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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:warfarin
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Accession:CHEBI:10033 term browser browse the term
Definition:A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.
Synonyms:exact_synonym: rac-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
 related_synonym: (Phenyl-1 acetyl-2 ethyl) 3-hydroxy-4 coumarine;   (RS)-Warfarin;   1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone;   2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-;   3-(1'-Phenyl-2'-acetylethyl)-4-hydroxycoumarin;   3-(Acetonylbenzyl)-4-hydroxycoumarin;   3-(Alpha-acetonylbenzyl)-4-hydroxycoumarin;   3-(alpha-Phenyl-beta-acetylaethyl)-4-hydroxycumarin;   3-(alpha-Phenyl-beta-acetylethyl)-4-hydroxycoumarin;   4-Hydroxy-3-(3-oxo-1-phenyl-butyl)-cumarin;   4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin;   Coumafene;   DL-3-(alpha-acetonylbenzyl)-4-hydroxycoumarin;   DL-warfarin;   Warf 10;   Zoocoumarin;   rac-warfarin;   racemic warfarin;   warfarina;   warfarine;   warfarinum
 xref: Beilstein:1293536;   CAS:81-81-2;   DrugBank:DB00682;   HMDB:HMDB0001935;   KEGG:C01541;   KEGG:D08682
 xref_mesh: MESH:D014859
 xref: PMID:13358873;   PMID:15578879;   PMID:18294321;   PMID:19294412;   PMID:24478171;   PMID:24973057;   PMID:25022924;   PMID:25023204;   PMID:25393417;   PMID:25466603;   PMID:25534862;   PMID:25537751;   PMID:25555316;   PMID:25683623;   PMID:25757926;   PMID:25823787;   PMID:25828628;   PMID:25830869;   PMID:25842804;   PMID:25845131;   PMID:25986145;   PMID:26114209;   PMID:26142522;   PMID:26142525;   PMID:26203765;   PMID:26238769;   Patent:US2427578;   Patent:US2765321;   Patent:US2777859;   Patent:US3239529;   Reaxys:1293536;   Wikipedia:Warfarin
 cyclic_relationship: is_conjugate_acid_of CHEBI:50393


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warfarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance
increases expression
ISO ABCB1 polymorphism affects the susceptibility to Warfarin
Warfarin results in increased expression of ABCB1A mRNA
CTD PMID:24092646, PMID:25312789, PMID:27397090 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 multiple interactions
increases response to substance
ISO [Magnesium deficiency co-treated with Phosphates] promotes the reaction [ABCC6 gene mutant form results in increased susceptibility to Warfarin] CTD PMID:23415960 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects response to substance ISO ABCG2 SNP affects the susceptibility to Warfarin CTD PMID:25300812 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP [Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of ACTA2 mRNA CTD PMID:23117658 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Actb actin, beta increases expression
decreases expression
ISO Warfarin results in increased expression of ACTB mRNA
Warfarin results in decreased expression of ACTB mRNA
CTD PMID:20493250 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Actr3 actin related protein 3 increases expression ISO Warfarin results in increased expression of ACTR3 mRNA CTD PMID:20493250 NCBI chr13:41,695,520...41,738,622
Ensembl chr13:41,695,183...41,738,658
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression
EXP Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of ADIPOQ protein]
Warfarin results in increased expression of ADIPOQ protein
CTD PMID:27488359 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Ahcy adenosylhomocysteinase decreases expression ISO Warfarin results in decreased expression of AHCY mRNA CTD PMID:20493250 NCBI chr 3:150,587,833...150,603,057
Ensembl chr 3:150,587,833...150,603,082
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP 6-N,N-diethyl-beta,gamma-dibromomethylene-D-ATP inhibits the reaction [[Warfarin co-treated with Phosphates] results in decreased phosphorylation of AKT1 protein]; [Warfarin co-treated with Phosphates] results in decreased phosphorylation of AKT1 protein; [Warfarin co-treated with Vitamin K 1] results in decreased phosphorylation of AKT1 protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased phosphorylation of AKT1 protein] CTD PMID:22659116, PMID:27212383 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin multiple interactions
affects binding
decreases expression
ISO
EXP
[Warfarin binds to ALB protein] inhibits the reaction [copper (II) diacetyl-di(N(4)-methylthiosemicarbazone) binds to ALB protein]; [Warfarin binds to ALB protein] inhibits the reaction [copper pyruvaldehyde bis(N(4)-methylthiosemicarbazone) complex binds to ALB protein]; Aspirin inhibits the reaction [Warfarin binds to ALB protein]; prodan inhibits the reaction [Warfarin binds to ALB protein]; Pyruvaldehyde inhibits the reaction [Warfarin binds to ALB protein]
Warfarin results in decreased expression of ALB protein
CTD PMID:10506189, PMID:12044178, PMID:18937368, PMID:19596536, PMID:20934417, PMID:20956006, PMID:22342526, PMID:25499135 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein increases expression ISO Warfarin results in increased expression of ALOX5AP mRNA CTD PMID:16698924 NCBI chr12:6,854,930...6,879,112
Ensembl chr12:6,854,920...6,879,154
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO Warfarin inhibits the reaction [BMP2 protein results in increased activity of ALPL protein]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]; Warfarin inhibits the reaction [RUNX2 protein results in increased expression of ALPL mRNA] CTD PMID:21910061 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Anxa4 annexin A4 decreases expression ISO Warfarin results in decreased expression of ANXA4 mRNA CTD PMID:20493250 NCBI chr 4:118,538,775...118,595,591
Ensembl chr 4:118,538,777...118,595,580
JBrowse link
G Anxa5 annexin A5 decreases expression ISO Warfarin results in decreased expression of ANXA5 mRNA CTD PMID:20493250 NCBI chr 2:123,162,477...123,194,730
Ensembl chr 2:123,162,461...123,193,130
JBrowse link
G Apoe apolipoprotein E increases response to substance
affects response to substance
ISO APOE gene mutant form results in increased susceptibility to Warfarin
APOE gene mutant form affects the susceptibility to Warfarin; APOE gene polymorphism affects the susceptibility to Warfarin; APOE polymorphism affects the susceptibility to Warfarin; APOE protein affects the susceptibility to Warfarin; APOE SNP affects the susceptibility to Warfarin
CTD PMID:15952022, PMID:16847429, PMID:17048007, PMID:17325732, PMID:21228733, PMID:23415960, PMID:25312789, PMID:28079798 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha increases expression ISO Warfarin results in increased expression of ARHGDIA mRNA CTD PMID:20493250 NCBI chr10:109,754,012...109,757,506
Ensembl chr10:109,754,004...109,757,550
JBrowse link
G Arse arylsulfatase E decreases activity ISO Warfarin results in decreased activity of ARSL protein CTD PMID:7720070 NCBI chr 2:122,876,645...122,884,673
Ensembl chr 2:122,877,286...122,884,360
JBrowse link
G Asph aspartate-beta-hydroxylase affects response to substance ISO ASPH gene SNP affects the susceptibility to Warfarin CTD PMID:27488176 NCBI chr 5:22,577,680...22,799,333
