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ONTOLOGY REPORT - ANNOTATIONS


Term:yohimbine
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Accession:CHEBI:10093 term browser browse the term
Definition:An indole alkaloid with alpha2-adrenoceptor antagonist activity. It is produced by Corynanthe johimbe and Rauwolfia serpentina.
Synonyms:exact_synonym: methyl 17alpha-hydroxyyohimban-16alpha-carboxylate
 related_synonym: (16alpha,17alpha)-17-hydroxyyohimban-16-carboxylic acid methyl ester;   17alpha-hydroxyyohimban-16alpha-carboxylic acid methyl ester;   Formula=C21H26N2O3;   InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1;   InChIKey=BLGXFZZNTVWLAY-SCYLSFHTSA-N;   Johimbin;   Quebrachin;   SMILES=[H][C@@]12CC[C@H](O)[C@H](C(=O)OC)[C@@]1([H])C[C@]1([H])N(CCc3c1[nH]c1ccccc31)C2;   Yohimbin;   aphrodine;   corynine;   quebrachine;   yohimbic acid methyl ester
 xref: Beilstein:4720812 "Beilstein";   Beilstein:97276 "Beilstein";   CAS:146-48-5 "ChemIDplus";   CAS:146-48-5 "KEGG COMPOUND";   CAS:146-48-5 "NIST Chemistry WebBook";   DrugBank:DB01392;   Drug_Central:3659 "DrugCentral";   KEGG:C09256;   KEGG:D08685;   KNApSAcK:C00001789;   LINCS:LSM-2779
 xref_mesh: MESH:D015016
 xref: VSDB:3010


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yohimbine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A JBrowse link 5 8,567,091 8,748,575 RGD:6480464
G Abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 JBrowse link 5 8,893,614 8,959,226 RGD:6480464
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 JBrowse link 19 43,782,308 43,838,332 RGD:6480464
G Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 JBrowse link 11 94,343,295 94,393,017 RGD:6480464
G Actg1 actin, gamma, cytoplasmic 1 JBrowse link 11 120,345,687 120,348,495 RGD:6480464
G Adam9 a disintegrin and metallopeptidase domain 9 (meltrin gamma) JBrowse link 8 24,949,611 25,017,040 RGD:6480464
G Adamts4 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 JBrowse link 1 171,250,129 171,262,267 RGD:6480464
G Adra2a adrenergic receptor, alpha 2a JBrowse link 19 54,045,259 54,048,982 RGD:6480464
G Adrb1 adrenergic receptor, beta 1 JBrowse link 19 56,722,117 56,725,150 RGD:6480464
G Aldoa aldolase A, fructose-bisphosphate JBrowse link 7 126,795,234 126,800,994 RGD:6480464
G Avpr1a arginine vasopressin receptor 1A JBrowse link 10 122,448,499 122,453,453 RGD:6480464
G Bhmt betaine-homocysteine methyltransferase JBrowse link 13 93,616,891 93,637,758 RGD:6480464
G Calu calumenin JBrowse link 6 29,348,106 29,376,675 RGD:6480464
G Cat catalase JBrowse link 2 103,453,904 103,485,153 RGD:6480464
G Ccng1 cyclin G1 JBrowse link 11 40,748,552 40,755,309 RGD:6480464
G Cd36 CD36 molecule JBrowse link 5 17,781,690 17,888,959 RGD:6480464
G Cdc14b CDC14 cell division cycle 14B JBrowse link 13 64,192,545 64,274,988 RGD:6480464
G Cemip2 cell migration inducing hyaluronidase 2 JBrowse link 19 21,778,340 21,858,360 RGD:6480464
G Clic1 chloride intracellular channel 1 JBrowse link 17 35,050,243 35,058,719 RGD:6480464
G Col2a1 collagen, type II, alpha 1 JBrowse link 15 97,975,602 98,004,724 RGD:6480464
G Crh corticotropin releasing hormone JBrowse link 3 19,693,401 19,695,396 RGD:6480464
G Cxcl12 chemokine (C-X-C motif) ligand 12 JBrowse link 6 117,168,535 117,181,368 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 9 57,676,937 57,683,655 RGD:6480464
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 JBrowse link 15 82,370,527 82,380,260 RGD:6480464
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 JBrowse link 5 145,854,607 145,879,854 RGD:6480464
G Fasn fatty acid synthase JBrowse link 11 120,805,958 120,825,166 RGD:6480464
