Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:voriconazole
go back to main search page
Accession:CHEBI:10023 term browser browse the term
Definition:A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. It is an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4.
Synonyms:exact_synonym: (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
 related_synonym: (R-(R*,S*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol;   (alphaR,betaS)-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol;   Formula=C16H14F3N5O;   InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1;   InChIKey=BCEHBSKCWLPMDN-MGPLVRAMSA-N;   SMILES=C[C@@H](c1ncncc1F)[C@](O)(Cn1cncn1)c1ccc(F)cc1F;   VCZ;   Vfend;   voriconazol;   voriconazolum
 alt_id: CHEBI:127308
 xref: Beilstein:7694998;   CAS:137234-62-9;   DrugBank:DB00582;   Drug_Central:2846;   KEGG:C07622;   KEGG:D00578;   LINCS:LSM-5244
 xref_mesh: MESH:D065819
 xref: PMID:12940129;   PMID:22718362;   PMID:23392902;   PMID:23527908;   PMID:23766489;   PMID:24102553;   Patent:EP440372;   Patent:US5278175;   Wikipedia:Voriconazole



show annotations for term's descendants           Sort by:
 
voriconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car1 carbonic anhydrase 1 decreases activity ISO Voriconazole results in decreased activity of CA1 protein CTD PMID:31478295 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Voriconazole results in decreased activity of CA2 protein CTD PMID:31478295 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Voriconazole results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects metabolic processing
decreases activity
ISO CYP2C19 protein affects the metabolism of Voriconazole
Voriconazole results in decreased activity of CYP2C19 protein
CTD PMID:15328084 PMID:15914520 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
decreases activity
ISO CYP3A4 protein affects the metabolism of Voriconazole
Voriconazole results in decreased activity of CYP3A4 protein
CTD PMID:15328084 PMID:15914520 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp51 cytochrome P450, family 51 multiple interactions
decreases response to substance
ISO CYP51A1 gene inhibits the reaction [Voriconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Voriconazole results in decreased metabolism of and results in increased abundance of 14-methylergosta-8,24(28)-dien-3,6-diol]; CYP51A1 gene inhibits the reaction [Voriconazole results in decreased metabolism of and results in increased abundance of Lanosterol]
CYP51A1 gene results in decreased susceptibility to Voriconazole
CTD PMID:18694951 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [NR1I2 protein co-treated with NR1I3 protein] affects the metabolism of Voriconazole CTD PMID:23274663 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [NR1I2 protein co-treated with NR1I3 protein] affects the metabolism of Voriconazole CTD PMID:23274663 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19659
    role 19634
      biological role 19633
        antimicrobial agent 17784
          antifungal agent 16213
            conazole antifungal agent 5495
              conazole antifungal drug 846
                voriconazole 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    p-block element atom 19607
                      carbon group element atom 19550
                        carbon atom 19547
                          organic molecular entity 19588
                            organic molecule 19506
                              organic cyclic compound 19324
                                organic heterocyclic compound 18682
                                  heteroarene 16681
                                    monocyclic heteroarene 14210
                                      azole 13579
                                        triazoles 6049
                                          triazole antifungal agent 5064
                                            triazole antifungal drug 69
                                              voriconazole 8
paths to the root