Ensembl chr 5:22,577,675...22,799,349
JBrowse link
G Axin2 axin 2 multiple interactions
increases expression
EXP [Warfarin co-treated with Vitamin K] results in increased expression of AXIN2 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of AXIN2 mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of AXIN2 mRNA] CTD PMID:23117658 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642
JBrowse link
G Axl Axl receptor tyrosine kinase multiple interactions
decreases phosphorylation
increases response to substance
decreases expression
EXP
ISO
[Warfarin co-treated with Vitamin K 1] results in decreased expression of AXL protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of AXL protein]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of AXL protein]
Warfarin results in decreased phosphorylation of AXL protein
AXL protein results in increased susceptibility to Warfarin
AXL protein promotes the reaction [Warfarin results in increased susceptibility to gemcitabine]; Vitamin K inhibits the reaction [Warfarin results in decreased expression of AXL protein modified form]; Warfarin inhibits the reaction [GAS6 protein results in increased activity of AXL protein]
Warfarin results in decreased expression of AXL protein; Warfarin results in decreased expression of AXL protein modified form
CTD PMID:15123721, PMID:26206560, PMID:27212383 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP [Warfarin co-treated with Vitamin K 1] results in decreased expression of BCL2 protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of BCL2 protein] CTD PMID:27212383 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions
increases expression
ISO
EXP
Warfarin inhibits the reaction [BMP2 protein results in increased activity of BGLAP protein]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of BGLAP mRNA]; Warfarin inhibits the reaction [menatetrenone results in increased carboxylation of BGLAP protein]; Warfarin inhibits the reaction [RUNX2 protein results in increased expression of BGLAP mRNA]; Warfarin inhibits the reaction [Vitamin K 1 results in increased carboxylation of BGLAP protein]; Warfarin inhibits the reaction [vitamin MK 7 results in increased carboxylation of BGLAP protein]
Warfarin results in increased expression of BGLAP mRNA; Warfarin results in increased expression of BGLAP protein modified form
[Warfarin co-treated with Vitamin K] results in increased expression of BGLAP mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of BGLAP mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of BGLAP mRNA]; Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of BGLAP protein modified form]
CTD PMID:21910061, PMID:23117658, PMID:23223575, PMID:27488359, PMID:31173816 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO
EXP
Warfarin inhibits the reaction [BMP2 protein results in increased activity of ALPL protein]; Warfarin inhibits the reaction [BMP2 protein results in increased activity of BGLAP protein]; Warfarin inhibits the reaction [BMP2 protein results in increased activity of RUNX2 protein]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of BGLAP mRNA]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of COL1A1 mRNA]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA]
[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA; [Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein]
CTD PMID:21910061, PMID:27412937 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G C1qbp complement C1q binding protein increases expression ISO Warfarin results in increased expression of C1QBP mRNA CTD PMID:20493250 NCBI chr10:57,613,876...57,618,527
Ensembl chr10:57,613,879...57,618,527
JBrowse link
G Calr calreticulin increases expression ISO Warfarin results in increased expression of CALR mRNA CTD PMID:20493250 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666
JBrowse link
G Calu calumenin decreases response to substance
affects response to substance
EXP
ISO
CALU protein results in decreased susceptibility to Warfarin
CALU gene SNP affects the susceptibility to Warfarin; CALU polymorphism affects the susceptibility to Warfarin
CTD PMID:11641264, PMID:20200517, PMID:27632229 NCBI chr 4:56,625,611...56,653,112
Ensembl chr 4:56,625,561...56,653,111
JBrowse link
G Casp3 caspase 3 decreases expression
increases expression
multiple interactions
ISO
EXP
Warfarin results in decreased expression of CASP3 mRNA
Warfarin results in increased expression of CASP3 protein modified form
[Warfarin co-treated with Vitamin K 1] results in increased cleavage of CASP3 protein
Warfarin results in increased expression of CASP3 mRNA
CTD PMID:19815060, PMID:20493250, PMID:23990204, PMID:26206560 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase increases activity EXP Warfarin results in increased activity of CAT protein CTD PMID:22342526 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
EXP Warfarin results in increased expression of CCND1 mRNA
[Warfarin co-treated with Vitamin K] results in increased expression of CCND1 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of CCND1 mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of CCND1 mRNA]
CTD PMID:23117658 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 increases expression ISO Warfarin results in increased expression of CCT5 mRNA CTD PMID:20493250 NCBI chr 2:84,667,578...84,678,730
Ensembl chr 2:84,667,633...84,678,790
JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A increases expression ISO Warfarin results in increased expression of CCT6A mRNA CTD PMID:20493250 NCBI chr12:30,491,584...30,501,813
Ensembl chr12:30,491,416...30,501,860
JBrowse link
G Cct8 chaperonin containing TCP1 subunit 8 decreases expression ISO Warfarin results in decreased expression of CCT8 mRNA CTD PMID:20493250 NCBI chr11:27,130,172...27,141,881
Ensembl chr11:27,130,172...27,141,881
JBrowse link
G Cdc42 cell division cycle 42 decreases expression ISO Warfarin results in decreased expression of CDC42 mRNA CTD PMID:20493250 NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300
JBrowse link
G Cdh1 cadherin 1 increases expression ISO Warfarin results in increased expression of CDH1 protein CTD PMID:26206560 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Clic1 chloride intracellular channel 1 decreases expression ISO Warfarin results in decreased expression of CLIC1 mRNA CTD PMID:20493250 NCBI chr20:5,040,314...5,049,166
Ensembl chr20:5,040,337...5,049,166
JBrowse link
G Cnn1 calponin 1 multiple interactions EXP [Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of CNN1 mRNA CTD PMID:23117658 NCBI chr 8:23,113,083...23,121,748
Ensembl chr 8:23,113,048...23,121,761
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression
ISO
EXP
Warfarin inhibits the reaction [BMP2 protein results in increased expression of COL1A1 mRNA]
[Warfarin co-treated with Vitamin K] results in increased expression of COL1A1 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of COL1A1 mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of COL1A1 mRNA]
CTD PMID:21910061, PMID:23117658, PMID:23223575 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 affects response to substance ISO COX15 gene affects the susceptibility to Warfarin CTD PMID:28686080 NCBI chr 1:263,494,850...263,511,510
