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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
gingerol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] |
CTD |
PMID:18385293 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
ISO |
gingerol inhibits the reaction [TNF protein results in decreased expression of ADIPOQ mRNA]; gingerol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein] |
CTD |
PMID:18577375 PMID:21851089 |
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NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
gingerol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:27451028 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
increases expression |
ISO |
gingerol results in increased expression of APAF1 mRNA; gingerol results in increased expression of APAF1 protein |
CTD |
PMID:19481070 |
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NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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G |
Atf2 |
activating transcription factor 2 |
multiple interactions |
ISO |
gingerol inhibits the reaction [TNF protein results in increased phosphorylation of ATF2 protein] |
CTD |
PMID:18577375 |
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NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [gingerol results in increased expression of BAX protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of BAX protein] gingerol results in increased expression of BAX mRNA; gingerol results in increased expression of BAX protein |
CTD |
PMID:18030663 PMID:19481070 PMID:25034532 PMID:28249781 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO |
gingerol results in decreased expression of BCL2 mRNA; gingerol results in decreased expression of BCL2 protein gingerol inhibits the reaction [Testosterone results in increased expression of BCL2 protein] [gingerol co-treated with Hydrogen Peroxide] results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BCL2 protein]; gingerol inhibits the reaction [Testosterone results in increased expression of BCL2 protein] |
CTD |
PMID:18030663 PMID:19481070 PMID:25034532 PMID:27451028 PMID:28249781 |
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NCBI chr13:22,689,783...22,853,920
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G |
Becn1 |
beclin 1 |
multiple interactions |
ISO |
[gingerol co-treated with Hydrogen Peroxide] results in increased expression of BECN1 protein |
CTD |
PMID:27451028 |
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NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Bid |
BH3 interacting domain death agonist |
multiple interactions decreases expression |
ISO |
Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BID protein] |
CTD |
PMID:25034532 |
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NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions decreases expression |
ISO |
Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BIRC5 protein]; gingerol inhibits the reaction [Testosterone results in increased expression of BIRC5 protein] |
CTD |
PMID:18030663 PMID:25034532 |
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NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Casp3 |
caspase 3 |
increases expression increases cleavage multiple interactions affects activity |
ISO EXP |
gingerol results in increased expression of CASP3 mRNA; gingerol results in increased expression of CASP3 protein gingerol results in increased cleavage of CASP3 protein gingerol inhibits the reaction [Chlorpyrifos results in increased activity of CASP3 protein] gingerol inhibits the reaction [Dextran Sulfate results in increased activity of CASP3 protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of CASP3 protein] gingerol affects the activity of CASP3 protein [TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of CASP3 protein] |
CTD |
PMID:17454143 PMID:18030663 PMID:19481070 PMID:25034532 PMID:28249781 PMID:28373059 PMID:28421826 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
multiple interactions increases cleavage affects activity |
ISO |
[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein] gingerol results in increased cleavage of CASP8 protein gingerol affects the activity of CASP8 protein |
CTD |
PMID:17454143 PMID:25034532 PMID:28249781 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases expression increases cleavage multiple interactions affects activity |
ISO |
gingerol results in increased expression of CASP9 mRNA; gingerol results in increased expression of CASP9 protein gingerol results in increased cleavage of CASP9 protein gingerol inhibits the reaction [Testosterone results in decreased expression of CASP9 protein] gingerol affects the activity of CASP9 protein |
CTD |
PMID:17454143 PMID:18030663 PMID:19481070 PMID:28249781 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions |
ISO EXP |
gingerol inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]; gingerol inhibits the reaction [Dextran Sulfate results in decreased activity of CAT protein]; gingerol inhibits the reaction [sodium arsenite results in decreased activity of CAT protein] gingerol inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein] |
CTD |
PMID:22285432 PMID:28373059 PMID:28421826 PMID:31004597 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
gingerol results in decreased expression of CCNB1 mRNA; gingerol results in decreased expression of CCNB1 protein |
CTD |
PMID:28249781 |
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NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnd1 |
cyclin D1 |
multiple interactions increases expression decreases expression |
ISO |
[gingerol co-treated with Cycloheximide] results in increased degradation of CCND1 protein gingerol results in increased expression of CCND1 mRNA; gingerol results in increased expression of CCND1 protein gingerol results in decreased expression of CCND1 mRNA; gingerol results in decreased expression of CCND1 protein |
CTD |
PMID:18058799 PMID:26498061 PMID:28249781 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccne1 |
cyclin E1 |
decreases expression |
ISO |
gingerol results in decreased expression of CCNE1 mRNA; gingerol results in decreased expression of CCNE1 protein |
CTD |
PMID:28249781 |
