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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ziprasidone
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Accession:CHEBI:10119 term browser browse the term
Definition:A piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms.
Synonyms:exact_synonym: 5-{2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-1,3-dihydro-2H-indol-2-one
 related_synonym: Formula=C21H21ClN4OS;   InChI=1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27);   InChIKey=MVWVFYHBGMAFLY-UHFFFAOYSA-N;   SMILES=Clc1cc2NC(=O)Cc2cc1CCN1CCN(CC1)c1nsc2ccccc12;   ziprasidona;   ziprasidonum
 xref: Beilstein:6669199;   CAS:146939-27-7;   DrugBank:DB00246;   Drug_Central:2865;   KEGG:C07568;   KEGG:D08687;   LINCS:LSM-5433
 xref_mesh: MESH:C092292
 xref: Patent:EP281309;   Patent:US4831031;   Wikipedia:Ziprasidone



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ziprasidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions
affects binding
EXP
ISO
ziprasidone results in decreased expression of and results in increased reduction of ALB protein
[ziprasidone results in increased reduction of Cysteine] which results in increased activity of ALB protein; stearic acid inhibits the reaction [ziprasidone binds to ALB protein]
CTD PMID:31400341 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Cat catalase increases expression EXP ziprasidone results in increased expression of CAT mRNA CTD PMID:32937854 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO ziprasidone results in increased expression of HMGCR mRNA CTD PMID:17052361 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO ziprasidone results in increased expression of HMGCS1 mRNA CTD PMID:17052361 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP ziprasidone results in increased expression of HMOX1 mRNA CTD PMID:32937854 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein] which results in increased susceptibility to ziprasidone CTD PMID:15996562 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions ISO ziprasidone inhibits the reaction [Ketanserin binds to HTR2A protein] CTD PMID:16314884 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO ziprasidone results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP ziprasidone results in increased expression of NQO1 mRNA CTD PMID:32937854 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO ziprasidone results in increased expression of SC5D mRNA CTD PMID:17052361 NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO ziprasidone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:30465787 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Sox17 SRY-box transcription factor 17 decreases localization ISO ziprasidone results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19803
    role 19779
      biological role 19806
        pharmacological role 19018
          antagonist 17236
            histamine antagonist 4889
              ziprasidone 12
                ziprasidone hydrochloride hydrate 0
                ziprasidone mesylate trihydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19803
    subatomic particle 19801
      composite particle 19801
        hadron 19830
          baryon 19830
            nucleon 19830
              atomic nucleus 19830
                atom 19801
                  main group element atom 19780
                    p-block element atom 19780
                      carbon group element atom 19728
                        carbon atom 19725
                          organic molecular entity 19725
                            organic molecule 19678
                              organic cyclic compound 19491
                                organic heterocyclic compound 18855
                                  organic heteropolycyclic compound 18262
                                    organic heterobicyclic compound 17228
                                      benzopyrrole 9723
                                        indoles 9412
                                          indolones 5931
                                            ziprasidone 12
                                              ziprasidone hydrochloride hydrate 0
                                              ziprasidone mesylate trihydrate 0
paths to the root