Ensembl chr 1:263,494,852...263,511,505
JBrowse link
G Cox5a cytochrome c oxidase subunit 5A increases expression ISO Warfarin results in increased expression of COX5A mRNA CTD PMID:20493250 NCBI chr 8:62,298,358...62,309,765
Ensembl chr 8:62,298,358...62,309,765
JBrowse link
G Crk CRK proto-oncogene, adaptor protein increases expression ISO Warfarin results in increased expression of CRK mRNA CTD PMID:20493250 NCBI chr10:63,829,731...63,855,999
Ensembl chr10:63,829,807...63,852,780
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
affects response to substance
ISO
EXP
Warfarin results in decreased expression of and affects the localization of CTNNB1 protein
CTNNB1 protein affects the susceptibility to Warfarin
Quercetin inhibits the reaction [Warfarin results in increased expression of and affects the localization of CTNNB1 protein]; Warfarin results in increased expression of and affects the localization of CTNNB1 protein
CTD PMID:23117658, PMID:23223575, PMID:26206560 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Warfarin results in decreased activity of CYP1A1 protein CTD PMID:18420780 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing
affects response to substance
ISO CYP1A2 protein affects the metabolism of Warfarin
CYP1A2 SNP affects the susceptibility to Warfarin
CTD PMID:14676821, PMID:15280511, PMID:28079798 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity ISO Warfarin results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 affects response to substance ISO CYP2C18 gene polymorphism affects the susceptibility to Warfarin; CYP2C18 protein affects the susceptibility to Warfarin CTD PMID:19752777 NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects response to substance
affects metabolic processing
multiple interactions
ISO CYP2C19 gene polymorphism affects the susceptibility to Warfarin; CYP2C19 polymorphism affects the susceptibility to Warfarin; CYP2C19 protein affects the susceptibility to Warfarin
CYP2C19 protein affects the metabolism of Warfarin
CYP2C19 gene polymorphism affects the metabolism of and affects the susceptibility to Warfarin; Omeprazole affects the reaction [CYP2C19 protein affects the metabolism of Warfarin]
CTD PMID:18520598, PMID:19752777, PMID:25652102, PMID:27356304 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Warfarin results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Warfarin results in decreased activity of CYP2D6 protein CTD PMID:18420780 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
affects response to substance
EXP Warfarin results in increased expression of CYP3A2 mRNA
CYP3A2 mRNA affects the susceptibility to Warfarin
CTD PMID:11531004 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects response to substance ISO CYP3A5 gene polymorphism affects the susceptibility to Warfarin; CYP3A5 protein affects the susceptibility to Warfarin CTD PMID:19752777 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Dctn2 dynactin subunit 2 decreases expression ISO Warfarin results in decreased expression of DCTN2 mRNA CTD PMID:20493250 NCBI chr 7:70,555,953...70,571,433
Ensembl chr 7:70,556,019...70,572,614
JBrowse link
G Ddhd1 DDHD domain containing 1 affects response to substance ISO DDHD1 gene SNP affects the susceptibility to Warfarin CTD PMID:27488176 NCBI chr15:19,963,639...20,032,263
Ensembl chr15:19,965,187...20,032,191
JBrowse link
G Ddt D-dopachrome tautomerase decreases expression ISO Warfarin results in decreased expression of DDT mRNA CTD PMID:20493250 NCBI chr20:13,827,153...13,829,624
Ensembl chr20:13,827,132...13,831,588
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase decreases expression ISO Warfarin results in decreased expression of DLST mRNA CTD PMID:20493250 NCBI chr 6:108,936,534...108,961,322
Ensembl chr 6:108,936,664...108,959,803
JBrowse link
G Dock7 dedicator of cytokinesis 7 increases expression ISO Warfarin results in increased expression of DOCK7 mRNA CTD PMID:20493250 NCBI chr 5:117,595,194...117,780,844
Ensembl chr 5:117,596,136...117,780,777
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 increases expression ISO Warfarin results in increased expression of DPYSL2 mRNA CTD PMID:20493250 NCBI chr15:43,475,640...43,581,725
Ensembl chr15:43,477,629...43,542,939
JBrowse link
G Dstn destrin, actin depolymerizing factor decreases expression ISO Warfarin results in decreased expression of DSTN mRNA CTD PMID:20493250 NCBI chr 3:138,024,508...138,051,304
Ensembl chr 3:138,024,508...138,051,298
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 decreases expression ISO Warfarin results in decreased expression of EEF2 mRNA CTD PMID:20493250 NCBI chr 7:11,401,501...11,406,771
Ensembl chr 7:11,401,501...11,406,771
JBrowse link
G Eif3i eukaryotic translation initiation factor 3, subunit I decreases expression ISO Warfarin results in decreased expression of EIF3I mRNA CTD PMID:20493250 NCBI chr 5:147,796,580...147,803,853
Ensembl chr 5:147,796,662...147,803,851
JBrowse link
G Emcn endomucin decreases expression ISO Warfarin results in decreased expression of EMCN protein CTD PMID:26206560 NCBI chr 2:242,634,319...242,715,489
Ensembl chr 2:242,634,399...242,714,182
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 increases expression EXP Warfarin results in increased expression of ENPP1 mRNA; Warfarin results in increased expression of ENPP1 protein CTD PMID:22659116 NCBI chr 1:21,748,201...21,813,205
Ensembl chr 1:21,748,261...21,813,371
JBrowse link
G Epha7 Eph receptor A7 affects response to substance ISO EPHA7 promoter SNP affects the susceptibility to Warfarin CTD PMID:30357299 NCBI chr 5:43,602,744...43,761,198
Ensembl chr 5:43,603,043...43,757,549
JBrowse link
G Ephx1 epoxide hydrolase 1 increases response to substance
affects response to substance
ISO EPHX1 protein results in increased susceptibility to Warfarin
EPHX1 gene polymorphism affects the susceptibility to Warfarin; EPHX1 gene SNP affects the susceptibility to Warfarin; EPHX1 intron SNP affects the susceptibility to Warfarin; EPHX1 polymorphism affects the susceptibility to Warfarin; EPHX1 SNP affects the susceptibility to Warfarin
CTD PMID:15900282, PMID:17496169, PMID:20842355, PMID:21192345, PMID:24092646, PMID:27632229, PMID:28079798 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Erp29 endoplasmic reticulum protein 29 decreases expression ISO Warfarin results in decreased expression of ERP29 mRNA CTD PMID:20493250 NCBI chr12:40,619,377...40,625,884
Ensembl chr12:40,619,377...40,625,883
JBrowse link
G F10 coagulation factor X decreases activity EXP Warfarin results in decreased activity of F10 protein CTD PMID:3490277, PMID:20371969 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
JBrowse link
G F2 coagulation factor II multiple interactions
decreases activity
decreases expression
affects response to substance
ISO
EXP
Fenofibrate promotes the reaction [Warfarin results in decreased expression of F2 protein]
Warfarin results in decreased activity of F2 protein
F2 gene polymorphism affects the susceptibility to Warfarin
