gingerol - Ontology Report - Rat Genome Database

gingerol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]

PMID:18385293

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

Adipoq

adiponectin, C1Q and collagen domain containing

multiple interactions

gingerol inhibits the reaction [TNF protein results in decreased expression of ADIPOQ mRNA]; gingerol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein]

PMID:18577375 PMID:21851089

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

Akt1

AKT serine/threonine kinase 1

multiple interactions

gingerol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]

PMID:27451028

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

Apaf1

apoptotic peptidase activating factor 1

increases expression

gingerol results in increased expression of APAF1 mRNA; gingerol results in increased expression of APAF1 protein

PMID:19481070

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

Atf2

activating transcription factor 2

multiple interactions

gingerol inhibits the reaction [TNF protein results in increased phosphorylation of ATF2 protein]

PMID:18577375

NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236

Bax

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

PMID:18030663 PMID:19481070 PMID:25034532 PMID:28249781 PMID:34962339

Acetylcysteine inhibits the reaction [gingerol results in increased expression of BAX protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of BAX protein]
gingerol results in increased expression of BAX mRNA; gingerol results in increased expression of BAX protein
gingerol inhibits the reaction [hypoxia-reoxygenation increases expression of Bax protein in neural crest-derived cells]

CTD
RGD

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

Bcl2

BCL2, apoptosis regulator

decreases expression
multiple interactions

gingerol results in decreased expression of BCL2 mRNA; gingerol results in decreased expression of BCL2 protein
[gingerol co-treated with Hydrogen Peroxide] results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BCL2 protein]; gingerol inhibits the reaction [Testosterone results in increased expression of BCL2 protein]
gingerol inhibits the reaction [hypoxia-reoxygenation decreases expression of Bcl2 protein in neural crest-derived cells]

CTD
RGD

PMID:18030663 PMID:19481070 PMID:25034532 PMID:27451028 PMID:28249781 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

Bdnf

brain-derived neurotrophic factor

multiple interactions

gingerol inhibits the reaction [hypoxia-reoxygenation decreases expression of Bdnf protein in neural crest-derived cells]

RGD

PMID:34962339

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

Becn1

beclin 1

multiple interactions

[gingerol co-treated with Hydrogen Peroxide] results in increased expression of BECN1 protein

PMID:27451028

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

Bid

BH3 interacting domain death agonist

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BID protein]

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

Birc5

baculoviral IAP repeat-containing 5

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BIRC5 protein]; gingerol inhibits the reaction [Testosterone results in increased expression of BIRC5 protein]

PMID:18030663 PMID:25034532

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

Casp3

caspase 3

increases expression
multiple interactions
affects activity
increases cleavage

ISO
EXP

gingerol results in increased expression of CASP3 mRNA; gingerol results in increased expression of CASP3 protein
[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of CASP3 protein]
gingerol affects the activity of CASP3 protein
gingerol inhibits the reaction [Dextran Sulfate results in increased activity of CASP3 protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of CASP3 protein]
gingerol inhibits the reaction [Chlorpyrifos results in increased activity of CASP3 protein]
gingerol results in increased cleavage of CASP3 protein

PMID:17454143 PMID:18030663 PMID:19481070 PMID:25034532 PMID:28249781 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Casp8

caspase 8

multiple interactions
affects activity
increases cleavage

[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein]
gingerol affects the activity of CASP8 protein
gingerol results in increased cleavage of CASP8 protein

PMID:17454143 PMID:25034532 PMID:28249781

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

Casp9

caspase 9

increases expression
affects activity
multiple interactions
increases cleavage

gingerol results in increased expression of CASP9 mRNA; gingerol results in increased expression of CASP9 protein
gingerol affects the activity of CASP9 protein
gingerol inhibits the reaction [Testosterone results in decreased expression of CASP9 protein]
gingerol results in increased cleavage of CASP9 protein

PMID:17454143 PMID:18030663 PMID:19481070 PMID:28249781

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

Cat

catalase

multiple interactions

ISO
EXP

gingerol inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]; gingerol inhibits the reaction [Dextran Sulfate results in decreased activity of CAT protein]; gingerol inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
gingerol inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]

PMID:22285432 PMID:28373059 PMID:28421826 PMID:31004597

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

Ccnb1

cyclin B1

decreases expression

gingerol results in decreased expression of CCNB1 mRNA; gingerol results in decreased expression of CCNB1 protein

