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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ziprasidone
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Accession:CHEBI:10119 term browser browse the term
Definition:A piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms.
Synonyms:exact_synonym: 5-{2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-1,3-dihydro-2H-indol-2-one
 related_synonym: Formula=C21H21ClN4OS;   InChI=1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27);   InChIKey=MVWVFYHBGMAFLY-UHFFFAOYSA-N;   SMILES=Clc1cc2NC(=O)Cc2cc1CCN1CCN(CC1)c1nsc2ccccc12;   ziprasidona;   ziprasidonum
 xref: Beilstein:6669199;   CAS:146939-27-7;   DrugBank:DB00246;   Drug_Central:2865;   KEGG:C07568;   KEGG:D08687;   LINCS:LSM-5433
 xref_mesh: MESH:C092292
 xref: Patent:EP281309;   Patent:US4831031;   Wikipedia:Ziprasidone



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ziprasidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions
affects binding
EXP
ISO
ziprasidone results in decreased expression of and results in increased reduction of ALB protein
ziprasidone binds to ALB protein
[ziprasidone results in increased reduction of Cysteine] which results in increased activity of ALB protein; stearic acid inhibits the reaction [ziprasidone binds to ALB protein]
CTD PMID:31400341 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Cat catalase increases expression EXP ziprasidone results in increased expression of CAT mRNA CTD PMID:32937854 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO ziprasidone results in increased expression of HMGCR mRNA CTD PMID:17052361 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO ziprasidone results in increased expression of HMGCS1 mRNA CTD PMID:17052361 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP ziprasidone results in increased expression of HMOX1 mRNA CTD PMID:32937854 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein] which results in increased susceptibility to ziprasidone CTD PMID:15996562 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions ISO ziprasidone inhibits the reaction [Ketanserin binds to HTR2A protein] CTD PMID:16314884 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO ziprasidone results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP ziprasidone results in increased expression of NQO1 mRNA CTD PMID:32937854 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO ziprasidone results in increased expression of SC5D mRNA CTD PMID:17052361 NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO ziprasidone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:30465787 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Sox17 SRY-box transcription factor 17 decreases localization ISO ziprasidone results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      biological role 20000
        pharmacological role 19064
          antagonist 16362
            histamine antagonist 4856
              ziprasidone 12
                ziprasidone hydrochloride hydrate 0
                ziprasidone mesylate trihydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            organic molecule 19809
                              organic cyclic compound 19572
                                organic heterocyclic compound 18799
                                  organic heteropolycyclic compound 18274
                                    organic heterobicyclic compound 17169
                                      benzopyrrole 9604
                                        indoles 9277
                                          indolones 5905
                                            ziprasidone 12
                                              ziprasidone hydrochloride hydrate 0
                                              ziprasidone mesylate trihydrate 0
paths to the root