CTD PMID:3490277, PMID:9681093, PMID:14656880 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G F5 coagulation factor V affects response to substance
decreases activity
ISO
EXP
F5 gene polymorphism affects the susceptibility to Warfarin; F5 protein affects the susceptibility to Warfarin
Warfarin results in decreased activity of F5 protein
CTD PMID:3490277, PMID:19752777 NCBI chr13:82,479,997...82,535,540
Ensembl chr13:82,479,998...82,535,534
JBrowse link
G F7 coagulation factor VII affects response to substance
decreases activity
multiple interactions
decreases expression
ISO
EXP
F7 gene mutant form affects the susceptibility to Warfarin; F7 gene polymorphism affects the susceptibility to Warfarin
Warfarin results in decreased activity of F7 protein
Fenofibrate promotes the reaction [Warfarin results in decreased expression of F7 protein]
CTD PMID:3490277, PMID:9681093, PMID:14656880, PMID:20371969, PMID:20885134 NCBI chr16:81,824,610...81,834,923
Ensembl chr16:81,824,111...81,834,945
JBrowse link
G F9 coagulation factor IX decreases activity
increases response to substance
EXP
ISO
Warfarin results in decreased activity of F9 protein
F9 gene alternative form results in increased susceptibility to Warfarin
CTD PMID:3490277, PMID:29450643 NCBI chr  X:143,097,507...143,141,791
Ensembl chr  X:143,097,525...143,141,794
JBrowse link
G Fgf5 fibroblast growth factor 5 affects response to substance ISO FGF5 gene affects the susceptibility to Warfarin CTD PMID:28686080 NCBI chr14:12,974,921...12,996,046
Ensembl chr14:12,974,921...12,995,584
JBrowse link
G Fpgs folylpolyglutamate synthase affects response to substance ISO FPGS gene polymorphism affects the susceptibility to Warfarin CTD PMID:25079360 NCBI chr 3:11,717,667...11,729,694
Ensembl chr 3:11,717,667...11,723,327
JBrowse link
G Fscn1 fascin actin-bundling protein 1 decreases expression ISO Warfarin results in decreased expression of FSCN1 mRNA CTD PMID:20493250 NCBI chr12:13,655,459...13,668,595
Ensembl chr12:13,656,554...13,668,515
JBrowse link
G G3bp1 G3BP stress granule assembly factor 1 increases expression ISO Warfarin results in increased expression of G3BP1 mRNA CTD PMID:20493250 NCBI chr10:40,812,858...40,846,252
Ensembl chr10:40,812,858...40,846,252
JBrowse link
G Gal3st1 galactose-3-O-sulfotransferase 1 increases expression ISO Warfarin results in increased expression of GAL3ST1 mRNA CTD PMID:27397090 NCBI chr14:84,231,473...84,247,371
Ensembl chr14:84,231,639...84,247,369
JBrowse link
G Gale UDP-galactose-4-epimerase decreases expression ISO Warfarin results in decreased expression of GALE mRNA CTD PMID:20493250 NCBI chr 5:154,310,453...154,314,959
Ensembl chr 5:154,310,453...154,314,955
JBrowse link
G Gas6 growth arrest specific 6 decreases expression
multiple interactions
decreases carboxylation
EXP
ISO
Warfarin results in decreased expression of GAS6 protein
Warfarin inhibits the reaction [GAS6 protein results in increased activity of AXL protein]
Warfarin results in decreased carboxylation of GAS6 protein
[Warfarin co-treated with Vitamin K 1] results in decreased expression of GAS6 protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of GAS6 protein]; Warfarin results in decreased activity of and results in decreased carboxylation of GAS6 protein
CTD PMID:9163328, PMID:19564549, PMID:26206560, PMID:27212383 NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757
JBrowse link
G Gdi2 GDP dissociation inhibitor 2 increases expression ISO Warfarin results in increased expression of GDI2 mRNA CTD PMID:20493250 NCBI chr17:70,299,177...70,325,864
Ensembl chr17:70,299,183...70,325,855
JBrowse link
G Gfap glial fibrillary acidic protein increases expression ISO Warfarin results in increased expression of GFAP mRNA; Warfarin results in increased expression of GFAP protein CTD PMID:27397090 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Ggcx gamma-glutamyl carboxylase affects response to substance
increases activity
increases response to substance
decreases response to substance
ISO
EXP
GGCX gene polymorphism affects the susceptibility to Warfarin; GGCX gene SNP affects the susceptibility to Warfarin; GGCX polymorphism affects the susceptibility to Warfarin
Warfarin results in increased activity of GGCX protein
GGCX protein results in increased susceptibility to Warfarin
GGCX gene polymorphism results in decreased susceptibility to Warfarin
CTD PMID:3490277, PMID:16676068, PMID:17049586, PMID:17496169, PMID:17764537, PMID:21195460, PMID:21326313, PMID:22161100, PMID:25042728, PMID:27632229 NCBI chr 4:100,277,345...100,293,097
Ensembl chr 4:100,277,391...100,293,250
JBrowse link
G Gmps guanine monophosphate synthase increases expression ISO Warfarin results in increased expression of GMPS mRNA CTD PMID:20493250 NCBI chr 2:154,555,967...154,590,662
Ensembl chr 2:154,555,871...154,590,662
JBrowse link
G Gprc6a G protein-coupled receptor, class C, group 6, member A multiple interactions EXP Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GPRC6A mRNA] CTD PMID:27488359 NCBI chr20:32,607,653...32,628,953
Ensembl chr20:32,607,653...32,628,953
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP [Warfarin co-treated with Vitamin K] results in increased phosphorylation of GSK3B protein; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased phosphorylation of GSK3B protein] CTD PMID:23117658 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hdac1 histone deacetylase 1 increases expression ISO Warfarin results in increased expression of HDAC1 mRNA CTD PMID:20493250 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 increases expression ISO Warfarin results in increased expression of HINT1 mRNA CTD PMID:20493250 NCBI chr10:40,208,236...40,211,981
Ensembl chr10:40,208,223...40,211,975
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of HMGCR mRNA] CTD PMID:27488359 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmox1 heme oxygenase 1 affects expression EXP Warfarin affects the expression of HMOX1 mRNA CTD PMID:22954530 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnrnpab heterogeneous nuclear ribonucleoprotein A/B increases expression ISO Warfarin results in increased expression of HNRNPAB mRNA CTD PMID:20493250 NCBI chr10:34,955,713...34,961,662
Ensembl chr10:34,955,716...34,961,608
JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like decreases expression ISO Warfarin results in decreased expression of HNRNPDL mRNA CTD PMID:20493250 NCBI chr14:11,199,114...11,204,670
Ensembl chr14:11,198,896...11,202,669
JBrowse link
G Hnrnpf heterogeneous nuclear ribonucleoprotein F increases expression ISO Warfarin results in increased expression of HNRNPF mRNA CTD PMID:20493250 NCBI chr 4:149,957,143...149,978,896
Ensembl chr 4:149,957,206...149,978,895
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K increases expression
decreases expression
ISO Warfarin results in increased expression of HNRNPK mRNA
Warfarin results in decreased expression of HNRNPK mRNA
CTD PMID:20493250 NCBI chr17:6,664,730...6,676,753
Ensembl chr17:6,665,659...6,676,654
JBrowse link