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 9 77,754,535 77,794,489 RGD:6480464
G Gsr glutathione reductase JBrowse link 8 33,653,238 33,698,162 RGD:6480464
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A JBrowse link 14 74,640,874 74,706,859 RGD:6480464
G Lpl lipoprotein lipase JBrowse link 8 68,880,555 68,906,932 RGD:6480464
G Lss lanosterol synthase JBrowse link 10 76,531,565 76,557,139 RGD:6480464
G Maoa monoamine oxidase A JBrowse link X 16,619,698 16,687,812 RGD:6480464
G Mir101a microRNA 101a JBrowse link 4 101,346,945 101,347,027 RGD:6480464
G Mir122 microRNA 122 JBrowse link 18 65,248,861 65,248,926 RGD:6480464
G Mir192 microRNA 192 JBrowse link 19 6,264,844 6,264,932 RGD:6480464
G Mlxipl MLX interacting protein-like JBrowse link 5 135,089,890 135,139,768 RGD:6480464
G Myct1 myc target 1 JBrowse link 10 5,593,728 5,606,789 RGD:6480464
G Nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta JBrowse link 16 55,811,375 55,838,954 RGD:6480464
G Nos2 nitric oxide synthase 2, inducible JBrowse link 11 78,920,787 78,960,226 RGD:6480464
G Npy neuropeptide Y JBrowse link 6 49,822,710 49,829,507 RGD:6480464
G Nqo1 NAD(P)H dehydrogenase, quinone 1 JBrowse link 8 107,388,225 107,403,205 RGD:6480464
G Nrip3 nuclear receptor interacting protein 3 JBrowse link 7 109,758,056 109,781,545 RGD:6480464
G Pla2g12a phospholipase A2, group XIIA JBrowse link 3 129,878,606 129,895,825 RGD:6480464
G Prl prolactin JBrowse link 13 27,057,570 27,065,204 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 150,100,031 150,108,234 RGD:6480464
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) JBrowse link 19 5,637,442 5,648,134 RGD:6480464
G Ren1 renin 1 structural JBrowse link 1 133,350,674 133,360,320 RGD:6480464
G Scd1 stearoyl-Coenzyme A desaturase 1 JBrowse link 19 44,394,450 44,407,709 RGD:6480464
G Thrsp thyroid hormone responsive JBrowse link 7 97,412,933 97,417,550 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464
G Txnrd1 thioredoxin reductase 1 JBrowse link 10 82,833,951 82,897,724 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20742
    role 20720
      biological role 20719
        pharmacological role 19007
          antagonist 15963
            dopamine receptor D2 antagonist 54
              yohimbine 51
Path 2
Term Annotations click to browse term
  CHEBI ontology 20742
    subatomic particle 20735
      composite particle 20735
        hadron 20735
          baryon 20735
            nucleon 20735
              atomic nucleus 20735
                atom 20735
                  main group element atom 20655
                    p-block element atom 20655
                      carbon group element atom 20391
                        carbon atom 20367
                          organic molecular entity 20367
                            organic group 19036
                              cyclic organic group 1848
                                organic heterobicyclic ring 1848
                                  indole skeleton 1848
                                    indole alkaloid 1848
                                      terpenoid indole alkaloid 1484
                                        monoterpenoid indole alkaloid 1474
                                          yohimban alkaloid 157
                                            yohimban 52
                                              17-yohimbol 51
                                                17alpha-yohimbol 51
                                                  yohimbic acid 51
                                                    yohimbine 51
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.