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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:zonisamide
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Accession:CHEBI:10127 term browser browse the term
Definition:A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position.
Synonyms:exact_synonym: 1-(1,2-benzisoxazol-3-yl)methanesulfonamide
 related_synonym: 1,2-Benzisoxazole-3-methanesulfonamide;   3-(Sulfamoylmethyl)-1,2-benzisoxazole;   Benzo[d]isoxazol-3-yl-methanesulfonamide;   Formula=C8H8N2O3S;   InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12);   InChIKey=UBQNRHZMVUUOMG-UHFFFAOYSA-N;   SMILES=NS(=O)(=O)Cc1noc2ccccc12;   zonisamida;   zonisamidum
 alt_id: CHEBI:139857
 xref: Beilstein:1077076;   CAS:68291-97-4;   DrugBank:DB00909;   Drug_Central:2872;   KEGG:C07504;   KEGG:D00538;   LINCS:LSM-3062
 xref_mesh: MESH:C022189
 xref: Patent:JP7877057;   Patent:US4172896;   Wikipedia:Zonisamide


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zonisamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ca3 carbonic anhydrase 3 multiple interactions ISO zonisamide binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Car1 carbonic anhydrase 1 multiple interactions ISO zonisamide binds to and results in decreased activity of CA1 protein CTD PMID:17826101 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO zonisamide binds to and results in decreased activity of CA2 protein CTD PMID:17826101 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions EXP DRD1 protein promotes the reaction [zonisamide affects the secretion of Dopamine]; DRD1 protein promotes the reaction [zonisamide affects the secretion of gamma-Aminobutyric Acid] CTD PMID:19482038 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP zonisamide inhibits the reaction [Tacrine results in increased expression of FOS protein] CTD PMID:18693129 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO zonisamide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GFAP protein] CTD PMID:19199078 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Ifng interferon gamma decreases expression ISO zonisamide results in decreased expression of IFNG protein CTD PMID:10982153 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Maob monoamine oxidase B multiple interactions
decreases activity
ISO zonisamide inhibits the reaction [[MAOB protein results in increased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased chemical synthesis of 1-Methyl-4-phenylpyridinium]; zonisamide inhibits the reaction [Selegiline binds to MAOB protein]
zonisamide results in decreased activity of MAOB protein
CTD PMID:19948168 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP zonisamide results in increased expression of NOS2 mRNA CTD PMID:12429386 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Slc1a1 solute carrier family 1 member 1 increases expression EXP zonisamide results in increased expression of SLC1A1 protein CTD PMID:12941455 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
JBrowse link
G Th tyrosine hydroxylase increases expression
multiple interactions
ISO Zonisamide results in increased expression of TH mRNA; Zonisamide results in increased expression of TH protein
zonisamide results in increased expression of TH protein
[zonisamide co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] affects the activity of TH protein; zonisamide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]
CTD PMID:19199078 PMID:19948168 PMID:20196486 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link

Term paths to the root
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  CHEBI ontology 19786
    role 19732
      chemical role 19281
        antioxidant 14389
          zonisamide 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19596
                        carbon atom 19586
                          organic molecular entity 19586
                            organic molecule 19519
                              organic cyclic compound 19349
                                organic heterocyclic compound 18574
                                  organic heteropolycyclic compound 18065
                                    organic heterobicyclic compound 16858
                                      benzoxazole 115
                                        benzisoxazole 74
                                          1,2-benzoxazoles 74
                                            zonisamide 11
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