G Hp haptoglobin increases expression EXP Warfarin results in increased expression of HP protein CTD PMID:22342526 NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression ISO Warfarin results in decreased expression of HSP90AB1 mRNA CTD PMID:20493250 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression ISO Warfarin results in increased expression of HSPA8 mRNA CTD PMID:20493250 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression ISO Warfarin results in increased expression of HSPD1 mRNA CTD PMID:20493250 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Il12a interleukin 12A increases expression EXP Warfarin results in increased expression of IL12A mRNA CTD PMID:22342526 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B increases expression EXP Warfarin results in increased expression of IL12B mRNA CTD PMID:22342526 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO
EXP
Warfarin inhibits the reaction [Vitamin K 2 results in decreased susceptibility to IL1B protein]
Warfarin results in decreased expression of IL1B mRNA
[Warfarin co-treated with Vitamin K] results in increased expression of IL1B mRNA
CTD PMID:20460758, PMID:23117658, PMID:29594315 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Warfarin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
decreases expression
decreases secretion
EXP
ISO
Warfarin results in increased expression of IL6 protein
[Warfarin co-treated with Vitamin K] results in increased expression of IL6 mRNA
Warfarin results in decreased expression of IL6 mRNA
Warfarin results in decreased secretion of IL6 protein
Warfarin results in decreased expression of IL6 protein
CTD PMID:18772604, PMID:22342526, PMID:23117658, PMID:26742017 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ipo5 importin 5 decreases expression ISO Warfarin results in decreased expression of IPO5 mRNA CTD PMID:20493250 NCBI chr15:106,243,110...106,293,326
Ensembl chr15:106,257,650...106,292,112
JBrowse link
G Isyna1 inositol-3-phosphate synthase 1 increases expression ISO Warfarin results in increased expression of ISYNA1 mRNA CTD PMID:20493250 NCBI chr16:20,589,497...20,592,333
Ensembl chr16:20,589,481...20,592,449
JBrowse link
G Krt18 keratin 18 decreases expression ISO Warfarin results in decreased expression of KRT18 mRNA CTD PMID:20493250 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Lasp1 LIM and SH3 protein 1 decreases expression ISO Warfarin results in decreased expression of LASP1 mRNA CTD PMID:20493250 NCBI chr10:85,744,662...85,785,130
Ensembl chr10:85,744,568...85,785,133
JBrowse link
G Mgp matrix Gla protein multiple interactions
decreases carboxylation
ISO
EXP
[[Warfarin co-treated with Vitamin K 1] results in decreased carboxylation of MGP protein] which results in decreased activity of MGP protein; [Warfarin co-treated with Vitamin K 1] results in decreased activity of MGP protein; [Warfarin co-treated with Vitamin K 1] results in decreased carboxylation of MGP protein; [Warfarin co-treated with Vitamin K 1] results in decreased expression of MGP mRNA
Warfarin results in decreased carboxylation of MGP protein
[Quercetin co-treated with Warfarin] results in decreased carboxylation of MGP protein; [Vitamin K co-treated with Warfarin] results in increased carboxylation of MGP protein; Warfarin inhibits the reaction [Vitamin K 1 results in increased expression of and results in increased secretion of MGP protein modified form]; Warfarin results in decreased expression of and results in decreased secretion of MGP protein; Warfarin results in decreased expression of and results in decreased secretion of MGP protein modified form
CTD PMID:21705322, PMID:23223575, PMID:23990204 NCBI chr 4:170,856,783...170,860,105
Ensembl chr 4:170,856,751...170,860,225
JBrowse link
G Mpo myeloperoxidase increases activity EXP Warfarin results in increased activity of MPO protein CTD PMID:26742017 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Myh1 myosin heavy chain 1 multiple interactions EXP [Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of MYH1 mRNA CTD PMID:23117658 NCBI chr10:53,740,841...53,764,610
Ensembl chr10:53,713,938...53,848,347
JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase affects response to substance ISO NEDD4 gene SNP affects the susceptibility to Warfarin CTD PMID:27488176 NCBI chr 8:79,323,408...79,408,842
Ensembl chr 8:79,323,408...79,408,833
JBrowse link
G Nmral1 NmrA like redox sensor 1 increases expression ISO Warfarin results in increased expression of NMRAL1 mRNA CTD PMID:20493250 NCBI chr10:11,045,924...11,055,154
Ensembl chr10:11,046,024...11,055,158
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 affects response to substance ISO NQO1 gene SNP affects the susceptibility to Warfarin; NQO1 polymorphism affects the susceptibility to Warfarin CTD PMID:23215885, PMID:26257249, PMID:27581200 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Warfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP2C9 mRNA; [Warfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Warfarin binds to and results in increased activity of NR1I2 protein CTD PMID:20735727 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nucb1 nucleobindin 1 increases expression ISO Warfarin results in increased expression of NUCB1 mRNA CTD PMID:20493250 NCBI chr 1:101,480,160...101,511,029
Ensembl chr 1:101,480,145...101,500,850
JBrowse link
G Numb NUMB, endocytic adaptor protein multiple interactions EXP [Warfarin co-treated with Vitamin K] results in increased expression of NUMB mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of NUMB mRNA] CTD PMID:23117658 NCBI chr 6:107,279,917...107,325,345
Ensembl chr 6:107,279,920...107,325,345
JBrowse link
G Oat ornithine aminotransferase decreases expression ISO Warfarin results in decreased expression of OAT mRNA CTD PMID:20493250 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
JBrowse link
G Orm1 orosomucoid 1 multiple interactions
affects binding
increases response to substance
affects response to substance
ISO Chlorpromazine inhibits the reaction [Warfarin binds to ORM1 protein alternative form]; Dipyridamole inhibits the reaction [Warfarin binds to ORM1 protein alternative form]; Lidocaine inhibits the reaction [Warfarin binds to ORM1 protein alternative form]; Progesterone inhibits the reaction [Warfarin binds to ORM1 protein alternative form]
ORM1 protein results in increased susceptibility to Warfarin
ORM1 gene polymorphism affects the susceptibility to Warfarin; ORM1 polymorphism affects the susceptibility to Warfarin
CTD PMID:8946472, PMID:17496169, PMID:23208322, PMID:26644206 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G Pa2g4 proliferation-associated 2G4 increases expression ISO Warfarin results in increased expression of PA2G4 mRNA CTD PMID:20493250 NCBI chr 7:2,979,587...2,987,055
Ensembl chr 7:2,979,588...2,987,055
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO Warfarin results in increased expression of PARP1 protein modified form CTD PMID:26206560 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdgfb platelet derived growth factor subunit B decreases expression EXP Warfarin results in decreased expression of PDGFB mRNA; Warfarin results in decreased expression of PDGFB protein CTD PMID:11290560 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 increases expression
decreases expression
