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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:wedelolactone
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Accession:CHEBI:10037 term browser browse the term
Definition:A member of the class of coumestans that is coumestan with hydroxy substituents as positions 1, 8 and 9 and a methoxy substituent at position 3.
Synonyms:exact_synonym: 1,8,9-trihydroxy-3-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one
 related_synonym: 1,8,9-trihydroxy-3-methoxycoumestan;   Formula=C16H10O7;   InChI=1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3;   InChIKey=XQDCKJKKMFWXGB-UHFFFAOYSA-N;   SMILES=COc1cc(O)c2c(c1)oc(=O)c1c3cc(O)c(O)cc3oc21
 xref: CAS:524-12-9;   KEGG:C10541;   KNApSAcK:C00002585;   LIPID_MAPS_instance:LMPK12090046
 xref_mesh: MESH:C051122
 xref: PMID:21315506;   PMID:21463376;   PMID:22198514;   PMID:22204306;   PMID:23076676;   PMID:23141142;   Reaxys:332398;   Wikipedia:Wedelolactone

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wedelolactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP wedelolactone inhibits the reaction [Methamphetamine results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:25631491 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp4 caspase 4 decreases expression EXP wedelolactone results in decreased expression of CASP4 protein alternative form CTD PMID:25631491 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652 		JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [wedelolactone results in increased cleavage of PARP1 protein] CTD PMID:22733624 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP wedelolactone inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein] CTD PMID:22207076 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169 		JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP wedelolactone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]; wedelolactone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]; wedelolactone inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]; wedelolactone inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]; wedelolactone inhibits the reaction [Smoke results in increased expression of EDNRB protein]; wedelolactone inhibits the reaction [TNF protein results in increased expression of EDNRB mRNA]; wedelolactone inhibits the reaction [TNF protein results in increased expression of EDNRB protein] CTD PMID:18718921 PMID:20561571 PMID:22207076 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions
decreases activity		 ISO [wedelolactone results in decreased activity of IKBKB protein] which results in decreased phosphorylation of NFKBIA protein CTD PMID:25450232 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO wedelolactone inhibits the reaction [TNF protein results in increased expression of IL6 mRNA] CTD PMID:27793764 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO wedelolactone inhibits the reaction [[Cisplatin co-treated with TNF protein] results in increased phosphorylation of JUN protein] CTD PMID:23103562 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP
ISO		 wedelolactone inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
[wedelolactone results in decreased activity of IKBKB protein] which results in decreased phosphorylation of NFKBIA protein		 CTD PMID:22207076 PMID:25450232 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 EXP
ISO		 wedelolactone inhibits the reaction [Methamphetamine results in increased cleavage of PARP1 protein]
wedelolactone results in increased cleavage of PARP1 protein
Acetylcysteine inhibits the reaction [wedelolactone results in increased cleavage of PARP1 protein]; Buthionine Sulfoximine promotes the reaction [wedelolactone results in increased cleavage of PARP1 protein]; CAT protein inhibits the reaction [wedelolactone results in increased cleavage of PARP1 protein]; S-ethyl glutathione inhibits the reaction [wedelolactone results in increased cleavage of PARP1 protein]		 CTD PMID:22733624 PMID:25631491 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO wedelolactone inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] CTD PMID:27793764 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO		 wedelolactone inhibits the reaction [TNF protein results in increased expression of RELA protein]
wedelolactone affects the localization of and results in decreased activity of RELA protein; wedelolactone inhibits the reaction [Palmitic Acid affects the localization of and results in increased activity of RELA protein]		 CTD PMID:22207076 PMID:26422990 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Sele selectin E multiple interactions ISO wedelolactone inhibits the reaction [Palmitic Acid results in increased expression of SELE mRNA] CTD PMID:26422990 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
decreases activity		 ISO [wedelolactone results in decreased activity of SLC22A6 protein] which results in increased susceptibility to and results in increased activity of aristolochic acid I CTD PMID:32159797 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
decreases activity		 ISO [wedelolactone results in decreased activity of SLC22A8 protein] which results in increased susceptibility to and results in increased activity of aristolochic acid I CTD PMID:32159797 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 wedelolactone inhibits the reaction [TNF protein results in increased expression of EDNRB mRNA]; wedelolactone inhibits the reaction [TNF protein results in increased expression of EDNRB protein]; wedelolactone inhibits the reaction [TNF protein results in increased expression of RELA protein]; wedelolactone inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein]; wedelolactone inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
wedelolactone inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; wedelolactone inhibits the reaction [TNF protein results in increased abundance of Thromboxane B2]; wedelolactone inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; wedelolactone inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
wedelolactone inhibits the reaction [[Cisplatin co-treated with TNF protein] results in increased phosphorylation of JUN protein]		 CTD PMID:22207076 PMID:23103562 PMID:27793764 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO wedelolactone inhibits the reaction [Palmitic Acid results in increased expression of VCAM1 mRNA] CTD PMID:26422990 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      biological role 19792
        biochemical role 19328
          metabolite 19308
            wedelolactone 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic ester 14370
                                        lactone 5993
                                          delta-lactone 3806
                                            coumestan 1775
                                              wedelolactone 17
paths to the root