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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:zalcitabine
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Accession:CHEBI:10101 term browser browse the term
Definition:A pyrimidine 2',3'-dideoxyribonucleoside compound having cytosine as the nucleobase.
Synonyms:related_synonym: 2',3'-Dideoxycytidine;   4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one;   DDC;   DDCYD;   Dideoxycytidine;   Formula=C9H13N3O3;   InChI=1S/C9H13N3O3/c10-7-3-4-12(9(14)11-7)8-2-1-6(5-13)15-8/h3-4,6,8,13H,1-2,5H2,(H2,10,11,14)/t6-,8+/m0/s1;   InChIKey=WREGKURFCTUGRC-POYBYMJQSA-N;   SMILES=Nc1ccn([C@H]2CC[C@@H](CO)O2)c(=O)n1
 xref: Beilstein:654956;   CAS:7481-89-2;   DrugBank:DB00943;   Drug_Central:2856;   HMDB:HMDB0015078;   KEGG:C07207;   KEGG:D00412;   LINCS:LSM-5915
 xref_mesh: MESH:D016047
 xref: PMID:11905988;   PMID:7727578;   Reaxys:654956;   Wikipedia:Zalcitabine


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zalcitabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation EXP Zalcitabine affects the phosphorylation of AKT1 protein CTD PMID:19781600 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin affects binding ISO Zalcitabine binds to ALB protein CTD PMID:15814459 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Ano3 anoctamin 3 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ANO3 mRNA CTD PMID:18606552 NCBI chr 3:101,843,516...102,203,368
Ensembl chr 3:101,840,630...102,151,489
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases response to substance ISO APEX1 protein mutant form results in increased susceptibility to Zalcitabine CTD PMID:17259346 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of ARNT2 mRNA CTD PMID:18606552 NCBI chr 1:146,399,217...146,556,437
Ensembl chr 1:146,399,217...146,556,171
JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of ATP2B4 mRNA CTD PMID:18606552 NCBI chr13:50,091,644...50,153,808
Ensembl chr13:50,091,430...50,153,823
JBrowse link
G Bptf bromodomain PHD finger transcription factor multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of BPTF mRNA CTD PMID:18606552 NCBI chr10:95,248,573...95,350,162
Ensembl chr10:95,250,294...95,349,789
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP Zalcitabine results in increased expression of CCL2 protein CTD PMID:17761732 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression EXP Zalcitabine results in increased expression of CXCL12 mRNA CTD PMID:17292584 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression EXP Zalcitabine results in increased expression of CXCR4 mRNA CTD PMID:17292584 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Dck deoxycytidine kinase affects response to substance ISO DCK protein affects the susceptibility to Zalcitabine CTD PMID:11952160 NCBI chr14:20,935,442...20,952,939
Ensembl chr14:20,935,369...20,953,095
JBrowse link
G Depdc1b DEP domain containing 1B multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of DEPDC1B mRNA CTD PMID:18606552 NCBI chr 2:39,980,796...40,069,982
Ensembl chr 2:40,000,313...40,069,975
JBrowse link
G Dlg5 discs large MAGUK scaffold protein 5 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of DLG5 mRNA CTD PMID:18606552 NCBI chr15:120,213...230,312
Ensembl chr15:120,372...228,977
JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ESRRG mRNA CTD PMID:18606552 NCBI chr13:106,063,799...106,683,353
Ensembl chr13:106,463,368...106,683,436
JBrowse link
G Fam81a family with sequence similarity 81, member A multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of FAM81A mRNA CTD PMID:18606552 NCBI chr 8:76,521,662...76,579,387
Ensembl chr 8:76,521,657...76,579,387
JBrowse link
G Fpgt fucose-1-phosphate guanylyltransferase multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of FPGT mRNA CTD PMID:18606552 NCBI chr 2:261,382,015...261,402,950
Ensembl chr 2:261,382,060...261,402,903
JBrowse link
G Gla galactosidase, alpha multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of GLA mRNA CTD PMID:18606552 NCBI chr  X:105,405,915...105,417,331
Ensembl chr  X:105,406,792...105,417,323
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A increases response to substance
increases expression
multiple interactions
ISO
EXP
HTR2A gene results in increased susceptibility to Zalcitabine
Zalcitabine results in increased expression of HTR2A protein
[alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Zalcitabine