ISO Warfarin results in increased expression of PDIA3 mRNA
Warfarin results in decreased expression of PDIA3 mRNA
CTD PMID:20493250 NCBI chr 3:113,376,983...113,400,707
Ensembl chr 3:113,376,983...113,400,707
JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 decreases expression ISO Warfarin results in decreased expression of PDIA4 mRNA CTD PMID:20493250 NCBI chr 4:77,470,636...77,489,535
Ensembl chr 4:77,470,636...77,489,535
JBrowse link
G Pgam1 phosphoglycerate mutase 1 decreases expression
increases expression
ISO Warfarin results in decreased expression of PGAM1 mRNA
Warfarin results in increased expression of PGAM1 mRNA
CTD PMID:20493250 NCBI chr 1:261,158,204...261,165,814
Ensembl chr 1:261,158,261...261,165,808
JBrowse link
G Pkm pyruvate kinase M1/2 decreases expression ISO Warfarin results in decreased expression of PKM mRNA CTD PMID:20493250 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Plp1 proteolipid protein 1 increases expression ISO Warfarin results in increased expression of PLP1 mRNA CTD PMID:27397090 NCBI chr  X:107,494,326...107,511,355
Ensembl chr  X:107,496,072...107,511,348
JBrowse link
G Por cytochrome p450 oxidoreductase affects response to substance ISO POR gene SNP affects the susceptibility to Warfarin CTD PMID:27488389 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha decreases expression ISO Warfarin results in decreased expression of PPP1CA mRNA CTD PMID:20493250 NCBI chr 1:219,439,953...219,443,570
Ensembl chr 1:219,439,953...219,443,570
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha increases expression ISO Warfarin results in increased expression of PPP2R1A mRNA CTD PMID:20493250 NCBI chr 1:60,717,386...60,736,629
Ensembl chr 1:60,717,386...60,736,609
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa increases response to substance
affects response to substance
ISO PROC protein results in increased susceptibility to Warfarin
PROC gene polymorphism affects the susceptibility to Warfarin
CTD PMID:17048007, PMID:17496169 NCBI chr18:24,918,402...24,928,822
Ensembl chr18:24,918,398...24,929,091
JBrowse link
G Pros1 protein S affects response to substance ISO PROS1 gene polymorphism affects the susceptibility to Warfarin; PROS1 protein affects the susceptibility to Warfarin CTD PMID:19752777 NCBI chr 7:1,206,648...1,288,140
Ensembl chr 7:1,206,648...1,288,134
JBrowse link
G Prss53 serine protease 53 affects response to substance ISO PRSS53 gene SNP affects the susceptibility to Warfarin CTD PMID:21590310 NCBI chr 1:199,331,108...199,337,129
Ensembl chr 1:199,331,787...199,336,451
JBrowse link
G Psma3 proteasome 20S subunit alpha 3 decreases expression ISO Warfarin results in decreased expression of PSMA3 mRNA CTD PMID:20493250 NCBI chr 6:93,423,029...93,444,223
Ensembl chr 6:93,423,002...93,444,240
JBrowse link
G Psma6 proteasome 20S subunit alpha 6 decreases expression ISO Warfarin results in decreased expression of PSMA6 mRNA CTD PMID:20493250 NCBI chr 6:76,174,460...76,205,429
Ensembl chr 6:76,174,452...76,205,426
JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 decreases expression ISO Warfarin results in decreased expression of PSMC2 mRNA CTD PMID:20493250 NCBI chr 4:9,867,132...9,881,383
Ensembl chr 4:9,867,101...9,881,484
JBrowse link
G Pth parathyroid hormone decreases activity ISO Warfarin results in decreased activity of PTH protein CTD PMID:11564701 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761
JBrowse link
G Rab1a RAB1A, member RAS oncogene family decreases expression ISO Warfarin results in decreased expression of RAB1A mRNA CTD PMID:20493250 NCBI chr14:104,475,082...104,500,176
Ensembl chr14:104,475,082...104,501,020
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO Warfarin results in decreased expression of RHOA mRNA CTD PMID:20493250 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rpl27 ribosomal protein L27 increases expression ISO Warfarin results in increased expression of RPL27 mRNA CTD PMID:20493250 NCBI chr10:89,352,864...89,356,563
Ensembl chr10:89,352,835...89,356,547
JBrowse link
G Rpl9 ribosomal protein L9 increases expression ISO Warfarin results in increased expression of RPL9 mRNA CTD PMID:20493250 NCBI chr14:44,524,419...44,527,613
Ensembl chr14:44,524,416...44,527,613
JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 increases expression ISO Warfarin results in increased expression of RPLP0 mRNA CTD PMID:20493250 NCBI chr12:46,791,528...46,794,797
Ensembl chr12:46,791,528...46,794,797
JBrowse link
G Rpsa ribosomal protein SA increases expression ISO Warfarin results in increased expression of RPSA mRNA CTD PMID:20493250 NCBI chr 8:128,806,053...128,809,987
Ensembl chr 8:128,806,129...128,809,986
JBrowse link
G Runx1 RUNX family transcription factor 1 increases expression
multiple interactions
EXP Warfarin results in increased expression of RUNX1 mRNA
Quercetin inhibits the reaction [Warfarin results in increased expression of RUNX1 mRNA]
CTD PMID:23223575 NCBI chr11:32,765,147...33,003,061
Ensembl chr11:32,769,165...33,003,021
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO
EXP
Warfarin inhibits the reaction [BMP2 protein results in increased activity of RUNX2 protein]; Warfarin inhibits the reaction [RUNX2 protein results in increased expression of ALPL mRNA]; Warfarin inhibits the reaction [RUNX2 protein results in increased expression of BGLAP mRNA]
[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 mRNA; [Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 protein; [Warfarin co-treated with Vitamin K] results in increased expression of RUNX2 mRNA; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 protein]; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of RUNX2 mRNA]
CTD PMID:21910061, PMID:23117658, PMID:27412937 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Ruvbl2 RuvB-like AAA ATPase 2 decreases expression ISO Warfarin results in decreased expression of RUVBL2 mRNA CTD PMID:20493250 NCBI chr 1:101,413,766...101,426,970
Ensembl chr 1:101,413,766...101,426,852
JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 decreases expression ISO Warfarin results in decreased expression of SAE1 mRNA CTD PMID:20493250 NCBI chr 1:78,277,524...78,333,281
Ensembl chr 1:78,277,515...78,333,321
JBrowse link
G Sephs1 selenophosphate synthetase 1 increases expression ISO Warfarin results in increased expression of SEPHS1 mRNA CTD PMID:20493250 NCBI chr17:77,312,562...77,340,934
Ensembl chr17:77,312,562...77,340,934
JBrowse link
G Serpinc1 serpin family C member 1 increases expression ISO Warfarin results in increased expression of SERPINC1 protein CTD PMID:73932 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link
G Slc15a2 solute carrier family 15 member 2 affects response to substance ISO SLC15A2 gene SNP affects the susceptibility to Warfarin CTD PMID:29234073 NCBI chr11:66,932,664...66,961,708
Ensembl chr11:66,932,614...66,961,713
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 affects response to substance ISO SLCO1B3 gene SNP affects the susceptibility to Warfarin CTD PMID:29234073 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Sp7 Sp7 transcription factor multiple interactions ISO Warfarin inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA] CTD PMID:21910061 NCBI chr 7:143,957,316...143,967,488