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NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases expression |
ISO |
gingerol results in decreased expression of CDK1 mRNA |
CTD |
PMID:28249781 |
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NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdk4 |
cyclin-dependent kinase 4 |
decreases expression |
ISO |
gingerol results in decreased expression of CDK4 protein |
CTD |
PMID:18058799 |
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NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
decreases expression |
ISO |
gingerol results in decreased expression of CDKN1A mRNA |
CTD |
PMID:28249781 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
decreases expression |
ISO |
gingerol results in decreased expression of CDKN1B mRNA |
CTD |
PMID:28249781 |
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NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
decreases expression multiple interactions |
ISO |
gingerol results in decreased expression of CEBPA mRNA; gingerol results in decreased expression of CEBPA protein GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA protein] |
CTD |
PMID:26498061 |
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NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
multiple interactions decreases expression |
ISO |
Acetylcysteine inhibits the reaction [gingerol results in decreased expression of CFLAR protein] |
CTD |
PMID:25034532 |
|
NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
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G |
Chek2 |
checkpoint kinase 2 |
multiple interactions |
ISO |
gingerol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of CHEK2 protein] |
CTD |
PMID:28988496 |
|
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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G |
Ctnnb1 |
catenin beta 1 |
affects localization increases expression multiple interactions |
ISO |
gingerol affects the localization of CTNNB1 protein gingerol results in increased expression of CTNNB1 mRNA gingerol results in increased expression of and affects the localization of CTNNB1 protein gingerol promotes the reaction [IL1B protein results in increased expression of CTNNB1 protein] |
CTD |
PMID:18058799 PMID:26498061 PMID:27645308 |
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NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
increases response to substance |
ISO |
CYP2C19 mRNA results in increased susceptibility to gingerol |
CTD |
PMID:29555536 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
gingerol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] |
CTD |
PMID:18385293 |
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NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G |
Dusp10 |
dual specificity phosphatase 10 |
increases expression |
ISO |
gingerol results in increased expression of DUSP10 mRNA |
CTD |
PMID:17151092 |
|
NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
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G |
Dvl2 |
dishevelled segment polarity protein 2 |
increases expression |
ISO |
gingerol results in increased expression of DVL2 mRNA |
CTD |
PMID:26498061 |
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NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820
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G |
Fas |
Fas cell surface death receptor |
affects activity |
ISO |
gingerol affects the activity of FAS protein |
CTD |
PMID:17454143 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Fasn |
fatty acid synthase |
decreases expression |
ISO |
gingerol results in decreased expression of FASN mRNA; gingerol results in decreased expression of FASN protein |
CTD |
PMID:26498061 |
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NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
ISO |
gingerol inhibits the reaction [Glucose results in increased secretion of FN1 protein] |
CTD |
PMID:21829520 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
ISO |
gingerol inhibits the reaction [Dextran Sulfate results in decreased expression of FSHB protein] |
CTD |
PMID:28421826 |
|
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
Gdf15 |
growth differentiation factor 15 |
increases expression multiple interactions |
ISO |
gingerol results in increased expression of GDF15 mRNA; gingerol results in increased expression of GDF15 protein GSK3B protein affects the reaction [gingerol results in increased expression of GDF15 protein]; PRKCE protein affects the reaction [gingerol results in increased expression of GDF15 protein]; Ro 31-8220 inhibits the reaction [gingerol results in increased expression of GDF15 protein] |
CTD |
PMID:18058799 |
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NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions increases response to substance increases phosphorylation increases expression |
ISO |
gingerol inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; gingerol inhibits the reaction [IL1B protein results in increased phosphorylation of GSK3B protein]; GSK3B protein affects the reaction [gingerol results in increased expression of GDF15 protein] GSK3B protein results in increased susceptibility to gingerol GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA protein]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG protein] gingerol results in increased phosphorylation of GSK3B protein gingerol results in increased expression of GSK3B protein |
CTD |
PMID:18058799 PMID:26498061 PMID:27645308 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of HIF1A mRNA] |
CTD |
PMID:21382473 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Htr3a |
5-hydroxytryptamine receptor 3A |
decreases activity |
ISO |
gingerol results in decreased activity of HTR3A protein |
CTD |
PMID:26456648 |
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NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
gingerol inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; gingerol inhibits the reaction [IL1B protein results in increased phosphorylation of GSK3B protein]; gingerol promotes the reaction [IL1B protein results in increased expression of CTNNB1 protein] gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B protein]; gingerol inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein] |
CTD |
