Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ziprasidone
go back to main search page
Accession:CHEBI:10119 term browser browse the term
Definition:A piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms.
Synonyms:exact_synonym: 5-{2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-1,3-dihydro-2H-indol-2-one
 related_synonym: Formula=C21H21ClN4OS;   InChI=1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27);   InChIKey=MVWVFYHBGMAFLY-UHFFFAOYSA-N;   SMILES=Clc1cc2NC(=O)Cc2cc1CCN1CCN(CC1)c1nsc2ccccc12;   ziprasidona;   ziprasidonum
 xref: Beilstein:6669199;   CAS:146939-27-7;   DrugBank:DB00246;   Drug_Central:2865;   KEGG:C07568;   KEGG:D08687;   LINCS:LSM-5433
 xref_mesh: MESH:C092292
 xref: Patent:EP281309;   Patent:US4831031;   Wikipedia:Ziprasidone


show annotations for term's descendants           Sort by:
 
ziprasidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions
affects binding
EXP
ISO
ziprasidone results in decreased expression of and results in increased reduction of ALB protein
ziprasidone binds to ALB protein
[ziprasidone results in increased reduction of Cysteine] which results in increased activity of ALB protein; stearic acid inhibits the reaction [ziprasidone binds to ALB protein]
CTD PMID:31400341 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO ziprasidone results in increased expression of HMGCR mRNA CTD PMID:17052361 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO ziprasidone results in increased expression of HMGCS1 mRNA CTD PMID:17052361 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein] which results in increased susceptibility to ziprasidone CTD PMID:15996562 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions ISO ziprasidone inhibits the reaction [Ketanserin binds to HTR2A protein] CTD PMID:16314884 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO ziprasidone results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO ziprasidone results in increased expression of SC5D mRNA CTD PMID:17052361 NCBI chr 8:46,525,406...46,537,014
Ensembl chr 8:46,525,400...46,537,050
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO ziprasidone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:30465787 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Sox17 SRY-box transcription factor 17 decreases localization ISO ziprasidone results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19783
    role 19728
      biological role 19728
        pharmacological role 18837
          antagonist 16278
            histamine antagonist 4619
              ziprasidone 9
                ziprasidone hydrochloride hydrate 0
                ziprasidone mesylate trihydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19783
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic molecule 19510
                              organic cyclic compound 19336
                                organic heterocyclic compound 18517
                                  organic heteropolycyclic compound 17978
                                    organic heterobicyclic compound 16782
                                      benzopyrrole 9544
                                        indoles 9212
                                          indolones 5858
                                            ziprasidone 9
                                              ziprasidone hydrochloride hydrate 0
                                              ziprasidone mesylate trihydrate 0
paths to the root