Ensembl chr 7:143,958,858...143,967,484
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO
EXP
[Warfarin co-treated with Vitamin K 1] results in increased expression of SPP1 mRNA
[Quercetin co-treated with Warfarin] results in increased expression of SPP1 mRNA; [Warfarin co-treated with Vitamin K] results in increased expression of SPP1 mRNA
CTD PMID:23117658, PMID:23223575, PMID:23990204 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression ISO Warfarin results in decreased expression of STIP1 mRNA CTD PMID:20493250 NCBI chr 1:222,274,133...222,293,139
Ensembl chr 1:222,274,133...222,293,148
JBrowse link
G Tagln transgelin multiple interactions ISO
EXP
[Warfarin co-treated with Vitamin K 1] results in decreased expression of TAGLN mRNA
[Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of TAGLN mRNA
CTD PMID:23117658, PMID:23990204 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tcf4 transcription factor 4 increases expression
multiple interactions
EXP Warfarin results in increased expression of TCF4 mRNA
[Warfarin co-treated with Vitamin K] results in increased expression of TCF4 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of TCF4 mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of TCF4 mRNA]
CTD PMID:23117658 NCBI chr18:65,285,320...65,507,983
Ensembl chr18:65,155,685...65,507,977
JBrowse link
G Tcp1 t-complex 1 increases expression ISO Warfarin results in increased expression of TCP1 mRNA CTD PMID:20493250 NCBI chr 1:48,025,664...48,033,343
Ensembl chr 1:48,025,663...48,033,396
JBrowse link
G Tgm2 transglutaminase 2 affects response to substance
multiple interactions
increases response to substance
ISO
EXP
[TGM2 protein affects the susceptibility to Warfarin] which affects the susceptibility to Quercetin; TGM2 protein affects the susceptibility to Warfarin
[Warfarin co-treated with Vitamin K] results in increased expression of and results in increased activity of TGM2 protein; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of and results in increased activity of TGM2 protein]; Quercetin inhibits the reaction [Warfarin results in increased activity of TGM2 protein]; Warfarin results in increased expression of and results in increased activity of TGM2 protein
TGM2 protein results in increased susceptibility to Warfarin
CTD PMID:23117658 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Thop1 thimet oligopeptidase 1 increases expression ISO Warfarin results in increased expression of THOP1 mRNA CTD PMID:20493250 NCBI chr 7:11,501,145...11,513,576
Ensembl chr 7:11,501,146...11,513,581
JBrowse link
G Tnf tumor necrosis factor decreases expression
increases expression
multiple interactions
decreases secretion
EXP Warfarin results in decreased expression of TNF mRNA
Warfarin results in increased expression of TNF
[Warfarin co-treated with Vitamin K] results in increased expression of TNF mRNA
Warfarin results in decreased secretion of TNF protein
CTD PMID:21565690, PMID:22342526, PMID:23117658, PMID:26742017 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases degradation
increases expression
ISO Warfarin results in increased degradation of TP53 protein
Warfarin results in increased expression of TRP53 mRNA; Warfarin results in increased expression of TRP53 protein
CTD PMID:14634213, PMID:29358327 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tuba1a tubulin, alpha 1A increases expression ISO Warfarin results in increased expression of TUBA1A mRNA CTD PMID:20493250 NCBI chr 7:140,637,287...140,640,953
Ensembl chr 7:140,637,287...140,640,953
JBrowse link
G Tuba1b tubulin, alpha 1B decreases expression
increases expression
ISO Warfarin results in decreased expression of TUBA1B mRNA
Warfarin results in increased expression of TUBA1B mRNA
CTD PMID:20493250 NCBI chr 7:140,614,746...140,617,721
Ensembl chr 7:140,614,752...140,617,721
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO Warfarin results in decreased expression of TUBB5 mRNA CTD PMID:20493250 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371
JBrowse link
G Tufm Tu translation elongation factor, mitochondrial decreases expression ISO Warfarin results in decreased expression of TUFM mRNA CTD PMID:20493250 NCBI chr 1:197,903,582...197,907,189
Ensembl chr 1:197,903,582...197,907,189
JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase decreases expression ISO Warfarin results in decreased expression of TYRO3 mRNA CTD PMID:18772604, PMID:27397090 NCBI chr 3:111,597,102...111,616,142
Ensembl chr 3:111,597,102...111,616,142
JBrowse link
G U2af2 U2 small nuclear RNA auxiliary factor 2 increases expression ISO Warfarin results in increased expression of U2AF2 mRNA CTD PMID:20493250 NCBI chr 1:72,312,260...72,329,828
Ensembl chr 1:72,312,727...72,329,856
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
affects response to substance
increases metabolic processing
ISO [UGT1A1 protein results in increased metabolism of Warfarin] which results in increased chemical synthesis of Glucuronides; [Warfarin binds to and results in decreased activity of UGT1A1 protein] which results in decreased glucuronidation of Estradiol; Warfarin binds to and results in decreased activity of UGT1A1 protein; Warfarin inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol]
UGT1A1 gene SNP affects the susceptibility to Warfarin; UGT1A1 polymorphism affects the susceptibility to Warfarin
CTD PMID:19408964, PMID:25312789, PMID:25393417, PMID:26223945 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO [Warfarin binds to and results in increased activity of UGT1A3 protein] which results in increased glucuronidation of vorinostat; Warfarin binds to and results in increased activity of UGT1A3 protein; Warfarin promotes the reaction [UGT1A3 protein results in increased glucuronidation of vorinostat] CTD PMID:25393417 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions ISO [Warfarin binds to and affects the activity of UGT1A9 protein] which affects the glucuronidation of Propofol; Warfarin affects the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]; Warfarin binds to and affects the activity of UGT1A9 protein CTD PMID:25393417 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 multiple interactions ISO [Warfarin binds to and results in decreased activity of UGT2B17 protein] which results in decreased glucuronidation of vorinostat; Warfarin binds to and results in decreased activity of UGT2B17 protein; Warfarin inhibits the reaction [UGT2B17 protein results in increased glucuronidation of vorinostat] CTD PMID:25393417 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO [Warfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine; Warfarin binds to and results in decreased activity of UGT2B7 protein; Warfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine] CTD PMID:25393417 NCBI chr14:22,597,103...22,619,968 JBrowse link
G Usp5 ubiquitin specific peptidase 5 decreases expression ISO Warfarin results in decreased expression of USP5 mRNA CTD PMID:20493250 NCBI chr 4:157,332,735...157,347,803
Ensembl chr 4:157,332,740...157,347,803
JBrowse link
