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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:101085 term browser browse the term
Definition:A sulfonamide that is benzene-1,3-disulfonamide in which the hydrogens at positions 4 and 5 are substituted by chlorine. An oral carbonic anhydrase inhibitor, it partially suppresses the secretion (inflow) of aqueous humor in the eye and so reduces intraocular pressure. It is used for the treatment of glaucoma.
Synonyms:related_synonym: 1,3-disulfamoyl-4,5-dichlorobenzene;   1,3-disulfamyl-4,5-dichlorobenzene;   3,4-dichloro-5-sulfamylbenzenesulfonamide;   4,5-DICHLOROBENZENE-1,3-DISULFONAMIDE;   4,5-dichloro-1,3-benzenedisulfonamide;   4,5-dichloro-1,3-disulfamoylbenzene;   4,5-dichloro-benzene-1,3-disulfonic acid diamide;   4,5-dichloro-m-benzenedisulfonamide;   DICHLORPHENAMIDE;   Dichlorophenamide;   Formula=C6H6Cl2N2O4S2;   InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14);   InChIKey=GJQPMPFPNINLKP-UHFFFAOYSA-N;   SMILES=NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(N)(=O)=O;   dichlofenamide;   diclofenamida;   diclofenamidum
 alt_id: CHEBI:4505;   CHEBI:47477
 xref: Beilstein:2703329;   CAS:120-97-8;   DrugBank:DB01144;   Drug_Central:864;   KEGG:C07459;   KEGG:D00518;   LINCS:LSM-3602
 xref_mesh: MESH:D004005
 xref: PDBeChem:I7A;   Patent:US2835702;   Wikipedia:Dichlorphenamide

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diclofenamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ca3 carbonic anhydrase 3 multiple interactions ISO Dichlorphenamide binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO Dichlorphenamide binds to and results in decreased activity of CA2 protein CTD PMID:17826101 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link

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  CHEBI ontology 20059
    role 20009
      application 19747
        pharmaceutical 19619
          drug 19619
            ophthalmology drug 418
              diclofenamide 2
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  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic molecule 19819
                              organic cyclic compound 19581
                                carbocyclic compound 18521
                                  benzenoid aromatic compound 17773
                                    benzenes 17574
                                      chlorobenzenes 13885
                                        dichlorobenzene 10990
                                          diclofenamide 2
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