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

Ccnd1

cyclin D1

multiple interactions
decreases expression
increases expression

[gingerol co-treated with Cycloheximide] results in increased degradation of CCND1 protein
gingerol results in decreased expression of CCND1 mRNA; gingerol results in decreased expression of CCND1 protein
gingerol results in increased expression of CCND1 mRNA; gingerol results in increased expression of CCND1 protein

PMID:18058799 PMID:26498061 PMID:28249781

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

Ccne1

cyclin E1

decreases expression

gingerol results in decreased expression of CCNE1 mRNA; gingerol results in decreased expression of CCNE1 protein

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

Cdk1

cyclin-dependent kinase 1

decreases expression

gingerol results in decreased expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

Cdk4

cyclin-dependent kinase 4

decreases expression

gingerol results in decreased expression of CDK4 protein

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

Cdkn1a

cyclin-dependent kinase inhibitor 1A

decreases expression

gingerol results in decreased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

Cdkn1b

cyclin-dependent kinase inhibitor 1B

decreases expression

gingerol results in decreased expression of CDKN1B mRNA

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

Cebpa

CCAAT/enhancer binding protein alpha

decreases expression
multiple interactions

gingerol results in decreased expression of CEBPA mRNA; gingerol results in decreased expression of CEBPA protein
GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA protein]

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

Cflar

CASP8 and FADD-like apoptosis regulator

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [gingerol results in decreased expression of CFLAR protein]

NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034

Chek2

checkpoint kinase 2

multiple interactions

gingerol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of CHEK2 protein]

PMID:28988496

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

Ctnnb1

catenin beta 1

affects localization
multiple interactions
increases expression

gingerol affects the localization of CTNNB1 protein
gingerol promotes the reaction [IL1B protein results in increased expression of CTNNB1 protein]
gingerol results in increased expression of and affects the localization of CTNNB1 protein
gingerol results in increased expression of CTNNB1 mRNA

PMID:18058799 PMID:26498061 PMID:27645308

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

Cyp2c6v1

cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1

increases response to substance

CYP2C19 mRNA results in increased susceptibility to gingerol

PMID:29555536

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

Cyp3a2

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

gingerol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]

PMID:18385293

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

Dusp10

dual specificity phosphatase 10

increases expression

gingerol results in increased expression of DUSP10 mRNA

PMID:17151092

NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716

Dvl2

dishevelled segment polarity protein 2

increases expression

gingerol results in increased expression of DVL2 mRNA

NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820

Fas

Fas cell surface death receptor

affects activity

gingerol affects the activity of FAS protein

PMID:17454143

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

Fasn

fatty acid synthase

decreases expression

gingerol results in decreased expression of FASN mRNA; gingerol results in decreased expression of FASN protein

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

Fn1

fibronectin 1

multiple interactions

gingerol inhibits the reaction [Glucose results in increased secretion of FN1 protein]

PMID:21829520

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

Fshb

follicle stimulating hormone subunit beta

multiple interactions

gingerol inhibits the reaction [Dextran Sulfate results in decreased expression of FSHB protein]

PMID:28421826

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

Gdf15

growth differentiation factor 15

increases expression
multiple interactions

gingerol results in increased expression of GDF15 mRNA; gingerol results in increased expression of GDF15 protein
GSK3B protein affects the reaction [gingerol results in increased expression of GDF15 protein]; PRKCE protein affects the reaction [gingerol results in increased expression of GDF15 protein]; Ro 31-8220 inhibits the reaction [gingerol results in increased expression of GDF15 protein]

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

Gsk3b

glycogen synthase kinase 3 beta

multiple interactions
increases expression
increases phosphorylation
increases response to substance

gingerol inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; gingerol inhibits the reaction [IL1B protein results in increased phosphorylation of GSK3B protein]; GSK3B protein affects the reaction [gingerol results in increased expression of GDF15 protein]
gingerol results in increased expression of GSK3B protein
gingerol results in increased phosphorylation of GSK3B protein
GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA protein]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG protein]
GSK3B protein results in increased susceptibility to gingerol

PMID:18058799 PMID:26498061 PMID:27645308

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

Hif1a

hypoxia inducible factor 1 subunit alpha

multiple interactions

gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of HIF1A mRNA]

PMID:21382473

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

Htr3a

5-hydroxytryptamine receptor 3A

decreases activity

gingerol results in decreased activity of HTR3A protein

PMID:26456648

NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389

Il1b

interleukin 1 beta

multiple interactions

PMID:27645308 PMID:28421826 PMID:31004597

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

Il6

interleukin 6

multiple interactions

gingerol inhibits the reaction [sodium arsenite results in increased expression of IL6 mRNA]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

