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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:zalcitabine
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Accession:CHEBI:10101 term browser browse the term
Definition:A pyrimidine 2',3'-dideoxyribonucleoside compound having cytosine as the nucleobase.
Synonyms:related_synonym: 2',3'-Dideoxycytidine;   4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one;   DDC;   DDCYD;   Dideoxycytidine;   Formula=C9H13N3O3;   InChI=1S/C9H13N3O3/c10-7-3-4-12(9(14)11-7)8-2-1-6(5-13)15-8/h3-4,6,8,13H,1-2,5H2,(H2,10,11,14)/t6-,8+/m0/s1;   InChIKey=WREGKURFCTUGRC-POYBYMJQSA-N;   SMILES=Nc1ccn([C@H]2CC[C@@H](CO)O2)c(=O)n1
 xref: Beilstein:654956;   CAS:7481-89-2;   DrugBank:DB00943;   Drug_Central:2856;   HMDB:HMDB0015078;   KEGG:C07207;   KEGG:D00412;   LINCS:LSM-5915
 xref_mesh: MESH:D016047
 xref: PMID:11905988;   PMID:7727578;   Reaxys:654956;   Wikipedia:Zalcitabine


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zalcitabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 affects phosphorylation ISO Zalcitabine affects the phosphorylation of AKT1 protein CTD PMID:19781600 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G ALB albumin affects binding EXP Zalcitabine binds to ALB protein CTD PMID:15814459 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G ANO3 anoctamin 3 multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ANO3 mRNA CTD PMID:18606552 NCBI chr11:26,188,808...26,663,289
Ensembl chr11:26,188,842...26,663,289 		JBrowse link
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases response to substance EXP APEX1 protein mutant form results in increased susceptibility to Zalcitabine CTD PMID:17259346 NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772 		JBrowse link
G ARNT2 aryl hydrocarbon receptor nuclear translocator 2 multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of ARNT2 mRNA CTD PMID:18606552 NCBI chr15:80,404,382...80,597,933
Ensembl chr15:80,404,350...80,597,933 		JBrowse link
G ATP2B4 ATPase plasma membrane Ca2+ transporting 4 multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of ATP2B4 mRNA CTD PMID:18606552 NCBI chr 1:203,626,832...203,744,081
Ensembl chr 1:203,626,832...203,744,081 		JBrowse link
G BPTF bromodomain PHD finger transcription factor multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of BPTF mRNA CTD PMID:18606552 NCBI chr17:67,825,503...67,984,378
Ensembl chr17:67,825,503...67,984,378 		JBrowse link
G C17orf75 chromosome 17 open reading frame 75 multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of C10H17ORF75 mRNA CTD PMID:18606552 NCBI chr17:32,328,441...32,350,014
Ensembl chr17:32,324,565...32,350,023 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 increases expression ISO Zalcitabine results in increased expression of CCL2 protein CTD PMID:17761732 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 increases expression ISO Zalcitabine results in increased expression of CXCL12 mRNA CTD PMID:17292584 NCBI chr10:44,370,165...44,385,097
Ensembl chr10:44,370,165...44,386,493 		JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 increases expression ISO Zalcitabine results in increased expression of CXCR4 mRNA CTD PMID:17292584 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,119,177 		JBrowse link
G DCK deoxycytidine kinase affects response to substance EXP DCK protein affects the susceptibility to Zalcitabine CTD PMID:11952160 NCBI chr 4:70,993,649...71,030,914
Ensembl chr 4:70,992,538...71,030,914 		JBrowse link
G DEPDC1B DEP domain containing 1B multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of DEPDC1B mRNA CTD PMID:18606552 NCBI chr 5:60,596,912...60,700,166
Ensembl chr 5:60,596,912...60,700,190 		JBrowse link
G DLG5 discs large MAGUK scaffold protein 5 multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of DLG5 mRNA CTD PMID:18606552 NCBI chr10:77,790,791...77,940,736
Ensembl chr10:77,790,791...77,926,755 		JBrowse link
G ESRRG estrogen related receptor gamma multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ESRRG mRNA CTD PMID:18606552 NCBI chr 1:216,503,246...217,137,702
Ensembl chr 1:216,503,246...217,137,755 		JBrowse link
G FAM81A family with sequence similarity 81 member A multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of FAM81A mRNA CTD PMID:18606552 NCBI chr15:59,397,981...59,523,555
Ensembl chr15:59,372,693...59,523,555 		JBrowse link
G FPGT fucose-1-phosphate guanylyltransferase multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of FPGT mRNA CTD PMID:18606552 NCBI chr 1:74,198,242...74,208,702
Ensembl chr 1:74,198,238...74,234,086 		JBrowse link
G GLA galactosidase alpha multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of GLA mRNA CTD PMID:18606552 NCBI chr  X:101,397,803...101,407,925
Ensembl chr  X:101,393,273...101,408,012 		JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A increases response to substance