PMID:27645308 PMID:28421826 PMID:31004597 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
gingerol inhibits the reaction [sodium arsenite results in increased expression of IL6 mRNA] |
CTD |
PMID:22285432 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Irs1 |
insulin receptor substrate 1 |
multiple interactions |
ISO |
gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 protein] |
CTD |
PMID:22285432 |
|
NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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G |
Irs2 |
insulin receptor substrate 2 |
multiple interactions |
ISO |
gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 protein] |
CTD |
PMID:22285432 |
|
NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
gingerol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein] |
CTD |
PMID:18577375 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Klkb1 |
kallikrein B1 |
multiple interactions decreases expression |
ISO |
gingerol inhibits the reaction [Testosterone results in increased expression of KLKB1 protein] gingerol results in decreased expression of KLKB1 protein |
CTD |
PMID:18030663 |
|
NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053
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G |
Lats1 |
large tumor suppressor kinase 1 |
increases expression |
ISO |
gingerol results in increased expression of LATS1 protein |
CTD |
PMID:32926756 |
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NCBI chr 1:2,160,411...2,193,640
Ensembl chr 1:2,160,411...2,193,640
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G |
Ldhc |
lactate dehydrogenase C |
multiple interactions |
ISO |
gingerol inhibits the reaction [Dextran Sulfate results in increased activity of LDHC protein] |
CTD |
PMID:28421826 |
|
NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378
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G |
Lep |
leptin |
multiple interactions |
ISO |
gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA]; gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP protein] |
CTD |
PMID:21851089 |
|
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
ISO |
gingerol inhibits the reaction [Dextran Sulfate results in decreased expression of LHB protein] |
CTD |
PMID:28421826 |
|
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G |
Lrp6 |
LDL receptor related protein 6 |
increases expression |
ISO |
gingerol results in increased expression of LRP6 mRNA |
CTD |
PMID:26498061 |
|
NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions |
ISO |
[gingerol co-treated with Hydrogen Peroxide] results in increased expression of MAP1LC3B protein modified form |
CTD |
PMID:27451028 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Map2k4 |
mitogen activated protein kinase kinase 4 |
multiple interactions |
ISO |
gingerol inhibits the reaction [TNF protein results in increased phosphorylation of MAP2K4 protein] |
CTD |
PMID:18577375 |
|
NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
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G |
Mmp2 |
matrix metallopeptidase 2 |
decreases expression multiple interactions decreases activity |
ISO |
gingerol results in decreased expression of MMP2 mRNA; gingerol results in decreased expression of MMP2 protein gingerol inhibits the reaction [YAP1 protein results in increased expression of MMP2 protein] gingerol results in decreased activity of MMP2 protein |
CTD |
PMID:17683926 PMID:32926756 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases expression decreases activity |
ISO |
gingerol results in decreased expression of MMP9 mRNA gingerol results in decreased activity of MMP9 protein |
CTD |
PMID:17683926 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP ISO |
gingerol inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein] gingerol inhibits the reaction [Benzo(a)pyrene results in increased activity of MPO protein]; gingerol inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein] |
CTD |
PMID:28373059 PMID:28421826 PMID:31004597 |
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NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions decreases expression |
ISO |
gingerol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MTOR protein] gingerol results in decreased expression of MTOR protein modified form |
CTD |
PMID:27451028 PMID:28249781 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
gingerol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] |
CTD |
PMID:18683823 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
gingerol affects the phosphorylation of and affects the activity of NFKBIA protein |
CTD |
PMID:17454143 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein]; gingerol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; gingerol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; gingerol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] |
CTD |
PMID:18683823 PMID:31004597 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
[TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein] |
CTD |
PMID:25034532 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions decreases expression |
ISO |
gingerol inhibits the reaction [sodium arsenite results in decreased expression of PPARG mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of PPARG protein]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG protein] gingerol results in decreased expression of PPARG mRNA; gingerol results in decreased expression of PPARG protein |
CTD |
PMID:22285432 PMID:26498061 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Prkce |
protein kinase C, epsilon |
multiple interactions |
ISO |
PRKCE protein affects the reaction [gingerol results in increased expression of GDF15 protein] |
CTD |
PMID:18058799 |
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NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
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G |
Ptges |
prostaglandin E synthase |
decreases expression increases expression |
ISO |
gingerol results in decreased expression of PTGES protein gingerol results in increased expression of PTGES mRNA |
CTD |
PMID:27645308 |
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NCBI chr 3:14,177,892...14,189,236
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
affects expression multiple interactions |
ISO |