G Vcp valosin-containing protein decreases expression
increases expression
ISO Warfarin results in decreased expression of VCP mRNA
Warfarin results in increased expression of VCP mRNA
CTD PMID:20493250 NCBI chr 5:58,426,548...58,445,953
Ensembl chr 5:58,426,549...58,445,953
JBrowse link
G Vdr vitamin D receptor affects response to substance ISO VDR gene SNP affects the susceptibility to Warfarin CTD PMID:28262345, PMID:29298995 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Vim vimentin decreases expression ISO Warfarin results in decreased expression of VIM protein CTD PMID:26206560 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 multiple interactions
decreases activity
affects abundance
decreases response to substance
affects response to substance
affects metabolic processing
increases response to substance
decreases metabolic processing
ISO
EXP
[CYP4F2 gene polymorphism co-treated with VKORC1 gene mutant form] affects the susceptibility to Warfarin; Warfarin binds to and results in decreased activity of VKORC1 protein; Warfarin inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]; Warfarin inhibits the reaction [VKORC1 protein results in increased reduction of vitamin K1 oxide]
Warfarin results in decreased activity of VKORC1 protein
VKORC1 gene polymorphism affects the abundance of Warfarin
VKORC1 3' UTR results in decreased susceptibility to Warfarin; VKORC1 gene mutant form results in decreased susceptibility to Warfarin; VKORC1 gene polymorphism results in decreased susceptibility to Warfarin
VKORC1 affects the susceptibility to Warfarin; VKORC1 gene affects the susceptibility to Warfarin; VKORC1 gene mutant form affects the susceptibility to Warfarin; VKORC1 gene polymorphism affects the susceptibility to Warfarin; VKORC1 gene SNP affects the susceptibility to Warfarin; VKORC1 intron polymorphism affects the susceptibility to Warfarin; VKORC1 intron SNP affects the susceptibility to Warfarin; VKORC1 polymorphism affects the susceptibility to Warfarin; VKORC1 promoter polymorphism affects the susceptibility to Warfarin; VKORC1 protein affects the susceptibility to Warfarin; VKORC1 protein polymorphism affects the susceptibility to Warfarin; VKORC1 protein SNP affects the susceptibility to Warfarin; VKORC1 SNP affects the susceptibility to Warfarin
Warfarin inhibits the reaction [VKORC1 protein affects the reduction of vitamin K1 oxide]
VKORC1 gene mutant form results in decreased susceptibility to Warfarin; VKORC1 protein polymorphism results in decreased susceptibility to Warfarin
VKORC1 protein mutant form affects the susceptibility to Warfarin
VKORC1 protein affects the metabolism of Warfarin
VKORC1 intron polymorphism results in increased susceptibility to Warfarin; VKORC1 protein results in increased susceptibility to Warfarin; VKORC1 results in increased susceptibility to Warfarin
VKORC1 gene polymorphism results in decreased metabolism of Warfarin
CTD PMID:14765194, PMID:14765195, PMID:15358623, PMID:15578879, PMID:15630486, PMID:15879509, PMID:15930419, PMID:16270629, PMID:16421894, PMID:16432637, PMID:16611750, PMID:16676068, PMID:16847429, PMID:16879214, PMID:16890578, PMID:16960144, PMID:17048007, PMID:17049586, PMID:17111199, PMID:17329985, PMID:17387222, PMID:17391071, PMID:17456829, PMID:17496169, PMID:17510308, PMID:17764537, PMID:17941040, PMID:17961434, PMID:17995970, PMID:18030307, PMID:18034619, PMID:18240904, PMID:18266023, PMID:18370846, PMID:18523153, PMID:18532998, PMID:18535201, PMID:18542936, PMID:18574025, PMID:18698879, PMID:18776969, PMID:18805772, PMID:19018718, PMID:19135231, PMID:19200363, PMID:19207028, PMID:19300499, PMID:19567378, PMID:19752777, PMID:19942260, PMID:19998810, PMID:20072124, PMID:20073138, PMID:20339978, PMID:20354686, PMID:20375999, PMID:20386359, PMID:20420818, PMID:20553802, PMID:20579077, PMID:20615525, PMID:20637959, PMID:20716240, PMID:20833655, PMID:20842355, PMID:20854800, PMID:21084764, PMID:21110192, PMID:21176721, PMID:21228733, PMID:21270790, PMID:21320153, PMID:21321468, PMID:21326313, PMID:21428138, PMID:21562147, PMID:21590310, PMID:21635147, PMID:21639946, PMID:21681008, PMID:21786578, PMID:21911247, PMID:22040439, PMID:22161100, PMID:22198820, PMID:22248286, PMID:22266406, PMID:22528326, PMID:22533669, PMID:22571356, PMID:22855348, PMID:22907842, PMID:22990331, PMID:23018795, PMID:23061746, PMID:23167228, PMID:23183958, PMID:23208322, PMID:23276529, PMID:23279643, PMID:23571513, PMID:23602689, PMID:23710884, PMID:23800980, PMID:23928358, PMID:23990957, PMID:24399734, PMID:24474498, PMID:24601977, PMID:24750390, PMID:24966969, PMID:24978953, PMID:25042728, PMID:25312789, PMID:25652102, PMID:25699611, PMID:25747538, PMID:25885753, PMID:25946405, PMID:25986145, PMID:26167638, PMID:26219158, PMID:26223945, PMID:26257249, PMID:26418980, PMID:26445138, PMID:26568290, PMID:26583785, PMID:26644206, PMID:26757860, PMID:26940072, PMID:26996562, PMID:27055637, PMID:27117082, PMID:27258224, PMID:27262824, PMID:27488176, PMID:27622442, PMID:27632229, PMID:27743182, PMID:27938396, PMID:28079798, PMID:28083852, PMID:28135054, PMID:28262345, PMID:28401802, PMID:28550460, PMID:28686080, PMID:28689179, PMID:28867752, PMID:29182754, PMID:29234073, PMID:29581108, PMID:29776386 NCBI chr 1:199,338,785...199,341,306
Ensembl chr 1:199,337,138...199,341,302
JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions ISO
EXP
Warfarin affects the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide]; Warfarin binds to and results in decreased activity of VKORC1L1 protein; Warfarin inhibits the reaction [VKORC1L1 protein results in increased metabolism of vitamin K1 oxide]; Warfarin inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]; Warfarin inhibits the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide] CTD PMID:23710884, PMID:23928358, PMID:29581108 NCBI chr12:30,218,825...30,268,990
Ensembl chr12:30,222,701...30,268,990
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon increases expression ISO Warfarin results in increased expression of YWHAE mRNA CTD PMID:20493250 NCBI chr10:63,884,338...63,921,709
Ensembl chr10:63,884,338...63,921,709
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 decreases expression ISO Warfarin results in decreased expression of ZEB1 protein CTD PMID:26206560 NCBI chr17:54,656,627...54,714,920
Ensembl chr17:54,658,463...54,714,914
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pesticide 16264
          rodenticide 5927
            warfarin 175
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  oxacycle 17185
                                    benzopyran 10135
                                      1-benzopyran 9851
                                        chromenes 931
                                          chromenone 851
                                            coumarins 573
                                              hydroxycoumarin 300
                                                4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one 175
                                                  (R)-warfarin 175
                                                    warfarin 175
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.