increases expression
multiple interactions		 ISO HTR2A gene results in increased susceptibility to Zalcitabine
Zalcitabine results in increased expression of HTR2A protein
[alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Zalcitabine		 CTD PMID:17888573 NCBI chr13:46,831,546...46,898,082
Ensembl chr13:46,831,546...46,897,076 		JBrowse link
G IL2RA interleukin 2 receptor subunit alpha decreases expression
multiple interactions		 EXP Zalcitabine results in decreased expression of IL2RA mRNA; Zalcitabine results in decreased expression of IL2RA protein
Zidovudine promotes the reaction [Zalcitabine results in decreased expression of IL2RA mRNA]; Zidovudine promotes the reaction [Zalcitabine results in decreased expression of IL2RA protein]		 CTD PMID:7606800 NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370 		JBrowse link
G IRF7 interferon regulatory factor 7 multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of IRF7 mRNA CTD PMID:18606552 NCBI chr11:612,555...615,950
Ensembl chr11:612,553...615,983 		JBrowse link
G KIF5A kinesin family member 5A multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of KIF5A mRNA CTD PMID:18606552 NCBI chr12:57,550,044...57,586,633
Ensembl chr12:57,546,026...57,586,633 		JBrowse link
G LAMA5 laminin subunit alpha 5 multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of LAMA5 mRNA CTD PMID:18606552 NCBI chr20:62,309,065...62,367,312
Ensembl chr20:62,307,955...62,367,312 		JBrowse link
G LUZP2 leucine zipper protein 2 multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of LUZP2 mRNA CTD PMID:18606552 NCBI chr11:24,497,053...25,082,638
Ensembl chr11:24,496,970...25,082,638 		JBrowse link
G MIDN midnolin multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of MIDN mRNA CTD PMID:18606552 NCBI chr19:1,248,583...1,259,143
Ensembl chr19:1,248,553...1,259,143 		JBrowse link
G MT-CO1 mitochondrially encoded cytochrome c oxidase I decreases expression
multiple interactions		 EXP
ISO		 Zalcitabine results in decreased expression of COX1 protein
Uridine inhibits the reaction [Zalcitabine results in decreased expression of COX1 protein]		 CTD PMID:17187420 PMID:18823003 PMID:20032772 NCBI chr MT:5,904...7,445
Ensembl chr MT:5,904...7,445 		JBrowse link
G MT-CO2 mitochondrially encoded cytochrome c oxidase II decreases expression ISO Zalcitabine results in decreased expression of COX2 mRNA CTD PMID:19781600 NCBI chr MT:7,586...8,269
Ensembl chr MT:7,586...8,269 		JBrowse link
G MT-CO3 mitochondrially encoded cytochrome c oxidase III decreases expression EXP Zalcitabine results in decreased expression of COX3 protein CTD PMID:17508937 NCBI chr MT:9,207...9,990
Ensembl chr MT:9,207...9,990 		JBrowse link
G NDUFB11 NADH:ubiquinone oxidoreductase subunit B11 multiple interactions EXP Zalcitabine inhibits the reaction [Cyclic AMP results in increased phosphorylation of NDUFB11 protein] CTD PMID:17904600 NCBI chr  X:47,142,216...47,145,491
Ensembl chr  X:47,142,071...47,145,466 		JBrowse link
G NECAB1 N-terminal EF-hand calcium binding protein 1 multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of NECAB1 mRNA CTD PMID:18606552 NCBI chr 8:90,791,775...90,959,393
Ensembl chr 8:90,791,741...90,959,393 		JBrowse link
G NKIRAS1 NFKB inhibitor interacting Ras like 1 multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of NKIRAS1 mRNA CTD PMID:18606552 NCBI chr 3:23,889,951...23,946,562
Ensembl chr 3:23,889,951...23,946,591 		JBrowse link
G NOTCH1 notch receptor 1 increases mutagenesis ISO Zalcitabine results in increased mutagenesis of NOTCH1 gene CTD PMID:18798262 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048 		JBrowse link
G NPY neuropeptide Y multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of NPY mRNA CTD PMID:18606552 NCBI chr 7:24,284,190...24,291,862
Ensembl chr 7:24,284,188...24,291,862 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of NTRK2 mRNA alternative form CTD PMID:18606552 NCBI chr 9:84,668,522...85,027,054
Ensembl chr 9:84,668,375...85,095,751 		JBrowse link
G PER2 period circadian regulator 2 multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of PER2 mRNA CTD PMID:18606552 NCBI chr 2:238,244,044...238,300,065
Ensembl chr 2:238,244,044...238,290,102 		JBrowse link
G RAB27B RAB27B, member RAS oncogene family multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of RAB27B mRNA CTD PMID:18606552 NCBI chr18:54,717,857...54,895,516
Ensembl chr18:54,717,860...54,895,516 		JBrowse link
G REG3A regenerating family member 3 alpha multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of REG3B mRNA; [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of REG3B protein CTD PMID:18606552 NCBI chr 2:79,157,006...79,159,753
Ensembl chr 2:79,157,003...79,159,753 		JBrowse link
G ROBO2 roundabout guidance receptor 2 multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ROBO2 mRNA CTD PMID:18606552 NCBI chr 3:75,906,675...77,649,964