CTD PMID:17888573 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases expression
multiple interactions
ISO Zalcitabine results in decreased expression of IL2RA mRNA; Zalcitabine results in decreased expression of IL2RA protein
Zidovudine promotes the reaction [Zalcitabine results in decreased expression of IL2RA mRNA]; Zidovudine promotes the reaction [Zalcitabine results in decreased expression of IL2RA protein]
CTD PMID:7606800 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Irf7 interferon regulatory factor 7 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of IRF7 mRNA CTD PMID:18606552 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Kif5a kinesin family member 5A multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of KIF5A mRNA CTD PMID:18606552 NCBI chr 7:70,515,832...70,552,897
Ensembl chr 7:70,513,343...70,556,827
JBrowse link
G Lama5 laminin subunit alpha 5 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of LAMA5 mRNA CTD PMID:18606552 NCBI chr 3:175,553,042...175,601,112
Ensembl chr 3:175,553,045...175,601,127
JBrowse link
G Luzp2 leucine zipper protein 2 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of LUZP2 mRNA CTD PMID:18606552 NCBI chr 1:111,849,494...112,067,502
NCBI chr 1:113,419,707...113,531,330
Ensembl chr 1:111,849,998...113,527,735
JBrowse link
G Midn midnolin multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of MIDN mRNA CTD PMID:18606552 NCBI chr 7:12,414,303...12,426,712
Ensembl chr 7:12,414,733...12,424,367
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I decreases expression
multiple interactions
ISO Zalcitabine results in decreased expression of COX1 protein
Uridine inhibits the reaction [Zalcitabine results in decreased expression of COX1 protein]
CTD PMID:17187420 PMID:18823003 PMID:20032772 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II decreases expression EXP Zalcitabine results in decreased expression of COX2 mRNA CTD PMID:19781600 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III decreases expression ISO Zalcitabine results in decreased expression of COX3 protein CTD PMID:17508937 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
JBrowse link
G Ndufb11 NADH:ubiquinone oxidoreductase subunit B11 multiple interactions ISO Zalcitabine inhibits the reaction [Cyclic AMP results in increased phosphorylation of NDUFB11 protein] CTD PMID:17904600 NCBI chr  X:1,787,266...1,789,524
Ensembl chr  X:1,787,266...1,789,524
JBrowse link
G Necab1 N-terminal EF-hand calcium binding protein 1 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of NECAB1 mRNA CTD PMID:18606552 NCBI chr 5:28,507,596...28,737,556
Ensembl chr 5:28,504,558...28,737,719
JBrowse link
G Nkiras1 NFKB inhibitor interacting Ras-like 1 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of NKIRAS1 mRNA CTD PMID:18606552 NCBI chr15:8,179,090...8,188,656
Ensembl chr15:8,179,102...8,183,682
JBrowse link
G Notch1 notch receptor 1 increases mutagenesis ISO Zalcitabine results in increased mutagenesis of NOTCH1 gene CTD PMID:18798262 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Npy neuropeptide Y multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of NPY mRNA CTD PMID:18606552 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of NTRK2 mRNA alternative form CTD PMID:18606552 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Per2 period circadian regulator 2 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of PER2 mRNA CTD PMID:18606552 NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
JBrowse link
G Rab27b RAB27B, member RAS oncogene family multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of RAB27B mRNA CTD PMID:18606552 NCBI chr18:68,486,006...68,644,595
Ensembl chr18:68,488,942...68,551,558
JBrowse link
G Reg3b regenerating family member 3 beta multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of REG3B mRNA; [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of REG3B protein CTD PMID:18606552 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510
JBrowse link
G RGD1310429 similar to Protein Njmu-R1 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of RGD1310429 mRNA CTD PMID:18606552 NCBI chr10:67,738,131...67,751,049
Ensembl chr10:67,739,103...67,751,002
JBrowse link
G Robo2 roundabout guidance receptor 2 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ROBO2 mRNA CTD PMID:18606552 NCBI chr11:11,062,866...12,618,793
Ensembl chr11:11,062,790...11,585,765
JBrowse link
