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Accession:CHEBI:10023 term browser browse the term
Definition:A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. It is an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4.
Synonyms:exact_synonym: (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
 related_synonym: (R-(R*,S*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol;   (alphaR,betaS)-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol;   Formula=C16H14F3N5O;   InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1;   InChIKey=BCEHBSKCWLPMDN-MGPLVRAMSA-N;   SMILES=C[C@@H](c1ncncc1F)[C@](O)(Cn1cncn1)c1ccc(F)cc1F;   VCZ;   Vfend;   voriconazol;   voriconazolum
 alt_id: CHEBI:127308
 xref: Beilstein:7694998;   CAS:137234-62-9;   DrugBank:DB00582;   Drug_Central:2846;   KEGG:C07622;   KEGG:D00578;   LINCS:LSM-5244
 xref_mesh: MESH:D065819
 xref: PMID:12940129;   PMID:22718362;   PMID:23392902;   PMID:23527908;   PMID:23766489;   PMID:24102553;   Patent:EP440372;   Patent:US5278175;   Wikipedia:Voriconazole

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voriconazole term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Car1 carbonic anhydrase 1 JBrowse link 2 88,185,204 88,227,486 RGD:6480464
G Car2 carbonic anhydrase 2 JBrowse link 2 88,097,740 88,112,868 RGD:6480464
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:6480464
G Cyp51 cytochrome P450, family 51 JBrowse link 4 27,175,564 27,194,018 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 13 89,585,072 89,591,278 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19779
    role 19727
      biological role 19726
        antimicrobial agent 17315
          antifungal agent 14870
            conazole antifungal agent 2886
              conazole antifungal drug 809
                voriconazole 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19779
    subatomic particle 19777
      composite particle 19777
        hadron 19777
          baryon 19777
            nucleon 19777
              atomic nucleus 19777
                atom 19777
                  main group element atom 19664
                    p-block element atom 19664
                      carbon group element atom 19559
                        carbon atom 19548
                          organic molecular entity 19548
                            organic molecule 19472
                              organic cyclic compound 19236
                                organic heterocyclic compound 18361
                                  heteroarene 15898
                                    monocyclic heteroarene 13313
                                      azole 12476
                                        triazoles 3618
                                          triazole antifungal agent 2362
                                            triazole antifungal drug 62
                                              voriconazole 7
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