA] |
CTD |
PMID:21382473 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF protein]; gingerol inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; gingerol inhibits the reaction [sodium arsenite results in increased expression of TNF mRNA]; gingerol inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; gingerol inhibits the reaction [TNF protein results in decreased expression of ADIPOQ mRNA]; gingerol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of ATF2 protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of MAP2K4 protein] gingerol inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein] |
CTD |
PMID:18577375 PMID:21851089 PMID:22285432 PMID:28373059 PMID:28421826 PMID:31004597 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfsf10 |
TNF superfamily member 10 |
multiple interactions increases response to substance |
ISO |
[gingerol results in increased expression of TP53 protein] which results in increased susceptibility to TNFSF10 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein]; TP53 protein affects the reaction [gingerol results in increased susceptibility to TNFSF10 protein] |
CTD |
PMID:25034532 |
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NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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G |
Tp53 |
tumor protein p53 |
increases expression multiple interactions |
ISO |
gingerol results in increased expression of TP53 protein [gingerol results in increased expression of TP53 protein] which results in increased susceptibility to TNFSF10 protein; [Testosterone co-treated with gingerol] results in increased expression of TP53 protein; gingerol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of TP53 protein]; TP53 protein affects the reaction [gingerol results in increased expression of TNFRSF10B protein]; TP53 protein affects the reaction [gingerol results in increased susceptibility to TNFSF10 protein] gingerol inhibits the reaction [Testosterone results in decreased expression of TRP53 protein] |
CTD |
PMID:18030663 PMID:25034532 PMID:28988496 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Vim |
vimentin |
decreases expression multiple interactions |
ISO |
gingerol results in decreased expression of VIM protein gingerol inhibits the reaction [YAP1 protein results in increased expression of VIM protein] |
CTD |
PMID:32926756 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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G |
Xiap |
X-linked inhibitor of apoptosis |
decreases expression |
ISO |
gingerol results in decreased expression of XIAP protein |
CTD |
PMID:25034532 |
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NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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G |
Yap1 |
Yes1 associated transcriptional regulator |
affects localization multiple interactions |
ISO |
gingerol affects the localization of YAP1 protein [gingerol co-treated with YAP1 protein] results in increased phosphorylation of YAP1 protein; gingerol inhibits the reaction [YAP1 protein results in increased expression of MMP2 protein]; gingerol inhibits the reaction [YAP1 protein results in increased expression of SNAI2 protein]; gingerol inhibits the reaction [YAP1 protein results in increased expression of VIM protein]; gingerol results in decreased expression of and results in increased phosphorylation of YAP1 protein |
CTD |
PMID:32926756 |
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NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010
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