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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:101085 term browser browse the term
Definition:A sulfonamide that is benzene-1,3-disulfonamide in which the hydrogens at positions 4 and 5 are substituted by chlorine. An oral carbonic anhydrase inhibitor, it partially suppresses the secretion (inflow) of aqueous humor in the eye and so reduces intraocular pressure. It is used for the treatment of glaucoma.
Synonyms:related_synonym: 1,3-disulfamoyl-4,5-dichlorobenzene;   1,3-disulfamyl-4,5-dichlorobenzene;   3,4-dichloro-5-sulfamylbenzenesulfonamide;   4,5-DICHLOROBENZENE-1,3-DISULFONAMIDE;   4,5-dichloro-1,3-benzenedisulfonamide;   4,5-dichloro-1,3-disulfamoylbenzene;   4,5-dichloro-benzene-1,3-disulfonic acid diamide;   4,5-dichloro-m-benzenedisulfonamide;   DICHLORPHENAMIDE;   Dichlorophenamide;   Formula=C6H6Cl2N2O4S2;   InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14);   InChIKey=GJQPMPFPNINLKP-UHFFFAOYSA-N;   SMILES=NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(N)(=O)=O;   dichlofenamide;   diclofenamida;   diclofenamidum
 alt_id: CHEBI:4505;   CHEBI:47477
 xref: Beilstein:2703329;   CAS:120-97-8;   DrugBank:DB01144;   Drug_Central:864;   KEGG:C07459;   KEGG:D00518;   LINCS:LSM-3602
 xref_mesh: MESH:D004005
 xref: PDBeChem:I7A;   Patent:US2835702;   Wikipedia:Dichlorphenamide

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diclofenamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ca3 carbonic anhydrase 3 multiple interactions ISO Dichlorphenamide binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
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G Car2 carbonic anhydrase 2 multiple interactions ISO Dichlorphenamide binds to and results in decreased activity of CA2 protein CTD PMID:17826101 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link

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  CHEBI ontology 19875
    role 19825
      application 19494
        pharmaceutical 19364
          drug 19364
            ophthalmology drug 406
              diclofenamide 2
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  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic molecule 19586
                              organic cyclic compound 19395
                                carbocyclic compound 18305
                                  benzenoid aromatic compound 17344
                                    benzenes 17087
                                      chlorobenzenes 13569
                                        dichlorobenzene 10621
                                          diclofenamide 2
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