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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:10112 term browser browse the term
Definition:A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. It is used for the management of chronic asthma.
Synonyms:exact_synonym: 1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea
 related_synonym: (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea;   Formula=C11H12N2O2S;   InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14);   InChIKey=MWLSOWXNZPKENC-UHFFFAOYSA-N;   Leutrol;   N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea;   N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea;   SMILES=CC(N(O)C(N)=O)c1cc2ccccc2s1;   Zyflo;   zileutonum
 xref: CAS:111406-87-2;   DrugBank:DB00744;   Drug_Central:2862;   KEGG:D00414;   LINCS:LSM-5084
 xref_mesh: MESH:C063449
 xref: PMID:19309543;   PMID:19645854;   PMID:20204486;   PMID:20436887;   Reaxys:4869674;   Wikipedia:Zileuton

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zileuton term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase decreases activity EXP zileuton results in decreased activity of ALOX5 protein CTD PMID:11509739 NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,858,975...90,907,094
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Term Annotations click to browse term
  CHEBI ontology 879
    role 859
      application 496
        anti-asthmatic agent 15
          anti-asthmatic drug 13
            zileuton 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 879
    subatomic particle 864
      composite particle 864
        hadron 864
          baryon 864
            nucleon 864
              atomic nucleus 864
                atom 864
                  main group element atom 854
                    p-block element atom 851
                      carbon group element atom 827
                        carbon atom 826
                          organic molecular entity 826
                            organic group 392
                              organic divalent group 390
                                organodiyl group 390
                                  carbonyl group 389
                                    carbonyl compound 389
                                      carboxylic acid 267
                                        carboacyl group 166
                                          univalent carboacyl group 166
                                            carbamoyl group 163
                                              carboxamide 163
                                                monocarboxylic acid amide 82
                                                  urea 6
                                                    ureas 5
                                                      zileuton 1
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