Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:voriconazole
go back to main search page
Accession:CHEBI:10023 term browser browse the term
Definition:A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. It is an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4.
Synonyms:exact_synonym: (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
 related_synonym: (R-(R*,S*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol;   (alphaR,betaS)-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol;   Formula=C16H14F3N5O;   InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1;   InChIKey=BCEHBSKCWLPMDN-MGPLVRAMSA-N;   SMILES=C[C@@H](c1ncncc1F)[C@](O)(Cn1cncn1)c1ccc(F)cc1F;   VCZ;   Vfend;   voriconazol;   voriconazolum
 alt_id: CHEBI:127308
 xref: Beilstein:7694998;   CAS:137234-62-9;   DrugBank:DB00582;   Drug_Central:2846;   KEGG:C07622;   KEGG:D00578;   LINCS:LSM-5244
 xref_mesh: MESH:D065819
 xref: PMID:12940129;   PMID:22718362;   PMID:23392902;   PMID:23527908;   PMID:23766489;   PMID:24102553;   Patent:EP440372;   Patent:US5278175;   Wikipedia:Voriconazole


show annotations for term's descendants           Sort by:
 
voriconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car1 carbonic anhydrase 1 decreases activity ISO Voriconazole results in decreased activity of CA1 protein CTD PMID:31478295 NCBI chr 2:86,829,436...86,872,209 JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Voriconazole results in decreased activity of CA2 protein CTD PMID:31478295 NCBI chr 2:86,741,625...86,756,766 JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects metabolic processing
decreases activity
ISO CYP2C19 protein affects the metabolism of Voriconazole
Voriconazole results in decreased activity of CYP2C19 protein
CTD PMID:15328084 PMID:15914520 NCBI chr 1:237,938,521...237,976,238 JBrowse link
G Cyp51 cytochrome P450, family 51 multiple interactions
decreases response to substance
ISO CYP51A1 gene inhibits the reaction [Voriconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Voriconazole results in decreased metabolism of and results in increased abundance of 14-methylergosta-8,24(28)-dien-3,6-diol]; CYP51A1 gene inhibits the reaction [Voriconazole results in decreased metabolism of and results in increased abundance of Lanosterol]
CYP51A1 gene results in decreased susceptibility to Voriconazole
CTD PMID:18694951 NCBI chr 4:30,036,956...30,055,410 JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [NR1I2 protein co-treated with NR1I3 protein] affects the metabolism of Voriconazole CTD PMID:23274663 NCBI chr11:62,460,213...62,496,665 JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [NR1I2 protein co-treated with NR1I3 protein] affects the metabolism of Voriconazole CTD PMID:23274663 NCBI chr13:83,632,940...83,638,193 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      biological role 19708
        antimicrobial agent 17369
          antifungal agent 15054
            conazole antifungal agent 2897
              conazole antifungal drug 836
                voriconazole 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    p-block element atom 19651
                      carbon group element atom 19570
                        carbon atom 19560
                          organic molecular entity 19560
                            organic molecule 19493
                              organic cyclic compound 19322
                                organic heterocyclic compound 18554
                                  heteroarene 16514
                                    monocyclic heteroarene 13389
                                      azole 12569
                                        triazoles 3643
                                          triazole antifungal agent 2358
                                            triazole antifungal drug 64
                                              voriconazole 6
paths to the root