Ins1

insulin 1

multiple interactions

gingerol inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of INS1 protein]; gingerol inhibits the reaction [sodium arsenite results in decreased secretion of INS1 protein]

PMID:21851089 PMID:22285432

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

Irs1

insulin receptor substrate 1

multiple interactions

gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 protein]

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

Irs2

insulin receptor substrate 2

multiple interactions

gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 protein]

NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482

Jun

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

gingerol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]

PMID:18577375

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

Klkb1

kallikrein B1

multiple interactions
decreases expression

gingerol inhibits the reaction [Testosterone results in increased expression of KLKB1 protein]
gingerol results in decreased expression of KLKB1 protein

PMID:18030663

NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053

Lats1

large tumor suppressor kinase 1

increases expression

gingerol results in increased expression of LATS1 protein

NCBI chr 1:2,160,411...2,193,640
Ensembl chr 1:2,160,411...2,193,640

Ldhc

lactate dehydrogenase C

multiple interactions

gingerol inhibits the reaction [Dextran Sulfate results in increased activity of LDHC protein]

PMID:28421826

NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378

Lep

leptin

multiple interactions

gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA]; gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP protein]

PMID:21851089

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

Lhb

luteinizing hormone subunit beta

multiple interactions

gingerol inhibits the reaction [Dextran Sulfate results in decreased expression of LHB protein]

PMID:28421826

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

Lrp6

LDL receptor related protein 6

increases expression

gingerol results in increased expression of LRP6 mRNA

NCBI chr 4:167,269,856...167,400,364
Ensembl chr 4:167,270,353...167,400,497

Map1lc3b

microtubule-associated protein 1 light chain 3 beta

multiple interactions

[gingerol co-treated with Hydrogen Peroxide] results in increased expression of MAP1LC3B protein modified form

PMID:27451028

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

Map2k4

mitogen activated protein kinase kinase 4

multiple interactions

gingerol inhibits the reaction [TNF protein results in increased phosphorylation of MAP2K4 protein]

PMID:18577375

NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993

Mir210

microRNA 210

multiple interactions

gingerol inhibits the reaction [hypoxia-reoxygenation increases expression of Mir210 miRNA in neural crest-derived cells]

RGD

PMID:34962339

NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454

Mmp2

matrix metallopeptidase 2

decreases expression
decreases activity
multiple interactions

gingerol results in decreased expression of MMP2 mRNA; gingerol results in decreased expression of MMP2 protein
gingerol results in decreased activity of MMP2 protein
gingerol inhibits the reaction [YAP1 protein results in increased expression of MMP2 protein]

PMID:17683926 PMID:32926756

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

Mmp9

matrix metallopeptidase 9

decreases expression
decreases activity

gingerol results in decreased expression of MMP9 mRNA
gingerol results in decreased activity of MMP9 protein

PMID:17683926

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

Mpo

myeloperoxidase

multiple interactions

EXP
ISO

gingerol inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]
gingerol inhibits the reaction [Benzo(a)pyrene results in increased activity of MPO protein]; gingerol inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]

PMID:28373059 PMID:28421826 PMID:31004597

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

Mtor

mechanistic target of rapamycin kinase

multiple interactions
decreases expression

gingerol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MTOR protein]
gingerol results in decreased expression of MTOR protein modified form

PMID:27451028 PMID:28249781

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

Nfkb1

nuclear factor kappa B subunit 1

multiple interactions

gingerol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]

PMID:18683823

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

Nfkbia

NFKB inhibitor alpha

multiple interactions

gingerol affects the phosphorylation of and affects the activity of NFKBIA protein

PMID:17454143

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

Nos2

nitric oxide synthase 2

multiple interactions

gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein]; gingerol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; gingerol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; gingerol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein]

PMID:18683823 PMID:31004597

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

Parp1

poly (ADP-ribose) polymerase 1

multiple interactions

[TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

Pparg

peroxisome proliferator-activated receptor gamma

multiple interactions
decreases expression

gingerol inhibits the reaction [sodium arsenite results in decreased expression of PPARG mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of PPARG protein]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG protein]
gingerol results in decreased expression of PPARG mRNA; gingerol results in decreased expression of PPARG protein

PMID:22285432 PMID:26498061

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

Prkce

protein kinase C, epsilon

multiple interactions

PRKCE protein affects the reaction [gingerol results in increased expression of GDF15 protein]

NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719

Ptges

prostaglandin E synthase

decreases expression
increases expression

gingerol results in decreased expression of PTGES protein
gingerol results in increased expression of PTGES mRNA

PMID:27645308

NCBI chr 3:14,177,892...14,189,236

Ptgs2

prostaglandin-endoperoxide synthase 2

affects expression
multiple interactions

gingerol affects the expression of PTGS2 mRNA; gingerol affects the expression of PTGS2 protein
gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]; gingerol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]

PMID:17454143 PMID:18683823 PMID:31004597

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

Rb1

RB transcriptional corepressor 1

decreases phosphorylation

gingerol results in decreased phosphorylation of RB1 protein

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

Rela

RELA proto-oncogene, NF-kB subunit

affects expression
affects localization
multiple interactions

gingerol affects the expression of RELA protein
gingerol affects the localization of RELA protein
gingerol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]

PMID:17454143 PMID:18683823

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

Rps6kb1

ribosomal protein S6 kinase B1

decreases expression

gingerol results in decreased expression of RPS6KB1 protein modified form

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

Slc2a4

solute carrier family 2 member 4

multiple interactions

gingerol inhibits the reaction [sodium arsenite results in decreased expression of SLC2A4 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of SLC2A4 protein]

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

Snai1

snail family transcriptional repressor 1

multiple interactions

gingerol inhibits the reaction [Glucose results in increased expression of SNAI1 mRNA]

PMID:21829520

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

Snai2

snail family transcriptional repressor 2

decreases expression
multiple interactions

gingerol results in decreased expression of SNAI2 protein
gingerol inhibits the reaction [YAP1 protein results in increased expression of SNAI2 protein]

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

Sod1

superoxide dismutase 1

multiple interactions

gingerol inhibits the reaction [Oxygen deficiency results in decreased activity of SOD1 protein]; gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of SOD1 mRNA]

PMID:21382473

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

Sod2

superoxide dismutase 2

multiple interactions

gingerol inhibits the reaction [Oxygen deficiency results in decreased activity of SOD2 protein]; gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of SOD2 mRNA]

PMID:21382473

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

Tnf

tumor necrosis factor

multiple interactions

ISO
EXP

gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF protein]; gingerol inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; gingerol inhibits the reaction [sodium arsenite results in increased expression of TNF mRNA]; gingerol inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; gingerol inhibits the reaction [TNF protein results in decreased expression of ADIPOQ mRNA]; gingerol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of ATF2 protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of MAP2K4 protein]
gingerol inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]

PMID:18577375 PMID:21851089 PMID:22285432 PMID:28373059 PMID:28421826 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Tnfsf10

TNF superfamily member 10

multiple interactions
increases response to substance

[gingerol results in increased expression of TP53 protein] which results in increased susceptibility to TNFSF10 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein]; TP53 protein affects the reaction [gingerol results in increased susceptibility to TNFSF10 protein]

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

Tp53

tumor protein p53

increases expression
multiple interactions

gingerol results in increased expression of TP53 protein
[gingerol results in increased expression of TP53 protein] which results in increased susceptibility to TNFSF10 protein; [Testosterone co-treated with gingerol] results in increased expression of TP53 protein; gingerol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of TP53 protein]; TP53 protein affects the reaction [gingerol results in increased expression of TNFRSF10B protein]; TP53 protein affects the reaction [gingerol results in increased susceptibility to TNFSF10 protein]
gingerol inhibits the reaction [Testosterone results in decreased expression of TRP53 protein]

PMID:18030663 PMID:25034532 PMID:28988496

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

Vim

vimentin

decreases expression
multiple interactions

gingerol results in decreased expression of VIM protein
gingerol inhibits the reaction [YAP1 protein results in increased expression of VIM protein]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

Xiap

X-linked inhibitor of apoptosis

decreases expression

gingerol results in decreased expression of XIAP protein

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

Yap1

Yes1 associated transcriptional regulator

affects localization
multiple interactions

gingerol affects the localization of YAP1 protein
[gingerol co-treated with YAP1 protein] results in increased phosphorylation of YAP1 protein; gingerol inhibits the reaction [YAP1 protein results in increased expression of MMP2 protein]; gingerol inhibits the reaction [YAP1 protein results in increased expression of SNAI2 protein]; gingerol inhibits the reaction [YAP1 protein results in increased expression of VIM protein]; gingerol results in decreased expression of and results in increased phosphorylation of YAP1 protein