G Scube1 signal peptide, CUB domain and EGF like domain containing 1 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of SCUBE1 mRNA CTD PMID:18606552 NCBI chr 7:124,501,988...124,620,755
Ensembl chr 7:124,501,988...124,620,703
JBrowse link
G Senp5 SUMO specific peptidase 5 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of SENP5 mRNA CTD PMID:18606552 NCBI chr11:72,035,540...72,070,679
Ensembl chr11:72,892,448...72,915,230
Ensembl chr11:72,892,448...72,915,230
JBrowse link
G Slc28a1 solute carrier family 28 member 1 multiple interactions
increases uptake
EXP Zalcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; Zalcitabine promotes the reaction [SLC28A1 protein results in increased export of Uridine]
SLC28A1 protein results in increased uptake of Zalcitabine
CTD PMID:8027026 PMID:8700147 PMID:8713072 NCBI chr 1:142,948,942...142,992,410
Ensembl chr 1:142,950,540...142,992,615
JBrowse link
G Slc29a3 solute carrier family 29 member 3 affects transport ISO SLC29A3 protein affects the transport of Zalcitabine CTD PMID:19164483 NCBI chr20:30,289,527...30,327,343
Ensembl chr20:30,287,424...30,327,361
JBrowse link
G Slc35g2 solute carrier family 35, member G2 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of SLC35G2 mRNA CTD PMID:18606552 NCBI chr 8:108,854,134...108,881,519
Ensembl chr 8:108,854,146...108,880,879
JBrowse link
G Slc4a8 solute carrier family 4 member 8 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of SLC4A8 mRNA CTD PMID:18606552 NCBI chr 7:142,397,352...142,467,398
Ensembl chr 7:142,397,371...142,464,158
JBrowse link
G St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ST8SIA3 mRNA CTD PMID:18606552 NCBI chr18:59,748,766...59,755,257
Ensembl chr18:59,748,444...59,755,226
JBrowse link
G Sv2b synaptic vesicle glycoprotein 2b multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of SV2B mRNA CTD PMID:18606552 NCBI chr 1:136,664,199...136,842,247
Ensembl chr 1:136,664,204...136,842,247
JBrowse link
G Tfam transcription factor A, mitochondrial affects expression ISO Zalcitabine affects the expression of TFAM protein CTD PMID:7849699 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Tk1 thymidine kinase 1 decreases expression ISO Zalcitabine results in decreased expression of TK1 mRNA; Zalcitabine results in decreased expression of TK1 protein CTD PMID:14659972 NCBI chr10:106,817,556...106,828,888
Ensembl chr10:106,817,601...106,828,884
JBrowse link
G Tk2 thymidine kinase 2 decreases expression ISO Zalcitabine results in decreased expression of TK2 mRNA CTD PMID:14659972 NCBI chr19:917,203...939,236
Ensembl chr19:917,203...939,221
JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 increases response to substance EXP TRPV4 protein results in increased susceptibility to Zalcitabine CTD PMID:18234883 NCBI chr12:47,698,915...47,737,902
Ensembl chr12:47,698,947...47,737,902
JBrowse link
G Tymp thymidine phosphorylase increases expression ISO Zalcitabine results in increased expression of TYMP protein CTD PMID:16457948 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Vgf VGF nerve growth factor inducible multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of VGF mRNA CTD PMID:18606552 NCBI chr12:22,677,302...22,680,630
Ensembl chr12:22,677,607...22,680,630
JBrowse link

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        biochemical role 19303
          antimetabolite 8504
            zalcitabine 52
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  CHEBI ontology 19767
    subatomic particle 19766
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                          organic molecular entity 19563
                            heteroorganic entity 19198
                              organochalcogen compound 18945
                                organooxygen compound 18872
                                  carbohydrates and carbohydrate derivatives 12287
                                    carbohydrate 12287
                                      carbohydrate derivative 11895
                                        glycosyl compound 10967
                                          N-glycosyl compound 5487
                                            nucleoside 5347
                                              deoxyribonucleoside 2734
                                                2',3'-dideoxyribonucleoside 557
                                                  pyrimidine 2',3'-dideoxyribonucleoside 552
                                                    zalcitabine 52
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