gingerol affects the expression of PTGS2 mRNA; gingerol affects the expression of PTGS2 protein gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]; gingerol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] |
CTD |
PMID:17454143 PMID:18683823 PMID:31004597 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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G |
Rb1 |
RB transcriptional corepressor 1 |
decreases phosphorylation |
ISO |
gingerol results in decreased phosphorylation of RB1 protein |
CTD |
PMID:18058799 |
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NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
affects expression multiple interactions affects localization |
ISO |
gingerol affects the expression of RELA protein gingerol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] gingerol affects the localization of RELA protein |
CTD |
PMID:17454143 PMID:18683823 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
decreases expression |
ISO |
gingerol results in decreased expression of RPS6KB1 protein modified form |
CTD |
PMID:28249781 |
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NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions |
ISO |
gingerol inhibits the reaction [sodium arsenite results in decreased expression of SLC2A4 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of SLC2A4 protein] |
CTD |
PMID:22285432 |
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NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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G |
Snai1 |
snail family transcriptional repressor 1 |
multiple interactions |
ISO |
gingerol inhibits the reaction [Glucose results in increased expression of SNAI1 mRNA] |
CTD |
PMID:21829520 |
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NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
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G |
Snai2 |
snail family transcriptional repressor 2 |
decreases expression multiple interactions |
ISO |
gingerol results in decreased expression of SNAI2 protein gingerol inhibits the reaction [YAP1 protein results in increased expression of SNAI2 protein] |
CTD |
PMID:32926756 |
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NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
gingerol inhibits the reaction [Oxygen deficiency results in decreased activity of SOD1 protein]; gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of SOD1 mRNA] |
CTD |
PMID:21382473 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
ISO |
gingerol inhibits the reaction [Oxygen deficiency results in decreased activity of SOD2 protein]; gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of SOD2 mRNA] |
CTD |
PMID:21382473 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF protein]; gingerol inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; gingerol inhibits the reaction [sodium arsenite results in increased expression of TNF mRNA]; gingerol inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; gingerol inhibits the reaction [TNF protein results in decreased expression of ADIPOQ mRNA]; gingerol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of ATF2 protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of MAP2K4 protein] gingerol inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein] |
CTD |
PMID:18577375 PMID:21851089 PMID:22285432 PMID:28373059 PMID:28421826 PMID:31004597 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfsf10 |
TNF superfamily member 10 |
multiple interactions increases response to substance |
ISO |
[gingerol results in increased expression of TP53 protein] which results in increased susceptibility to TNFSF10 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein]; TP53 protein affects the reaction [gingerol results in increased susceptibility to TNFSF10 protein] |
CTD |
PMID:25034532 |
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NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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G |
Tp53 |
tumor protein p53 |
increases expression multiple interactions |
ISO |
gingerol results in increased expression of TP53 protein gingerol inhibits the reaction [Testosterone results in decreased expression of TRP53 protein] [gingerol results in increased expression of TP53 protein] which results in increased susceptibility to TNFSF10 protein; [Testosterone co-treated with gingerol] results in increased expression of TP53 protein; gingerol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of TP53 protein]; TP53 protein affects the reaction [gingerol results in increased expression of TNFRSF10B protein]; TP53 protein affects the reaction [gingerol results in increased susceptibility to TNFSF10 protein] |
CTD |
PMID:18030663 PMID:25034532 PMID:28988496 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Vim |
vimentin |
decreases expression multiple interactions |
ISO |
gingerol results in decreased expression of VIM protein gingerol inhibits the reaction [YAP1 protein results in increased expression of VIM protein] |
CTD |
PMID:32926756 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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G |
Xiap |
X-linked inhibitor of apoptosis |
decreases expression |
ISO |
gingerol results in decreased expression of XIAP protein |
CTD |
PMID:25034532 |
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NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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G |
Yap1 |
Yes1 associated transcriptional regulator |
affects localization multiple interactions |
ISO |
gingerol affects the localization of YAP1 protein [gingerol co-treated with YAP1 protein] results in increased phosphorylation of YAP1 protein; gingerol inhibits the reaction [YAP1 protein results in increased expression of MMP2 protein]; gingerol inhibits the reaction [YAP1 protein results in increased expression of SNAI2 protein]; gingerol inhibits the reaction [YAP1 protein results in increased expression of VIM protein]; gingerol results in decreased expression of and results in increased phosphorylation of YAP1 protein |
CTD |
PMID:32926756 |
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NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010
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