Ensembl chr 3:75,906,695...77,649,964 		JBrowse link
G SANBR SANT and BTB domain regulator of CSR multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of SANBR mRNA CTD PMID:18606552 NCBI chr 2:61,065,871...61,138,032
Ensembl chr 2:61,065,871...61,138,034 		JBrowse link
G SCUBE1 signal peptide, CUB domain and EGF like domain containing 1 multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of SCUBE1 mRNA CTD PMID:18606552 NCBI chr22:43,197,280...43,343,372
Ensembl chr22:43,197,280...43,343,372 		JBrowse link
G SENP5 SUMO specific peptidase 5 multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of SENP5 mRNA CTD PMID:18606552 NCBI chr 3:196,867,920...196,934,714
Ensembl chr 3:196,867,856...196,934,714 		JBrowse link
G SLC28A1 solute carrier family 28 member 1 multiple interactions
increases uptake		 ISO Zalcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; Zalcitabine promotes the reaction [SLC28A1 protein results in increased export of Uridine]
SLC28A1 protein results in increased uptake of Zalcitabine		 CTD PMID:8027026 PMID:8700147 PMID:8713072 NCBI chr15:84,884,662...84,975,649
Ensembl chr15:84,884,654...84,945,798 		JBrowse link
G SLC29A3 solute carrier family 29 member 3 affects transport EXP SLC29A3 protein affects the transport of Zalcitabine CTD PMID:19164483 NCBI chr10:71,319,259...71,381,423
Ensembl chr10:71,319,259...71,381,423 		JBrowse link
G SLC35G2 solute carrier family 35 member G2 multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of SLC35G2 mRNA CTD PMID:18606552 NCBI chr 3:136,819,126...136,855,888
Ensembl chr 3:136,818,647...136,855,888 		JBrowse link
G SLC4A8 solute carrier family 4 member 8 multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of SLC4A8 mRNA CTD PMID:18606552 NCBI chr12:51,391,446...51,515,763
Ensembl chr12:51,391,317...51,515,763 		JBrowse link
G ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ST8SIA3 mRNA CTD PMID:18606552 NCBI chr18:57,352,557...57,368,931
Ensembl chr18:57,352,557...57,371,731 		JBrowse link
G SV2B synaptic vesicle glycoprotein 2B multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of SV2B mRNA CTD PMID:18606552 NCBI chr15:91,099,588...91,302,565
Ensembl chr15:91,099,950...91,302,565 		JBrowse link
G TFAM transcription factor A, mitochondrial affects expression EXP Zalcitabine affects the expression of TFAM protein CTD PMID:7849699 NCBI chr10:58,385,410...58,399,220
Ensembl chr10:58,385,345...58,399,220 		JBrowse link
G TK1 thymidine kinase 1 decreases expression EXP Zalcitabine results in decreased expression of TK1 mRNA; Zalcitabine results in decreased expression of TK1 protein CTD PMID:14659972 NCBI chr17:78,174,079...78,187,204
Ensembl chr17:78,174,091...78,187,233 		JBrowse link
G TK2 thymidine kinase 2 decreases expression EXP Zalcitabine results in decreased expression of TK2 mRNA CTD PMID:14659972 NCBI chr16:66,508,003...66,550,291
Ensembl chr16:66,508,003...66,552,544 		JBrowse link
G TRPV4 transient receptor potential cation channel subfamily V member 4 increases response to substance ISO TRPV4 protein results in increased susceptibility to Zalcitabine CTD PMID:18234883 NCBI chr12:109,783,087...109,833,398
Ensembl chr12:109,783,087...109,833,406 		JBrowse link
G TYMP thymidine phosphorylase increases expression EXP Zalcitabine results in increased expression of TYMP protein CTD PMID:16457948 NCBI chr22:50,525,752...50,530,085
Ensembl chr22:50,525,752...50,530,032 		JBrowse link
G VGF VGF nerve growth factor inducible multiple interactions ISO [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of VGF mRNA CTD PMID:18606552 NCBI chr 7:101,162,509...101,169,952
Ensembl chr 7:101,162,509...101,165,569 		JBrowse link
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  CHEBI ontology 26041
    role 25957
      biological role 25936
        biochemical role 25170
          antimetabolite 10595
            zalcitabine 53
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  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            heteroorganic entity 24773
                              organochalcogen compound 24384
                                organooxygen compound 24061
                                  carbohydrates and carbohydrate derivatives 16791
                                    carbohydrate 16791
                                      carbohydrate derivative 15665
                                        glycosyl compound 13730
                                          N-glycosyl compound 6130
                                            nucleoside 5973
                                              deoxyribonucleoside 2993
                                                2',3'-dideoxyribonucleoside 578
                                                  pyrimidine 2',3'-dideoxyribonucleoside 573
                                                    zalcitabine 53
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