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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Xylometazoline
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Accession:CHEBI:10082 term browser browse the term
Definition:An alkylbenzene that has formula C16H24N2.
Synonyms:related_synonym: Formula=C16H24N2;   InChI=1S/C16H24N2/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15/h8-9H,6-7,10H2,1-5H3,(H,17,18);   InChIKey=HUCJFAOMUPXHDK-UHFFFAOYSA-N;   SMILES=Cc1cc(cc(C)c1CC1=NCCN1)C(C)(C)C;   otrivine;   rhinoxilin;   xylometazoline HCl;   xylometazoline hydrochloride
 xref: CAS:526-36-3;   Drug_Central:3658;   HMDB:HMDB0015640;   KEGG:C07913;   KEGG:D08684;   LINCS:LSM-5262
 xref_mesh: MESH:C009695


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Xylometazoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenergic receptor, alpha 1a affects binding
multiple interactions
ISO xylometazoline binds to ADRA1A protein
xylometazoline inhibits the reaction [ADRA1A protein binds to Prazosin]
CTD PMID:20030735 NCBI chr14:66,635,251...66,771,240
Ensembl chr14:66,635,251...66,771,168
JBrowse link
G Adra1b adrenergic receptor, alpha 1b affects binding
multiple interactions
ISO xylometazoline binds to ADRA1B protein
xylometazoline inhibits the reaction [ADRA1B protein binds to Prazosin]
CTD PMID:20030735 NCBI chr11:43,774,605...43,901,250
Ensembl chr11:43,774,606...43,901,210
JBrowse link
G Adra1d adrenergic receptor, alpha 1d affects binding
multiple interactions
ISO xylometazoline binds to ADRA1D protein
xylometazoline inhibits the reaction [ADRA1D protein binds to Prazosin]
CTD PMID:20030735 NCBI chr 2:131,545,357...131,562,497
Ensembl chr 2:131,545,850...131,562,283
JBrowse link
G Adra2a adrenergic receptor, alpha 2a affects binding
multiple interactions
ISO xylometazoline binds to ADRA2A protein
xylometazoline inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]
CTD PMID:20030735 NCBI chr19:54,045,259...54,048,982
Ensembl chr19:54,044,151...54,048,982
JBrowse link
G Adra2b adrenergic receptor, alpha 2b multiple interactions ISO [xylometazoline binds to and results in increased activity of ADRA2B protein] which results in increased abundance of Calcium; xylometazoline binds to and results in increased activity of ADRA2B protein; xylometazoline inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan] CTD PMID:20030735 NCBI chr 2:127,363,179...127,367,221
Ensembl chr 2:127,363,208...127,367,221
JBrowse link
G Adra2c adrenergic receptor, alpha 2c affects binding
multiple interactions
ISO xylometazoline binds to ADRA2C protein
xylometazoline inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan]
CTD PMID:20030735 NCBI chr 5:35,278,566...35,281,763
Ensembl chr 5:35,278,319...35,281,763
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO xylometazoline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,584,189...12,628,489
Ensembl chr17:12,584,132...12,628,488
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21720
    role 21698
      chemical role 20825
        environmental contaminant 19355
          benzene 5709
            alkylbenzene 3380
              Xylometazoline 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 21720
    subatomic particle 21706
      composite particle 21706
        hadron 21706
          baryon 21706
            nucleon 21706
              atomic nucleus 21706
                atom 21706
                  main group element atom 21621
                    main group molecular entity 21621
                      s-block molecular entity 21158
                        hydrogen molecular entity 21094
                          hydrides 20358
                            organic hydride 19899
                              organic fundamental parent 19899
                                hydrocarbon 19748
                                  cyclic hydrocarbon 17896
                                    monocyclic hydrocarbon 5879
                                      annulene 5709
                                        aromatic annulene 5709
                                          benzene 5709
                                            alkylbenzene 3380
                                              Xylometazoline 7
paths to the root